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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 5, 1975 - Issue 1
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Original Articles

Preparation of Salicylaldehydes via the Ortho-Lithio Derivatives of Methoxymethyl-Protected Phenols

Pages 65-78 | Received 15 Nov 1974, Published online: 05 Dec 2006

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  • The rate of the metalation of I appears to be much faster than the rate observed in this laboratory during lithiation under similar conditions of various other aromatic ethers including p-cresol methyl ether. This suggests a similar influence of the methoxymethoxy substituent upon the rate of metalation as was recently demonstrated for the 2-methoxyethoxy substituent (reference 9)
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