References
- Jacob , P. , Anderson , S. , Meshul , C. , Shulgin , A. and Castagnoli , N. 1977 . J. Med. Chem. , 20 : 1235
- Meth-Cohn , O. and Tarnowski , B. 1978 . Synthesis. , : 56
- Meyer , R. H. United States Patent #3956395 . May 11, 1976 .
- Although secondary and tertiary mercaptans provide excellent yields of the ortho-alkyltho substituted benzaldehydes with 2-bromobenzaldehyde, the use of the alkoxy substituted bromobenzaldehydes affords mixture of the desired products and dehalogenated starting materials.
- In the caes of 4,5-methylenedioxy-2-bromobenzaldehyde (1d), cleavage of the methlenedioxy ether was the major pathway.
- Ketones react in a similar fashion. Unpublished results from these laboratories.
- Kametani , T. , Hirai , Kajiwara , Y. and Takahashi , M. 1975 . Chem. Pharm. Bull. , 23 : 2634
- Pschorr , R. 1912 . Liebigs. Ann. Chem. , 291 : 23
- Kametani , T. , Teriu , T. , Ozimo , T. and Fukumoto , K . 1969 . J. Chem. Soc., (C) , : 874
- Daliacker , F. 1960 . Liebias. Ann. Chem. , 603 : 14
- Kametani , T. , Takahashi , T. , Ihara , M. and Fukumoto , K. 1976 . J. Chem. Soc., Perkin Trans. I. , : 389
- Brown , E. and Robin , J. P. 1978 . Tetrahedron Lett. , : 3613
- Barfknecht , C. F. and Nichols , D. E. 1971 . J. Med. Chem. , 14 : 370