Pharmacokinetics of tramadol and its major metabolites following rectal and intravenous administration in dogs

Reference

• Barth , H , Giertz , H , Schmal , A and Lorenz , W . 1987 . Anaphylactoid reactions and histamine release do not occur after application of the opioid tramadol . Agents and Actions , 20 : 310 – 313 .
   PubMedGoogle Scholar
• de Sousa , AB , Santos , AC , Schramm , SG , Porta , V , Górniak , SL , Florio , JC and de Souza Spinosa , H . 2008 . Pharmacokinetics of tramadol and O-desmethyltramadol in goats after intravenous and oral administration . Journal of Veterinary Pharmacology and Therapeutics , 31 : 45 – 51 .
   PubMed Web of Science ®Google Scholar
• Elghazali , M , Barezaik , IM , Abdel , Hadi , Eltayeb , FM , Al , Masri and Wasfi , IA . 2008 . The pharmacokinetics, metabolism and urinary detection time of tramadol in camels . Veterinary Journal , 178 : 272 – 277 .
   PubMedGoogle Scholar
• Gabrielsson , J and Weiner , D. 2002 . Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications , Stockholm, , Sweden : Swedish Pharmaceutical Press .
   Google Scholar
• Gillen , C , Haurand , M , Kobelt , DJ and Wnendt , S . 2000 . Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor . Naunyn-Schmiedeberg's Archives of Pharmacology , 362 : 116 – 121 .
   PubMed Web of Science ®Google Scholar
• Giorgi , M , Saccomanni , G , Daniello , MR , Manera , C , Soldani , G , Ferrarini , PL and Giusiani , M . 2006 . In vitro metabolism of tramadol in horses: preliminary data . Journal of Veterinary Pharmacology and Therapeutics , 29 : 124 – 124 .
   Google Scholar
• Giorgi , M , Soldani , G , Manera , C , Ferrarini , PL , Sgorbini , M and Saccomanni , G . 2007 . Pharmacokinetics of tramadol and its metabolites M1, M2 and M5 in horses following intravenous, immediate release (fasted/fed) and sustained release single dose administration . Journal of Equine Veterinary Science , 27 : 481 – 488 .
   Web of Science ®Google Scholar
• Giorgi , M , Del , Carlo , Sgorbini , M and Saccomanni , G . 2009 a . “ Pharmacokinetics of tramadol and its metabolites M1, M2 and M5 in donkeys following intravenous and oral immediate release single dose administration ” . In Journal of Equine Veterinary Science (In press)
   Google Scholar
• Giorgi , M , Saccomanni , G , Lebkowska-Wieruszewska , B and Kowalski , C . 2009 b . Pharmacokinetic evaluation of tramadol and its major metabolites after single oral sustained tablet administration in the dog: a pilot study . Veterinary Journal , 180 : 253 – 255 .
   PubMedGoogle Scholar
• Grond , S and Sablotzki , A . 2004 . Clinical pharmacology of tramadol . Clinical Pharmacokinetics , 43 : 879 – 923 .
   PubMed Web of Science ®Google Scholar
• Grond , S , Meuser , T , Uragg , H , Stahlberg , HJ and Lehmann , KA . 1999 . Serum concentrations of tramadol enantiomers during patient-controlled analgesia . British Journal of Clinical Pharmacology , 48 : 254 – 257 .
   PubMed Web of Science ®Google Scholar
• Gupta , PJ . 2007 . Suppositories in anal disorders: a review . European Review for Medical and Pharmacological Sciences , 11 : 165 – 170 .
   PubMedGoogle Scholar
• Hojo , T , Ohno , R , Shimoda , M and Kokue , E . 2002 . Enzyme and plasma protein induction by multiple oral administrations of phenobarbital at a therapeutic dosage regimen in dogs . Journal of Veterinary Pharmacology and Therapeutics , 25 : 121 – 127 .
   PubMedGoogle Scholar
• Kögel , B , Englberger , W , Hennies , HH and Friderichs , E . 1999 . “ Involvement of metabolites in the analgesic action of tramadol ” . In Proceedings of the 9th World Congress of Pain 523 – 523 .
   Google Scholar
• KuKanich , B and Papich , MG . 2004 . Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs . Journal of Veterinary Pharmacology and Therapeutics , 27 : 239 – 246 .
   PubMed Web of Science ®Google Scholar
• Lehmann , KA , Kratzenberg , U , Schroeder-Bark , B and Horrichs-Haermeyer , G . 1990 . Postoperative patient-controlled analgesia with tramadol: analgesic efficacy and minimum effective concentrations . Clinical Journal of Pain , 6 : 212 – 220 .
   PubMed Web of Science ®Google Scholar
• Lintz , W , Erlaçin , S , Frankus , E and Uragg , H . 1981 . Biotransformation of tramadol in man and animal . Arzneimittel-Forschung , 31 : 1932 – 1943 .
   PubMed Web of Science ®Google Scholar
• Lintz , W , Barth , H , Osterloh , G and Schmidt-Böthelt , E. 1998 . Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations. 3rd Communication: suppositories . Arzneimittel-Forschung , 48 : 889 – 899 .
   PubMedGoogle Scholar
• Malonne , H , Sonet , B , Streel , B , Lebrun , S , De , Niet , Sereno , A and Vanderbist , F . 2004 . Pharmacokinetic evaluation of a new oral sustained release dosage form of tramadol . British Journal of Clinical Pharmacology , 57 : 270 – 278 .
   PubMed Web of Science ®Google Scholar
• Nakamura , A , Yamamoto , Y , Tasaki , T , Sugimoto , C , Masuda , M , Kazusaka , A and Fujita , S . 1995 . Purification and characterization of a dog cytochrome P450 isozyme belonging to the CYP2D subfamily and development of its antipeptide antibody . Drug Metabolism and Disposition , 23 : 1268 – 1273 .
   PubMed Web of Science ®Google Scholar
• Nosal'ova , G , Strapkova , A and Korpas , J . 1991 . Relationship between the antitussic and analgesic activity of substances . Acta Physiologica Hungarica , 77 : 173 – 178 .
   PubMedGoogle Scholar
• Pypendop , BH and Ilkiw , JE . 2008 . Pharmacokinetics of tramadol, and its metabolite O-desmethyl-tramadol, in cats . Journal of Veterinary Pharmacology and Therapeutics , 31 : 52 – 59 .
   PubMed Web of Science ®Google Scholar
• Raffa , RB , Friderichs , E , Reimann , W , Shank , RP , Codd , EE and Vaught , JL . 1992 . Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an ‘atypical’ opioid analgesic . Journal of Pharmacology and Experimental Therapeutics , 260 : 275 – 285 .
   PubMed Web of Science ®Google Scholar
• Raffa , RB , Friderichs , E , Reimann , W , Shank , RP , Codd , EE , Vaught , JL , Jacoby , HI and Selve , N . 1993 . Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol . Journal of Pharmacology and Experimental Therapeutics , 267 : 331 – 340 .
   PubMed Web of Science ®Google Scholar
• Schwartz , S and Pateman , T . 2004 . “ Preclinical pharmacokinetics ” . In Handbook of Bioanalysis and Drug Metabolism , Edited by: Evans , G . 113 – 131 . Boca Raton FL, , USA : CRC Press LLC . In:
   Google Scholar
• Scott , LJ and Perry , CM . 2000 . Tramadol: a review of its use in perioperative pain . Drugs , 60 : 139 – 176 .
   PubMed Web of Science ®Google Scholar
• Shilo , Y , Britzi , M , Eytan , B , Lifschitz , T , Soback , S and Steinman , A . 2008 . Pharmacokinetics of tramadol in horses after intravenous, intramuscular and oral administration . Journal of Veterinary Pharmacology and Therapeutics , 31 : 60 – 65 .
   PubMed Web of Science ®Google Scholar
• Subrahmanyam , V , Renwick , AB , Walters , DG , Young , PJ , Price , RJ , Tonelli , AP and Lake , BG . 2001 . Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes . Drug Metabolism and Disposition , 29 : 1146 – 1155 .
   PubMed Web of Science ®Google Scholar
• Warren , PM , Taylor , JH , Nicholson , KE , Wraith , PK and Drummond , GB . 2000 . Influence of tramadol on the ventilatory response to hypoxia in humans . British Journal of Anaesthesia , 85 : 211 – 216 .
   PubMed Web of Science ®Google Scholar
• Wilder-Smith , CH and Bettiga , A . 1997 . The analgesic tramadol has minimal effect on gastrointestinal motor function . British Journal of Clinical Pharmacology , 43 : 71 – 75 .
   PubMedGoogle Scholar
• Yamaoka , K , Terumichi , N and Uno , T . 1978 . Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations . Journal of Pharmacokinetics and Biopharmaceutics , 6 : 165 – 175 .
   PubMedGoogle Scholar
• Zwaveling , J , Bubbers , S , van , Meurs , Schoemaker , RC , van , Heel , Vermeij , P and Burggraaf , J . 2004 . Pharmacokinetics of rectal tramadol in postoperative paediatric patients . British Journal of Anaesthesia , 93 : 224 – 227 .
   PubMed Web of Science ®Google Scholar