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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 8-9
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Research Article

Accelerator mass spectrometry (AMS): recent experience of its use in a clinical study and the potential future of the technique

G. Young Division of Bioanalysis and Drug Metabolism, Glaxo Wellcome Research and Development Ltd, Park Road, Ware SG12 ODP, UK
,
W. Ellis Division of Bioanalysis and Drug Metabolism, Glaxo Wellcome Research and Development Ltd, Park Road, Ware SG12 ODP, UK
,
J. Ayrton Division of Bioanalysis and Drug Metabolism, Glaxo Wellcome Research and Development Ltd, Park Road, Ware SG12 ODP, UK
,
E. Hussey Division of Bioanalysis and Drug Metabolism, Glaxo Wellcome Research and Development Ltd, Park Road, Ware SG12 ODP, UK
&
B. Adamkiewicz Division of Bioanalysis and Drug Metabolism, Glaxo Wellcome Research and Development Ltd, Park Road, Ware SG12 ODP, UK
Pages 619-632 | Published online: 22 Sep 2008

References

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  • FREEMAN, S. P. H. T., KING, J. C., VIEIRA, N. E., WOODHOUSE, L. R. and YERGEY, A. L., 1997, Human calcium metabolism including bone resorption measured with 41 Ca tracer. Nuclear Instruments and Methods in Physics Research, B123, 266–270.
  • GARNER, R. C., 2000, Accelerator mass spectrometry in pharmaceutical research and development — a new ultrasensitive analytical method for isotope measurement. Current Drug Metabolism, 1, 205–213.
  • GARNER, R. C., BARKER, J., FLAVELL, C., GARNER, J. V., WHATTAM, M., YOUNG, G. C., CUSSANS, N., JEZEQUEL, S. and LEONG, D., 2000, A validation study comparing accelerator mass spectrometry and liquid scintillation counting for analysis of [14C]-labelled drugs in plasma, urine and faecal extracts. Journal of Pharmaceutical and Biomedical Analysis, 24, 197–209.
  • ICH GUIDELINE 1996, The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use ( ICH) Guideline, 1996, Q2B Validation of Analytical Procedures: Methodology.
  • KAYE, B., GARNER, R. C., MAUTHE, R. J., FREEMAN, S. P. H. T. and TURTELTAUB, K. W., 1997, A preliminary evaluation of accelerator mass spectrometry in the biomedical field. Journal of Pharmaceutical and Biomedical Analysis, 16, 541–543.
  • NELSON, D. E., KORTELING, R. G. and SCOTT, W. R., 1977, Carbon-14: direct detection at natural concentrations. Science, 198, 507–508.
  • VOGEL, J. S., 1992, Rapid production of graphite without contamination for biomedical ANIS. Radiocarbon, 34, 344–350.

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