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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 8-9
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Research Article

Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog

D. K. Walker Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
,
K. C. Beaumont Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
,
P. Comby Centre de Recherche Pfizer, BP 159, 37401 Amboise Cedex, France
,
K. M. Evans Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
,
J. I. Gedge Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
,
R. C. Halliday Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
,
S. J. Roffey Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
&
P. A. Wright Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
 show all
Pages 651-664 | Published online: 22 Sep 2008

References

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  • WALKER, D. K., ACKLAND, M. J., JAMES, G. C., MUIRHEAD, G. J., RANCE, D. J., WASTALL, P. and WRIGHT, P. A., 1999, Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man. Xenobiotica, 29, 297–310.
  • WALLIS, R. M., CORBIN, J. D., FRANCIS, S. H. and Ews, P., 1999, Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. American Journal of Cardiology, 83, 3C–12C.

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