Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 2
39
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Identification of the human P450 enzymes involved in the in vitro metabolism of the synthetic steroidal hormones Org 4060 and Org 30659

, , , &
Pages 109-118 | Published online: 22 Sep 2008

References

  • AOYAMA, T., YAMANO, S., WAXMAN, D. J., LAPENSON, D. P., MEYER, U. A., FISCHER, V., TYNDALE, R., INABA, T., KALOW, W., GELBOIN, H. V. and GONZALEZ, F. J., 1989, Cytochrome P450 hPCN3, a novel cytochrome P-450 Ma gene product that is differentially expressed in adult human liver. Journal of Biological Chemistry, 264, 10388–10395.
  • BALDWIN, S. J., BLOOMER, J. C., SMITH, G. J., ÄYRTON, A. D., CLARKE, S. E. and CHENERY, R. J., 1995, Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9. Xenobiotica, 25, 261–270.
  • DECKERS, G. H., SCHOONEN, W. G. and KLOOSTERBOER, H. J., 1992, Receptor binding and biological studies with norethisterone derivatives. In Proceedings of the 74th Annual Meeting of the Endocrine Society (Bethesda: Endocrine Society), p. 234.
  • GENTILE, D. M., VERHOEVEN, C. H. J., SHIMADA, T. and BACK, D. J., 1998, The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel. Journal of Pharmacology and Experimental Therapeutics, 287, 975–982.
  • GUENGERICH, F. P., 1996, In vitro techniques for studying drug metabolism. Journal of Pharmacokinetks and Biopharmacology, 24, 521–533.
  • HUNT, C. M., WATKINS, P. B., SAENGER, P., STAVE, G. M., BARLASCINI, N., WATLINGTON, C. 0., WRIGHT, J. T. and GUZELIAN, P. S., 1992, Heterogeneity of CYP3A isoforms metabolizing erythomycin and cortisol. Clinical Pharmacology and Therapeutics, 51, 18–23.
  • Li, A. P., KAMINSKI, D. L. and RASMUSSSEN, A, 1995, Substrates of human hepatic cytochrome P450 3A4. Toxicology, 104, 1–8.
  • LOWRY, 0. H., ROSEBROUGH, N. J., FARR, A. L. and RANDALL, R. J., 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.
  • OMURA, T. and SATO, R., 1964, The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry, 239, 2370–2378.
  • SCHMIDER, J., GREENBLATT', D. J., MOLTKE, L. L. V, KARSOV, D., VENA, R., FRIEDMAN, H. L. and SHADER, R. I., 1997, Biotransformation of mestranol to ethinyl oestradiol in vitro: the role of Cytochrome P-450 2C9 and metabolic inhibitors. Journal of Clinical Pharmacology, 37, 193–200.
  • SHIMADA, T., YAMAZAKI, H., MIMURA, M., INUI, Y. and GUENGERICH, F. P., 1994, Interindividual variation in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of Pharmacology and Experimental Therapeutics, 270, 414–423.
  • VERHOEVEN, C. H. J., KREBBERS, S. F. M., WAGENAARS, G. N., BOOY, C. J., GROOTHUIS, G. M. M., OLINGA, P. and Vos, R. M. E., 1998, The in vitro and in vivo metabolism of the progestagen Org 30659 in several species. Drug Metabolism and Disposition, 26, 1102–1112.
  • WAXMAN, D. J., ÄTTISANO, C., GUENGERICH, F. P. and LAPENSON, D. P., 1988, Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6[3-hydroxylase cytochrome P450 enzyme. Archives of Biochemistry and Biophysics, 263, 424–436.
  • WILKINSON, G. R., 1996, Cytochrome P4503A (CYP3A) metabolism: prediction of the in vivo activity in humans. Journal of Pharmacokinetics and Biopharmacology, 24, 475–490.
  • WRIGHTON, S. A., RING, B. J., WATKINS, P. B. and VANDENBRANDEN, M., 1989, Identification of a polymorphically expressed member of the human cytochrome P450III Family. Molecular Pharmacology, 36, 97–105.
  • WRIGirroN, S. A., VANDENBRANDEN, M. and RING, B. J., 1996, The human drug metabolizing cytochromes P450. Journal of Pharmacokinetics and Biopharmacology, 24, 461–473.
  • YAMAZAKI, H. and SHIMADA, T., 1997, Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9 and 3A4 in human liver microsomes. Archives of Biochemistry and Biophysics, 346, 161–169.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.