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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 11
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Research Article

Disposition of LY333531, a selective protein kinase C β inhibitor, in the Fischer 344 rat and beagle dog

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Pages 1045-1052 | Published online: 22 Sep 2008

References

  • BREWER, E., VITALE, K., MANN, M., LOWES, S., HUMPHRIES, D., Li, Q., GARNER, C. O. and HENION, J. 1999. Determination of LY333531 and its desmethyl metabolite in plasma from multiple species by API LC/MS/MS. In Proceedings of the 47th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics. Dallas, TX.
  • DANIS, R. P., BINGAMAN, D. P., JIROUSEK, M. R. and YANG, Y., 1998, Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKC 13 inhibition with LY333531. Investigative Ophthalmology and Visual Science, 39, 171–179.
  • ISHH., JIROUSEK, M. R., KOYA, D., TAKAGI, C., XIA, P., CLERMONT, A., BURSELL, S.-E., KERN, T. S., BALLAs, L. M., HEATH, W. F., STRAMM, L. E., FEENER, E. P. and KING, G. L., 1996, Amelioration of vascular dysfunctions in diabetic rats by an oral PKC /I inhibitor. Science, 272, 728–731.
  • KOWLURU, R., JIROUSEK, M., STRAMM, L., ENGERMAN, R. and KERN, T., 1996, Diabetes-induced disorders of retinal protein kinase C and Na,K-ATPase are inhibited by LY333531. Diabetes, 45(S2), 16A.
  • KOWLURU, R. A., JIROUSEK, M. R., STRAMM, L. E., FARID, N. A., ENGERMAN, R. L. and KERN, T. S., 1998, Abnormalities of retinal metabolism in diabetes or experimental galactosemia. V. Relationship between protein kinase C ATPases. Retinal protein kinase C in diabetes. Diabetes, 47, 464–469.
  • KOYA, D. and KING, G. L., 1998, Protein kinase C activation and the development of diabetic complications. Diabetes 47, 859–866.

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