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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 11
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Research Article

Differential induction of midazolam metabolism in the small intestine and liver by oral and intravenous dexamethasone pretreatment in rat

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Pages 975-984 | Published online: 22 Sep 2008

References

  • CHUNG, W. G., Rou, H. K., KIM, H. M. and CHA, Y. N., 1998, Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine, identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patterns. Chemical and Biological Interactions, 113, 1–14.
  • EECKHOUDT, S. L., DESAGER, J. P., HORSMANS, Y., DE WINNE, A. J. and VERBEECK, R. K., 1998, Sensitive assay for midazolam and its metabolite 11-hydroxymidazolam in human plasma by capillary high-performance liquid chromatography. Journal of Chromatography B, 710, 165–171.
  • GHOSAL, A., SATO, R., THOMAS, P. E., Bust', E. and MOORE, D., 1996, Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cDNA-expressed human cytochrome P450. Drug Metabolism and Disposition, 24, 940–947.
  • GORSKI, J. C., HALL, S. D., JONES, D. R., VANDENBRANDEN, M. and WRIGHTON, S. A., 1994, Regioselective biotransformation of midazolam by members of the human cytochrome P450 (CYP3A) subfamily. Biochemical Pharmacology, 47, 1643–1653.
  • GUSHCHIN, G. V., GUSHCHIN, M. I., GERBER, N. and BOYD, R. T., 1999, A novel cytochrome P450 3A isoenzyme in rat intestinal microsomes. Biochemical and Biophysical Research Communications, 255, 394–398.
  • HIGASHIKAWA, F., MURAKAWI, T., KANEDA, T. and TAKANO, M., 1995, In vivo and in vitro metabolic clearance of midazolam, a cytochrome P450 3A substrate, by the liver under normal and increased enzyme activity in rats. Journal of Pharmaceutics and Pharmacology, 51, 405–410.
  • KAMINSKY, L. S. and Fasco, M. J., 1992, Small intestinal cytochrome P450. Critical Reviews in Toxicology, 21, 407–422.
  • KEELAN, M., DORING, K., TAVERNINI, M., WIERZBICKI, E., CLANDININ, M. T. and THOMSON, A. B., 1994, Dietary omega 3 fatty acids and cholesterol modify enterocyte microsomal membrane fosfolipids, cholesterol content and phospholipid enzyme activities in diabetic rats. Lipids, 29, 851–858.
  • KOLARS, J. C., SCHMIEDLIN-REN, P., DOBBINS, W. O., SCHUETZ, J., WRIGHTON, S. A. and WATKINS, P. B., 1992, Heterogeneity of cytochrome P450IIIA expression in rat gut Epithelia. Gastroenterology, 102, 1186–1198.
  • KRISHNA, D. R. and KLOTZ, U., 1994, Extrahepatic metabolism of drugs in humans. Clinical Pharmacokinetics, 26,144–160.
  • LECLERCQ, I., SALIEZ, A., WALLEMACQ, P. E., HORSMANS, Y. and LAMBOTTE L., 1997, The monoethylglycinexylidide test does not correctly evaluate lidocaine metabolism after ischemic liver injury in the rat. Hepatology, 26, 1182–1188.
  • LOWRY, O. H., ROSEBROUGH, N. J., FAR, A. L. and RkNDALL, R. J., 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.
  • Lu, A. Y. and WEST, S. B., 1979, Multiplicity of mammalian microsomal cytochromes P-450. Pharmacology Reviews, 31, 277–295.
  • PORTER, T. D. and COON, M. J., 1991, Cytochrome P450: multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms. Journal of Biological Chemistry, 266, 13469–13472.
  • RENDIC, S. and DI CARLO, F. J., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metabolism Reviews, 29, 413–580.
  • SCHMIEDLIN-REN, P., BENEDICT, P. E., DOBBINS, W. O., GHOSH, M., KOLARS, J. C. and WATKINS, P. B., 1993, Cultured adult rat jejunal explants as a model for studying regulation of CYP3A. Biochemical Pharmacology, 46, 905–918.
  • TELKADA, M. B., PEREIRA, T. M. and LECHNER, M.-C., 1992, Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development. Archives in Biochemistry and Biophysics, 298, 715–725.
  • THUMMEL, K. E., O'SHEA, D., PAINE, M. F., SHEN, D. D., LUNZE, K. L., PERKINS, J. D. and WILKINSON, G. R., 1996, Oral first-pass elimination of midazolam involves both gastro-intestinal and hepatic CYP3A-mediated metabolism. Clinical Pharmacology and Therapeutics, 59, 491–502.
  • THUMMEL, K. E. and WILKINSON, G. R., 1998, In vitro and in vivo drug interactions involving human CYP3A. Annual Reviews in Pharmacology and Toxicology, 38, 389–430.
  • WATANABE, M., TATEISHI, T., ASOH, M., NAKURA, H., TANAKA, M., KUMAI, T. and KOBAYASHI, S., 1998, Effects of glucocorticoids on pharmacokinetics and pharmacodynamics of midazolam in rats. Life Sciences, 63, 1685–1692.
  • WATKINS, P. B., WRIGHTON, S. A., SCHUETZ, E. G., MOLOWA, D. T. and GUZELIAN, P. S., 1987, Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. Journal of Clinical Investigation, 80, 1029–1036.
  • WONG, S. G., LIN, E. H. and MARKS, G. S., 1999, Cytochrome CYP sources of N-alkylprotoporphyrin IX after administration of porphyrogenic xenobiotics to rats. Drug Metabolism and Disposition, 27, 960–965.
  • WU, C.-Y., BENET, L. Z., HERBERT, M. F., GUPTA, S. K., ROWLAND, M., GOMEZ, D. Y. and WACHER, V. J., 1995, Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporin. Clinical Pharmacology and Therapeutics, 58, 492–497.
  • ZHANG, Q.-Y., WIKO, J., DUNBAR, D. and KAMINSKY, L., 1996, Characterization of rat small intestinal cytochrome P450 composition and inducibility. Drug Metabolism and Disposition, 24, 322–328.

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