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Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 7
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Research Article

Application of 1 H- and 19 F-NMR spectroscopy in the investigation of the urinary and biliary excretion of 3,5-, 2,4-ditrifluoromethylbenzoic and pentafluorobenzoic acids in rat

C. A. Blackledge Department of Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College of Science Technology and Medicine, South Kensington, London SW7 2AZ, UK
,
J. K. Nicholson Department of Drug Metabolism and Pharmacokinetics, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield SK10 4TG, UK
,
J. A. Evans Department of Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College of Science Technology and Medicine, South Kensington, London SW7 2AZ, UK
,
C. Rodgers Department of Drug Metabolism and Pharmacokinetics, AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield SK10 4TG, UK
&
I. D. Wilson Department of Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College of Science Technology and Medicine, South Kensington, London SW7 2AZ, UK
Pages 605-613 | Published online: 22 Sep 2008

References

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  • CALDWELL. J., 1984, Xenobiotic acyl- coenzymes A: critical intermediates in the biochemical pharmacology and toxicology of carboxylic acids. Biochemical Society Transactions, 12, 9–11.
  • CALDWELL, J., 1985, Novel xenobiotic-lipid conjugates. Biochemical Society Transactions, 13, 852–854.
  • CUPID, B. C., BEDDELL, C. R., WILSON, I. D., LINDON, J. C. and NICHOLSON, J. K., 1996, Quantitative structure-metabolism relationships for substituted benzoates in the rabbit: prediction of urinary excretion of glycine and glucuronide conjugates. Xenobiotica, 26, 157–176.
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  • GHAURI, F. Y., BLACKLEDGE, C. A., GLEN, R. C., SWEATMAN, B. C., LINDON, J. C., BEDDELL, C. R., WILSON, I. D. and NICHOLSON, J. K., 1992b, Quantitative structure—metabolism relationships of substituted benzoic acids in the rat. Computational chemistry, NMR spectroscopy and computer pattern recognition studies. Biochemical Pharmacology, 44, 1935–1946.
  • LENZ, E. M., WILSON, I. D., WRIGHT, B., PARTRIDGE, E. A., RODGERS, C. T., LINDON, J. C. and NICHOLSON, J. K., 2002, A comparison of quantitative NMR and radiolabelling studies of the metabolism and excretion of Statil (3-(4-bromo-2-fluorobenzy1)-4-oxo-3H-phthalazin-1-ylacetic acid in the rat. Journal of Pharmaceutical and Biomedical Analysis, 28, 31–43.
  • SPURWAY, T. D., GARTLAND, K. P. R., WARRANDER, A., PICKFORD, R., NICHOLSON, J. K. and WILSON, I. D., 1990, Proton nuclear magnetic resonance of urine and bile from paracetamol dosed rats. Journal of Pharmaceutical and Biomedical Analysis, 8, 969–973.
  • WILSON, I. D. and IsmAiL, I. M., 1986, A rapid method for the isolation and identification of drug metabolites from human urine using solid phase extraction and proton NNIR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, 4, 663–665.
  • WILSON, I. D. and NICHOLSON, J. K., 1988, Solid phase extraction and NMR spectroscopy (SPEC-NiVIR) for the rapid identification of drug metabolites in urine. Journal of Pharmaceutical and Biomedical Analysis, 6, 151–165.
  • WILSON, I. D. and NICHOLSON, J. K., 1987, Solid phase extraction chromatography and nuclear magnetic resonance spectroscopy for the isolation of drug metabolites in urine. Analytical Chemistry, 59, 2830–2832.

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