Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 32, 2002 - Issue 11
45
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population

, , , , , , & show all
Pages 1053-1062 | Published online: 22 Sep 2008

References

  • BOUCHER, P., SEREE, E., VIDON, C., DE SOUZA, A. C., VILLARD, P. H., CHAMBON, R., BARRA, Y. and VALLON, J. J., 2000, Dietary lipid affect human ethanol-inducible CYP2E1 gene expression in vivo in mononuclear cells. Life Science, 67, 1307–1316.
  • BURCKART, G. J., FRYE, R. F., KELLY, P., BRANCH, R. A., JAux, A., FUNG, J. J., STARZL, T. E. and VENKATARAMANAN, R., 1998, Induction of CYP2E1 activity in liver transplant patients as measured by chlorzoxazone 6-hydroxylation. Clinical Pharmacology and Therapeutics, 63, 296–302.
  • CARRIER, V., GOASDURR, T., RATANASAVANH, D., MOREL, F., GAUTIER, J. C., GUILLOUZO, A., BEAUNE, P. and BERTHOU, F., 1993, Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone. Chemical Research in Toxicology, 6, 852–857.
  • CARRIERE, V., BERTHOU, F., BAIRD, S., BELLOE, C., BEAUNE, P. and DE WAZIERS, I., 1996, Human cytochrome P450 2E1 (CYP2E1): from genotype to phenotype. Pharmacogenetics, 6, 203–211.
  • FRYE, R. F., ADEDOYIN, A., MAURO, K., MATZKE, G. R. and BRANCH, R. A., 1998, Use of chlorzoxazone as an in vivo probe of cytochrome P450 2E1: choice of dose and phenotypic trait measure. Journal of Clinical Pharmacology, 38, 82–89.
  • FUHR, U., 2000, Induction of drug metabolising enzymes. Clinical Pharmacokinetics, 38, 493–504.
  • GARTON, K. J., YUEN P., MEINWALD, J., THUMMEL, K. E. and KHARASCH, E. D., 1995, Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1. Drug Metabolism and Disposition, 23, 1426–1430.
  • GORSKI, J. C., JONES, D. R., WRIGHTON, S. A. and HALL, S. D., 1997, Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone. Xenobiotica, 27, 243–256.
  • HAN, X. M. and Zuou, H. H., 2000, Polymorphism of CYP450 and cancer susceptibility. Ada Pharmacologica Sinica, 21, 673–679.
  • HANNON-FLETCHER, M. P., OKANE, M. J., MOLES, K. W., BARNETT, Y. A. and BARNETT, C. R., 2001, Lymphocyte cytochrome P450-CYP2E1 expression in human IDDM subjects. Food and Chemical Toxicology, 39, 125–132.
  • HAYASHI, S., WANTANABE, J. and KAVAJIRI, K., 1991, Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of human cytochrome P4502E1 gene. Journal of Biochemistry, 110, 559–565.
  • HUNT, C. M., STRATER, S. and STAVE, E. M., 1990, Effect of normal aging on the activity of human hepatic cytochrome P450IIEI. Biochemical Pharmacology, 40, 1666–1669.
  • INGELMAN-SUNDBERG, M., JOHANSSON, I., YIN, H., TERELIUS, Y., ELIASSON, E., CLOT, P. and ALBANO, E., 1993, Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease. Alcohol, 10, 447–452.
  • JOHANSSON, I., LINDROS, K. O., ERIKSSON, H. and INGELMAN-SUNDBERG, M., 1990, Transcriptional control of CYP2E1 in the perivenous liver region and during starvation. Biochemical and Biophysical Research Communications, 173, 331–338.
  • KHARASCH, E. D. and THUMMEL, K. E., 1993, Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology, 79, 795–807.
  • KHARASCH, E. D., HANKINS, D. C. and Cox, K., 1999a, Clinical isoflurane metabolism by cytochrome P450 2E1. Anesthesiology, 90, 766–771.
  • KHARASCH, E. D., HANKINS, D. C., JUBERT, C., THUMMEL, K. E. and TARADAY, J. K., 1999b, Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1. Drug Metabolism and Disposition, 27, 717–723.
  • Kim, R. B., O'SHEA, D. and WILKINSON, G. R., 1995 Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphism. Clinical Pharmacology and Therapeutics, 57, 645–655.
  • Kim, R. B., O'SHEA, D. and WILKINSON, G. R., 1994, Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxylation of chlorzoxazone: a putative measure of CYP2E1 activity. Pharmacogenetics, 4,162–165.
  • KIM, R. B., YAMAZAKI, H., CHIBA, K., O'SHEA, D., MIMURA, M., GUENGERICH, F. P., ISHIZAKI, T., SHIMADA, T. and WILKINSON, G. R., 1996, In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians. Journal of Pharmacology and Experimental Therapeutics, 279, 4–11.
  • KURATA, N., NISHIMURA, Y., IwasE, M., FISCHER, N. E., TANG, B. K., INABA, T. and YASUHARA, H., 1998, Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica, 28, 1041–1047.
  • LE MARCHAND, L., WILKINSON, G. R. and WILKENS, L. R., 1999, Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiology, Biomarkers and Prevention, 8, 495–500.
  • LIN, D. X., TANG, Y. M., PENG, Q., Lu, S. X., AMBROSONE, C. B. and KADLUBAR, F. F., 1998, Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases Ti, P1, and M1 and cytochrome P450 2E1. Cancer Epidemiology, Biomarkers and Prevention, 7, 1013–1018.
  • LOIZOU, G. D. and COCKER, J., 2001, The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone. Human and Experimental Toxicology, 20, 321–327.
  • LU, S. H., Cum, S. X., YANG, W. X., Hu, X. N., Goo, L. P. and Li, F. M., 1991, Relevance of N-nitrosamines to oesophageal cancer in China. IARC Scientific Publications, 105,11–17.
  • LUCAS, D., BERTHOU, F., GIRRE, C., POITRENAUD, F. and MENEZ, J. F., 1993, High-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in serum: a tool for indirect evaluation of cytochrome P4502E1 activity in humans. Journal of chromatography, 622, 79–86.
  • LUCAS, D., FAREZ, C., BARDOU, L. G., VAISSE, J., ATTALI, J. R. and VALENSI, P., 1998, Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation. Fundamental and Clinical Pharmacology, 12, 553–558.
  • LUCAS, D., FERRARA, R., GONZALEZ, E., BODENEZ, P., ALBORES, A., MANNO, M. and BERTHOU, F., 1999, Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans. Pharmacogenetics, 9,377–388.
  • LUCAS, D., MENEZ, C., GIRRE, C., BERTHOU, F., BODENEZ, P., JOANNET, I., HISPARD, E., BARDOU, L. G. and MENEZ, J. F., 1995, Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects. Pharmacogenetics, 5,298–304.
  • MANYIKE, P. T., KHARASCH, E. D., KALHORN, T. F. and SLATTERY, J. T., 2000, Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Clinical Pharmacology and Therapeutics, 67, 275–282.
  • MORIMOTO, M., HAGBJORK, A. L., NAND, A. A., INGELMAN-SUNDBERG, M., LINDROS, K. O., Fu, P. C., ALBANO, E. and FRENCH, S. W., 1993, Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis. Alcohol, 10, 459–464.
  • ONO, S., HATANAKA, T., HOTTA, H., TSUTSUI, M., SATOH, T. and GONZALEZ, F. J., 1995, Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1. Pharmacogenetics, 5, 143–150.
  • O'SHEA, D., Davis, S. N., Kim, R. B. and WILKINSON, G. R., 1994, Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity. Clinical Pharmacology and Therapeutics, 56, 359–367.
  • PAN, J., HONG, J. Y. and YANG, C. S., 1992, Post-transcriptional regulation of mouse renal cytochrome P450 2E1 by testosterone. Archives of Biochemistry and Biophysics, 299, 110–115.
  • PETER, R., BOCKER, R., BEAUNE, P. H., IWASAKI, M., GUENGERICH, F. P. and YANG, C. S., 1990, Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-45011EI. Chemical Research in Toxicology, 3, 566–573.
  • PRESCOTT, L. F., 2000, Paracetamol, alcohol and the liver. British Journal of Clinical Pharmacology, 49, 291–301.
  • RAUCY, J. L., SCHULTZ, E. D., WESTER, M. R., ARORA, S., JOHNSTON, D. E., OMDAHL, J. L. and CARPENTER, S. P., 1997, Human lymphocyte cytochrome P450 2E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity. Drug Metabolism and Disposition, 25, 1429–1435.
  • ROTHMAN, N., SMITH, M. T., HAYES, R. B., TRAVER, R. D., HOENER, B., CAMPLEMAN, S., Li, G. L., DOSEMECI, M., LINET, M., ZHANG, L., XI, L., WACHOLDER, S., Lu, W., MEYER, K. B., TITENKO HOLLAND, N., STEWART, J. T., YIN, S. and Ross, D., 1997, Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQ01 609C T mutation and rapid fractional excretion of chlorzoxazone. Cancer Research, 57, 2839–2842.
  • SHIMADA, T., YAMAZAKI, H., MIMURA, M., INUI, Y. and GUENGERICH, F. P., 1994, Interindividual variation in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, cardinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of Pharmacology and Experimental Therapeutics, 270, 414–423.
  • STREETMAN, D. S., BEATING, J. S. and NAFZIGER, A. N., 2000, Phenotype of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotype. Pharmacogenetics, 10, 187–216.
  • TAN, W., SONG, N., WANG, G. Q., Liu, Q., TANG, H. J., KADLUBAR, F. F. and LIN, D. X., 2000, Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases Ml, Ti, and P1 on susceptibility to esophageal cancer among high-risk individuals in China. Cancer Epidemiology, Biomarkers and Prevention, 9, 551–556.
  • TANAKA, E., TERADA, M. and MISAWA, S., 2000, Cytochrome P450 2E1: its clinical and toxicological role. Journal of Clinical Pharmacy and Therapeutics, 25, 165–175.
  • UEMATSU, F., Kutuctii, H. and MOTOMIYA, M., 1991, Association between restriction fragment length polymorphism of human cytochrome P4502E1 and susceptibility to lung cancer. Japanese Journal of Cancer Research, 82, 254–256.
  • UPADHYA, S. C., TIRUMALAI, P. S., BOYD, M. R., MORI, T. and RAVINDRANATH, V., 2000, Cytochrome P4502E (CYP2E) in brain: constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization. Archives of Biochemistry and Biophysics, 373, 23–34.
  • VESELL, E. S., SEATON, T. D. and A-Rumm, Y. I., 1995, Studies on interindividual variations of CYP2E1 using chlorzaxazone as an in vivo probe. Pharmacogenetics, 5, 53–57.
  • VIEIRA, I., PASANEN, M., RAUNIO, H. and CRESTEIL, T., 1998, Expression of CYP2E1 in human lung and kidney during development and in full-term placenta: a differential methylation of the gene is involved in the regulation process. Pharmacology and Toxicology, 83, 183–187.
  • WANDEL, C., NEFF, S., KEPPLER, G., BOHRER, H., STOCKINGER, K., WILKINSON, G. R., WOOD, M. and MARTIN, E., 1997, The relationship between cytochrome P4502E1 activity and plasma fluoride levels after sevoflurane anesthesia in humans. Anesthesia and Analgesia, 85, 924–930.
  • WU, X., Amos, C. I., KEMP, B. L., Sol, H., JIANG, H., WAN, Y. and SPITZ, M. R., 1998, Cytochrome P450 2E1 DraI polymorphisms in lung cancer in minority populations. Cancer Epidemiology, Biomarkers and Prevention, 7, 13–18.
  • YU, Y., TAYLOR, P. R., Li, J. Y., DAWSEY, S. M., WANG, G. Q., Guo, W. D., WANG, W., Liu, B. Q., BLOT, W. J. and SHEN, Q., 1993, Retrospective cohort study of risk-factors for esophageal cancer in Linxian, People's Republic of China. Cancer Causes and Control, 4, 195–202.
  • ZAND, R., NELSON, S. D., SLATTERY, J. T., THUMMEL, K. E., KALHORN, T. F., ADAMS, S. P. and WRIGHT, J. M., 1993, Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans. Clinical Pharmacology and Therapeutics, 54, 142–149.
  • ZHOU, H. H. and Liu, Z. Q., 2000, Ethnic difference in drug metabolism. Clinical Chemistry and Laboratory Medicine, 38, 899–903.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.