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Xenobiotica
the fate of foreign compounds in biological systems
Volume 35, 2005 - Issue 1
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Research Article

AhR and PPARa: antagonistic effects on CYP2B and CYP3A, and additive inhibitory effects on CYP2C11

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Pages 51-68 | Received 02 Aug 2004, Published online: 22 Sep 2008

References

  • Alexander DL, Ganem LG, Fernandez-Salguero P, Gonzalez F, Jefcoate CR. 1998. Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis. Journal of Cellular Science 111:3311-3322.
  • Amacher DE, Schomaker SJ. 1998. Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes. Toxicology Letters 94:115-125.
  • Badger TM, Ronis MJ, Frank SJ, Chen Y, He L. 2003. Effects of chronic ethanol on hepatic and renal CYP2C11 in the male rat: interactions with the Janus-kinase 2-signal transducer and activators of transcription proteins 5b pathway. Endocrinology 144:3969-3976.
  • Bars RG, Bell DR, Elcombe CR. 1993. Induction of cytochrome P450 and peroxisomal enzymes by clofibric acid in vivo and in vitro. Biochemical Pharmacology 45:2045-2053.
  • Bhathena A, Lee C, Riddick DS. 2002. Suppression of cytochrome P450 2C11 by aromatic hydrocarbons: mechanistic insights from studies of the 50-flanking region of the CYP2C11 gene. Drug Metabolism and Disposition 30:1385-1392.
  • Bocos C, Gottlicher M, Greating K, Banner C, Enmark E, Teboul M, Crickmore A, Gustafsson JA. 1995. Fatty acid activation of peroxisome proliferator-activated receptor (PPAR). Journal Steroid Biochemistry and Molecular Biology 53:467-473.
  • Bonilla S, Redonnet A, Noel-Suberville C, Goubet R, Pallt V, Higueret P. 2001. Effect of a pharmacological activation of PPAR on the expression of RAR and TR in rat liver. Journal of Physiology and Biochemistry 57:1-8.
  • Caruso JA, Laird DW, Batist G. 1999. Role of HSP90 in mediating cross-talk between the estrogen receptor and the Ah receptor signal transduction pathways. Biochemistry and Pharmacology 58:1395-403.
  • Chao C, Youssef J, Reziekhaleigh M, Birnbaum LS, Bader M. 2002. Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X-receptor alpha, but not peroxisome proliferator-activated receptor alpha. Mechanism of Ageing and Development 123:1469-1476.

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