References
- Austin RP, Barton P, Cockroft SL, Wenlock MC, Riley RJ. 2002. The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties. Drug Metab Disposit 30:1497–1503.
- Banker MJ, Clark TH, Williams JA. 2003. Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding. J Pharmaceut Sci 92:967–974.
- Barter ZE, Chowdry JE, Harlow JR, Snawder JE, Lipscomb JC, Rostami-Hodjegan A. 2008. Covariation of human microsomal protein per gram of liver with age: absence of influence of operator and sample storage may justify inter laboratory data pooling. Drug Metab Disposit 36:1–5.
- Benet LZ, Hoener BA. 2002. Changes in plasma protein binding have little clinical relevance. Clin Pharmacol Ther 71:115–121.
- Brown HS, Griffin M, Houston JB. 2007. Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance. Drug Metab Disposit 35:293–301.
- De Buck SS, Sinha VK, Fenu LA, Gilissen RA, Mackie CE, Nijsen MJ. 2007. The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools. Drug Metab Disposit 35:649–659.
- Emoto C, Iwasaki K. 2007. Approach to predict the contribution of cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage: the effect of the expression of cytochrome b5 with recombinant P450 enzymes. Xenobiotica 37:986–999.
- Gertz M, Kilford PJ, Houston JB, Galetin A. 2008. Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations. Drug Metab Disposit 36:535–542.
- Hallifax D, Houston JB. 2006. Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement. Drug Metab Disposit 34:724–726.
- Howgate EM, Rowland, Yeo K, Proctor NJ, Tucker GT, Rostami-Hodjegan A. 2006. Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability. Xenobiotica 36:473–497.
- Koganti A, Zhang W, Cheesborough M, Terrell CM, Silber PM, Jensen CB. 2005. Metabolic stability and clearance of pharmaceutical chemicals in pre-pooled cryopreserved human hepatocytes. Drug Metab Rev 37(4 Suppl. 2):212.
- Li AP. 2001. Screening for human ADME/Tox drug properties in drug discovery. Drug Disc Today 6:357–366.
- Lobell M, Sivarajah V. 2003. In silico prediction of aqueous solubility, human plasma protein binding and volume of distribution of compounds from calculated pKa and AlogP98 values. Mol Diversity 7:69–87.
- Obach RS. 1997. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. Drug Metab Disposit 25:1359–1369.
- Obach RS. 1999. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab Disposit 27:1350–1359.
- Rolan PE. 1994. Plasma protein binding displacement interactions — why are they still regarded as clinically important? Br J Clin Pharmacol 37:125–128.
- Sheiner LB, Beal SL. 1981. Some suggestions for measuring predictive performance. J Pharmacokinet Biopharmaceut 9:503–512.
- Skaggs SM, Foti RS, Fisher MB. 2006. A streamlined method to predict hepatic clearance using human liver microsomes in the presence of human plasma. J Pharmacol Toxicol Meth 53:284–290.
- Taylor C, Janisewski J, Whalen K. 2006. Integrated high-throughput ADME: a 384-well human liver microsome assay to determine metabolic profiles of 1800 compounds per week. Poster shown at the Annual Meeting of American Association of Pharmaceutical Scientists.
- Turner DB, Rowland-Yeo K, Tucker GT, Rostami-Hodjegan A. 2006. Prediction of non-specific hepatic microsomal binding from readily available physicochemical properties. Drug Metab Rev 38(Suppl. 1):162.
- Wienkers LC, Heath TG. 2005. Predicting in vivo drug interactions from in vitro drug discovery data. Nat Rev Drug Disc 4:825–833.
- Yamazaki K, Kanaoka M. 2004. Computational prediction of the plasma protein-binding percent of diverse pharmaceutical compounds. J Pharmaceut Sci 93:1480–1494.