Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 11
265
Views
10
CrossRef citations to date
0
Altmetric
Xenobiotic Transporters

Multidrug and toxin extrusion protein 1-mediated interaction of metformin and Scutellariae radix in rats

, , , , , & show all
Pages 998-1007 | Received 29 Sep 2016, Accepted 02 Nov 2016, Published online: 28 Nov 2016

References

  • Akao T, Sato K, Hanada M. (2009). Hepatic contribution to a marked increase in the plasma concentration of baicalin after oral administration of its aglycone, baicalein, in multidrug resistance-associated protein 2-deficient rat. Biol Pharm Bull 32:2079–82
  • Amin M, Suksomboon N. (2014). Pharmacotherapy of type 2 diabetes mellitus: an update on drug-drug interactions. Drug Saf 37:903–19
  • Arjmandi BH, Ormsbee LT, Elam ML, et al. (2014). A combination of Scutellaria baicalensis and Acacia catechu extracts for short-term symptomatic relief of joint discomfort associated with osteoarthritis of the knee. J Med Food 17:707–13
  • Becker ML, Visser LE, van Schaik RH, et al. (2009). Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study. Diabetes 58:745–9
  • Chang S, Han K, Wang JH, et al. (2015). Effect of Atractylodes Rhizoma Alba, Houttuyniae herba, Lonicerae flos, Scutellariae radix and Coptidis rhizoma extracts combined with metformin on the antioxidant and adipocyte differentiate inhibition. J Korean Med Obes Res 15:24–32
  • Choi YH, Kim SG, Lee MG. (2006). Dose-independent pharmacokinetics of metformin in rats: hepatic and gastrointestinal first-pass effects. J Pharm Sci 95:2543–52
  • Freeman JS, Gross B. (2012). Potential drug interactions associated with treatments for type 2 diabetes and its comorbidities: a clinical pharmacology review. Expert Rev Clin Pharmacol 5:31–42
  • Fu Y, Luo J, Jia Z, et al. (2014). Baicalein protects against type 2 diabetes via promoting islet β-cell function in obese diabetic mice. Int J Endocrinol 2014:846742
  • Gibaldi M, Perrier D. 1982. Pharmacokinetics. New York: Marcel Dekker
  • Gong L, Goswamic S, Giacomini KM, et al. (2012). Metformin pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genom 22:820–7
  • He MY, Deng YX, Shi QZ, et al. (2014). Comparative pharmacokinetic investigation on baicalin and wogonoside in type-2 diabetic and normal rats after oral administration of traditional Chinese medicine Huanglian Jiedu decoction. J Ethnopharmacol 155:334–42
  • Higgins JW, Bedwell DW, Zamek-Gliszczynski MJ. (2012). Ablation of both organic cation transporter Oct 1 and Oct 2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics. Drug Metab Dispos 40:1170–7
  • Katz A, Nambi SS, Mather K, et al. (2000). Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402–10
  • Kekuda R, Prasad PD, Wu X, et al. (1998). Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 273:15971–9
  • Knop J, Hoier E, Ebner T, et al. (2015). Renal tubular secretion of pramipexole. Eur J Pharm Sci 15:73–8
  • Kudolo GB, Wang W, Javors M, Blodgett J. (2006). The effect of the ingestion of Ginko biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects-a double blind placebo-controlled, crossover study. Clin Nutr 25:606–16
  • Kwon M, Choi YA, Choi MK. (2015). Organic cation transporter-mediated drug-drug interaction potential between berberine and metformin. Arch Pharm Res 38:849–56
  • Ito S, Kusuhara H, Kuroiwa Y, et al. (2010). Potent and specific inhibition of mMate1-mediated efflux of type 1 organic cations in the liver and kidney by pyrimethamine. J Pharmacol Exp Ther 333:341–50
  • Lee AL, Chen BC, Mou CH, et al. (2016). Association of traditional chinese medicine therapy and the risk of vascular complications in patients with type II diabetes mellitus: a nationwide, retrospective, taiwanese-registry, cohort study. Medicine (Baltimore) 95:e2536
  • Lee YK, Chin YW, Choi YH. (2013). Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats. Food Chem Toxicol 59:153–9
  • Li M, Shi A, Pang H, et al. (2014). Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects. J Ethnopharmacol 156:210–15
  • Liu SZ, Deng YX, Chen B, et al. (2013). Anti-hyperglycemic effect of the traditional Chinese Scutellaria coptis herb couple and its main components in streptozotocin-induced diabetic rats. J Ethnopharmacol 145:490–8
  • Ma YR, Huang J, Shao YY, et al. (2015a). Inhibitory effect of atenolol on urinary excretion of metformin via down-regulating multidrug and toxin extrusion protein 1 (rMate1) expression in the kidney of rats. Eur J Pharm Sci 68:18–26
  • Ma YR, Qin H, Jin Y, et al. (2015b). Gender-related differences in the expression of organic cation transporter 2 and its role in urinary excretion of metformin in rats. Eur J Drug Metab Pharmacokinet 17:1–7
  • Madiraju AK, Erion DM, Rahimi Y, et al. (2014). Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 510:542–6
  • May M, Schindler C. (2016). Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab 7:69–83
  • Meng Q, Liu K. (2014). Pharmacokinetic interactions between herbal medicines and prescribed drugs: focus on drug metabolic enzymes and transporters. Curr Drug Metab 15:791–807
  • Nies AT, Hofmann U, Resch C, et al. (2011). Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs). PLoS One 6:e22163
  • Noh K, Kang Y, Nepal MR, et al. (2016). Role of intestinal microbiota in baicalin-induced drug interaction and its pharmacokinetics. Molecules 21:337
  • Otsuka M, Matsumoto T, Morimoto R, et al. (2005). A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 102:17923–8
  • Puranik AS, Halade G, Kumar S, et al. (2011). Cassia auriculata: Aspects of safety pharmacology and drug interaction. Evid Based Complement Alternat Med 2011:915240
  • Rehman S, Choi M, Choe L, Yoo H. (2015). Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management. Arch Pharm Res 38:1281–98
  • Rojas LB, Gomes MB. (2013). Metformin: an old but still the best treatment for type 2 diabetes. Diabetol Metab Syndr 5:6
  • Shen Z, Yeh LT, Wallach K, et al. (2016). In vitro and in vivo interaction studies between lesinurad, a selective urate reabsorption inhibitor, and major liver or kidney transporters. Clin Drug Investig 36:443–52
  • Shu Y, Sheardown SA, Brown C, et al. (2007). Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 117:1422–31
  • Sobieraj DM, Freyer CW. (2010). Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 44:1334–7
  • Song IS, Kong TY, Jeong HU, et al. (2014). Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo. BMC Complement Altern Med 14:251
  • Song KH, Lee SH, Kim BY, et al. (2013). Extracts of Scutellaria baicalensis reduced body weight and blood triglyceride in db/db mice. Phytother Res 27:244–50
  • Stage TB, Pedersen RS, Damkier P, et al. (2015). Intake of St John's wort improves the glucose tolerance in healthy subjects who ingest metformin compared with metformin alone. Br J Clin Pharmacol 79:298–306
  • Stocker SL, Morrissey KM, Yee SW, et al. (2013). The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther 93:186–94
  • Tabatabaei-Malazy O, Larijani B, Abdollahi M. (2015). Targeting metabolic disorders by natural products. J Diabetes Metab Disord 14:57
  • Tsuda M, Terada T, Mizuno T, et al. (2009). Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin. Mol Pharmacol 75:1280–6
  • Waisundara VY, Hsu A, Huang D, Tan BK. (2008). Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Am J Clin Med 36:517–40
  • Waisundara VY, Hsu A, Tan BK, Huang D. (2009). Baicalin improves antioxidant status of streptozotocin-induced diabetic Wistar rats. J Agric Food Chem 57:4096–102
  • Wu X, Ma J, Ye Y, Lin G. (2016). Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions. J Chromatogr B 2016:236–53
  • Yonezawa A, Inui K. (2011). Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics. Br J Pharmacol 164:1817–25
  • Zamek-Gliszcynski MJ, Bao JQ, Day JS, Higgins JW. (2013). Metformin sinusoidal efflux from the liver is consistent with negligible biliary excretion and absence of enterohepatic cycling. Drug Metab Dispos 41:1967–71

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.