Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 4
257
Views
14
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Metabolism studies on hydroxygenkwanin and genkwanin in human liver microsomes by UHPLC-Q-TOF-MS

, , , , &
Pages 332-341 | Received 03 Mar 2017, Accepted 12 Apr 2017, Published online: 05 May 2017

References

  • Chen YY, Guo JM, Tang YP, et al. (2015). Pharmacokinetic profile and metabolite identification of yuanhuapine, a bioactive component in Daphne genkwa by ultra-high performance liquid chromatography coupled with tandem mass spectrometry. J Pharm Biomed Anal 112:60–9
  • Du LY, Qian DW, Shang EX, et al. (2015). UPLC-Q-TOF/MS-based screening and identification of the main flavonoids and their metabolites in rat bile, urine and feces after oral administration of Scutellaria baicalensis extract. J Ethnopharmacol 169:156–62
  • Gao Y, Liu F, Fang L, et al. (2014). Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages. PLoS One 9:e96741
  • Hong JY, Nam JW, Seo EK, et al. (2010). Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa. Chem Pharm Bull 58:234–7
  • Jia PP, Zhang YQ, Zhang QY, et al. (2016). Metabolism studies on prim-O-glucosylcimifugin and cimifugin in human liver microsomes by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry. Biomed Chromatogr 30:1498–505
  • Liang J, Xu F, Zhang YZ, et al. (2013). The profiling and identification of the absorbed constituents and metabolites of Paeoniae Radix Rubra decoction in rat plasma and urine by the HPLC-DAD-ESI-IT-TOF-MSn technique: a novel strategy for the systematic screening and identification of absorbed constituents and metabolites from traditional Chinese medicines. J Pharm Biomed Anal 83:108–21
  • Liu MY, Zhao SH, Wang ZQ, et al. (2014). Identification of metabolites of deoxyschizandrin in rats by UPLC-Q-TOF-MS/MS based on multiple mass defect filter data acquisition and multiple data processing techniques. J Chromatogr B: Anal Technol Biomed Life Sci 949:115–26
  • Park BY, Min BS, Oh SR, et al. (2006). Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti-complement activity. Phytother Res 20:610–13
  • Reley RJ, McGinnity DF, Austin RP. (2005). A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes. Drug Metab Dispos 33:1304–11
  • Smith JN, Mehinagic D, Nag S, et al. (2017). In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def, p]chrysene-11,12 diol in rodent and human hepatic microsomes. Toxicol Lett 269:23–32
  • Song YQ, Zhang SX, Liu H, et al. (2013). Determination of genkwanin in rat plasma by liquid chromatography-tandem mass spectrometry: application to a bioavailability study. J Pharm Biomed Anal 84:129–34
  • Sun YP, Jia PP, Yuan L, et al. (2015). Investigating the in vitro stereoselective metabolism of m-nisoldipine enantiomers: characterization of metabolites and cytochrome P450 isoforms involved. Biomed Chromatogr 29:1893–900
  • Tao JH, Zhao M, Wang DG, et al. (2015). UPLC-Q-TOF/MS-based screening and identification of two major bioactive components and their metabolites in normal and CKD rat plasma, urine and feces after oral administration of Rehmannia glutinosa Libosch extract. J Chromatogr B: Anal Technol Biomed Life Sci 1001:98–106
  • Tao JH, Wang DG, Yang C, et al. (2015). Biotransformation of luteoloside by a newly isolated human intestinal bacterium using UHPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci 991:1–8
  • The Pharmacopeia Commission of People’s Republic of China. (2015). Pharmacopoeia of the People’s Republic of China. Beijing: Chinese Medical Science and Technology Press, 159
  • Tian TT, Jin YR, Ma YH, et al. (2015). Identification of metabolites of oridonin in rats with a single run on UPLC-Triple-TOF-MS/MS system based on multiple mass defect filter data acquisition and multiple data processing techniques. J Chromatogr B: Anal Technol Biomed Life Sci 1006:80–92
  • Wang X, Song ZJ, He X, et al. (2015). Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APC(Min/+) mice. Int Immunopharmacol 29:701–7
  • Wang Y, Xu YS, Yin LH, et al. (2013). Synergistic anti-glioma effect of hydroxygenkwanin and Apigenin in vitro. Chem Biol Interact 206:346–55
  • Yao DG, Wang YF, Huo CH, et al. (2017). Study on the metabolites of isoalantolactone in vivo and in vitro by ultra performance liquid chromatography combined with Triple TOF mass spectrometry. Food Chem 214:328–38
  • Yang J, Qian DW, Jiang S, et al. (2012). Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci 898:95–100
  • Zhang X, Yao Y, Lou Y, et al. (2010). Metabolism of ebracteolata compound B studied in vitro with human liver microsomes, HepG2 cells, and recombinant human enzymes. Drug Metab Dispos 38:2157–65

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.