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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 7
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General Xenobiochemistry

The impact of azole antifungal drugs on imatinib metabolism in human liver microsomes

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Pages 753-761 | Received 19 Mar 2018, Accepted 03 May 2018, Published online: 25 Mar 2019

References

  • Barratt DT, Cox HK, Menelaou A, et al. (2016). CYP2C8 genotype significantly alters imatinib metabolism in chronic myeloid leukaemia patients. Clin Pharmacokinet 56:1–9.
  • Dutreix C, Peng B, Mehring G, et al. (2004). Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects. Cancer Chemother Pharmacol 54:290.
  • Eechoute K, Sparreboom A, Burger H, et al. (2011). Drug transporters and imatinib treatment: implications for clinical practice. Clin Cancer Res 17:406–15.
  • Filppula AM, Neuvonen M, Laitila J, et al. (2013a). Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response. Drug Metab Dispos 41:50–9.
  • Filppula AM, Tornio A, Niemi M, et al. (2013b). Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite. Clin Pharmacol Ther 35:383–93.
  • Francis J, Dubashi B, Sundaram R, et al. (2015). A study to explore the correlation of ABCB1, ABCG2, OCT1 genetic polymorphisms and trough level concentration with imatinib mesylate-induced thrombocytopenia in chronic myeloid leukemia patients. Cancer Chemother Pharmacol 76:1185–9.
  • Gambillara E, Laffitte E, Widmer N, et al. (2005). Severe pustular eruption associated with imatinib and voriconazole in a patient with chronic myeloid leukemia. Dermatology 211:363–5.
  • Gibbs MA, Thummel KE, Shen DD, Kunze KL. (1999). Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. Drug Metab Dispos 27:180–7.
  • Groll AH, Castagnola E, Cesaro S, et al. (2014). Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation. Lancet Oncol 15:e327–40.
  • Groll AH, Townsend R, Desai A, et al. (2017). Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4. Transpl Infect Dis 19:e12751.
  • Guengerich FP. (2008). Cytochrome p450 and chemical toxicology. Chem Res Toxicol 21:70–83.
  • Hamadeh IS, Klinker KP, Borgert SJ, et al. (2017). Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections. Pharmacogenet Genomics 27:190.
  • Isoherranen N, Kunze KL, Allen KE, et al. (2004). Role of itraconazole metabolites in CYP3A4 inhibition. Drug Metab Dispos 32:1121–31.
  • Jeong S, Nguyen PD, Desta Z. (2009a). Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A. Antimicrob Agents Chemother 53:541–51.
  • Jeong S, Nguyen PD, Desta Z. (2009b). Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A. Antimicrob Agents Chemother 53:541–51.
  • Jiang W, Wang X, Xu X, Kong L. (2010). Effect of Schisandra sphenanthera extract on the concentration of tacrolimus in the blood of liver transplant patients. Int J Clin Pharmacol Ther 48:224–9.
  • Kaartama R, Jarho P, Savolainen J, et al. (2011). Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam. J Chromatogr B 879:1668–76.
  • Kc VDE, Pereboom M, Er VDH, et al. (2014). Insufficient fluconazole exposure in pediatric cancer patients and the need for therapeutic drug monitoring in critically ill children. Clin Infect Dis 59:1527–33.
  • Khan MS, Barratt DT, Somogyi AA. (2015). Impact of CYP2C8*3 polymorphism on in vitro metabolism of imatinib to N-desmethyl imatinib. Xenobiotica 46:278–87.
  • Kim H, Shin D, Kang HJ, et al. (2015). Successful empirical antifungal therapy of intravenous itraconazole with pharmacokinetic evidence in pediatric cancer patients undergoing hematopoietic stem cell transplantation. Clin Drug Investig 35:437–46.
  • Kozakai K, Yamada Y, Oshikata M, et al. (2014). Cocktail-substrate approach-based high-throughput assay for evaluation of direct and time-dependent inhibition of multiple cytochrome P450 isoforms. Drug Metab Pharmacok 29:198–207.
  • Lazar JD, Wilner KD. (1990). Drug interactions with fluconazole. Rev Infect Dis 12:S327–S33.
  • Lin G, Wang C, Qiu X, et al. (2014). Differential effects of ketoconazole, itraconazole and voriconazole on the pharmacokinetics of imatinib and its main metabolite GCP74588 in rat. Drug Dev Ind Pharm 40:1616–22.
  • Moody DE, Liu F, Fang WB. (2015). Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism. J Anal Toxicol 39:374–86.
  • Nebot N, Crettol S, D'Esposito F, et al. (2010). Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes. Br J Pharmacol 161:1059.
  • Niwa T, Shiraga T, Takagi A. (2005). Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull 28:1805–8.
  • O'Brien SG, Meinhardt P, Bond E, et al. (2003). Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. Br J Cancer 89:1855–9.
  • Peng B, Lloyd P, Schran H. (2005). Clinical pharmacokinetics of imatinib. Clin Pharmacokinet 44:879–94.
  • Peterlin P, Chauvin C, Le SG, et al. (2018). Fungal prophylaxis with a gastro-resistant posaconazole tablet for patients with hematological malignancies: final result of the POSANANTES study. Antimicrob Agents Chemother AAC 62:01746-17.
  • Solano C, Slavin M, Shaul AJ, et al. (2017). Economic evaluation of azoles as primary prophylaxis for the prevention of invasive fungal infections in Spanish patients undergoing allogeneic haematopoietic stem cell transplant. Mycoses 60:79–88.
  • VAN Erp NP, Gelderblom H, Karlsson MO, et al. (2007). Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib. Clinic Cancer Res 13:7394–400.
  • VON Moltke LL, Greenblatt DJ, Schmider J, et al. (1996). Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents. J Clin Pharmacol 36:783–91.
  • Wexler D, Courtney R, Richards W, et al. (2004). Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study. Eur J Pharm Sci 21:645–53.
  • Xin HW, Li Q, Wu XC, et al. (2011). Effects of Schisandra sphenanthera extract on the blood concentration of tacrolimus in renal transplant recipients. Eur J Clin Pharmacol 67:1309–11.
  • Zhang S, Pillai VC, Mada SR, et al. (2012). Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes. Xenobiotica 42:409–16.
  • Zhong JS, Meng FY, Xu D, et al. (2012). Correlation between imatinib trough concentration and efficacy in chinese chronic myelocytic leukemia patients. Acta Haematologica 127:221–7.

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