References
- Bazzoni G, Dejana E. (2004). Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev 84:869–901.
- Begley DJ, Brightman MW. (2003). Structural and functional aspects of the blood-brain barrier. Prog Drug Res 61:39–78.
- Dalgliesh CE, Tabechian H. (1956). Comparison of the metabolism of uniformly 14C-labelled L-phenylalanine, L-tyrosine and L-tryptophan in the rat. Biochem J 62:625–33.
- Herde MK, Geist K, Campbell RE, Herbison AE. (2011). Gonadotropin-releasing hormone neurons extend complex highly branched dendritic trees outside the blood-brain barrier. Endocrinology 152:3832–41.
- Kondo T, Kurata Y, Yoshida K, Yoshimura Y. (1995). Disposition of DN-2327, a new anxiolytic, in rats, dogs, and monkeys. Biol Pharm Bull 18:330–6.
- MacLean DB, Matsui H, Suri A, et al. (2014). Sustained exposure to the investigational Kisspeptin analog, TAK-448, down-regulates testosterone into the castration range in healthy males and in patients with prostate cancer: results from two phase 1 studies. J Clin Endocrinol Metab 99:E1445–53.
- Matsui H, Masaki T, Akinaga Y, et al. (2014). Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide. Eur J Pharmacol 735:77–85.
- Matsui H, Tanaka A, Yokoyama K, et al. (2012). Chronic administration of the metastin/kisspeptin analog KISS1-305 or the investigational agent TAK-448 suppresses hypothalamic pituitary gonadal function and depletes plasma testosterone in adult male rats. Endocrinology 153:5297–308.
- Neale RJ, Waterlow JC. (1974). The metabolism of 14C-labelled essential amino acids given by intragastric or intravenous infusion to rats on normal and protein-free diets. Br J Nutr 32:11–25.
- Nishizawa N, Takatsu Y, Kumano S, et al. (2016). Design and Synthesis of an investigational nonapeptide KISS1 receptor (KISS1R) agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with highly potent testosterone-suppressive activity and excellent water solubility. J Med Chem 59:8804–11.
- Nitta T, Hata M, Gotoh S, et al. (2003). Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 161:653–60.
- Ohtaki T, Shintani Y, Honda S, et al. (2001). Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411:613–7.
- Pardridge W. (1998). Introduction to the blood-brain barrier. Cambridge, UK: Cambridge University Press.
- Tanayama S, Kobayashi T, Kanai Y. (1978). Metabolism of 3-(2', 4', 5'-triethoxybenzoyl) propionic acid, a new biliary smooth muscle relaxant with choleretic activity. I. Disposition after a single administration in rats and dogs. Xenobiotica 8:365–75.
- Tanayama S, Shirakawa Y, Kanai Y, Suzuoki Z. (1974). Metabolism of 8-chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)-benzodiazepine (D-40TA), a new central depressant. I. Absorption, distribution and excretion in rats. Xenobiotica 4:33–47.