Reduced systemic exposure and brain uptake of donepezil in rats with scopolamine-induced cognitive impairment

References

• Abcam. (2018). Instructions for use acetylcholinesterase assay kit [online]. Abcam. Available from: https://www.abcam.com/acetylcholinesterase-assay-kit-colorimetric-ab138871-protocols.html#top-341 [last accessed 29 May 2019].
   Google Scholar
• Bhateria M, Ramakrishna R, Pakala DB, et al. (2015). Development of an LC-MS/MS method for simultaneous determination of memantine and donepezil in rat plasma and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci 1001:131–9.
   PubMed Web of Science ®Google Scholar
• Chen BH, Park JH, Kim DW, et al. (2018). Melatonin improves cognitive deficits via restoration of cholinergic dysfunction in a mouse model of scopolamine-induced amnesia. ACS Chem Neurosci 9:2016–24.
   PubMed Web of Science ®Google Scholar
• Ellman GL, Courtney KD, Andres V, Jr, et al. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95.
   PubMed Web of Science ®Google Scholar
• Food and Drug Administration. (2005). Guidance for industry estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers [online]. Food and Drug Administration. Available from: https: //www.fda.gov/media/72309/download [last accessed 29 May 2019].
   Google Scholar
• Food and Drug Administration. (2018). Guidance for industry bioanalytical method validation [online]. Food and Drug Administration. Available from: https://www.fda.gov/downloads/drugs/guidances/ucm070107.pdf [last accessed 29 May 2019].
   Google Scholar
• Funaki Y, Kato M, Iwata R, et al. (2003). Evaluation of the binding characteristics of [5-(11)C-methoxy]Donepezil in the rat brain for in vivo visualization of acetylcholinesterase. J Pharmacol Sci 91:105–12.
   PubMed Web of Science ®Google Scholar
• Goh CW, Aw CC, Lee JH, et al. (2011). Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. Drug Metab Dispos 39:402–11.
   PubMed Web of Science ®Google Scholar
• Hosseini M, Mohammadpour T, Karami R, et al. (2015). Effects of the hydro-alcoholic extract of Nigella sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chin J Integr Med 21:438–44.
   PubMed Web of Science ®Google Scholar
• Ionita R, Postu PA, Beppe GJ, et al. (2017). Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine. Behav Brain Funct 13:5.
   PubMed Web of Science ®Google Scholar
• Kasa P, Papp H, Kasa P, Jr, et al. (2000). Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain. Neuroscience 101:89–100.
   PubMed Web of Science ®Google Scholar
• Khuroo AH, Gurule SJ, Monif T, et al. (2012). ESI-MS/MS stability-indicating bioanalytical method development and validation for simultaneous estimation of donepezil, 5-desmethyl donepezil and 6-desmethyl donepezil in human plasma. Biomed Chromatogr 26:636–49.
   PubMed Web of Science ®Google Scholar
• Klinkenberg I, Blokland A. (2010). The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev 34:1307–50.
   PubMed Web of Science ®Google Scholar
• Kosasa T, Kuriya Y, Matsui K, et al. (2000). Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cholinesterase activity in rats. Eur J Pharmacol 389:173–9.
   PubMed Web of Science ®Google Scholar
• Lee B, Sur B, Shim J, et al. (2014). Acupuncture stimulation improves scopolamine-induced cognitive impairment via activation of cholinergic system and regulation of BDNF and CREB expressions in rats. BMC Complement Altern Med 14: 338.
   PubMed Web of Science ®Google Scholar
• Lv C, Li Q, Zhang Y, et al. (2013). A UFLC-MS/MS method with a switching ionization mode for simultaneous quantitation of polygalaxanthone III, four ginsenosides and tumulosic acid in rat plasma: application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats. J Mass Spectrom 48:904–13.
   PubMed Web of Science ®Google Scholar
• Mano Y, Hotta K, Kusano K. (2016). Simultaneous determination of donepezil and its three metabolites in human plasma using LC-MS-MS. J Chromatogr Sci 54:1328–35.
   PubMed Web of Science ®Google Scholar
• Marshall K, Fritz K, Thom W, et al. (2012). Toxic interaction between fluoxetine and donepezil: a case of cholinergic toxidrome. J Neuropsychiatry Clin Neurosci 24:E50.
   PubMed Web of Science ®Google Scholar
• Matsui K, Mishima M, Nagai Y, et al. (1999). Absorption, distribution, metabolism, and excretion of donepezil (Aricept) after a single oral administration to Rat. Drug Metab Dispos 27:1406–14.
   PubMed Web of Science ®Google Scholar
• Medicine and Healthcare Products Regulatory Agency. (2010). Donepezil hydrochloride 5 mg and 10 mg film-coated tablet [online]. Medicine and Healthcare Products Regulatory Agency. Available from: http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con081897.pdf [last accessed 29 May 2019].
   Google Scholar
• Ngoupaye GT, Pahaye DB, Ngondi J, et al. (2017). Gladiolus dalenii lyophilisate reverses scopolamine-induced amnesia and reduces oxidative stress in rat brain. Biomed Pharmacother 91:350–7.
   PubMed Web of Science ®Google Scholar
• Ozarowski M, Mikolajczak PL, Piasecka A, et al. (2017). Effect of Salvia miltiorrhiza root extract on brain acetylcholinesterase and butyrylcholinesterase activities, their mRNA levels and memory evaluation in rats. Physiol Behav 173:223–30.
   PubMed Web of Science ®Google Scholar
• Patel BN, Sharma N, Sanyal M, et al. (2008). Quantitation of donepezil and its active metabolite 6-O-desmethyl donepezil in human plasma by a selective and sensitive liquid chromatography-tandem mass spectrometric method. Anal Chim Acta 629:145–57.
   PubMed Web of Science ®Google Scholar
• Pilli NR, Inamadugu JK, Kondreddy N, et al. (2011). A rapid and sensitive LC-MS/MS method for quantification of donepezil and its active metabolite, 6-O-desmethyl donepezil in human plasma and its pharmacokinetic application. Biomed Chromatogr 25:943–51.
   PubMed Web of Science ®Google Scholar
• Pollock D, Cunningham E, Mcguinness B, et al. (2017). Pisa syndrome due to donepezil: pharmacokinetic interactions to blame? Age Ageing 46:529–30.
   PubMed Web of Science ®Google Scholar
• Putcha L, Cintron NM, Tsui J, et al. (1989). Pharmacokinetics and oral bioavailability of scopolamine in normal subjects. Pharm Res 6:481–5.
   PubMed Web of Science ®Google Scholar
• Qu Z, Zhang J, Yang H, et al. (2017). Prunella vulgaris L., an edible and medicinal plant, attenuates scopolamine-induced memory impairment in rats. J Agric Food Chem 65:291–300.
   PubMed Web of Science ®Google Scholar
• Renaud B, Denoroy L, Collin-Chavagnac D, et al. 2018. Clinical CNS microdialysis of glutamate with a special methodological focus on human spinal cord. In: S. Parrot and L. Denoroy, eds. Biochemical approaches for glutamatergic neurotransmission. New York, NY: Springer New York, 523–58.
   Google Scholar
• Rogers SL, Doody RS, Mohs RC, et al. (1998). Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil Study Group. Arch Intern Med 158:1021–31.
   PubMed Web of Science ®Google Scholar
• Ruela ALM, Santos MG, Figueiredo EC, et al. (2014). LC-PDA and LC-MS studies of donepezil hydrochloride degradation behaviour in forced stress conditions %. J Brazilian Chem Soc 25:2094–101.
   Web of Science ®Google Scholar
• Shi X, Tang Y, Zhu H, et al. (2014). Comparative tissue distribution profiles of five major bio-active components in normal and blood deficiency rats after oral administration of Danggui Buxue Decoction by UPLC-TQ/MS. J Pharm Biomed Anal 88:207–15.
   PubMed Web of Science ®Google Scholar
• Sugimoto H, Ogura H, Arai Y, et al. (2002). Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor. Jpn J Pharmacol 89:7–20.
   PubMedGoogle Scholar
• Van Dam D, De Deyn PP. (2011). Animal models in the drug discovery pipeline for Alzheimer's disease. Br J Pharmacol 164:1285–300.
   PubMed Web of Science ®Google Scholar
• Yang T, Liu S, Wang CH, et al. (2015). Comparative pharmacokinetic and tissue distribution profiles of four major bioactive components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe. J Pharm Biomed Anal 114:152–8.
   PubMed Web of Science ®Google Scholar