Comprehensive metabolism study of swertiamarin in rats using ultra high-performance liquid chromatography coupled with Quadrupole-Exactive Orbitrap mass spectrometry

References

• Cai, W., et al., 2020. A systematic strategy for rapid identification of chlorogenic acids derivatives in Duhaldea nervosa using UHPLC-Q-Exactive Orbitrap mass spectrometry. Arabian journal of chemistry, 13 (2), 3751–3761.
   Web of Science ®Google Scholar
• Chen, J.L., et al., 2019. The anti-inflammation, anti-oxidative and anti-fibrosis properties of swertiamarin in cigarette smoke exposure-induced prostate dysfunction in rats. Aging, 11 (22), 10409–10421.
   PubMedGoogle Scholar
• Chen, W.J. and Wang, J.W., 2017. Protective effect of gentianine, a compound from Du Huo Ji Sheng Tang, against Freund's complete adjuvant-induced arthritis in rats. Inflammation, 40, 1401–1408.
   PubMed Web of Science ®Google Scholar
• Di Ottavio, F., et al., 2020. A UHPLC–HRMS based metabolomics and chemoinformatics approach to chemically distinguish 'super foods' from a variety of plant-based foods. Food chemistry, 313, 10.
   Web of Science ®Google Scholar
• Fujii, M., et al., 2019. Synthesis of gentianine N-oxide by enzymatic hydrolysis of swertiamarin in the presence of hydroxylamine and reaction pathway to gentianine and gentianol. Tetrahedron letters, 60 (10), 721–725.
   Web of Science ®Google Scholar
• Gao, X., et al., 2020. Systematic screening and assignment of flavones in total flavones of Abelmoschus manihot based on high-performance liquid chromatography time-of-flight mass spectrometry analysis and mass defect filter. Chinese journal of analytical chemistry, 48, 262–268.
   Web of Science ®Google Scholar
• Gavard, R., et al., 2020. KairosMS: a new solution for the processing of hyphenated ultrahigh resolution mass spectrometry data. Analytical chemistry, 92 (5), 3775–3786.
   PubMed Web of Science ®Google Scholar
• Hairul-Islam, M.I., et al., 2017. Swertiamarin, a natural steroid, prevent bone erosion by modulating RANKL/RANK/OPG signaling. International immunopharmacology, 53, 114–124.
   PubMed Web of Science ®Google Scholar
• Hua, L., et al., 2019. The cancer drug fraction of metabolism database. CPT: pharmacometrics & systems pharmacology, 8 (7), 511–519.
   PubMedGoogle Scholar
• Liang, Y.Y., et al., 2018. A comprehensive screening and identification of genistin metabolites in rats based on multiple metabolite templates combined with UHPLC–HRMS analysis. Molecules, 23 (8), 1862.
   Web of Science ®Google Scholar
• Liu, W.H., Wang, Q., and Chang, J.X., 2019. Global metabolomic profiling of trastuzumab resistant gastric cancer cells reveals major metabolic pathways and metabolic signatures based on UHPLC-Q exactive-MS/MS. RSC advances, 9 (70), 41192–41208.
   PubMed Web of Science ®Google Scholar
• Liu, X.W., et al., 2011. Gentianine protects hippocampal neurons in a rat model of recurrent febrile convulsion. Neural regeneration research, 6, 1130–1135.
   Web of Science ®Google Scholar
• Mihailovic, V., et al., 2020. Blackstonia perfoliata (L.) Huds. (Gentianaceae): a promising source of useful bioactive compounds. Industrial crops and products, 145, 11.
   Web of Science ®Google Scholar
• Niu, Y.X., et al., 2020. Iridoids from Vitex negundo var. heterophylla and their antioxidant activities. Phytochemistry letters, 35, 186–190.
   Web of Science ®Google Scholar
• Shi, M.G., et al., 2020. Pharmacokinetics and metabolic profiles of swertiamarin in rats by liquid chromatography combined with electrospray ionization tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis, 179, 9.
   Web of Science ®Google Scholar
• Stavrianidi, A., 2020. A classification of liquid chromatography mass spectrometry techniques for evaluation of chemical composition and quality control of traditional medicines. Journal of chromatography A, 1609, 25.
   Web of Science ®Google Scholar
• Tenuta, M.C., et al., 2020. Contribution of flavonoids and iridoids to the hypoglycaemic, antioxidant, and nitric oxide (NO) inhibitory activities of Arbutus unedo L. Antioxidants, 9 (2), 184.
   Web of Science ®Google Scholar
• Tian, C-w., et al., 2017. Anti-mutagenicity of swertiamarin and its metabolite in incubated system of human intestinal flora. Chinese herbal medicines, 9 (1), 92–95.
   Web of Science ®Google Scholar
• Vaidya, H., Goyal, R.K., and Cheema, S.K., 2013. Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-γ gene expression in 3T3-L1 cells. Phytotherapy research, 27 (4), 624–627.
   PubMed Web of Science ®Google Scholar
• Vaijanathappa, J., et al., 2020. Molecular docking, antiproliferative and anticonvulsant activities of swertiamarin isolated from Enicostemma axillare. Bioorganic chemistry, 94, 7.
   Web of Science ®Google Scholar
• Wang, S.S., et al., 2014. Highly sensitive determination of new metabolite in rat plasma after oral administration of swertiamarin by liquid chromatography/time of flight mass spectrometry following picolinoyl derivatization. Biomedical chromatography, 28 (7), 939–946.
   PubMed Web of Science ®Google Scholar
• Wang, H., et al., 2019. Neuroprotective effect of swertiamain on cerebral ischemia/reperfusion injury by inducing the Nrf2 protective pathway. ACS chemical neuroscience, 10 (5), 2276–2286.
   PubMed Web of Science ®Google Scholar
• Wang, C.C., et al., 2020a. Iridoids: research advances in their phytochemistry. Molecules, 25 (2), 287.
   PubMed Web of Science ®Google Scholar
• Wang, L.W., et al., 2020b. Antidepressant effects and mechanisms of the total iridoids of Valeriana jatamansi on the brain-gut axis. Planta medica, 86 (3), 172–179.
   PubMed Web of Science ®Google Scholar
• Wang, X.B., et al., 2020c. Suspect and non-target screening of pesticides and pharmaceuticals transformation products in wastewater using QTOF-MS. Environment international, 137, 12.
   Web of Science ®Google Scholar
• Wang, Y.F., Harrington, P.D., and Chen, P., 2020d. Analysis of phenolic compositions in cranberry dietary supplements using UHPLC–HRMS. Journal of food composition and analysis, 86, 10.
   Web of Science ®Google Scholar
• Wang, Z.G., et al., 2012. Determination of novel nitrogen-containing metabolite after oral administration of swertiamarin to rats. Journal of Asian natural products research, 14 (2), 176–181.
   PubMed Web of Science ®Google Scholar
• Wijnant, K., et al., 2020. Validated ultra-high-performance liquid chromatography hybrid high-resolution mass spectrometry and laser-assisted rapid evaporative ionization mass spectrometry for salivary metabolomics. Analytical chemistry, 92 (7), 5116–5124.
   PubMed Web of Science ®Google Scholar
• Wu, T., Zhang, Q.R., and Song, H.P., 2018. Swertiamarin attenuates carbon tetrachloride (CCl4)-induced liver injury and inflammation in rats by regulating the TLR4 signaling pathway. Brazilian journal of pharmaceutical sciences, 54 (4), 9.
   Web of Science ®Google Scholar
• Wu, X.H., et al., 2015a. Determination of the metabolic profile of gentianine after oral administration to rats by high performance liquid chromatography/electrospray ionization-trap mass spectrometry. Journal of chromatography. B, analytical technologies in the biomedical and life sciences, 989, 98–103.
   PubMed Web of Science ®Google Scholar
• Wu, X.H., et al., 2015b. New analytical method for the study of metabolism of swertiamarin in rats after oral administration by UPLC-TOF-MS following DNPH derivatization. Biomedical chromatography, 29 (8), 1184–1189.
   PubMed Web of Science ®Google Scholar
• Yang, Y., et al., 2019. Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice. Phytomedicine, 59, 152782.
   PubMed Web of Science ®Google Scholar
• Zhang, M., et al., 2020. A natural AKT inhibitor swertiamarin targets AKT-PH domain, inhibits downstream signaling, and alleviates inflammation. The FEBS journal, 287 (9), 1816–1829.
   PubMed Web of Science ®Google Scholar
• Zhang, Q.Q. and Feng, F., 2020. A novel insight into the potential toxicity mechanisms of Zhi-Zi-Hou-Po decoction by dynamic urinary metabolomics based on UHPLC-Q-Exactive Orbitrap-MS. Journal of chromatography B, 1142, 10.
   Web of Science ®Google Scholar
• Zhang, Q.R., et al., 2019. Swertiamarin ameliorates carbon tetrachloride-induced hepatic apoptosis via blocking the PI3K/Akt pathway in rats. The Korean journal of physiology & pharmacology, 23 (1), 21–28.
   PubMed Web of Science ®Google Scholar
• Zhao, W.J., et al., 2018. Rapid screening and identification of daidzein metabolites in rats based on UHPLC-LTQ-Orbitrap mass spectrometry coupled with data-mining technologies. Molecules, 23 (1), 151.
   PubMed Web of Science ®Google Scholar