Xenobiotica, Volume 51, Issue 4 (2021)

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Xenobiotica, Volume 51, Issue 4 (2021)

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General Xenobiochemistry

Article
Preliminary in vitro assessment of pharmacokinetic drug-drug interactions of EST64401 and EST64514, two sigma-1 receptor antagonists
Raquel F. Reinoso, Sandra Yeste, Eva Ayet, María José Pretel, Ariadna Balada & Maria Teresa Serafini
Pages: 373-386
Published online: 20 Jan 2021
AbstractforPreliminary in vitro assessment of pharmacokinetic drug-drug interactions of EST64401 and EST64514, two sigma-1 receptor antagonists | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
Assessment of pharmacokinetic mycophenolic acid clearance models using Monte Carlo numerical analysis
Aleksandra Catić-Đorđević, Ivan Pavlović, Ana Spasić, Nikola Stefanović, Dragana Pavlović, Ivana Damnjanović, Branka Mitić & Radmila Veličković-Radovanović
Pages: 387-393
Published online: 24 Jan 2021
AbstractforAssessment of pharmacokinetic mycophenolic acid clearance models using Monte Carlo numerical analysis | Full Text | References | PDF (1.3 MB) | EPUB
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Article
In vitro metabolism of HMTD and blood stability and toxicity of peroxide explosives (TATP and HMTD) in canines and humans
Michelle D. Gonsalves, Lindsay McLennan, Angela L. Slitt, James L. Smith & Jimmie C. Oxley
Pages: 394-403
Published online: 20 Jan 2021
AbstractforIn vitro metabolism of HMTD and blood stability and toxicity of peroxide explosives (TATP and HMTD) in canines and humans | Full Text | References | PDF (1.7 MB) | EPUB
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Clinical Pharmacokinetics and Metabolism

Article
Verification of a cocktail approach for quantitative drug–drug interaction assessment: a comparative analysis between the results of a single drug and a cocktail drug
Motoyasu Miura, Shinya Uchida, Shimako Tanaka, Chiaki Kamiya, Naoki Katayama, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Junichi Kawakami, Hiroshi Watanabe & Noriyuki Namiki
Pages: 404-412
Published online: 13 Jan 2021
AbstractforVerification of a cocktail approach for quantitative drug–drug interaction assessment: a comparative analysis between the results of a single drug and a cocktail drug | Full Text | References | PDF (1.4 MB) | EPUB
  • 380 Views
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Article
Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans
Lydia Wang-Lakshman, Anisha E. Mendonza, Roland Huber, Markus Walles, YanLing He & Venkateswar Jarugula
Pages: 413-426
Published online: 12 Jan 2021
AbstractforPharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Article
Single dose pharmacokinetics of topical iodiconazole creams in healthy Chinese volunteers
Lili Wu, Ke Zhou, Wenkai Zong, Yun Chen & Chunquan Sheng
Pages: 427-433
Published online: 31 Jan 2021
AbstractforSingle dose pharmacokinetics of topical iodiconazole creams in healthy Chinese volunteers | Full Text | References | PDF (1.2 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Rapid determination of the pharmacokinetics and metabolic fate of gefitinib in the mouse using a combination of UPLC/MS/MS, UPLC/QToF/MS, and ion mobility (IM)-enabled UPLC/QToF/MS
Billy J. Molloy, Adam King, Lauren G. Mullin, Lee A. Gethings, Robert Riley, Robert S. Plumb & Ian D. Wilson
Pages: 434-446
Published online: 08 Feb 2021
AbstractforRapid determination of the pharmacokinetics and metabolic fate of gefitinib in the mouse using a combination of UPLC/MS/MS, UPLC/QToF/MS, and ion mobility (IM)-enabled UPLC/QToF/MS | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 259 Views
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Article
Inhibitory effect of ketoconazole, quinidine and 1-aminobenzotriazole on pharmacokinetics of l-tetrahydropalmatine and its metabolite in rats
Weibin Xiao, Zhirong Deng, Chongfa Lai, Haoyang Lu, Mutu Huang, Yuguan Wen & Lei Shi
Pages: 447-454
Published online: 07 Jan 2021
AbstractforInhibitory effect of ketoconazole, quinidine and 1-aminobenzotriazole on pharmacokinetics of l-tetrahydropalmatine and its metabolite in rats | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Comprehensive metabolism study of swertiamarin in rats using ultra high-performance liquid chromatography coupled with Quadrupole-Exactive Orbitrap mass spectrometry
Beibei Ma, Tianyu Lou, Tingting Wang, Ruiji Li, Jinhui Liu, Shangyue Yu, Yudong Guo, Zhibin Wang & Jing Wang
Pages: 455-466
Published online: 07 Jan 2021
AbstractforComprehensive metabolism study of swertiamarin in rats using ultra high-performance liquid chromatography coupled with Quadrupole-Exactive Orbitrap mass spectrometry | Full Text | References | PDF (2.1 MB) | EPUB
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Xenobiotic Transporters

Article
Differential in vitro interactions of the Janus kinase inhibitor ruxolitinib with human SLC drug transporters
Arnaud Bruyère, Marc Le Vée, Elodie Jouan, Stephanie Molez, Anne T. Nies & Olivier Fardel
Pages: 467-478
Published online: 02 Feb 2021
AbstractforDifferential in vitro interactions of the Janus kinase inhibitor ruxolitinib with human SLC drug transporters | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Pharmacogenetics

Article
Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19
Shogo Matsumoto, Shotaro Uehara, Hidetaka Kamimura, Hiroshi Ikeda, Satoshi Maeda, Machiko Hattori, Megumi Nishiwaki, Kazuhiko Kato & Hiroshi Yamazaki
Pages: 479-493
Published online: 17 Jan 2021
AbstractforHuman total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19 | Full Text | References | PDF (2.7 MB) | EPUB
  • 2252 Views
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Open Access
Article
Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques
Yasuhiro Uno, Shotaro Uehara, Norie Murayama & Hiroshi Yamazaki
Pages: 494-499
Published online: 17 Jan 2021
AbstractforGenetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques | Full Text | References | PDF (1 MB) | EPUB
  • 132 Views
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