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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 6
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Animal Pharmacokinetics and Metabolism

Identification of the metabolites produced following Iris tectorum Maxim oral administration and a network pharmacology-based analysis of their potential pharmacological properties

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Pages 680-688 | Received 10 Feb 2021, Accepted 19 Mar 2021, Published online: 07 Apr 2021

References

  • Bai, X., et al., 2010. Isolation and identification of urinary metabolites of kakkalide in rats. Drug metabolism and disposition: the biological fate of chemicals, 38 (2), 281–286.
  • Bai, X., et al., 2014. Excretion of tectorigenin in rat urine orally administrated at different dosages by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. European journal of drug metabolism and pharmacokinetics, 40 (3), 255–266.
  • Buemi, M.R., et al., 2019. Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety. European journal of medicinal chemistry, 163, 443–452.
  • Chen, Y., et al., 2008. Identification of metabolites of tectoridin in-vivo and in-vitro by liquid chromatography-tandem mass spectrometry. The journal of pharmacy and pharmacology, 60 (6), 709–716.
  • Dassault Systèmes BIOVIA. 2017. Discovery Studio Modeling Environment. San Diego CA: Dassault Systèmes.
  • Fang, R., et al., 2007. Isolation and structure determination of triterpenes from Iris tectorum. Phytochemistry, 68 (9), 1242–1247.
  • Fang, R., Houghton, P.J., and Hylands, P.J., 2008. Cytotoxic effects of compounds from Iris tectorum on human cancer cell lines. Journal of ethnopharmacology, 118 (2), 257–263.
  • Gao, B., et al., 2021. Identification and characterization of the chemical components of Iris tectorum Maxim. and evaluation of their nitric oxide inhibitory activity. Rapid communications in mass spectrometry, 35 (1), e8959.
  • Han, T., et al., 2012. In vitro evaluation of tectoridin, tectorigenin and tectorigenin sodium sulfonate on antioxidant properties. Food and chemical toxicology, 50 (2), 409–414.
  • Kang, K.S., et al., 2009. Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway. Molecules and cells, 27 (3), 351–357.
  • Lee, H.U., Bae, E.A., and Kim, D.H., 2005. Hepatoprotective Effect of tectoridin and tectorigenin on tert-butyl hyperoxide-induced liver injury. Journal of pharmacological sciences, 97 (4), 541–544.
  • Li, S., and Zhang, B., 2013. Traditional Chinese medicine network pharmacology: theory, methodology and application. Chinese journal of natural medicines, 11 (2), 110–120.
  • Ma, Y.H., et al., 2012. C-glycosylflavones from the leaves of Iris tectorum Maxim. Acta Pharmaceutica Sinica B, 2 (6), 598–601.
  • Pan, C.H., et al., 2008. Tectorigenin Inhibits IFN-gamma/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells. Archives of pharmacal research, 31 (11), 1447–1456.
  • Qu, J.L., et al., 2012. Pharmacokinetics of conjugated metabolites in rat plasma after oral administration of tectoridin. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 902, 61–69.
  • Qu, J.L., et al., 2014. Excretion of tectoridin metabolites in rat urine and bile orally administrated at different dosages and their inhibitory activity against aldose reductase. Fitoterapia, 99, 99–108.
  • Sarda, S., et al., 2014. HPLC–MS profiling and structural identification of [14C]‑diclofenac metabolites in mouse bile. Chromatographia, 77 (3–4), 233–239.
  • Shin, J.E., et al., 2006. Estrogenic effect of main components kakkalide and tectoridin of Puerariae flos and their metabolites. Biological & pharmaceutical bulletin, 29 (6), 1202–1206.
  • Shu, P., et al., 2010. Analysis of flavonoids and phenolic acids in Iris tectorum by HPLC-DAD-ESI-MSn. Chinese journal of natural medicines, 8 (3), 202–207.
  • Takahashi, K., et al., 2000. Iridals from Iris tectorum and Belamcanda chinensis. Phytochemistry, 53 (8), 925–929.
  • The State Commission of Chinese Pharmacopoeia. 2015. Part I. Pharmacopoeia of People’s Republic of China. Beijing: China Medical Science Press, 41–42.
  • Vernier, W., et al., 2010. Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation. Bioorganic & medicinal chemistry, 18 (9), 3307–3319.
  • Xiong, Y., et al., 2010. Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanol-induced liver steatosis in mice. Toxicology, 276 (1), 64–72.
  • Xie, G.Y., et al., 2014. Phenolic metabolite profiles and antioxidants assay of three Iridaceae medicinal plants for traditional Chinese medicine "She-gan" by on-line HPLC-DAD coupled with chemiluminescence (CL) and ESI-Q-TOF-MS/MS. Journal of pharmaceutical and biomedical analysis, 98, 40–51.
  • Yang, M., et al., 2015. Comparative pharmacokinetic profiles of tectorigenin in rat plasma by UPLC-MS/MS after oral administration of Iris tectorum Maxim extract and pure tectoridin. Journal of pharmaceutical and biomedical analysis, 114, 34–41.
  • Zakšauskas, A., et al., 2018. Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases. European journal of medicinal chemistry, 156, 61–78.
  • Zhang, W.D., et al., 2011. Simultaneous determination of tectorigenin, irigenin and irisflorentin in rat plasma and urine by UHPLC-MS/MS: application to pharmacokinetics. Journal of chromatography B, 879 (31), 3735–3741.
  • Zhang, C.L., et al., 2014. Iridal-type triterpenoids with neuroprotective activities from Iris tectorum. Journal of natural products, 77 (2), 411–415.
  • Zhang, C.L., et al., 2015a. Polycycloiridals A-D, four iridal-type triterpenoids with an α-terpineol moiety from Iris tectorum. Organic letters, 17 (22), 5686–5689.
  • Zhang, C.L., et al., 2015b. Cytotoxic iridal-type triterpenoids from Iris tectorum. Tetrahedron, 71 (34), 5579–5583.
  • Zhang, C.L., et al., 2016a. Two new flavonoid glycosides from Iris tectorum. Phytochemistry letters, 15, 63–65.
  • Zhang, C.L., et al., 2016b. Lignans from the rhizomes of Iris tectorum. Fitoterapia, 108, 93–97.
  • Zhang, C.L., et al., 2017a. Iritectol G, a novel iridal-type triterpenoid from Iris tectorum displays anti-epileptic activity in vitro through inhibition of sodium channels. Fitoterapia, 122, 20–25.
  • Zhang, C.L., et al., 2017b. Polycycloiridals with a cyclopentane ring from Iris tectorum. Journal of natural products, 80 (1), 156–161.
  • Zhang, C.L., et al., 2017c. Apocynin derivatives from Iris tectorum. Journal of Asian natural products research, 19 (2), 128–133.

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