Metal-metal interaction and metal toxicity: a comparison between mammalian and D. melanogaster

References

• Adams, M.D., et al., 2000. The genome sequence of Drosophila melanogaster. Science, 287 (5461), 2185–2195.
   PubMed Web of Science ®Google Scholar
• Aschner, M., Onishchenko, N., and Ceccatelli, S., 2010. Toxicology of alkylmercury compounds. Metal ions in life sciences, 7, 403–434.
   PubMedGoogle Scholar
• Asselman, J., et al., 2013. Transcription patterns of genes encoding four metallothionein homologs in Daphnia pulex exposed to copper and cadmium are time- and homolog-dependent. Aquatic toxicology, 142–143, 422–430.
   PubMed Web of Science ®Google Scholar
• Banci, L., et al., 2008. Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer. Proceedings of the national academy of sciences of sciences, 105 (19), 6803–6808.
   PubMed Web of Science ®Google Scholar
• Banks, S.A., and Skilleter, G.A., 2010. Implementing marine reserve networks: a comparison of approaches in New South Wales (Australia) and New Zealand. Marine policy, 34 (2), 197–207.
   Web of Science ®Google Scholar
• Barrick, D., 1995. Depletion and replacement of protein metal ligands. Current opinion in biotechnology, 6, 411–418.
   PubMed Web of Science ®Google Scholar
• Beaugé, L., and Campos, M., 1983. Calcium inhibition of the ATPase and phosphatase activities of (Na++K+)-ATPase. Biochimica et biophysica acta, 729 (1), 137–149.
   PubMed Web of Science ®Google Scholar
• Bressler, J., et al., 2004. Divalent metal transporter 1 in lead and cadmium transport. Annals of the New York academy of sciences, 1012, 142–152.
   PubMed Web of Science ®Google Scholar
• Bridwell-Rabb, J., et al., 2014. Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry. Biochemistry, 53, 4904–4913.
   PubMed Web of Science ®Google Scholar
• Burke, R., Commons, E., and Camakaris, J., 2008. Expression and localisation of the essential copper transporter DmATP7 in Drosophila neuronal and intestinal tissues. International journal of biochemistry & cell biology, 40, 1850–1860.
   PubMed Web of Science ®Google Scholar
• Calap-Quintana, P., et al., 2017. Drosophila melanogaster models of metal-related human diseases and metal toxicity. International journal of molecular sciences, 18, 1456.
   PubMed Web of Science ®Google Scholar
• Callaghan, A., and Denny, N., 2002. Evidence for an interaction between p-glycoprotein and cadmium toxicity in cadmium-resistant and -susceptible strains of Drosophila melanogaster. Ecotoxicology & environmental safety, 52, 211–213.
   PubMed Web of Science ®Google Scholar
• Chandra, S., et al., 2016. Dme-miR-314-3p modulation in Cr(VI) exposed Drosophila affects DNA damage repair by targeting mus309. Journal of hazardous materials, 304, 360–369.
   PubMed Web of Science ®Google Scholar
• Chiang, S., et al., 2016. Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia. Clinical science, 130, 853–870.
   PubMed Web of Science ®Google Scholar
• Dai, L., et al., 2015. xCT, not just an amino-acid transporter: a multi-functional regulator of microbial infection and associated diseases. Frontiers in microbiology., 6, 120.
   PubMed Web of Science ®Google Scholar
• Devi, K.D., et al., 2001. In vivo genotoxic effect of cadmium chloride in mice leukocytes using comet assay. Teratogenesis, carcinogenesis, and mutagenesis, 21 (5), 325–333.
   PubMedGoogle Scholar
• Disimplicio, P., et al., 1990. The relationship between gamma-glutamyl transpeptidase and Hg levels in Se/Hg antagonism in mouse liver and kidney. Pharmacological research, 22 (4), 515–526.
   PubMed Web of Science ®Google Scholar
• Donovan, A., et al., 2005. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell metabolism, 1, 191–200.
   PubMed Web of Science ®Google Scholar
• Drago, D., et al., 2008. Aluminum modulates effects of beta amyloid(1-42) on neuronal calcium homeostasis and mitochondria functioning and is altered in a triple transgenic mouse model of Alzheimer's disease. Rejuvenation research, 11, 861–871.
   PubMed Web of Science ®Google Scholar
• Ducros, V., 1992. Chromium metabolism. A literature review. Biological trace element research, 32, 65–77.
   PubMed Web of Science ®Google Scholar
• Dudev, T., and Lim, C., 2014. Competition among metal ions for protein binding sites: determinants of metal ion selectivity in proteins. Chemical reviews, 114 (1), 538–556.
   PubMed Web of Science ®Google Scholar
• Elsenhans, B., et al., 2011. Does lead use the intestinal absorptive pathways of iron? Impact of iron status on murine 210Pb and 59Fe absorption in duodenum and ileum in vivo. Toxicology, 284, 7–11.
   PubMed Web of Science ®Google Scholar
• Erikson, K.M., et al., 2007. Manganese neurotoxicity: a focus on the neonate. Pharmacology & therapeutics., 113, 369–377.
   PubMed Web of Science ®Google Scholar
• Espinoza, A., et al., 2012. Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA. Biological trace element research, 146, 281–286.
   PubMed Web of Science ®Google Scholar
• Fahmy, M.A., and Aly, F., 2000. In vivo and in vitro studies on the genotoxicity of cadmium chloride in mice. Journal of applied toxicology, 20 (3), 231–238.
   PubMed Web of Science ®Google Scholar
• Farina, M., Rocha, J.B., and Aschner, M., 2011. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life sciences, 89, 555–563.
   PubMed Web of Science ®Google Scholar
• Folwell, J., Barton, C., and Shepherd, D., 2006. Immunolocalisation of the D-melanogaster Nramp homologue Malvolio to gut and Malpighian tubules provides evidence that Malvolio and Nramp2 are orthologous. The journal of experimental biology, 209, 1988–1995.
   PubMed Web of Science ®Google Scholar
• Gadad, B., et al., 2008. Molecular toxicity of aluminium in relation to neurodegeneration. Indian Journal of Medical Research, 128, 556.
   Web of Science ®Google Scholar
• Gaudet, P., et al., 2011. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics, 12 (5), 449–462.
   PubMed Web of Science ®Google Scholar
• Girijashanker, K., et al., 2008. Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter. Molecular pharmacology, 73, 1413–1423.
   PubMed Web of Science ®Google Scholar
• Geiser, D., and Winzerling, J., 2011. Insect transferrins: Multifunctional proteins. Biochim biophys acta, 1820, 437–451.
   Google Scholar
• González-Morales, N., et al., 2015. Ferritin is required in multiple tissues during Drosophila melanogaster development. PLoS One, 10, e0133499.
   PubMed Web of Science ®Google Scholar
• Goyer, R.A., 1997. Toxic and essential metal interactions. Annual review of nutrition, 17, 37.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Mejia, M.E., et al., 2014. Metallothionein-1 and nitric oxide expression are inversely correlated in a murine model of Chagas disease. Memórias Do Instituto Oswaldo Cruz, 109 (2), 174–181.
   PubMed Web of Science ®Google Scholar
• Gray, N.K., et al., 1996. Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Proceedings of the national academy of sciences of the United States of America, 93, 4925–4930.
   PubMed Web of Science ®Google Scholar
• Gunshin, H., et al., 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature, 388, 482–488.
   PubMed Web of Science ®Google Scholar
• Haile, D.J., 1999. Regulation of genes of iron metabolism by the iron-response proteins. The American journal of the medical sciences, 318, 230–240.
   PubMed Web of Science ®Google Scholar
• Halliwell, B., and Gutteridge, J.M., 1990. Role of free radicals and catalytic metal ions in human disease: an overview. Methods in enzymology, 186, 1–85.
   PubMed Web of Science ®Google Scholar
• Harris, W.R., and Chen, Y., 1994. Electron paramagnetic resonance and difference ultraviolet studies of Mn2+ binding to serum transferrin. Journal of inorganic biochemistry, 54, 1–19.
   PubMed Web of Science ®Google Scholar
• He, L., et al., 2006. ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties. Molecular pharmacology, 70, 171–180.
   PubMed Web of Science ®Google Scholar
• Hentze, M.W., et al., 2010. Two to tango: regulation of Mammalian iron metabolism. Cell, 142, 24–38.
   PubMed Web of Science ®Google Scholar
• Hirsch, H.V.B., et al., 2012. Drosophila melanogaster as a model for lead neurotoxicology and toxicogenomics research. Frontiers in genetics, 3, 68.
   PubMedGoogle Scholar
• Jacobs, A., et al., 1972. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. British medical journal, 4, 206–208.
   PubMed Web of Science ®Google Scholar
• Kambe, T., et al., 2004. Overview of mammalian zinc transporters. Cellular and molecular life sciences: CMLS, 61, 49–68.
   PubMed Web of Science ®Google Scholar
• Kim, H., Wu, X., and Lee, J., 2013. SLC31 (CTR) family of copper transporters in health and disease. Molecular aspects of medicine, 34, 561–570.
   PubMed Web of Science ®Google Scholar
• Kinnesaffran, E., et al., 1993. Inhibition of Na,K-ATPase by cadmium: different mechanisms in different species. Toxicology and applied pharmacology, 121 (1), 22–29.
   PubMed Web of Science ®Google Scholar
• Kodama, H., Fujisawa, C., and Bhadhprasit, W., 2012. Inherited copper transport disorders: biochemical mechanisms, diagnosis, and treatment. Current drug metabolism, 13, 237–250.
   PubMed Web of Science ®Google Scholar
• Kurama, T., Kurata, S., and Natori, S., 1995. Molecular characterization of an insect transferrin and its selective incorporation into eggs during oogenesis. European journal of biochemistry, 228, 229–235.
   PubMedGoogle Scholar
• Kwong, R.W., Andrés, J.A., and Niyogi, S., 2010. Molecular evidence and physiological characterization of iron absorption in isolated enterocytes of rainbow trout (Oncorhynchus mykiss): implications for dietary cadmium and lead absorption. Aquatic toxicology, 99, 343–350.
   PubMed Web of Science ®Google Scholar
• Lambert, L.A., 2012. Molecular evolution of the transferrin family and associated receptors. BBA - general subjects, 1820, 244–255.
   PubMed Web of Science ®Google Scholar
• Lambert, L., and Mitchell, S., 2007. Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family. Journal of Molecular Evolution, 64 (1), 113–128.
   PubMed Web of Science ®Google Scholar
• Leslie, E.M., Haimeur, A., and Waalkes, M.P., 2004. Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required. The journal of biological chemistry, 279, 32700–32708.
   PubMed Web of Science ®Google Scholar
• Leung, J., et al., 2007. Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells. Blood, 109, 740–746.
   PubMed Web of Science ®Google Scholar
• Li, Y., et al., 1995. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nature genetics 11, 376–381.
   PubMed Web of Science ®Google Scholar
• Lind, M.I., et al., 2006. Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein. Journal of biological chemistry, 281, 18707–18714.
   PubMed Web of Science ®Google Scholar
• Liu, Z., et al., 2006. Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. Biochemical and biophysical research communications, 351, 424–430.
   PubMed Web of Science ®Google Scholar
• Liu, Z.H., et al., 2019. Oxidative stress caused by Lead (Pb) induces iron deficiency in Drosophila melanogaster. Chemosphere, 243, 125428.
   PubMed Web of Science ®Google Scholar
• Liuzzi, J.P., and Cousins, R.J., 2004. Mammalian zinc transporters. Annual review of nutrition, 24, 151–172.
   PubMed Web of Science ®Google Scholar
• Magos, L., and Webb, M., 1978. Theoretical and practical considerations on the problem of metal–metal interaction. Environmental health perspectives, 25, 151–154.
   PubMed Web of Science ®Google Scholar
• Maret, W., 2010. Metalloproteomics, metalloproteomes, and the annotation of metalloproteins. Metallomics: integrated biometal science, 2, 117–125.
   PubMed Web of Science ®Google Scholar
• Martinez-Finley, E.J., et al., 2012. Cellular transport and homeostasis of essential and nonessential metals. Metallomics, 4, 593–605.
   PubMed Web of Science ®Google Scholar
• Matés, J.M., 2000. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology, 153 (1-3), 83–104.
   PubMed Web of Science ®Google Scholar
• Mathew, B., and Beeregowda, K., 2018. Assessment of lead toxicity using drosophila melanogaster as a model. Journal of clinical toxicology, 08 (02), 380–386.
   Google Scholar
• McKenna, I.M.., et al., 2001. K- ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas. Mutation research/genetic toxicology and environmental mutagenesis, 490, 57–65.
   PubMed Web of Science ®Google Scholar
• McMahon, R.J., and Cousins  , 1998. Mammalian zinc transporters. Journal of nutrition, 128(4), 667–670.
   PubMed Web of Science ®Google Scholar
• Metzendorf, C., Wu, W., and Lind, M., 2009. Overexpression of Drosophila mitoferrin in I(2)mbn cells results in dysregulation of Fer1HCH expression. The biochemical journal, 421, 463–471.
   PubMed Web of Science ®Google Scholar
• Missirlis, F., et al., 2007. Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin. Genetics, 177, 89–100.
   PubMed Web of Science ®Google Scholar
• Navarro, J.A., et al., 2015. Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Free radical biology and medicine, 85, 71–82.
   PubMed Web of Science ®Google Scholar
• Nichol, H., Law, J.H., and Winzerling, J.J., 2002. Iron metabolism in insects. Annual review of entomology, 47, 535–559.
   PubMed Web of Science ®Google Scholar
• Niyogi, S., Kent, R., and Wood, C. M., 2008. Effects of water chemistry variables on gill binding and acute toxicity of cadmium in rainbow trout (Oncorhynchus mykiss): A biotic ligand model (BLM) approach. Comparative biochemistry and physiology. Toxicology & pharmacology, 148, 305–314.
   Google Scholar
• Niyogi, S., and Wood, C.M., 2004. Kinetic analyses of waterborne Ca and Cd transport and their interactions in the gills of rainbow trout (Oncorhynchus mykiss) and yellow perch (Perca flavescens), two species differing greatly in acute waterborne Cd sensitivity. Journal of comparative physiology. B, biochemical, systemic, and environmental physiology, 174, 243–253.
   PubMed Web of Science ®Google Scholar
• Norgate, M., et al., 2006. Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7. Molecular biology of the cell, 17, 475–484.
   PubMed Web of Science ®Google Scholar
• Park, J.D., Cherrington, N.J., and Klaassen, C.D., 2002. Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicological sciences., 68, 288–294.
   PubMed Web of Science ®Google Scholar
• Patrick, L., 2013. Mercury toxicity and antioxidants: part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity. Alternative medicine review a journal of clinical therapeutic, 7, 456.
   Google Scholar
• Pérez-Rafael, S., et al., 2012. Is MtnE, the fifth Drosophila metallothionein, functionally distinct from the other members of this polymorphic protein family? Metallomics, 4 (4), 342–349.
   PubMed Web of Science ®Google Scholar
• Petris, M.J., 2004. The SLC31 (Ctr) copper transporter family. Pflügers Archiv, 447, 752–755.
   PubMed Web of Science ®Google Scholar
• Priest, N.D., 2004. The biological behaviour and bioavailability of aluminium in man, with special reference to studies employing aluminium-26 as a tracer: review and study update. Journal of environmental monitoring: JEM, 6, 375–403.
   PubMed Web of Science ®Google Scholar
• Qian, Y., et al., 1999. Effect of lead exposure and accumulation on copper homeostasis in cultured C6 rat glioma cells. Toxicology and applied pharmacology., 158, 41–49.
   PubMed Web of Science ®Google Scholar
• Qian, Y., Tiffany-Castiglioni, E., and Harris, E.D. 1997. A Menkes P-type ATPase involved in copper homeostasis in the central nervous system of the rat. Molecular brain research, 48, 60.
   PubMedGoogle Scholar
• Qiang, W., et al., 2017. Metal-metal interaction mediates the iron induction of Drosophila MtnB. Biochemical and biophysical research communications, 487, 646–652.
   PubMed Web of Science ®Google Scholar
• Redenti, S., and Chappell, R.L., 2004. Localization of zinc transporter-3 (ZnT-3) in mouse retina. Vision research, 44, 3317–3321.
   PubMed Web of Science ®Google Scholar
• Reid, S.D., and Mcdonald, D.G., 1988. Effects of cadmium, copper, and low pH on ion fluxes in the rainbow trout, Salmo gairdneri. Canadian journal of fisheries and aquatic sciences, 45 (2), 244–253.
   Web of Science ®Google Scholar
• Reiter, L.T., et al., 2001. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome research, 11, 1114–1125.
   PubMed Web of Science ®Google Scholar
• Richardson, D.R., et al., 2010. Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proceedings of the national academy of sciences of the United States of America, 107, 10775–10782.
   PubMed Web of Science ®Google Scholar
• Rodella, L.F., et al., 2008. Aluminium exposure induces Alzheimer's disease-like histopathological alterations in mouse brain. Histology & histopathology, 23, 433–439.
   PubMed Web of Science ®Google Scholar
• Rodriguez, K., 2015. Wilson’s disease: a review of what we have learned. World journal of hepatology, 7, 2859.
   PubMed Web of Science ®Google Scholar
• Ruden, D.M., et al., 2009. Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead. NeuroToxicology, 30, 898–914.
   PubMed Web of Science ®Google Scholar
• Schmidt, P., Kunst, C., and Culotta, V., 2000. Copper activation of superoxide dismutase 1 (SOD1) in vivo - Role for protein-protein interactions with the copper chaperone for SOD1. The journal of biological chemistry, 275, 33771–33776.
   PubMed Web of Science ®Google Scholar
• Selvaraj, A., et al., 2005. Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Genes & development, 19 (8), 891–896.
   PubMed Web of Science ®Google Scholar
• Sendamarai, A.K., et al., 2008. Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle. Proceedings of the national academy of sciences of the United States of America, 105, 7410–7415.
   PubMed Web of Science ®Google Scholar
• Shan, L., Cullen, W.R., and Thomas, D.J., 1999. Methylarsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductase. Chemical research in toxicology, 12, 924–930.
   PubMed Web of Science ®Google Scholar
• Shinkai, Y., et al., 2009. Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. Toxicology and applied pharmacology., 237, 232–236.
   PubMed Web of Science ®Google Scholar
• Simons, T.J., 1988. Active transport of lead by the calcium pump in human red cell ghosts. Journal of physiology, 405, 105–113.
   PubMed Web of Science ®Google Scholar
• Sooksa-Nguan, T., et al., 2009. Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration. The. Journal of biological chemistry, 284, 354–362.
   PubMed Web of Science ®Google Scholar
• Stohs, S.J., et al., 2000. Oxidative mechanisms in the toxicity of chromium and cadmium ions. Journal of environmental pathology toxicology & oncology, 19, 201.
   PubMedGoogle Scholar
• Szuster-Ciesielska, A., et al., 2000. The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology, 145, 159–171.
   PubMed Web of Science ®Google Scholar
• Tang, H.W., Liang, Y.X., and Hu, X.H., 1994. Effects of low level lead exposure on behavior of young rats. Acta pharmacologica sinica, 15, 316.
   Web of Science ®Google Scholar
• Tang, X., and Zhou, B., 2013. Ferritin is the key to dietary iron absorption and tissue iron detoxification in Drosophila melanogaster. The FASEB journal, 27, 288–298.
   PubMed Web of Science ®Google Scholar
• Tomas, M., et al., 2013. The sea urchin metallothionein system: comparative evaluation of the SpMTA and SpMTB metal-binding preferences. FEBS open bio, 3, 89–100.
   PubMed Web of Science ®Google Scholar
• Touret, N., et al., 2003. Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor. The journal of biological chemistry, 278, 25548–25557.
   PubMed Web of Science ®Google Scholar
• Vannucci, S.J., Gibbs, E.M., and Simpson, I.A., 1997. Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice. The American journal of physiology, 272, E267–74.
   PubMed Web of Science ®Google Scholar
• Vasudevaraju, P., et al., 2008. Molecular toxicity of aluminum in relation to neurodegeneration. The Indian journal of medical research, 128, 545–556.
   PubMed Web of Science ®Google Scholar
• Verelst, W., and Asard, H., 2003. A phylogenetic study of cytochrome b561 proteins. Genome biology, 4, R38.
   PubMed Web of Science ®Google Scholar
• Wan, R., et al., 2020. Impaired postnatal myelination in a conditional knockout mouse for the ferritin heavy chain in oligodendroglial cells. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 40 (40), 7609–7624.
   PubMed Web of Science ®Google Scholar
• Witkiewicz-Kucharczyk, A., and Bal, W., 2006. Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis. Toxicology letters, 162, 29–42.
   PubMed Web of Science ®Google Scholar
• Wu, Z., et al., 2012. Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production. Neurobiology of aging, 33, 199.e1-12.
   PubMed Web of Science ®Google Scholar
• Xiao, G., et al., 2019. Transferrin 1 functions in iron trafficking and genetically interacts with ferritin in Drosophila melanogaster. Cell reports, 26, 748–758.e5.
   PubMed Web of Science ®Google Scholar
• Xiao, G., et al., 2014. The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster. Elife, 3, e03191.
   PubMed Web of Science ®Google Scholar
• Yepiskoposyan, H., et al., 2006. Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc. Nucleic acids research, 34, 4866–4877.
   PubMed Web of Science ®Google Scholar
• Yokel, R.A., et al., 2002. Aluminum citrate uptake by immortalized brain endothelial cells: implications for its blood-brain barrier transport. Brain research, 930, 101–110.
   PubMed Web of Science ®Google Scholar
• Yoshiga, T., et al., 1999. Drosophila melanogaster transferrin. European journal of biochemistry, 260, 414–420.
   PubMedGoogle Scholar
• Yu, Y., et al., 2020. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis (with comment). Blood, 136 (6), 726–739.
   PubMed Web of Science ®Google Scholar
• Zhang, B., et al., 2003. Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein. Molecular and cellular biology., 23, 8471–8485.
   PubMed Web of Science ®Google Scholar
• Zhou, H., Cadigan, K.M., and Thiele, D.J., 2003. A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. The journal of biological chemistry, 278, 48210–48218.
   PubMed Web of Science ®Google Scholar
• Zucker, R.S., 1996. Exocytosis: a molecular and physiological perspective. Neuron, 17, 1049–1055.
   PubMed Web of Science ®Google Scholar