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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 7
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General Xenobiochemistry

Evaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D3-induced intestinal cell lines

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Pages 771-777 | Received 12 Mar 2021, Accepted 29 Apr 2021, Published online: 17 May 2021

References

  • Achira, M., et al., 1999. Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4. AAPS pharmScience, 1 (4), 14–19.
  • Ai, Z., et al., 2019. Effect of stereochemical configuration on the transport and metabolism of catechins from green tea across Caco-2 monolayers. Molecules, 24 (6), 1185.
  • Aiba, T., et al., 2005. The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180. Drug metabolism and pharmacokinetics, 20 (4), 268–274.
  • De Gottardi, A., et al., 2004. The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer. Digestive diseases and sciences, 49 (6), 982–989.
  • Dresser, G.K., Bailey, D.G., and Carruthers, S.G., 2000. Grapefruit juice-felodipine interaction in the elderly. Clinical pharmacology and therapeutics, 68 (1), 28–34.
  • Englund, G., et al., 2014. Cytochrome p450 inhibitory properties of common efflux transporter inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 42 (3), 441–447.
  • Fahmi, O.A., et al., 2008. A combined model for predicting CYP3A4 clinical net drug-drug interaction based on CYP3A4 inhibition, inactivation, and induction determined in vitro. Drug metabolism and disposition: the biological fate of chemicals, 36 (8), 1698–1708.
  • Fitzsimmons, M.E., and Collins, J.M., 1997. Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism. Drug metabolism and disposition: the biological fate of chemicals, 25 (2), 256–266.
  • Gibbs, M.A., et al., 2000. Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells. Pharmaceutical research, 17 (3), 299–305.
  • Gibbs, M.A., et al., 1999. Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. Drug metabolism and disposition, 27 (2), 180–187.
  • Gnerre, C., et al., 2004. Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics, 14 (10), 635–645.
  • Greenblatt, D.J., et al., 2003. Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice. Clinical pharmacology and therapeutics, 74 (2), 121–129.
  • Guengerich, F.P., 1999. Cytochrome P-450 3A4: regulation and role in drug metabolism. Annual review of pharmacology and toxicology, 39, 1–17.
  • Hong, J., et al., 2003. Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochemical and biophysical research communications, 310 (1), 222–227.
  • Hou, X.L., et al., 2007. Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1alpha,25 dihydroxyvitamin D3 treated Caco-2 cells. International journal of pharmaceutics, 337 (1–2), 169–177.
  • Kabeya, T., et al., 2018. Cyclic AMP signaling promotes the differentiation of human induced pluripotent stem cells into intestinal epithelial cells. Drug metabolism and disposition, 46 (10), 1411–1419.
  • Korobkova, E.A., 2015. Effect of natural polyphenols on CYP metabolism: implications for diseases. Chemical research in toxicology, 28 (7), 1359–1390.
  • Lown, K.S., Ghosh, M., and Watkins, P.B., 1998. Sequences of intestinal and hepatic cytochrome P450 3A4 cDNAs are identical. Drug metabolism and disposition: the biological fate of chemicals, 26 (2), 185–187.
  • Misaka, S., et al., 2013. Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes. Drug metabolism and pharmacokinetics, 28 (3), 244–249.
  • Mizoi, K., et al., 2020b. Usefulness and limitations of mRNA measurement in HepaRG cells for evaluation of cytochrome P450 induction. Fundamental toxicological sciences, 7 (1), 9–14.
  • Mizoi, K., et al. 2020a. Establishment of a primary human hepatocyte spheroid system for evaluating metabolic toxicity using dacarbazine under conditions of CYP1A2 induction. Drug metabolism and pharmacokinetics, 35 (2), 201–206.
  • Paine, M.F., Criss, A.B., and Watkins, P.B., 2004. Two major grapefruit juice components differ in intestinal CYP3A4 inhibition kinetic and binding properties. Drug metabolism and disposition: the biological fate of chemicals, 32 (10), 1146–1153.
  • Piana, C., et al., 2008. Validation of reference genes for qPCR studies on Caco-2 cell differentiation. European journal of pharmaceutics and biopharmaceutics, 69 (3), 1187–1192.
  • Piver, B., et al. 2001. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicology letters, 125 (1–3), 83–91.
  • Rendic, S., and Di Carlo, F.J., 1997. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug metabolism reviews, 29 (1–2), 413–580.
  • Roberts, A.G., et al., 2011. The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. Biochemistry, 50 (50), 10804–10818.
  • Sachar, M., Kelly, E.J., and Unadkat, J.D., 2019. Mechanisms of CYP3A induction during pregnancy: studies in HepaRG cells. The AAPS journal, 21 (3), 45.
  • Schmiedlin-Ren, P., et al., 1997. Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3. Molecular pharmacology, 51 (5), 741–754.
  • Shimada, T., et al., 2010. Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chemical research in toxicology, 23 (12), 1921–1935.
  • Shimada, T., et al., 1994. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of pharmacology and experimental therapeutics., 270 (1), 414–423.
  • Thummel, K.E., et al., 2001. Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. Molecular pharmacology, 60 (6), 1399–1406.
  • Tsujimoto, M., et al., 2009. The structure-activity correlation on the inhibitory effects of flavonoids on cytochrome P450 3A activity. Biological & pharmaceutical bulletin, 32 (4), 671–676.
  • von Moltke, L.L., et al., 2004. Interaction of triazolam and ketoconazole in P-glycoprotein-deficient mice. Drug metabolism and disposition: the biological fate of chemicals, 32 (8), 800–804.
  • Wienkers, L.C., and Heath, T.G., 2005. Predicting in vivo drug interactions from in vitro drug discovery data. Nature reviews. drug discovery, 4 (10), 825–833.
  • Zheng, X.E., et al., 2012. Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D3 function in human colon adenocarcinoma LS180 cells. Biochemical pharmacology, 84 (3), 391–401.

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