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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 5
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Animal Pharmacokinetics and Metabolism

Pomegranate peel polyphenols interaction with intestinal flora and its metabolic transformation

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Pages 442-452 | Received 24 Mar 2022, Accepted 29 Apr 2022, Published online: 23 Aug 2022

References

  • Al-Muammar MN, Khan F. 2012. Obesity: the preventive role of the pomegranate (Punica granatum). Nutrition. 28(6):595–604.
  • Aviram M, Dornfeld L. 2001. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 158(1):195–198.
  • Cerdá B, Llorach R, Cerón J, Espín J, Tomás-Barberán F. 2003. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr. 42(1):18–28.
  • Cerdá B, Periago P, Espín J, Tomás-Barberán F. 2005a. Identification of urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds. J Agric Food Chem. 53(14):5571–5576.
  • Cerdá B, Tomás-Barberán F, Espín J. 2005b. Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability. J Agric Food Chem. 53(2):227–235.
  • Duda-Chodak A, Tarko T, Satora P, Sroka P. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. Eur J Nutr. 2015;54(3):325–341.
  • Du L, Li J, Zhang X, Wang L, Zhang W, Yang M, Hou C. 2019. Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4/NF-κB pathway activation. Food Nutrition Research. 63:1–12.
  • Espín J, Larrosa M, García-Conesa M, Tomás-Barberán F. 2013. Biological significance of urolithins, the gut microbial ellagic acid-derived metabolites: the evidence so far. Evid Based Complementary Altern Med. 2013:1–715.
  • Faria A, Calhau C. 2011. The bioactivity of pomegranate: impact on health and disease. Crit Rev Food Sci Nutr. 51(7):626–634.
  • García-Villalba R, Beltrán D, Espín J, Selma MV, Tomás-Barberán F. 2013. Time course production of urolithins from ellagic acid by human gut microbiota. J Agric Food Chem. 61(37):8797–8806.
  • Gil MI, Tomás-Barberán F, Hess-Pierce B, Holcroft DM, Kader AA. 2000. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem. 48(10):4581–4589.
  • Gil-Izquierdo A, Zafrilla P, Tomas-Barberan FA. 2002. An in vitro method to simulate phenolic compound release from the food matrix in the gastrointestinal tract. Eur Food Res Technol. 214(2):155–159.
  • González-Sarrías A, Giménez-Bastida JA, García-Conesa MT, Gómez-Sánchez MB, García-Talavera NV, Gil-Izquierdo A, Sánchez-Alvarez C, Fontana-Compiano LO, Morga-Egea JP, Pastor-Quirante FA, et al. 2010. Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. Mol Nutr Food Res. 54(3):311–322.
  • González-Trujano M, Pellicer F, Mena P, Moreno D, García-Viguera C. 2015. Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins. Int J Food Sci Nutr. 66(4):395–399.
  • Guilloteau P, Martin L, Eeckhaut V, Ducatelle R, Zabielski R, Immerseel FV. 2010. From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr Res Rev. 23(2):366–384.
  • Gullon B, Pintado ME, Fernández-López J, Pérez-Álvarez J, Viuda-Martos M. 2015. In vitro gastrointestinal digestion of pomegranate peel (Punica granatum) flour obtained from co-products: changes in the antioxidant potential and bioactive compounds stability. J Funct Foods. 19:617–628.
  • Hou C, Zhang W, Li J, Du L, Lv O, Zhao S, Li J. 2019. Beneficial effects of pomegranate on lipid metabolism in metabolic disorders. Mol Nutr Food Res. 63(16):1800773.
  • Huang D. 2018. Relationship between intestinal flora structure and fecal fatty acids under different diets. Northeast Agricultural University.
  • Huang Z-W, Zhou X-D, Xiao Y, Liu T-J, Li J-Y. 2005. Effects of 11 natural drugs on the growth and acid production of lactobacillus in vitro. Shanghai Kou Qiang Yi Xue. 14(1):67–70.
  • Jang YS, Im JA, Choi SY, Lee JI, Lee SY. Metabolic engineering of Clostridium acetobutylicum for butyric acid production with high butyric acid selectivity. Metab Eng. 2014;23:165–174.
  • Kim ND, Mehta R, Yu W, Neeman I, Livney T, Amichay A, Poirier D, Nicholls P, Kirby A, Jiang W, et al. 2002. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat. 71(3):203–217.
  • Landete JM. 2011. Ellagitannins, ellagic acid and their derived metabolites: a review about source, metabolism, functions and health. Food Res Int. 44(5):1150–1160.
  • Lansky EP, Newman RA. 2007. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol. 109(2):177–206.
  • Larrosa M, González-Sarrías A, Yá?Ez-Gascón M, Selma MV, Azorín-Ortu? OM, Toti S, Tomás-Barberán F, Dolara P, Espín J. 2010. Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. J Nutr Biochem. 21(8):717–725.
  • Le Z, Qi Z, Ma W, Feng T, Shen H, Zhou M. 2017. A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota. Food Funct. 8:4644–4656.
  • Lee CJ, Chen LG, Liang WL, Wang CC. 2010. Anti-inflammatory effects of Punica granatum Linne in vitro and in vivo. Food Chem. 118(2):315–322.
  • Li G, Li J. 2010. Procedure on extraction phenolics from the skin of Punica granatum. Shaanxi Agric Sci. 56:20–24.
  • Li JK, Li GX, Zhao YH, Yu CZ. 2009. Composition of pomegranate peel polyphenols and its antioxidant activities. Scientia Agricultura Sinica. 42:4035–4041.
  • Li J, Xu H, Sun Z, Hou Q, Kwok L-Y, Laga W, Wang Y, Ma H, Yu Z, Menghe B, et al. 2016. Effect of dietary interventions on the intestinal microbiota of Mongolian hosts. Science Bulletin. 61(20):1605–1614.
  • Pagliarulo C, De Vito V, Picariello G, Colicchio R, Pastore G, Salvatore P, Volpe MG. 2016. Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food Chem. 190:824–831.
  • Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D. 2005. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 16(6):360–367.
  • Seeram NP, Lee R, Heber D. 2004. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin Chim Acta. 348(1-2):63–68.
  • Shaban NZ, El-Kersh M, El-Rashidy FH, Habashy NH. 2013. Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats. Food Chem. 141(3):1587–1596.
  • Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM. 2008. Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition. 24(7–8):733–743.
  • Stenman LK, Burcelin R, Lahtinen S. 2016. Establishing a causal link between gut microbes, body weight gain and glucose metabolism in humans – towards treatment with probiotics. Benef Microbes. 7(1):11–22.
  • Tehranifar A, Zarei M, Nemati Z, Esfandiyari B, Vazifeshenas MR. 2010. Investigation of physico-chemical properties and antioxidant activity of twenty Iranian pomegranate (Punica granatum L.) cultivars. Sci Horti. 126(2):180–185.
  • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. 2006. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 444(7122):1027–1031.
  • Wu D, Ma X, Tian W. 2013. Pomegranate husk extract, punicalagin and ellagic acid inhibit fatty acid synthase and adipogenesis of 3T3-L1 adipocyte. J Funct Foods. 5(2):633–641.
  • Zhao R, Long X, Yang J, Du L, Zhang X, Li J, Hou C. 2019. Pomegranate peel polyphenols reduce chronic low-grade inflammatory responses by modulating gut microbiota and decreasing colonic tissue damage in rats fed a high-fat diet. Food Funct. 10(12):8273–8285.
  • 조창희, 장유신, 이상엽. 2015. Metabolic engineering of Clostridium acetobutylicum for enhanced butyric acid production. Theories and Applications of Chem. Eng. 21:396.

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