Xenobiotica, Volume 52, Issue 5 (2022)

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Xenobiotica, Volume 52, Issue 5 (2022)

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General Xenobiochemistry

Article
Curcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity in vitro
Viktoriia Burkina, Galia Zamaratskaia & Martin Krøyer Rasmussen
Pages: 435-441
Published online: 04 Jul 2022
AbstractforCurcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity in vitro | Full Text | References | PDF (1.3 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Pomegranate peel polyphenols interaction with intestinal flora and its metabolic transformation
Haidan Shi, Junqi Yang & Jianke Li
Pages: 442-452
Published online: 23 Aug 2022
AbstractforPomegranate peel polyphenols interaction with intestinal flora and its metabolic transformation | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 230 Views
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Article
Pharmacokinetics and mass balance of vericiguat in rats and dogs and distribution in rats
Wiebke Janssen, Thomas Schwarz, Ulf Bütehorn, Wolfram Steinke, Steffen Sandmann, Dieter Lang, Armin Kern, Frank Hucke & Michael Gerisch
Pages: 453-462
Published online: 23 Jun 2022
AbstractforPharmacokinetics and mass balance of vericiguat in rats and dogs and distribution in rats | Full Text | References | PDF (1,010.8 KB) | EPUB | Supplemental
  • 398 Views
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Article
Pharmacokinetics and pharmacodynamic interaction of bergamottin with atorvastatin in rats
Xinjuan Zhang, Jinyao Guo, Jin Li, Chen Chen & Guijun Su
Pages: 463-467
Published online: 28 Jun 2022
AbstractforPharmacokinetics and pharmacodynamic interaction of bergamottin with atorvastatin in rats | Full Text | References | PDF (703 KB) | EPUB
  • 207 Views
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Article
Disposition study of the novel dipeptidyl peptidase 4 inhibitor cetagliptin in rats
Jinmiao Lu, Yan Hao, Fuzhi Zhang, Huiping Pan, Juping Ding, Qiang Yu & Tong Wang
Pages: 468-475
Published online: 27 Jun 2022
AbstractforDisposition study of the novel dipeptidyl peptidase 4 inhibitor cetagliptin in rats | Full Text | References | PDF (1 MB) | EPUB
  • 64 Views
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Article
Preclinical pharmacokinetics, CYP phenotyping, and tissue distribution study of novel anti-breast cancer candidate S-011-1559
Sarvesh Kumar Verma, Arpon Biswas, Mukesh Kumar, Anjali Mishra, Abhijit Deb Choudhury, Sristi Agrawal, Sachin Nashik Sanap, Amol Chhatrapati Bisen, Ashok Kumar Sharma, Gautam Panda & Rabi Sankar Bhatta
Pages: 476-487
Published online: 21 Jul 2022
AbstractforPreclinical pharmacokinetics, CYP phenotyping, and tissue distribution study of novel anti-breast cancer candidate S-011-1559 | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 231 Views
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Article
Non-clinical studies indicating lack of interactions between iron/calcium ions and linzagolix, an orally available GnRH antagonist
Kaoru Kobayashi, Motohiro Tezuka, Yasuyuki Toyoda, Takao Kurooka, Emiko Oota, Yasuaki Tamai, Yoshikazu Abe, Sumiyoshi Kiguchi & Takuro Endo
Pages: 488-497
Published online: 09 Aug 2022
AbstractforNon-clinical studies indicating lack of interactions between iron/calcium ions and linzagolix, an orally available GnRH antagonist | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Molecular Toxicology

Article
The chlorophenoxy herbicide MCPA: a mechanistic basis for the observed differences in toxicological profile in humans and rats versus dogs
Alex Gledhill, Rachael Bowen, Michael Bartels, Andrew Bond, Git Chung, Colin Brown, Keith Pye & Tarang Vora
Pages: 498-510
Published online: 28 Jul 2022
AbstractforThe chlorophenoxy herbicide MCPA: a mechanistic basis for the observed differences in toxicological profile in humans and rats versus dogs | Full Text | References | PDF (2 MB) | EPUB
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Xenobiotic Transporters

Article
In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes
Mikina Takiyama, Takashi Matsumoto, Noriko Kaifuchi, Yasuharu Mizuhara, Eiji Warabi, Katsuya Ohbuchi & Kazushige Mizoguchi
Pages: 511-519
Published online: 25 Jul 2022
AbstractforIn vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Open Access

Pharmacogenetics

Article
Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity
Ning Wang, Shaochen Guo, Haiting Liu, Yangming Ding, Rong Yao, Zhongquan Liu, Hui Zhu, Xi Chen, Xinting Yang, Xiaoyou Chen & Yu Lu
Pages: 520-526
Published online: 29 Jun 2022
AbstractforRelevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity | Full Text | References | PDF (676.3 KB) | EPUB | Supplemental
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Article
Association of ABCG2 polymorphisms with susceptibility to anti-tuberculosis drug-induced hepatotoxicity in the Chinese population
Nannan Wang, Xinyu Chen, Zhuolu Hao, Honggang Yi & Shaowen Tang
Pages: 527-533
Published online: 04 Jul 2022
AbstractforAssociation of ABCG2 polymorphisms with susceptibility to anti-tuberculosis drug-induced hepatotoxicity in the Chinese population | Full Text | References | PDF (794.4 KB) | EPUB | Supplemental
  • 211 Views
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