Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 4
98
Views
3
CrossRef citations to date
0
Altmetric
Xenobiotic Transporters

Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2

, , , &
Pages 389-396 | Received 16 Apr 2022, Accepted 16 May 2022, Published online: 26 May 2022

References

  • Aleksunes LM, Klaassen CD. 2012. Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice. Drug Metab Dispos. 40(7):1366–1379.
  • Chai X, Zeng S, Xie W. 2013. Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond. Expert Opin Drug Metab Toxicol. 9(3):253–266.
  • Chen T, Wang C, Liu Q, Meng Q, Sun H, Huo X, Sun P, Peng J, Liu Z, Yang X, et al. 2015. Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway. Cancer Biol Ther. 16(1):106–114.
  • Chufan EE, Kapoor K, Ambudkar SV. 2016. Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein. Biochem Pharmacol. 101:40–53.
  • de Jonge-Peeters S, Kuipers F, de Vries EG, Vellenga E. 2007. ABC transporter expression in hematopoietic stem cells and the role in AML drug resistance. Crit Rev Oncol Hematol. 62(3):214–226.
  • Escherich G, Zimmermann M, Janka-Schaub G. 2013. Doxorubicin or daunorubicin given upfront in a therapeutic window are equally effective in children with newly diagnosed acute lymphoblastic leukemia. A randomized comparison in trial CoALL 07-03. Pediatr Blood Cancer. 60(2):254–257.
  • Haferlach T, Schmidts I. 2020. The power and potential of integrated diagnostics in acute myeloid leukaemia. Br J Haematol. 188(1):36–48.
  • Hosny M, Zheng MS, Zhang H, Chang HW, Woo MH, Son JK, Lee SK. 2014. (-)-Catechin glycosides from Ulmus davidiana. Arch Pharm Res. 37(6):698–705.
  • Huang L, Huang M, Li YH, Li RM, Zeng Y, Kuang SY, Zhang L, Wang YT, Bi HC. 2013. Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn. J Ethnopharmacol. 148(2):596–602.
  • Jung MJ, Heo SI, Wang MH. 2008. Free radical scavenging and total phenolic contents from methanolic extracts of Ulmus davidiana. Food Chem. 108(2):482–487.
  • Kantarjian HM, Keating MJ, Freireich EJ. 2018. Toward the potential cure of leukemias in the next decade. Cancer. 124(22):4301–4313.
  • Kim EH, Jo CS, Ryu SY, Kim SH, Lee JY. 2018. Anti-osteoclastogenic diacetylenic components of Dendropanax morbifera. Arch Pharm Res. 41(5):506–512.
  • Kim YC, Lee MK, Sung SH, Kim SH. 2007. Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production. Fitoterapia. 78(3):196–199.
  • Kundu JK, Rouf AS, Hossain MN, Hasan CM, Rashid MA. 2000. Antitumor activity of epifriedelanol from Vitis trifolia. Fitoterapia. 71(5):577–579.
  • Lee GY, Jang DS, Kim J, Kim CS, Kim YS, Kim JH, Kim JS. 2008. Flavan-3-ols from Ulmus davidiana var. japonica with inhibitory activity on protein glycation. Planta Med. 74(15):1800–1802.
  • Lee JC, Lee KY, Son YO, Choi KC, Kim J, Truong TT, Jang YS. 2005. Plant-originated glycoprotein, G-120, inhibits the growth of MCF-7 cells and induces their apoptosis. Food Chem Toxicol. 43(6):961–968.
  • Lee MK, Sung SH, Lee HS, Cho JH, Kim YC. 2001. Lignan and neolignan glycosides from Ulmus davidiana var. japonica. Arch Pharm Res. 24(3):198–201.
  • Li Y, Huang L, Zeng X, Zhong G, Ying M, Huang M, Bi H. 2014. Down-regulation of P-gp expression and function after Mulberroside A treatment: potential role of protein kinase C and NF-kappa B. Chem Biol Interact. 213:44–50.
  • Li H, Hui L, Xu W, Shen H, Chen Q, Long L, Zhu X. 2012. Modulation of P-glycoprotein expression by triptolide in adriamycin-resistant K562/A02 cells. Oncol Lett. 3(2):485–489.
  • Nabekura T, Hiroi T, Kawasaki T, Uwai Y. 2015. Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein. Biomed Pharmacother. 70:140–145.
  • Pan J, Miao D, Chen L. 2018. Germacrone reverses adriamycin resistance in human chronic myelogenous leukemia K562/ADM cells by suppressing MDR1 gene/P-glycoprotein expression. Chem Biol Interact. 288:32–37.
  • Ren J, Xu Y, Huang Q, Yang J, Yang M, Hu K, Wei K. 2015. Chabamide induces cell cycle arrest and apoptosis by the Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Anticancer Drugs. 26(5):498–507.
  • Rigalli JP, Tocchetti GN, Weiss J. 2019. Modulation of ABC Transporters by Nuclear Receptors: Physiological, Pathological and Pharmacological Aspects. Curr Med Chem. 26(7):1079–1112.
  • Saidijam M, Karimi Dermani F, Sohrabi S, Patching SG. 2018. Efflux proteins at the blood-brain barrier: review and bioinformatics analysis. Xenobiotica. 48(5):506–532.
  • Sengupta A, Banerjee D, Chandra S, Banerji SK, Ghosh R, Roy R, Banerjee S. 2007. Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression. Leukemia. 21(5):949–955.
  • Shin DY, Kim HS, Min KH, Hyun SS, Kim SA, Huh H, Choi EC, Choi YH, Kim J, Choi SH, et al. 2000. Isolation of a potent anti-MRSA sesquiterpenoid quinone from Ulmus davidiana var. japonica. Chem Pharm Bull. 48(11):1805–1806.
  • Thompson PA, Kantarjian HM, Cortes JE. 2015. Diagnosis and treatment of chronic myeloid Leukemia in 2015. Mayo Clin Proc. 90(10):1440–1454.
  • Toyoda Y, Hagiya Y, Adachi T, Hoshijima K, Kuo MT, Ishikawa T. 2008. MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions. Xenobiotica. 38(7-8):833–862.
  • Umsumarng S, Pitchakarn P, Sastraruji K, Yodkeeree S, Ung AT, Pyne SG, Limtrakul P. 2015. Reversal of human multi-drug resistance leukaemic cells by stemofoline derivatives via inhibition of P-glycoprotein function. Basic Clin Pharmacol Toxicol. 116(5):390–397.
  • van der Kolk DM, de Vries EG, Müller M, Vellenga E. 2002. The role of drug efflux pumps in acute myeloid leukemia. Leuk Lymphoma. 43(4):685–701.
  • Whyte-Allman SK, Hoque MT, Jenabian MA, Routy JP, Bendayan R. 2017. Xenobiotic nuclear receptors pregnane X receptor and constitutive androstane receptor regulate antiretroviral drug efflux transporters at the blood-testis barrier. J Pharmacol Exp Ther. 363(3):324–335.
  • Yang HH, Son JK, Jung B, Zheng M, Kim JR. 2011. Epifriedelanol from the root bark of Ulmus davidiana inhibits cellular senescence in human primary cells. Planta Med. 77(5):441–449.
  • Yi YJ, Jia XH, Zhu C, Wang JY, Chen JR, Wang H, Li YJ. 2018. Solanine reverses multidrug resistance in human myelogenous leukemia K562/ADM cells by downregulating MRP1 expression. Oncol Lett. 15(6):10070–10076.
  • Zhou SF. 2008. Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiotica. 38(7–8):802–832.
  • Zhou X, Ma X, Sun H, Li X, Cao H, Jiang Y, Wang P, Xie S, Li Y, Sun Y. 2020. Let-7b regulates the adriamycin resistance of chronic myelogenous leukemia by targeting AURKB in K562/ADM cells. Leuk Lymphoma. 61(14):3451–3459.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.