The chlorophenoxy herbicide MCPA: a mechanistic basis for the observed differences in toxicological profile in humans and rats versus dogs

References

• Bartels M, Brown C, Chung G, Chan M, Terry C, Gehen S, Corvaro M. 2020. Review of the pharmacokinetics and metabolism of triclopyr herbicide in mammals: Impact on safety assessments. Regul Toxicol Pharmacol. 116:104714.
   PubMedGoogle Scholar
• Basit A, Radi Z, Vaidya V, Karasu M, Prasad B. 2019. Kidney cortical transporter expression across species using quantitative proteomics. Drug Metab Dispos. 47(8):802–808.
   PubMed Web of Science ®Google Scholar
• Bleasby K, Castle JC, Roberts CJ, Cheng C, Bailey WJ, Sina JF, Kulkarni AV, Hafey MJ, Evers R, Johnson JM, et al. 2006. Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition. Xenobiotica. 36(10-11):963–988.
   PubMed Web of Science ®Google Scholar
• Brown C, Chung G. 2019. In vitro permeability studies of MCPA in primary dog, rat and human proximal tubule cell monolayers. Newcastle upon Tyne, UK: Newcells Biotech Ltd. Report No. RSA-17-10-2018.
   Google Scholar
• Brown C, Sayer R, Windass A, Haslam I, De Broe M, D'Haese C, Verhulst A. 2008. Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling. Toxicol Appl Pharmacol. 233(3):428–438.
   PubMed Web of Science ®Google Scholar
• Burckhardt G. 2012. Drug transport by organic anion transporters (OATS). Pharmacol Ther. 136(1):106–130.
   PubMed Web of Science ®Google Scholar
• Elo HA, Ylitalo P. 1979. Distribution of 2-methyl-4-chlorophenoxyacetic acid and 2,4-dichlorophenoxyacetic acid in male rats: evidence for the involvement of the central nervous system in their toxicity. Toxicol Appli Pharmacol. 51(3):439–446.
   PubMedGoogle Scholar
• Eraly S, Bush K, Sampogna R, Bhatnagar V, Nigam S. 2004. The molecular pharmacology of organic anion transporters: from DNA to FDA? Mol Pharmacol. 65(3):479–487.
   PubMed Web of Science ®Google Scholar
• [EC] European Commission Health & Consumer Protection Directorate-General. 2008. Review report for the active substance MCPA. SANCO/4062/2001-final
   Google Scholar
• Fjeldstad P, Wannag A. 1977. Human urinary excretion of the herbicide 2-methyl-4-chlorophenoxyacetic acid. Scand J Work Environ Health. 3(2):100–103.
   PubMedGoogle Scholar
• Granero GE, Amidon GL. 2008. Possibility of enterohepatic recycling of ketoprofen in dogs. Int J Pharm. 349(1-2):166–171.
   PubMed Web of Science ®Google Scholar
• Hallworth S. 2019. MCPA: Plasma protein binding species comparison. Alderley Park, UK: Concept Life Sciences. Report No. REP180134
   Google Scholar
• Hardwick T. 1999. (¹⁴C)-MCPA: Absorption and Excretion in the Beagle Dog. Harrogate, UK: Covance Labs Ltd. Report No. 729/197-D1141
   Google Scholar
• Jahanshahi M, Stow RA. 1995. (¹⁴C)-MCPA: Absorption, Distribution, Metabolism and Excretion in the Rat. Harrogate, UK: Corning Hazelton. Report No. 1149/5-1011)
   Google Scholar
• Kolmodin-Hedman B, Höglund S, Swensson A, Akerblom M. 1983. Studies on phenoxy acid herbicides. II. Oral and dermal uptake and elimination in urine of MCPA in humans. Arch Toxicol. 54(4):267–273.
   PubMedGoogle Scholar
• Lappin GJ, Hardwick TD, Stow R, Pigott GH, Van Ravenzwaay B. 2002. Absorption, metabolism and excretion of 4-chloro-2-methylphenoxyacetic acid (MCPA) in rat and dog. Xenobiotica. 32(2):153–163.
   PubMed Web of Science ®Google Scholar
• Lindh CH, Littorin M, Amilon AA, Jönsson BA. 2008. Analysis of phenoxyacetic acid herbicides as biomarkers in human urine using liquid chromatography/triple quadrupole mass spectrometry. Rapid Commun Mass Spectrom. 22(2):143–150.
   PubMedGoogle Scholar
• Lindquist NG. 1974. An autoradiographic study on the distribution of the herbicide 4-chloro-2-methylphenoxyacetic acid in pregnant mice. Toxicol Appl Pharmacol. 30(2):227–236.
   Google Scholar
• Priymenko N, Garnier F, Ferre J-P, Delatour P, Toutain P-L. 1998. Enantioselectivity of the enterohepatic recycling of carprofen in the Dog. Drug Metab Dispos. 26(2):170–176.
   PubMedGoogle Scholar
• Roberts DM, Dawson AH, Senarathna L, Mohamed F, Cheng R, Eaglesham G, Buckley NA. 2011. Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning. Toxicol Lett. 201(3):270–276.
   PubMedGoogle Scholar
• Sekine T, Cha S, Endou H. 2000. The multispecific organic anion (OAT) family. Pflugers Arch. 440(3):337–350.
   PubMedGoogle Scholar
• Takeuchi T, Jinno F, Ebihara T, Moriya Y, Kadotani R, Tagawa Y, Kondo T, Itoh T, Asahi S. 2013. Species differences of organic anion transporters involved in the renal uptake of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, between rats and dogs. Biopharm Drug Dispos. 34(4):236–246.
   PubMedGoogle Scholar
• Timchalk C. 2004. Comparative inter-species pharmacokinetics of phenoxyacetic acid herbicides and related organic acids. Evidence that the dog is not a relevant species for evaluation of human health risk. Toxicology. 200(1):1–19.
   PubMed Web of Science ®Google Scholar
• Timchalk CA, Nolan RJ, Billington RA, Eisenbrandt DL. 2002. Inter-species pharmacokinetic comparison of organic acid herbicides. Is the dog a relevant species for evaluation of human health risk? Pract Appl Toxicokinet. Model Risk Assess Chem. 5:79–107.
   Google Scholar
• VanWert A, Gionfriddo M, Sweet D. 2010. Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos. 31(1):1–71.
   PubMed Web of Science ®Google Scholar
• Vriend J, Pye K, Brown C. 2021. In vitro models for accurate prediction of renal tubular xenobiotic transport in vivo. Curr Opin Toxicol. 25:15–22.
   Google Scholar
• Zou L, Stecula A, Gupta A, Prasad B, Chien H-C, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, et al. 2018. Molecular mechanisms for species differences in organic anion transporter 1, OAT1: implications for renal drug toxicity. Mol Pharmacol. 94(1):689–699.
   PubMed Web of Science ®Google Scholar