Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 12
41
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Gender difference in the elimination of 2-methoxyethanol, methoxyacetic acid and ethoxyacetic acid in rat

&
Pages 1237-1244 | Published online: 22 Sep 2008

References

  • CLARKE, D . O., ELswicK, B. A., WELSCH, F. and CONOLLY, R. B., 1993, Pharmacokinetics of 2-methoxyethanol and 2-methoxyacetic acid in the pregnant mouse: A physiologically based methematicalmodel. Toxicology and Applied Pharmacology, 121, 239–252.
  • CHEEVER, K. L., PLOTNICK, H. B., RocHARDs, D. E. and WEIGEL, W. W., 1984, Metabolism and excretion of 2 -ethoxyethanolin the adult male rat. Environmental Health perspectives, 57, 241–248.
  • FOSTER, P. M. D., BLACKBURN, D. M., MOORE, R. B. and LLOYD, S. C., 1986, Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat. Toxicology Letters, 32, 73–80.
  • FOSTER, P.M. D., CREASY, D. M., FOSTER, J. R., THOMAS, L. V., COOK, MW. and GANGOLLI S . D 1983, Testicular toxicity of ethylene glycol monomethyl and monoethyl ethers in the rat. Toxicology and Applied Pharmacology, 69, 385–399.
  • FOSTER, P.M. D., LLOYD, S. C. and BLACKBURN, D. M., 1987, Comparison of the in vivo and in vitro testicular effects produced by methoxy-, ethoxy- and N-butoxy acetic acids in the rat. Toxicology, 43, 17–30.
  • GHANAYEM, B. I., SANDERS, J. M., CLARK, A.-M., BAILER, J. and MATTHEWS, H. B., 1990, Effects of dose, age, inhibitionof metabolism and eliminationon the toxicokinetics of 2-butoxyethanol and its metabolites. T he journal of Pharmacology and Experimental Therapeutics, 253, 136–143.
  • GRAY, T. J. B., Moss, E. J., CREASY, D. M. and GANGOLLI, S. D., 1985, Studies of the toxicity of some glycol ethers and alkoxyacetic acids in primary testicular cell cultures. Toxicology and Applied Pharmacology, 79, 490–501.
  • GROESENEKEN, D., VEULEMANS, H., MASSCHELEIN, R. and VAN VLEM, E., 1988, Comparative urinary excretion of ethoxyacetic acid in man and rat after single low doses of ethylene glycol monoethyl ether. Toxicology Letters, 41, 57–68.
  • HARDIN, B. D., NIEMEIR, R. W., SMITH, R. J., KuczuN, M. H., MATHINOS, P. R. and WEAVER, T. F. 1982, Teratogenicity of 2-ethoxyethanolby dermal application.Drug and Chemical Toxicology, 5, 277–294.
  • JOHANSON, G.,1988, Aspects of biologicalmonitoringof exposure to glycol ethers. Toxicology Letters, 43, 5–21.
  • JOHANSON, G., 1989, Analysis of ethylene glycol ether metabolites in urine by extractive alkylation and electron-capture gas chromatography. Archives of Toxicology, 63, 107–111.
  • LAMB, J. C., MARONPOT, R. R., GULATI, D. K., RUSSELL, V. S., HOMMEL -BARNES, L. and SABHARWAL R. P., 1985, Reproductiveand developmentaltoxicity of ethylene glycol in the mouse. Toxicology and Applied Pharmacology, 81, 100–112.
  • MEDINSKY, M. A., SINGH, G., BECHTOLD, W. E., BOND, J. A., SABOURIN, P. J., BIRNBAUM, L. S. and HENDERSON, R. F., 1990, Dispositionon the three glycol ethers administered in drinkingwater to male E344/N rast. Toxicology and Applied Pharmacology, 102, 443–445.
  • MILLER, R. R., CARREON, R. E., YOUNG, J. T. and MCKENNA, M. J., 1982, Toxicity of methoxyacetic acid in rats Fundamental and Applied Toxicology, 2, 158–160.
  • MILLER, R. R., HERMANN, E. A., LANGVARDT, R. W., McKENNA, M. J. and SCHWETZ, B. A., 1983, Comparative metabolism and disposition of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in male rats. Toxicology and Applied Pharmacology, 67, 229–237.
  • MOSS, E. J., THOMAS, L. V., COOK, M. W., WALTERS, D. G., FOSTER, P.M. D., CREASY, D. M. and GRAY, T. J. B., 1985, The role of metabolism in 2-methoxyethanol-induced testicular toxicity. Toxicology and Applied Pharmacology, 79, 480–489.
  • NAGANO, K., NAKAYAMA, E., OOBAYASHI, H., YAMADA, T., ADACHI, H., NISHIZAWA, T., OZAWA, H., NAKAICHI, M., OKUDA, H., MINAMI, K. and YAMAZAKI, K.,1981,Embryotoxiceffects of ethylene glycol monomethyl ether in mice. Toxicology, 20, 335–343.
  • NELSON, B. K., SETZER, J. V., BRIGHTWELL, W. S., MATHINOS, P. R., KUCZUK, M. H., WEAVER, T. E. and GOAD, P. T., 1984, Comparativeinhalationteratogenicityof four glycol ether solvents and an amino derivative rats. Environmental Health Perspectives, 57, 261–271.
  • SABOURIN, P. J., MEDINSKY, M. A., THURMOND, F., BIRNBAUM, L. S. and HENDERSON, R. F., 1992, Effect of dose on the disposition of methoxyethanol, ethoxyethanol and buthoxyethanol administered dermally to male F344/n rats. Fundamental and Applied Toxicology, 19, 124–132.
  • SKETT, P., 1988, Biochemicalbasis of sex differencesin drug metabolism .Pharmacology and Therapeutics, 38, 269–304.
  • SMALLWOOD, A. W., DEBORD, K. E. and LOWRY, L. K., 1984, Analyses of ethylene glycol monoalkyl ethers and their proposed metabolitesin blood and urine. Environmental Health Perspectives, 575, 249–253.
  • YONEMOTO, J., BROWN, N. A. and WEBB, M., 1984, Effects of dimethoxyethyl phthalate, mono-methoxyethyl phthalate, 2-methoxyethanol and methoxyacetic acid on post implantation rat embryos in culture. Toxicology Letters, 21, 97–102.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.