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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 10
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Research Article

Metabolism of a bisphosphonate ester (PNU-91638) in rat

J. G. SLATTER* Drug Metabolism Research, Pharmacia & Upjohn Co., 301 Henrietta Street, Kalamazoo, MI 49007, USA
,
K. L. FEENSTRA Drug Metabolism Research, Pharmacia & Upjohn Co., 301 Henrietta Street, Kalamazoo, MI 49007, USA
,
M. J. HAUER Drug Metabolism Research, Pharmacia & Upjohn Co., 301 Henrietta Street, Kalamazoo, MI 49007, USA
,
P. E. SANDERS Drug Metabolism Research, Pharmacia & Upjohn Co., 301 Henrietta Street, Kalamazoo, MI 49007, USA
,
J. J. VRBANAC Drug Metabolism Research, Pharmacia & Upjohn Co., 301 Henrietta Street, Kalamazoo, MI 49007, USA
,
G. SCOTT Drug Metabolism Research, Pharmacia & Upjohn Co., 301 Henrietta Street, Kalamazoo, MI 49007, USA
&
W. SPEED Drug Metabolism Research, Pharmacia & Upjohn Co., 301 Henrietta Street, Kalamazoo, MI 49007, USA
 show all
Pages 1039-1051 | Published online: 22 Sep 2008

References

  • HAWKINS, D. R., 1992, Biotransformations, vol. 4 (Cambridge: Royal Society of Chemistry Information Services).
  • NUGENT, R. A., 1993, Bisphosphonic acid derivatives as antiarthritic agents. European Patent 4464858–A.
  • SASS, S. and FISHER, T. L., 1979, Chemical ionization and electron impact mass spectrometry of some organophosphonate compounds. Organic Mass Spectrometry, 14, 257–264.
  • SCHUETTE, M. R., JUDY, R. W., FEENSTRA, K. L., GREENFIELD, J. C., and SLATTER, J. G., 1995, Alkyl esters of bisphosphonic acids do not bind to calcified tissues : whole body autoradiography studies on ['4C]1.3-91502 in rats. Quarterly Journal of Nuclear Medicine, 39, 80–81.
  • SILVERSTEIN, R. M., BASSLER, G. C. AND MORRILL, T. C., 1981, Spectrometric Identification of Organic Compounds (New York: Wiley), pp. 322–323.
  • SLATIER, J. G., FEENSTRA, K. L., HAUER, M. J., KLOOSTERMAN, D. A., PARTON, A. H., SANDERS, P. E., SCOTT, G. and SPEED, W., 1996, Metabolism of the bisphosphonate ester U-91502 in rats. Drug Metabolism and Disposition, 24, 65–73.

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