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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 10
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Research Article

Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril

B. KAYE* Department of Drug Metabolism, OE Early Clinical Research Group and Exploratory Drug Delivery Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
,
C. J. BREARLEY Department of Drug Metabolism, OE Early Clinical Research Group and Exploratory Drug Delivery Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
,
N. J. CUSSANS Department of Drug Metabolism, OE Early Clinical Research Group and Exploratory Drug Delivery Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
,
M. HERRON Department of Drug Metabolism, OE Early Clinical Research Group and Exploratory Drug Delivery Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
,
M. J. HUMPHREY Department of Drug Metabolism, OE Early Clinical Research Group and Exploratory Drug Delivery Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
&
A. R. MOLLATT Department of Drug Metabolism, OE Early Clinical Research Group and Exploratory Drug Delivery Group, Pfizer Central Research, Sandwich CT13 9NJ, UK
Pages 1091-1102 | Published online: 22 Sep 2008

References

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  • TOCCO, D. J., DELUNA, F. A., DUNCAN, E. W., VASSIL, T. C. and ULm, E. H., 1982, The physiological disposition and metabolism of enalapril maleate in laboratory animals. Drug Metabolism and Disposition, 10, 15–19.
  • ULM, E. H., 1983, Enalapril maleate (MK-421), a potent, nonsulfhydryl angiotensin-converting enzyme inhibitor: absorption, disposition and metabolism in man. Drug Metabolism Reviews, 14, 99–110.
  • ULM, E. H., HICHENS, M., GOMEZ, H. J., TILL, A. E., HAND, E., VASSIL, T. C., BIOLLAZ, J., BRUNNER, H. R. and SCHELLING, J. L., 1982, Enalapril maleate and a lysine analogue (MK-521): disposition in man. British Journal of Clinical Pharmacology, 14, 357–362.
  • WITTE, P. U., IRmisco, R., HAJDU, P. and METZGER, H., 1984, Pharmacokinetics and pharmacodynamics of a novel orally active angiotensin-converting enzyme inhibitor (HOE 498) in healthy subjects. European Journal of Clinical Pharmacology, 27, 577–581.

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