Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 3
36
Views
6
CrossRef citations to date
0
Altmetric
Research Article

First-pass metabolism and biliary recirculation of droloxifene in the female Sprague- Dawley rat

, &
Pages 257-264 | Published online: 22 Sep 2008

References

  • CASSIDY, M. K. and HOUSTON, J. B., 1980, In vivo assessment of extrahepatic conjugative metabolism in first pass effects using the model compound phenol. Journal of Pharmaceutics and Pharmacology, 32, 57–59.
  • CONWAY, W. D., S INGHVI, S. M GIBALDI, M. and B OYES, RN., 1973, The effect of route of administration on the metabolic fate of terbutaline in the rat. Xenobiotica, 3,813–821.
  • GIBALDI, M. and FELDMAN, S. 1970, Mechanisms of surfactant effects on drug absorption. Journal of Pharmaceutical Science, 59, 579–589.
  • GRILL, H. J. and FOLLOW, K., 1991, Pharmacokinetics of droloxifene and its metabolites in breast cancer patients. American Journal of Clinical Oncology, 14 (suppl. 2), S21–29.
  • ILETT, K. F. and D OLLERY, C. T., 1980, Isoprenaline conjugation—a 'true first-pass effect' in the dog intestine. Journal of Pharmaceutics and Pharmacology, 32, 362.
  • KAWAKAMI, J., YAMAMURA, J., SANTA, T., KOTAKI, H., U CHINO, K., SAWADA, Y. and IGA, T., 1993, Kinetic analysis of glycyrrhetic acid, and active metabolite of glycyrrhizin, in rats: Role of enterohepatic circulation. Journal of Pharmaceutical Science, 82, 301–305.
  • MORRISON, R. A., BURKETT, D. E., ARNOLD, M. E., D'A RIENZO, C. J. and WEINSTEIN, S. H., 1991, Sites of first-pass bioactivation (hydrolysis) of orally administered zofenapril calcium in dogs. Pharmaceutical Research, 8, 370–375.
  • NOBLE, S. and M ARKHAM, A., 1995, Cyclosporin : a review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion- based formulation (NeoraP). Drugs, 50, 924–941.
  • SWINYARD, E. A., 1990, Gastrointestinal drugs. In Remingtons Pharmaceutical Sciences, edited by A. R. Gennaro (Easton: Mack), p. 782.
  • TANAKA, Y., S EKIGUCHI M S AWAMOTO, T., HATA, T., Esumi, Y., S UGAI S. and NINOMIYA, S., 1994, Pharmacokinetics of droloxifene in mice, rats, monkeys, premenopausal and postmenopausal patients. European Journal of Drug Metabolism and Pharmacokinetics, 19, 47–58.
  • TESS, D. A., COLE, R. O. and TOLER, S. M 1995, Sensitive method for the quantitation of droloxifene in plasma and serum by high-performance liquid chromatography employing fluorimetric detection. Journal of Chromatography B, 674,. 253–260.
  • ZHONG, W. Z., WILLIAMS, M. G., COOK, K. J., V ANDEGR1ESSEN, T. L., Jos, B. W. and ROUSCH, K. E., 1994, First- pass effect of cis-3,4- dichloro-N-methyl- N- (2- (1-pyrrolidiny1)- cyclohexyl)- benza-mide (U-54494) in rats—a model with multiple cannulas for investigation of gastrointestinal and hepatic metabolism. Pharmaceutical Research, 11, 1524–1529.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.