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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 3
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Research Article

Pharmacokinetics of and CYP1A induction by pyridine and acetone in the rat : interactions and effects of route of exposure

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Pages 265-277 | Published online: 22 Sep 2008

References

  • AGARWAL, R., JUGERT, F. K., KHAN, S. G., BICKERS, D. R., MERK, H. F. and M UKHTAR, H., 1994, Evidence for multiple inducible cytochrome P450 isozymes in Sencar mouse skin by pyridine. Biochemical and Biophysical Research Communications, 199, 1400–1406.
  • ATSDR, 1991, Toxicological Profile for Pyridine (US Department of Health and Human Services, Public Health Service, Agency for Toxic Substance and Disease Registry).
  • BARNETT, C. R., PETRIDES, L., WILSON, J., FLATT, P. R. and I ONNIDES, C., 1992, Induction of rat hepatic mixed- function oxidases by acetone and other physiological ketones: their role in diabetes induced changes in cytochrome P450 proteins. Xenobiotica, 22, 1441–1450.
  • BRONDEAU, M. T., BAN, M., BONNET, P., GUENIER, J. P. and DE CEAURRIZ, J., 1989, Acetone compared to other ketones in modifying the hepatotoxicity of inhaled 1,2-dichlorobenzene in rats and mice. Toxicological Letters, 49, 69–78.
  • CARLSON, G. P. and DAY, B. J., 1992, Induction by pyridine of cytochrome P45011E1 and xenobiotic metabolism in rat lung and liver. Pharmacology, 44, 117–123.
  • CASAZZA, J. P., FELVER, M. E. and VEECH, R. L., 1984, The metabolism of acetone in rat. Journal of Biological Chemistry, 259, 231–236.
  • DAMANI, L. A., CROOKS, P. A., SHAKER, M. S., CALDWELL, J., D'S OUZA, J. and SMITH, R. L., 1982, Species differences in the metabolite C- and N- oxidation, and N- methylation of[14C]pyridine in vivo. Xenobiotica, 12, 527–534.
  • D'SOUZA, J., CALDWELL, J. and SMITH, R. L., 1980, Species variations in the N-methylation and quaternization of [14 C]pyridine. Xenobiotica, 10, 151–157.
  • FISEROVA -BERGEROVA, V. and DIAZ, M. L., 1986, Determination and prediction of tissue-gas partition coefficients. International Archives of Occupational and Environmental Health, 58, 75–87.
  • FORKERT, P. G., REDZA, Z. M., MANGOS, S., PARK, S. S. and T AM, S. P., 1994, Induction and regulation of CYP2E1 in murine liver after acute and chronic acetone administration. Drug Metabolism and Disposition, 22, 248–253.
  • GAD, S. S. and WEIL, C. S., 1994, Statistics for Toxicologists. In Principles and Methods of Toxicology, edited by A. W. Hayes (New York: Raven), pp. 221–274.
  • GUENGERICH, F. P., 1990, Characterization of roles of human cytochrome P-450 enzymes in carcinogen metabolism. Asia Pacific Journal of Pharmacology, 5, 327–345.
  • GUERIN, M. R., JENKINS, R. A. and T OMKINS, B. A., 1992, Properties and measures of environmental tobacco smoke. In The Chemistry of Environmental Tobacco Smoke, edited by M. Eisenberg (Chelsea, MI: Lewis), pp. 63–86.
  • GUTHRIE, F. E. and HODGSON, E., 1987, Absorption and distribution of toxicants. In Modern Toxicology, edited by E. Hodgson and P. E. Levi (New York: Elsevier), pp. 23–50.
  • HOTCHKISS, J. A., KIM, S. G., NOVAK, R. F. and DAHL, A. R., 1993, Enhanced Hepatic Expression of P45011E1 following inhalation exposure to pyridine. Toxicology and Applied Pharmacology, 118, 98–104.
  • IARC (INTERNATIONAL AGENCY FOR RESEARCH ON CANCER), 1986, Evaluation of the Carcinogenic Risk of Chemicals to Humans—Tobacco Smoking. IARC Monographs vol. 38 (Lyon, IARC), pp. 86–87.
  • IBA, M M. and THOMAS, P. E., 1988, Activation of 3,3 '-dichlorobenzidine in rat liver microsomes to mutagens : involvement of cytochrome P- 450d. Carcinogenesis, 9, 717–723.
  • IBA, M. M., BENETT, S., S TORCH, A., GHOSAL, A. and THOMAS, P. E., 1993, Synergistic induction of rat microsomal CYP1A1 and CYP1A2 by acetone in combination with pyridine. Cancer Letters, 74, 69–74.
  • INGLIS, J. K., 1980, Introduction to Laboratory Animal Science and Technology (New York: Pergamon), 256 257
  • KIM, S. G., WILLIAMS, D. E., S CHUETZ, E.G., GUZELIAN, P. S. and NOVAK, R. F., 1988, Pyridine induction of cytochrome P-450 in the rat: role of P-450j (alcohol inducible form) in pyridine N-oxidation. Journal of Pharmacology and Experimental Therapeutics, 246, 1175–1182.
  • KIM, S. G., SHEHIN, S. E., STATES, J. C. and NOVAK, R. F., 1990, Evidence for increased translational efficiency in the induction of P45011E1 by solvents: analysis of P450IIE1 mRNA polyribosomal distribution. Biochemical and Biophysical Research Communications, 172, 767–774.
  • KIM, S. G., REDDY, S. L., STATES, J. C. and NOVAK, R. F., 1991a, Pyridine effects on expression and molecular regulation of the cytochrome P4501A gene subfamily. Molecular Pharmacology, 40, 52–57.
  • KIM, S. G., PHILPOT, R. M. and NOVAK, R. F., 1991b, Pyridine effects on P45011E1, IIB and IVB expression in rabbit liver: characterization of high- and low-affinity pyridine N-oxygenases. Journal of Pharmacology and Experimental Therapeutics, 259, 470–477.
  • KIM, H., PUTT, D., REDDY, S., HOLLENBERG, P. F. and NOVAK, R. F., 1993, Enhanced expression of rat hepatic CYP2B1 /2B2 and 2E1 by Pyridine : differential induction kinetics and molecular basis of expression. Journal of Pharmacology and Experimental Therapeutics, 267, 927–936.
  • KUMAGAI, S. and M ATSUNAGA I., 1995, Physiologically based pharmacokinetic model for acetone. Occupational and Environmental Medicine, 52, 344–352.
  • KURATA, N., H URST, H. E., BENZ, F. W., K EMPER, R. A. and W ADDELL W J., 1991, Studies on inhibition and induction of metabolism of ethyl carbamate by acetone and related compounds. Drug Metabolism and Disposition, 19, 388–393.
  • LONGO, V. and I NGELMAN - S UNDBERG, M., 1993, Acetone-dependent regulation of cytochromes P4502E1 and P4502B1 in rat nasal mucosa. Biochemical Pharmacology, 46, 1945–1951.
  • LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L. and RANDALL, R. J., 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 267–275.
  • OKUDA, Y., 1959, Studies on the methylation of pyridine-compound in animal organisms. Journal of Biochemistry, 46, 73–78.
  • PARK, K. S., SoHN, D. H., VEECH, R. L. and SONG, B. J., 1992, Pre-translational induction of pentoxyresorufin O-depentylase by pyridine. Biochemical and Biophysical Research Communica-tions, 185, 676–682.
  • RENWICK, A. G., 1994, Toxicokinetics- pharmacokinetics in toxicology. In Principles and Methods of Toxicology, 3rd edn, edited by A. W. Hayes (New York: Raven), pp. 101–146.
  • SATO, A. and NAKAormi), T., 1979, Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil. British Journal of Industrial Medicine, 36, 231–234.
  • SHAKER, M. S., CROOKS, P. A. and D AMANI, L. A., 1982, High-performance liquid chromatographic analysis of the in vivo metabolites of Npyridine. Journal of Chromatography, 237, 489–495.
  • SONG, B. J., VEECH, R. L., PARK, S. S., GELBOIN, H. V. and GONZALES, F. J., 1989, Induction of rat hepatic N- nitrosodimethyl amine demethylase by acetone is due to protein stabilization. Journal of Biological Chemistry, 264, 3568–3572.
  • WIGAEUS, E., L OF, A. and N ORDQVIST, M., 1982, Distribution and elimination of 2-[14q- acetone in mice after inhalation exposure. Scandinavian Journal of Work and Environmental Health, 8, 121–128.
  • WILKE, T. J., JONDORF W R. and Pow's, G., 1989, Oxidative metabolism of 14 C- pyridine by human and rat tissue subcellular fractions. Xenobiotica, 19, 1013–1022.
  • YANG, H.-Y. L., N AMKUNG, M. J. and JUCHAU, M. R., 1988, Cytochrome P-450-dependent bio-transformation of phenoxazone ethers in the rat conceptus during early organogenesis : evidence of multiple P-450 isozymes. Molecular Pharmacology, 349, 67–73.

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