Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 10
Submit an article Journal homepage
20
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Biotransformation of an antihypertensive arylalkylamine analogue in the rat

W. N. WU Division of Preclinical Development and OE Division of Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
Pages 957-972 | Published online: 22 Sep 2008

References

  • BEAN, B. P., 1984, Nitrendipine block of cardiac calcium channels: high affinity binding to the inactivated state. Proceedings of the National. Academy of Sciences, USA, 81, 6388–6392.
  • BRANNAN, M. D., CARMOSIN, R. J., CARSON, J. R., FLAIM, S. F., GILL, A., GLEASON, M. M., KEELY S. L., LUDOVICI, D. W., PITTS, P. M., VILLANI, F. J. and REBARCHAK, M. C., 1986, 2-Ethynyl-benzenealkanamines, a new class of calcium entry blockers. 191st American Chemical Society National Meeting, abstract MED 1–13.
  • CARSON, J. R., 1987, Aralkyl(arylethynyl)aralkylamines and their use as vasodilators and anti-hypertensives. US Patent No. 4,661,635.
  • CARSON, J. R., ALMOND H. R., BRANNAN, M. D., CARMOSIN, R. J., FLAIM, S. F., GILL, A., GLEASON, M. M., KEELY, S. L., LUDOVICI, D. W., PITIS P. M., REBARCHAK, M. C. and VILLANI, F. J., 1988, 2-Ethynylbenzenealkanamines, a new class of calcium entry blockers. Journal of Medical Chemistry, 31, 630–636.
  • FLAIM, S. F., GLEASON, M. M., HEDBERG, A., SHANK, R. P., MCCULLOUGH, J. R., GILL, A., DAMIAN(), B. P., BRANNAN, M. D., and CARSON, J. R., 1991, Structurally novel anti-hypertensive compound, McN-5691, is a calcium channel blocker in vascular smooth muscle. Journal of Pharmacology and Experimental Therapeutics, 256, 279–288.
  • FLAIM, S. F., STRAN1ERI, M. T., GILL, A., CARSON, J. R. and BRANNAN, M. D., 1988; Effects of the novel calcium channel blocker, McN-5691, on cardiocirculatory dynamics and cardiac output distribution in conscious spontaneously hypertensive rat. Journal of Cardiovascular Pharmacology, 11, 489–500.
  • FLECKENSTEIN, A., 1983, History of calcium antagonists. Circulation Research, 52, 1–16.
  • FLECKENSTEIN, A., 1984, Calcium Antagonists and Cardiovascular Disease, edited by L. H. Opie (New York: Raven), pp. 9–28.
  • NG, K. T., HOLLAND, ML., Wu, W. N., Heebner, E. T., Hills, J. F. and MCGHEE, V. L., 1987, Disposition and pharmacokinetics in rats of McN-5691 (RWJ-26240). ISSX/SOT North American Symposium on Endogenous Factors in the Toxicity of Xenobiotics, abstract.
  • TESTA, B. and JENNER, P., 1976, Chemical and Biochemical Aspects, Drug Metabolism, Vol. 4 (New York: Marcel Dekker), pp. 173–180.
  • Wu, W. N., MASUCCI, J. A. and CALDWELL, G. W., 1991, Biotransformation in rats and dogs of McN-5691, a potential anti-hypertensive drug. FASEB Journal, 5, abstract 4862.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.