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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 8
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Research Article

Absorption, distribution, metabolism and excretion of cizolirtine, a new analgesic compound, in rat and dog

L. MARTINEZ Department of Pharmacokinetics and Drug Metabolism, Laboratorios Dr Esteve, S.A., Av. Mare de Deu de Montserrat 221, 08041 Barcelona, Spain
,
M. T. SERAFINI Department of Pharmacokinetics and Drug Metabolism, Laboratorios Dr Esteve, S.A., Av. Mare de Deu de Montserrat 221, 08041 Barcelona, Spain
,
M. J. PRETEL Department of Pharmacokinetics and Drug Metabolism, Laboratorios Dr Esteve, S.A., Av. Mare de Deu de Montserrat 221, 08041 Barcelona, Spain
,
A. GARCIA-SORET Department of Pharmacokinetics and Drug Metabolism, Laboratorios Dr Esteve, S.A., Av. Mare de Deu de Montserrat 221, 08041 Barcelona, Spain
,
T. MORAGON Department of Pharmacokinetics and Drug Metabolism, Laboratorios Dr Esteve, S.A., Av. Mare de Deu de Montserrat 221, 08041 Barcelona, Spain
&
S. PUIG Department of Pharmacokinetics and Drug Metabolism, Laboratorios Dr Esteve, S.A., Av. Mare de Deu de Montserrat 221, 08041 Barcelona, Spain
Pages 859-871 | Published online: 22 Sep 2008

References

  • CATURLA, M. C., SALOMO J., SOLER, M., MARTINEZ, L. and ROSER, R., 1991, Validation of GC method to measure a new analgesic (E-4018) in biological samples. Comparison between HPLC and GC method. Journal of Pharmaceutical and Biomedical Analysis, 9, 1181–1184.
  • FAR, A. J., COLOMBO, A., COLOMBO, M., FORT, M. and GUTdRREZ, B., 1989, E-4018: a new analgesic agent. Proceedings of the Sockdad Espaifola de FarmacologM, Revista de Farmacologia Clínica y Experimental, 6, 233.
  • Luo, H., HAWES, E. M., McKAY, G., KoRcorNsiu, E. D. and MrooA, K. K., 1991, N(+ )-glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H1-antihistamines in humans. Xenobiotica, 21, 1281–1288.
  • MOTOR, N., HAYAMA, E. and SHIGEMAISU, A., 1995, Radioluminography for quantitative autora-diography of 14C. European Journal of Drug Metabolism and Pharmacokinetics, 20, 89–105.
  • SAimo, E. L. and SArmo, P., 1991, A quantitative method for measuring labeled compounds with whole-body autoradiography in tissue sections. Journal of Pharmacological Methods, 26, 53–59.
  • TONN, G. R., ABBOTT, F. S., RURAK, D. W. and AXELSON J. E., 1995, Simultaneous analysis of diphenylmethoxyacetic acid, a metabolite of diphenhydramine, and its deuterium-labeled stable isotope analog in ovine plasma and urine. Journal of Chromatography B: Biomedical Applications, 663, 67–81.
  • ZANE, P. A., O'BucK, A. J., WALTER, R. E., ROBERTSON, P. and TRIPP, S. L., 1997, Validation of procedures for quantitative whole-body autoradiography using digital imaging. Journal of Pharmaceutical Sciences, 86, 733–738.

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