Dendrimers in targeted drug delivery applications: a review of diseases and cancer

References

• Mandal, A. K. Hydroxyapatite Nanoparticles as Delivery System in Combating Various Diseases. Int. J. Curr. Adv. Res. 2018, 7, 15869–15877.
   Google Scholar
• Kalomiraki, M.; Thermos, K.; Chaniotakis, N. A. Dendrimers as Tunable Vectors of Drug Delivery Systems and Biomedical and Ocular Applications. Int. J. Nanomed. 2016, 11, 1–12.
   PubMed Web of Science ®Google Scholar
• Morikawa, A. Comparison of Properties among Dendritic and Hyperbranched Poly (Ether Ether Ketone)s and Linear Poly (Ether Ketone)s. Molecules. 2016, 21, 219. DOI: 10.3390/molecules21020219.
   Web of Science ®Google Scholar
• Singh, J.; Jain, K.; Mehra, N. K.; Jain, N. K. Dendrimers in Anticancer Drug Delivery: Mechanism of Interaction of Drug and Dendrimers. Artific. Cells Nanomed. Biotechnol. 2016, 44, 1626–1634. DOI: 10.3109/21691401.2015.1129625.
   PubMed Web of Science ®Google Scholar
• Lombardo, D. Modeling Dendrimers Charge Interaction in Solution: Relevance in Biosystems. Biochem. Res. Int. 2014, 837651, 1–10.
   Google Scholar
• Kannan, R. M.; Nance, E.; Kannan, S.; Tomalia, D. A. Emerging Concepts in Dendrimer-Based Nanomedicine: From Design Principles to Clinical Applications. J. Intern. Med. 2014, 276, 579–617. DOI: 10.1111/joim.12280.
   PubMed Web of Science ®Google Scholar
• Tripathy, S.; Das, M. K. Dendrimers and Their Applications as Novel Drug Delivery Carriers. J. Appl. Pharmaceutic. Sci. 2013, 3, 142–149.
   Google Scholar
• Abbasi, E.; Aval, S. F.; Akbarzadeh, A.; Milani, M.; Nasrabadi, H. T.; Joo, S. W.; Hanifehpour, Y.; Nejati-Koshki, K.; Pashaei-Asl, R. Dendrimers: Synthesis, Applications, and Properties. Nanoscale Res. Lett. 2014, 9, 247. DOI: 10.1186/1556-276X-9-247.
   PubMed Web of Science ®Google Scholar
• Thatikonda, S.; Yellanki, S. K.; D., S. C.; Arjun, D.; Balaji, A. Dendrimers-A New Class of Polymers. Int. J. Pharmaceutic. Sci. Res. 2013, 4, 2174–2183.
   Google Scholar
• Satsangi, A.; Roy, S. S.; Satsangi, R. K.; Tolcher, A. W.; Vadlamudi, R. K.; Goins, B.; Ong, J. L. Synthesis of a Novel, Sequentially Active-Targeted Drug Delivery Nanoplatform for Breast Cancer Therapy. Biomater. 2015, 59, 88–101. DOI: 10.1016/j.biomaterials.2015.03.039.
   PubMed Web of Science ®Google Scholar
• Thakur, S.; Kesharwani, P.; Tekade, R. K.; Jain, N. K. Impact of PEGylation on Biopharmaceutical Properties of Dendrimers. Polym. 2015, 59, 67–92. DOI: 10.1016/j.polymer.2014.12.051.
   Web of Science ®Google Scholar
• Chaudhari, H. S.; Popat, R. R.; Adhao, V. S.; Shrikhande, V. N. Dendrimers: Novel Carriers for Drug Delivery. J. Appl. Pharmaceutic. Res. 2016, 4, 1–19.
   Google Scholar
• Somani, S.; Blatchford, D. R.; Millington, O.; Stevenson, M. L.; Dufes, C. Transferrin-Bearing Polypropylenimine Dendrimer for Targeted Gene Delivery to the Brain. J. Control. Rel. 2014, 188, 78–86. DOI: 10.1016/j.jconrel.2014.06.006.
   PubMed Web of Science ®Google Scholar
• Somani, S.; Robb, G.; Pickard, B. S.; Dufes, C. Enhanced Gene Expression in the Brain following Intravenous Administration of Lactoferrin-Bearing Poly Propylenimine Dendriplex. J. Control. Rel. 2015, 217, 235–242. DOI: 10.1016/j.jconrel.2015.09.003.
   PubMed Web of Science ®Google Scholar
• Mendes, L. P.; Pan, J.; Torchilin, V. P. Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy. Molecules. 2017, 22, 1401. DOI: 10.3390/molecules22091401.
   PubMed Web of Science ®Google Scholar
• Yang, J.; Zhang, Q.; Chang, H.; Cheng, Y. Surface-Engineered Dendrimers in Gene Delivery. Chem. Rev. 2015, 115, 5274–5300. DOI: 10.1021/cr500542t.
   PubMed Web of Science ®Google Scholar
• AlRobaian, M.; Chiam, K. Y.; Blatchford, D. R.; Dufes, C. Therapeutic Efficacy of Intravenously Administered Transferring-Conjugated Dendriplexes on Prostate Carcinomas. Nanomed. (Lond.) 2014, 9, 421–434. DOI: 10.2217/nnm.13.25.
   PubMed Web of Science ®Google Scholar
• Lim, L. Y.; Koh, P. Y.; Somani, S.; Al Robaian, M.; Karim, R.; Yean, Y. L.; Mitchell, J.; Tate, R. J.; Edrada-Ebel, R.; Blatchford, D. R.; et al. Tumor Regression following Intravenous Administration of Lactoferrin- and Lactoferricin-Bearing Dendriplexes. Nanomed. 2015, 11, 1445–1454. DOI: 10.1016/j.nano.2015.04.006.
   PubMed Web of Science ®Google Scholar
• Altwaijry, N.; Somani, S.; Parkinson, J. A.; Tate, R. J.; Keating, P.; Warzecha, M.; Mackenzie, G. R.; Leung, H. Y.; Dufes, C. Regression of Prostate Tumors after Intravenous Administration of Lactoferrin-Bearing Polypropylenimine Dendriplexes Encoding TNF-α, TRAIL and Interleukin-12. Drug Deliv. 2018, 25, 679–689. DOI: 10.1080/10717544.2018.1440666.
   PubMed Web of Science ®Google Scholar
• Somani, S.; Laskar, P.; Altwaijry, N.; Kewcharoenvong, P.; Irving, C.; Robb, G.; Pickard, B. S.; Dufes, C. PEGylation of Polypropylenimine Dendrimers: Effects on Cytotoxicity, DNA Condensation, Gene Delivery and Expression in Cancer Cells. Sci. Rep. 2018, 8, 9410. DOI: 10.1038/s41598-018-27400-6.
   PubMed Web of Science ®Google Scholar
• Xu, L.; Zhang, H.; Wu, Y. Dendrimer Advances for the Central Nervous System Delivery of Therapeutics. ACS Chem. Neurosci. 2014, 5, 2–13. DOI: 10.1021/cn400182z.
   PubMed Web of Science ®Google Scholar
• Zhang, M.; Zhu, J.; Zheng, Y.; Guo, R.; Wang, S.; Mignani, S.; Caminade, A. M.; Majoral, J. P.; Shi, X. Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy. Pharmaceut. 2018, 10, 162. DOI: 10.3390/pharmaceutics10030162.
   Web of Science ®Google Scholar
• Koo, H.; Huh, M. S.; Sun, I. C.; Yuk, S. H.; Choi, K.; Kim, K.; Kwon, I. C. In Vivo Targeted Delivery of Nanoparticles for theranosis. Acc. Chem. Res. 2011, 44, 1018–1028. DOI: 10.1021/ar2000138.
   PubMed Web of Science ®Google Scholar
• Madaan, K.; Kumar, S.; Poonia, N.; Lather, V.; Pandita, D. Dendrimers in Drug Delivery and Targeting: Drug-Dendrimer Interactions and Toxicity Issues. J. Pharm. Bioall. Sci. 2014, 6, 139–150.
   PubMedGoogle Scholar
• Choudhary, S.; Gupta, L.; Rani, S.; Dave, K. K.; Gupta, U. Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules. Front. Pharmacol. 2017, 8, 261. DOI: 10.3389/fphar.2017.00261.
   PubMed Web of Science ®Google Scholar
• Jean-d’Amour, T. T.; Grindley, B. Polyester Dendrimers: Smart Carriers for Drug Delivery. Polym. 2014, 6, 179–213.
   Web of Science ®Google Scholar
• Twibarine, J. K.; Grindley, T. B. Efficient and Controllably Selective Preparation of Esters Using Uranium-Based Coupling Agents. Org. Lett. 2011, 13, 2988–2991.
   PubMed Web of Science ®Google Scholar
• Mohammadi, M. R.; Nojoomi, A.; Mozafari, M.; Dubnika, A.; Inayathullah, M.; Rajadas, J. Nanomaterials Engineering for Drug Delivery: A Hybridization Approach. J. Mater. Chem. B. 2017, 5, 3995–4018. DOI: 10.1039/C6TB03247H.
   PubMed Web of Science ®Google Scholar
• Parajapati, S. K.; Maurya, S. D.; Das, M. K.; Tilak, V. K.; Verma, K. K.; Dhakar, R. C. Dendrimers in Drug Delivery, Diagnosis and Therapy: Basics and Potential Applications. J. Drug Deliv. Therapeut. 2016, 6, 67–92.
   Google Scholar
• Yang, H.; Lopina, S. T. Extended Release of a Novel Antidepressant, Venlafaxine, Based on Anionic Polyamidoamine Dendrimers and Poly (Ethylene Glycol)-Containing Semi-Interpenetrating Networks. J. Biomed. Mater. Res. A. 2005, 72, 107–114.
   PubMed Web of Science ®Google Scholar
• Najlah, M.; Freeman, S.; Attwood, D.; D'Emanuele, A. In Vitro Evaluation of Dendrimer Prodrugs for Oral Drug Delivery. Int. J. Pharm. 2007, 336, 183–190. DOI: 10.1016/j.ijpharm.2006.11.047.
   PubMed Web of Science ®Google Scholar
• D’Emanuele, A.; Jevprasesphant, R.; Penny, J.; Attwood, D. The Use of a Dendrimer-Propranolol Prodrug to Bypass Efflux Transporters and Enhance Oral Bioavailability. J. Control. Rel 2004, 95, 447–453. DOI: 10.1016/j.jconrel.2003.12.006.
   PubMed Web of Science ®Google Scholar
• Parajapati, S. K.; Maurya, S. D.; Das, M. K.; Tilak, V. K.; Verma, K. K.; Dhakar, R. C. Potential Application of Dendrimers in Drug Delivery: A Concise Review and Update. J. Drug Deliv. Therapeut. 2016, 6, 71–88.
   Google Scholar
• Kaminskas, L. M.; McLeod, V. M.; Kelly, B. D.; Sberna, G.; Boyd, B. J.; Williamson, M.; Owen, D. J.; Porter, C. J. A Comparison of Changes to Doxorubicin Pharmacokinetics, Antitumor Activity, and Toxicity Mediated by PEGylated Dendrimer and PEGylated Liposome Drug Delivery Systems. Nanomed. 2012, 8, 103–111. DOI: 10.1016/j.nano.2011.05.013.
   PubMed Web of Science ®Google Scholar
• Pasut, G.; Scaramuzza, S.; Schiavon, O.; Mendichi, R.; Veronese, F. M. PEG-Epirubicin Conjugates with High Drug Loading. J. Bioact. Compat. Polym. 2005, 20, 213–230. DOI: 10.1177/0883911505053377.
   Web of Science ®Google Scholar
• Soto-Castro, D.; Cruz-Morales, J. A.; Ramirez, A. M. T.; Guadarrama, P. Solubilization and Anticancer-Activity Enhancement of Methotrexate by Novel Dendrimeric Nanomedicines Synthesized in One-Step Reaction. Bioorg. Chem. 2012, 41-42, 13–21. DOI: 10.1016/j.bioorg.2012.01.002.
   PubMed Web of Science ®Google Scholar
• Zhou, Z.; D’Emanuele, A.; Attwood, D. Solubility Enhancement of Paclitaxel Using a Linear Dendritic Block Copolymer. Int. J. Pharm. 2013, 452, 173–179. DOI: 10.1016/j.ijpharm.2013.04.075.
   PubMed Web of Science ®Google Scholar
• Karel, U.; Katerina, H.; Vladimir, S.; Aristides, B.; Jiri, T.; Radek, Z. Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control and Clinical Studies. Chem. Rev. 2016, 116, 5338–5431.
   PubMed Web of Science ®Google Scholar
• Garcia-Gallego, S.; Franci, G.; Folanga, A.; Gomez, R.; Folliero, V.; Galdiero, S.; de la Mata, F. J.; Galdiero, M. Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials. Molecules. 2017, 22, 1581. DOI: 10.3390/molecules22101581.
   PubMed Web of Science ®Google Scholar
• Gautam, S. P.; Gupta, A. K.; Sharma, A.; Gautam, T. M. Synthesis and Analytical Characterization of Ester and Amine Terminated PAMAM Dendrimers. Glob. J. Med. Res Pharma. Drug Discov. Toxicol. Med. 2013, 13, 1.
   Google Scholar
• Hu, W.; Cheng, L.; Cheng, L.; Zheng, M.; Lei, Q.; Hu, Z.; Xu, M.; Qiu, L.; Chen, D. Redox and pH-Responsive Poly (Amidoamine) Dendrimer-Poly (Ethylene Glycol) Conjugates with Disulfide Linkages for Efficient Intracellular Drug Release. Colloids Surf. B. Biointerf. 2014, 123, 254–263. DOI: 10.1016/j.colsurfb.2014.09.024.
   PubMed Web of Science ®Google Scholar
• Agrawal, A.; Kulkarni, S. Dendrimers: A New Generation Carrier. Int. J. Res. Dev. Pharm. Life Sci. 2015, 4, 1700–1712.
   Google Scholar
• Mekuria, S. L.; Debele, T. A.; Tsai, H. C. PAMAM Dendrimer Based Targeted Nanocarrier for Bioimaging and Therapeutic Agents. RSC Adv. 2016, 6, 63761–63772. DOI: 10.1039/C6RA12895E.
   Web of Science ®Google Scholar
• Das, B.; Patra, S. Antimicrobials: Meeting the Challenges of Antibiotic Resistance through Nanotechnology. In Nanostructures for Antimicrobial Therapy, Ficai A, Grumezescu A. M., Eds. Bucharest, Romania: Elsevier Book Publications, 2017; pp 1–22.
   Google Scholar
• Goudarzi, M.; Navidinia, M. Overview Perspective of Bacterial Strategies of Resistance to Biocides and Antibiotics. Arch. Clin. Infect. Dis. 2019, 14, e65744.
   Web of Science ®Google Scholar
• Gumustus, M.; Sengel-Turk, C. T.; Gumustas, A.; Ozkan, S. A.; Uslu, B. Effecr of Polymer-Based Nanoparticles on the Assay of Antimicrobial Drug Delivery Systems. In Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics, Grumezescu A. M., Ed. Bucharest, Romania: Elsevier Book Publications, 2017; cp 5, pp 67–103.
   Google Scholar
• Fox, L. J.; Richardson, R. M.; Briscoe, W. H. PAMAM Dendrimer-Cell Membrane Interactions. Adv. Colloid. Interf. Sci. 2018, 257, 1–18. DOI: 10.1016/j.cis.2018.06.005.
   PubMed Web of Science ®Google Scholar
• Svenson, S.; Tomalia, D. A. Dendrimers in Biomedical Applications-Reflections on the Field. Adv. Drug Deliv. Rev. 2012, 64, 102–115. DOI: 10.1016/j.addr.2012.09.030.
   Web of Science ®Google Scholar
• Kaur, D.; Jain, K.; Mehra, N. K.; Kesharwani, P.; Jain, N. K. A Review on Comparative Study of PPI and PAMAM Dendrimers. J. Nanopart. Res. 2016, 18, 146. DOI: 10.1007/s11051-016-3423-0.
   Web of Science ®Google Scholar
• Moura, L. T. F.; Malfanti, A.; Peres, C.; Matos, A. I.; Guegain, E.; Sainz, V.; Zloh, M.; Vicent, M. J.; Florindo, H. F. Functionalized Branched Polymers: Promising Immunomodulatory Tools for the Treatment of Cancer and Immune Disorders. Mater. Horiz. 2019, 6, 1956–1973. DOI: 10.1039/C9MH00628A.
   Web of Science ®Google Scholar
• Shukla, S. K.; Govender, P. P.; Tiwari, A. Polymeric Micellar Structures for Biosensor Technology. Adv. Biomembr. Lipid Self Assem. 2016, 24, 143–161. DOI: 10.1016/bs.abl.2016.04.005.
   Google Scholar
• Dzmitruk, V.; Apartsin, E.; Ihnatsyeu-Kachan, A.; Abashkin, V.; Shcharbin, D.; Bryszewska, M. Dendrimers Show Promise for siRNA and microRNA Therapeutics. Pharmaceutics. 2018, 10, 126. DOI: 10.3390/pharmaceutics10030126.
   PubMed Web of Science ®Google Scholar
• Wu, L. P.; Ficker, M.; Christensen, J. B.; Trohopoulos, P. N.; Moghimi, S. M. Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges. Bioconjugate Chem. 2015, 26, 1198–1211. DOI: 10.1021/acs.bioconjchem.5b00031.
   PubMed Web of Science ®Google Scholar
• Mhleoatika, Z.; Aderibigbe, B. A. Application of Dendrimers for the Treatment of Infectious Diseases. Molecules. 2018, 23, 2205. DOI: 10.3390/molecules23092205.
   Web of Science ®Google Scholar
• de Menezes, J. P. B.; Guedes, C. E. S.; Petersen, A. L. d O. A.; Fraga, D. B. M.; Veras, P. S. T. Advances in Development of New Treatment for Leishmaniasis. Biomed Res Int. 2015, 2015, 815023.
   PubMed Web of Science ®Google Scholar
• Croft, S. L.; Olliaro, P. Leishmaniasis Chemotherapy-Challenges and Opportunities. Clin. Microbiol. Infect. 2011, 17, 1478–1483. DOI: 10.1111/j.1469-0691.2011.03630.x.
   PubMed Web of Science ®Google Scholar
• Jain, K.; Verma, A. K.; Mishra, P. R.; Jain, N. K. Characterization and Evaluation of Amphotericin B Loaded Conjugated Poly (Propylene Imine) Dendrimers. Nanomed. 2015, 11, 705–713. DOI: 10.1016/j.nano.2014.11.008.
   PubMed Web of Science ®Google Scholar
• Daftarian, P. M.; Stone, G. W.; Kovalski, L.; Kumar, M.; Vosoughi, A.; Urbieta, M.; Blackwelder, P.; Dikici, E.; Serafini, P.; Duffort, S.; et al. A Targeted and Adjuvanted Nanocarrier Lowers the Effective Dose of Liposomal Amphotericin B and Enhances Adaptive Immunity in Murine Cutaneous Leishmaniasis. J. Infect. Dis. 2013, 208, 1914–1922. DOI: 10.1093/infdis/jit378.
   PubMed Web of Science ®Google Scholar
• Jain, K.; Verma, K. A.; Mishra, P. R.; Jain, N. K. Surface-Engineered Dendrimeric Nanoconjugates for Macrophage Targeted Delivery of Amphotericin B: Formulation Development and in Vitro and in Vivo Evaluation. J. Infect. Dis. 2013, 208, 1914–1922.
   PubMed Web of Science ®Google Scholar
• Noriega-Luna, B.; Godinez, L. A.; Rodriguez, F. J.; Rodriguez, A.; de Larrea, G. Z. L.; Sosa-Ferreyra, C. F.; Mercado-Curiel, R. F.; Manriquez, J.; Bustos, E. Applications of Dendrimers in Drug Delivery Agents, Diagnosis, Therapy, and Detection. J. Nanomater. 2014, 507273.
   Web of Science ®Google Scholar
• de Araujo, R. V.; Santos, S. D. S.; Ferreira, E. I.; Giarolla, J. New Advances in General Biomedical Applications of PAMAM Dendrimers. Molecules. 2018, 23, 2849. DOI: 10.3390/molecules23112849.
   Web of Science ®Google Scholar
• Jain, K.; Gupta, U.; Jain, N. K. Dendronized Nanoconjugates of Lysine and Folate for Treatment of Cancer. Eur. J. Pharm. Biopharm. 2014, 87, 500–509. DOI: 10.1016/j.ejpb.2014.03.015.
   PubMed Web of Science ®Google Scholar
• Kaur, A.; Jain, K.; Mehra, N. K.; Jain, N. Development and Characterization of Surface Engineered PPI Dendrimers for Targeted Drug Delivery. Artif. Cells Nanomed. Biotechnol. 2017, 45, 414–425. DOI: 10.3109/21691401.2016.1160912.
   PubMed Web of Science ®Google Scholar
• Majoros, I. J.; Williams, C. R.; Becker, A.; Baker, J. R. J. Methotrexate Delivery via Folate Targeted Dendrimer-Based Nanotherapeutic Platform. Wires. Nanomed. Nanobiotechnol. 2009, 1, 502–510. DOI: 10.1002/wnan.37.
   PubMed Web of Science ®Google Scholar
• Sing, P.; Gupta, U.; Asthana, A.; Jain, N. K. Folate and folate-PEG-PAMAM Dendrimers: Synthesis, Characterization, and Targeted Anticancer Drug Delivery Potential in Tumor Bearing Mice. Bioconjugate Chem. 2008, 19, 2239–2252. DOI: 10.1021/bc800125u.
   PubMed Web of Science ®Google Scholar
• Castro, R. I.; Forero-Doria, O.; Guzman, L. Perspectives of Dendrimer-Based Nanoparticles in Cancer Therapy. An. Acad. Bras. Ciênc. 2018, 90, 2331–2346. DOI: 10.1590/0001-3765201820170387.
   PubMed Web of Science ®Google Scholar
• Senapati, S.; Mahanta, A. K.; Kumar, S.; Maiti, P. Controlled Drug Delivery Vehicles for Cancer Treatment and Their Performance. Signal Transd. Target. Ther. 2018, 3, 7. DOI: 10.1038/s41392-017-0004-3.
   PubMed Web of Science ®Google Scholar
• Malik, N.; Wiwattanapatapee, R.; Klopsch, R.; Lorenz, K.; Frey, H.; Weener, J. W.; Meijer, E. W.; Paulus, W.; Duncan, R. Dendrimers: Relationship between Structure and Biocompatibility in Vitro, and Preliminary Studies on the Biodistribution of 125I-Labelled Polyamidoamine Dendrimers in Vivo. J. Control. Rel. 2000, 68, 299–302. DOI: 10.1016/S0168-3659(00)00283-2.
   Web of Science ®Google Scholar
• Wilbur, D. S.; Pathare, P. M.; Hamlin, D. K.; Buhler, K. R.; Vessella, R. L. Biotin Reagents for Antibody Pretargeting: Synthesis, Radioiodination, and Evaluation of Biotinylated Starburst Dendrimers. Bioconjugate Chem. 1998, 9, 813–825. DOI: 10.1021/bc980055e.
   PubMed Web of Science ®Google Scholar
• Yang, H.; Morris, J. J.; Lopina, S. T. Polyethylene Glycol-Polyamidoamine Dendritic Micelle as Solubility Enhancer and the Effect of the Length of Polyethylene Glycol Arms on the Solubility of Pyrene in Water. J. Colloid. Interf. Sci. 2004, 273, 148–154. DOI: 10.1016/j.jcis.2003.12.023.
   PubMed Web of Science ®Google Scholar
• Kojima, C.; Kono, K.; Maruyama, K.; Takagishi, T. Synthesis of Polyamidoamine Dendrimers Having Poly (Ethylene Glycol) Grafts and Their Ability to Encapsulate Anticancer Drugs. Bioconjugate Chem. 2000, 11, 910–917. DOI: 10.1021/bc0000583.
   PubMed Web of Science ®Google Scholar
• DeJesus, O. L. P.; Ihre, H. R.; Gagne, L.; Frechet, J. M. J.; Szoka, F. C. Polyester Dendritic Systems for Drug Delivery Applications, in Vitro and in Vivo Evaluation. Bioconjugate Chem. 2002, 13, 453–461.
   PubMed Web of Science ®Google Scholar
• Mc Nerny, D. Q.; Leroueil, P. R.; Baker, J. R. Understanding Specific and Non Specific Toxicities: A Requirement for the Development of Dendrimer-Based Pharmaceuticals. Wires. Nanomed. Nanobiotechnol. 2010, 2, 249–259. DOI: 10.1002/wnan.79.
   PubMed Web of Science ®Google Scholar
• Chauhan, A. S.; Jain, N. K.; Diwan, P. V.; Khopade, A. J. Solubility Enhancement of Indomethacin with Poly (Amidoamine) Dendrimers and Targeting to Inflammatory Regions of Arthritic Rats. J. Drug Target. 2004, 12, 575–583. DOI: 10.1080/10611860400010655.
   PubMed Web of Science ®Google Scholar
• Asthana, A.; Chauhan, A. S.; Diwan, P. V.; Jain, N. K. Poly (Amidoamine) (PAMAM) Dendritic Nanostructures for Controlled Site-Specific Delivery of Acidic anti-Inflammatory Active Ingredient. AAPS Pharm. Sci. Tech. 2005, 6, E536–542. DOI: 10.1208/pt060367.
   PubMed Web of Science ®Google Scholar
• Bhadra, D.; Yadav, A. K.; Bhadra, S.; Jain, N. K. Glycodendrimeric Nanoparticulate Carriers of Primaquine Phosphate for Liver Targeting. Int. J. Pharm. 2005, 295, 221–233. DOI: 10.1016/j.ijpharm.2005.01.026.
   PubMed Web of Science ®Google Scholar
• Shukla, R.; Thomas, T. P.; Peters, J.; Kotlyar, A.; Myc, A.; Baker, J. R. Tumor Angiogenic Vasculature Targeting with PAMAM dendrimer-RGD Conjugates. Chem. Commun. 2005, 46, 5739–5741.
   PubMed Web of Science ®Google Scholar
• Majoros, I. J.; Myc, A.; Thomas, T.; Mehta, C. B.; Baker, J. R. PAMAM Dendrimer-Based Multifunctional Conjugate for Cancer Therapy: Synthesis, Characterization, and Functionality. Biomacromol. 2006, 7, 572–579. DOI: 10.1021/bm0506142.
   PubMed Web of Science ®Google Scholar
• Thomas, T. P.; Majoros, I. J.; Kotlyar, A.; Kukowska, L. J. F.; Bielinska, A.; Myc, A.; Baker, J. R. J. Targeting and Inhibition of Cell Growth by an Engineered Dendritic Nanodevice. J. Med. Chem. 2005, 48, 3729–3735. DOI: 10.1021/jm040187v.
   PubMed Web of Science ®Google Scholar
• Majoros, I. J.; Thomas, T. P.; Mehta, C. B.; Baker, J. R. Poly (Amidoamine) Dendrimer-Based Multi-Functional Engineered Nanomedicine for Cancer Therapy. J. Med. Chem. 2005, 48, 5892–5899. DOI: 10.1021/jm0401863.
   PubMed Web of Science ®Google Scholar
• Barth, R. F.; Wu, G.; Yang, W.; Binns, P. J.; Riley, K. J.; Patel, H.; Coderre, J. A.; Tjarks, W.; Bandyopadhyaya, A. K.; Thirumamagal, B. T. S.; et al. Neutron Capture Therapy of Epidermal Growth Factor (plus) Gliomas Using Boronated Cetuximab (IMC-C225) as a Delivery Agent. Appl. Radiat. Isot. 2004, 61, 899–903. DOI: 10.1016/j.apradiso.2004.05.004.
   PubMed Web of Science ®Google Scholar
• Barth, R. F.; Adams, D. M.; Soloway, A. H.; Alam, F.; Darby, M. V. Boronated Star Burst Dendrimer Monoclonal-Antibody Immunoconjugates – Evaluation as a Potential Delivery System for Neutron-Capture Therapy. Bioconjugate Chem. 1994, 5, 58–66. DOI: 10.1021/bc00025a008.
   PubMed Web of Science ®Google Scholar
• Yang, W. L.; Barth, R. F.; Adams, D. M.; Ciesielski, M. J.; Fenstermaker, R. A.; Shukla, S.; Tjarks, W.; Caligiuri, M. A. Convection-enhanced delivery of boronated epidermal growth factor for molecular targeting of EGF receptor-positive gliomas. Cancer Res. 2002, 62, 6552–6558.
   PubMed Web of Science ®Google Scholar
• Yang, W. L.; Barth, R. F.; Adams, D. M.; Soloway, A. H. Intratumoral Delivery of Boronated Epidermal Growth Factor for Neutron Capture Therapy of Brain Tumors. Bioconjugate Chem. 1997, 57, 4333–4339.
   Google Scholar
• Yang, W.; Barth, R. F.; Wu, G.; Bandyopadhyaya, A. K.; Thirumamagal, B. T. S.; Tjarks, W.; Binns, P. J.; Riley, K.; Patel, H.; Coderre, J. A.; et al. Boronated Epidermal Growth Factor as a Delivery Agent for Neutron Capture Therapy of EGF Receptor Positive Gliomas. Appl. Radiat. Isot. 2004, 61, 981–985. DOI: 10.1016/j.apradiso.2004.05.071.
   PubMed Web of Science ®Google Scholar
• Duncan, R.; Izzo, L. Dendrimer Biocompatibility and Toxicity. Adv. Drug Deliv. Rev. 2005, 57, 2215–2237. DOI: 10.1016/j.addr.2005.09.019.
   PubMed Web of Science ®Google Scholar
• Kukowska-Latallo, J. F.; Raczka, E.; Quintana, A.; Chen, C.; Rymaszewski, M.; Baker, J. R. Intravascular and Endobronchial DNA Delivery to Murine Lung Tissue Using a Novel, Nonviral Vector. Hum. Gene Ther. 2000, 11, 1385–1395. DOI: 10.1089/10430340050057468.
   PubMed Web of Science ®Google Scholar
• Kihara, F.; Arima, H.; Tsutsumi, T.; Hirayama, F.; Uekama, K. In Vitro and in Vivo Gene Transfer by an Optimized Alpha-Cyclodextrin Conjugate with Polyamidoamine Dendrimer. Bioconjugate Chem. 2003, 14, 342–350. DOI: 10.1021/bc025613a.
   PubMed Web of Science ®Google Scholar
• Wada, K.; Arima, H.; Tsutsumi, T.; Chihara, Y.; Hattori, K.; Hirayama, F.; Uekama, K. Improvement of Gene Delivery Mediated by Mannosylated Dendrimer/[Alpha] – Cyclodextrin Conjugates. J. Control Rel. 2005, 104, 397–413. DOI: 10.1016/j.jconrel.2005.02.016.
   PubMed Web of Science ®Google Scholar
• Mamede, M.; Saga, T.; Ishimori, T.; Higashi, T.; Sato, N.; Kobayashi, H.; Brechbiel, M. W.; Konishi, J. Hepatocyte Targeting of 111In-Labeled oligo-DNA with Avidin or Avidin-Dendrimer Complex. J. Control Rel. 2004, 95, 133–141. DOI: 10.1016/j.jconrel.2003.11.015.
   PubMed Web of Science ®Google Scholar
• Dufes, C.; Keith, W. N.; Bilsland, A.; Proutski, I.; Uchegbu, I. F.; Schatzlein, A. G. Synthetic Anticancer Gene Medicine Exploits Intrinsic Antitumor Activity of Cationic Vector to Cure Established Tumors. Cancer Res. 2005, 65, 8079–8084. DOI: 10.1158/0008-5472.CAN-04-4402.
   PubMed Web of Science ®Google Scholar
• Schatzlein, A. G.; Zinselmeyer, B. H.; Elouzi, A.; Dufes, C.; Chim, Y. T. A.; Roberts, C. J.; Davies, M. C.; Munro, A.; Gray, A. I.; Uchegbu, I. F. Preferential Liver Gene Expression with Polypropylenimine Dendrimers. J. Control. Rel. 2005, 101, 247–258. DOI: 10.1016/j.jconrel.2004.08.024.
   PubMed Web of Science ®Google Scholar
• Tack, F.; Bakker, A.; Maes, S.; Dekeyser, N.; Bruining, M.; Elissen-Roman, C.; Janicot, M.; Brewster, M.; Janssen, H. M.; De Waal, B. F. M.; et al. Modified Poly (Propylene Imine) Dendrimers as Effective Transfection Agents for Catalytic DNA Enzymes (DNAzymes). J. Drug Target. 2006, 14, 69–86. DOI: 10.1080/10611860600635665.
   PubMed Web of Science ®Google Scholar
• Nair, L. S.; Laurencin, C. T. Biodegradable Polymers as Biomaterials. Prog. Polym. Sci. 2007, 32, 762–798. DOI: 10.1016/j.progpolymsci.2007.05.017.
   Web of Science ®Google Scholar
• Mehvar, R. Dextrans for Targeted and Sustained Delivery of Therapeutic and Imaging Agents. J Control. Rel. 2000, 69, 1–25. DOI: 10.1016/S0168-3659(00)00302-3.
   PubMed Web of Science ®Google Scholar
• Knorr, V.; Ogris, M.; Wagner, E. An Acid Sensitive Ketal-Based Polyethylene Glycol-Oligoethylenimine Copolymer Mediates Improved Transfection Efficiency at Reduced Toxicity. Pharm. Res. 2008, 25, 2937–2945. DOI: 10.1007/s11095-008-9700-6.
   PubMed Web of Science ®Google Scholar
• Luo, K.; Yang, J.; KopečKová, P.; KopečEk, Jich.; Biodegradable Multiblock Poly [N-(2-Hydroxypropyl) Methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization and Click Chemistry. Macromolecules. 2011, 44, 2481–2488. DOI: 10.1021/ma102574e.
   PubMed Web of Science ®Google Scholar
• Pan, H.; Yang, J.; KopečKová, P.; KopečEk, J.; Backbone Degradable Multiblock N-(2-Hydroxypropyl) Methacrylamide Copolymer Conjugates via Reversible Addition-Fragmentation Chain Transfer Polymerization and Thiol-Ene Coupling Reaction. Biomacromolecules. 2011, 12, 247–252. DOI: 10.1021/bm101254e.
   PubMed Web of Science ®Google Scholar
• Yang, J.; Luo, K.; Pan, H.; Kopeckova, P.; Kopecek, J. Synthesis of Biodegradable Multi-Block Copolymers by Click Coupling of RAFT-Generated Heterotelechelic Poly HPMA Conjugates. React. Funct. Polym. 2011, 71, 294–302. DOI: 10.1016/j.reactfunctpolym.2010.10.005.
   PubMed Web of Science ®Google Scholar
• Barz, M.; Wolf, F. K.; Canal, F.; Koynov, K.; Vicent, M. J.; Frey, H.; Zentel, R. Synthesis, Characterization and Preliminary Biological Evaluation of P(HPMA)-b-P(LLA) Copolymers: A New Type of Functional Biocompatible Block Copolymer. Macromol. Rapid Commun. 2010, 3, 1492–1500.
   Web of Science ®Google Scholar
• Matsumura, Y.; Maeda, H. A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs. Cancer Res. 1986, 46, 6387–6392.
   PubMed Web of Science ®Google Scholar
• Seymour, L. W.; Duncan, R.; Strohalm, J.; Kopecek, J. Effect of Molecular Weight (MW) of N-(2-Hydroxypropyl) Methacrylamide Copolymers on Body Distribution and Rate of Excretion after Subcutaneous, Intraperitoneal, and Intravenous Administration to Rats. J. Biomed. Mater. Res. 1987, 21, 1341–1358. DOI: 10.1002/jbm.820211106.
   PubMed Web of Science ®Google Scholar
• Chauhan, A. S.; Diwan, P. V.; Jain, N. K.; Tomalia, D. A. Unexpected in Vivo anti-Inflammatory Activity Observed for Simple, Surface Functionalized Poly (Amidoamine) Dendrimers. Biomacromolecules. 2009, 10, 1195–1202. DOI: 10.1021/bm9000298.
   PubMed Web of Science ®Google Scholar
• Martinet, L.; Fleury, C.S.; Gadelorge, M.; Dietrich, G.; Bourin, P.; Fournie, J. J.; Poupot, R. A Regulatory Cross-Talk between Vγ9Vδ2 T Lymphocytes and Mesenchymal Stem Cells. Eur. J. Immunol. 2009, 39, 752–762. DOI: 10.1002/eji.200838812.
   PubMed Web of Science ®Google Scholar
• Martinet, L.; Jean, C.; Dietrich, G.; Fournie, J. J.; Poupot, R. PGE2 Inhibits Natural Killer and γδ T Cell Cytotoxicity Triggered NKR and TCR through a cAMP-Mediated PKA Type I-Dependent Signaling. Biochem. Pharmacol. 2010, 80, 838–845. DOI: 10.1016/j.bcp.2010.05.002.
   PubMed Web of Science ®Google Scholar
• Vannucci L.; Fiserová A.; Sadalapure K.; Lindhorst T.; Kuldová M.; Rossmann P.; Horváth O.; Kren V.; Krist P.; Bezouska K.; et al. Effects of n-Acetyl-Glucosamine-Coated Glycodendrimers as Biological Modulators in the b16f10 Melanoma Model in Vivo. Int. J. Oncol. 2003, 23, 285–296.
   PubMed Web of Science ®Google Scholar
• Shaunak S.; Thomas S.; Gianasi E.; Godwin A.; Jones E.; Teo I.; Mireskandari K.; Luthert P.; Duncan R.; Patterson S.; et al. Polyvalent Dendrimer Glucosamine Conjugates Prevent Scar Tissue Formation. Nat. Biotechnol. 2004, 22, 977–984. DOI: 10.1038/nbt995.
   PubMed Web of Science ®Google Scholar
• Poupot M.; Griffe L.; Marchand P.; Maraval A.; Rolland O.; Martinet L.; L’Faqihi-Olive F.; Turrin C.; Caminade A.; Fournié J.; et al. Design of Phosphorylated Dendritic Architectures to Promote Human Monocyte Activation. Faseb J. 2006, 20, 2339–2351. DOI: 10.1096/fj.06-5742com.
   PubMed Web of Science ®Google Scholar
• Espinosa, E.; Belmant, C.; Sicard, H.; Poupot, R.; Bonneville, M.; Fournié, J. J. Y2k + 1 State-of-the-Art on Non-Peptide Phosphoantigens, a Novel Category of Immunostimulatory Molecules. Microbes Infect. 2001, 3, 645–654. DOI: 10.1016/S1286-4579(01)01420-4.
   PubMed Web of Science ®Google Scholar
• Martinet, L.; Poupot, R.; Fournie, J. J. Pitfalls on the Roadmap to γδ T Cell-Based Cancer Immunotherapies. Immunol. Lett. 2009, 124, 1–8. DOI: 10.1016/j.imlet.2009.03.011.
   PubMed Web of Science ®Google Scholar
• Griffe L.; Poupot M.; Marchand P.; Maraval A.; Turrin C.; Rolland O.; Métivier P.; Bacquet G.; Fournié J.; Caminade A.; et al. Multiplication of Human Natural Killer Cells by Nanosized Phosphate-Capped Dendrimers. Angew. Chem. Int. Ed. 2007, 46, 2523–2526. DOI: 10.1002/anie.200604651.
   PubMed Web of Science ®Google Scholar
• Portevin, D.; Poupot, M.; Rolland, O.; Turrin, C. O.; Fournie, J. J.; Majoral, J. P.; Caminade, A. M.; Poupot, R. Regulatory Activity of Azabisphosphonate-Capped Dendrimers on Human CD+ T Cell Proliferation Enhances Ex-Vivo Expansion of NK Cells from PBMCs for Immunotherapy. J. Transl. Med. 2009, 7, 82. DOI: 10.1186/1479-5876-7-82.
   PubMed Web of Science ®Google Scholar
• Fruchon, S.; Poupot, M.; Martinet, L.; Turrin, C. O.; Majoral, J. P.; Fournie, J. J.; Caminade, A. M.; Poupot, R. Anti-Inflammatory and Immunosuppressive Activation of Human Monocytes by a Bio-Active Dendrimer. J. Leukoc. Biol. 2009, 85, 553–562. DOI: 10.1189/jlb.0608371.
   PubMed Web of Science ®Google Scholar
• Rele, S. M.; Cui, W.; Wang, L.; Hou, S.; Barr-Zarse, G.; Tatton, D.; Gnanou, Y.; Esko, J. D.; Chaikof, E. L. Dendrimer-like PEO Glycopolymers Exhibit Anti-inflammatory Properties. J. Am. Chem. Soc. 2005, 127, 10132–10133. DOI: 10.1021/ja0511974.
   PubMed Web of Science ®Google Scholar
• Ulbrich, H.; Eriksson, E.; Lindbom, L. Leukocyte and Endothelial Cell Adhesion Molecules as Targets for Therapeutic Interventions in Inflammatory Disease. Trends Pharmacol. Sci. 2003, 24, 640–647. DOI: 10.1016/j.tips.2003.10.004.
   PubMed Web of Science ®Google Scholar
• Khalid H.; Mukherjee S.; O'Neill L.; Byrne H. Structural Dependence of in Vitro Cytotoxicity, Oxidative Stress and Uptake Mechanisms of Poly (Propylene Imine) Dendritic Nanoparticles. J. Appl. Toxicol. 2016, 36, 464–473.
   PubMed Web of Science ®Google Scholar