Smart polymers for colon targeted drug delivery systems: a review

References

• Ciftci, K. Alternative Approaches to the Treatment of Colon Cancer. Eur. J. Pharm. Biopharm. 1996, 42, 160–170.
   Web of Science ®Google Scholar
• Hanuer, S. B. Inflammatory Bowel Disease. N. Engl. J. Med. 1996, 334, 841–848.
   PubMed Web of Science ®Google Scholar
• Chourasia, M. K.; Jain, S. K. Polysaccharides for Colon Targeted Drug Delivery. Drug Deliv. 2004, 11, 129–148. doi:10.1080/10717540490280778.
   PubMed Web of Science ®Google Scholar
• Chourasia, M. K.; Jain, S. K. Pharmaceutical Approaches to Colon Targeted Drug Delivery Systems. J. Pharm. Pharm. Sci. 2003, 6, 33–66.
   PubMed Web of Science ®Google Scholar
• Lengyel, M.; Kállai-Szabó, N.; Antal, V.; Laki, A. J.; Antal, I. Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery. Sci. Pharm. 2019, 87, 20–31. doi:10.3390/scipharm87030020.
   Web of Science ®Google Scholar
• Philip, A. K.; Philip, B. Colon Targeted Drug Delivery Systems: A Review on Primary and Novel Approaches. Oman Med. J. 2010, 25, 79–87. doi:10.5001/omj.2010.24.
   PubMedGoogle Scholar
• Shukla, R. K.; Tiwari, A. Carbohydrate Polymers: Applications and Recent Advances in Delivering Drugs to the Colon. Carbohyd. Polym. 2012, 88, 399–416. doi:10.1016/j.carbpol.2011.12.021.
   Web of Science ®Google Scholar
• Amidon, S.; Brown, J. E.; Dave, V. S. Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches. AAPS PharmSciTech 2015, 16, 731–741. doi:10.1208/s12249-015-0350-9.
   PubMed Web of Science ®Google Scholar
• Gupta, A.; Mittal, A.; Gupta, A. K. Colon Targeted Drug Delivery Systems-A Review. Rus. J. Biopharm. 2011, 3, 3–13.
   Google Scholar
• Sangeetha, G.; Begum, M. J.; Reddemma, S.; Rajendra, Y. Colon Targeted Drug Delivery System: A Review. Int. J. Pharm. Technol. 2011, 3, 1657–1672.
   Google Scholar
• Vassallo, M.; Camilleri, M.; Phillips, S. F.; Brown, M. L.; Chapman, N. J.; Thomforde, G. M. Transit through the Proximal Colon Influences Stool Weight in the Irritable Bowel Syndrome. Gastroenterology 1992, 102, 102–108. doi:10.1016/0016-5085(92)91789-7.
   PubMed Web of Science ®Google Scholar
• Reddy, S. N.; Bazzocchi, G.; Chan, S.; Akashi, K.; Villanueva-Meyer, J.; Yanni, G.; Mena, I.; Snape, W. J. Jr. Colonic Motility and Transit in Health and Ulcerative Colitis. Gastroenterology 1991, 101, 1289–1297. doi:10.1016/0016-5085(91)90079-Z.
   PubMed Web of Science ®Google Scholar
• Yang, L.; Chu, J. S.; Fix, J. A. Colon-Specific Drug Delivery: New Approaches and In Vitro/In Vivo Evaluation. Int. J. Pharm. 2002, 235, 1–15. doi:10.1016/S0378-5173(02)00004-2.
   PubMed Web of Science ®Google Scholar
• Rubinstein, A. Natural Polysaccharides as Targeting Tools of Drugs to the Human Colon. Drug Dev. Res. 2000, 50, 435–439. doi:10.1002/1098-2299(200007/08)50:3/4<435::AID-DDR26>3.0.CO;2-5.
   Web of Science ®Google Scholar
• Rubinstein, A. Microbially Controlled Drug Delivery to the Colon. Biopharm. Drug Dispos. 1990, 11, 465–475. doi:10.1002/bdd.2510110602.
   PubMed Web of Science ®Google Scholar
• Kinget, R.; Kalala, W.; Vervoort, L.; Mooter, G. U. Colonic Drug Targeting. J. Drug Target. 1998, 6, 129–149. doi:10.3109/10611869808997888.
   PubMed Web of Science ®Google Scholar
• Saffran, M.; Kumar, G. S.; Savariar, C.; Burnham, J. C.; Williams, F.; Neckers, D. C. A New Approach to the Oral Administration of Insulin and Other Peptide Drugs. Science 1986, 233, 1081–1084. doi:10.1126/science.3526553.
   PubMed Web of Science ®Google Scholar
• Shantha, K. L.; Ravichandran, P.; Rao, K. P. Azo Polymeric Hydrogels for Colon Targeted Drug Delivery. Biomaterials 1995, 16, 1313–1318. doi:10.1016/0142-9612(95)91046-2.
   PubMed Web of Science ®Google Scholar
• Lee, S. H.; Bajracharya, R.; Min, J. Y.; Han, J. W.; Park, B. J.; Han, H. K. Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements. Pharmaceutics 2020, 12, 68–20. doi:10.3390/pharmaceutics12010068.
   PubMed Web of Science ®Google Scholar
• Sarangi, M. K.; Rao, M. E. B.; Parcha, V.; Upadhyay, A. Tailoring of Colon Targeting with Sodium alginate-Assam Bora Rice Starch Based Multi Particulate System Containing Naproxen. Starch-Starke 2020.
   Web of Science ®Google Scholar
• Semde, R.; Amighi, K.; Devleeschouwe, M. J.; Moes, A. J. Effect of Pectinolytic Enzymes on the Theophylline Release from Pellets Coated with Water Insoluble Polymers Containing Pectin HM or Calcium Pectinate. Int. J. Pharm. 2000, 197, 181–192.
   PubMed Web of Science ®Google Scholar
• MacLeod, G. S.; Fell, J. T.; Collett, J. H.; Sharma, H. L.; Smith, A. M. Selective Drug Delivery to the Colon Using Pectin: Chitosan: Hydroxypropyl Methylcellulose Film Coated Tablets. Int. J. Pharm. 1999, 187, 251–257. doi:10.1016/S0378-5173(99)00196-9.
   PubMed Web of Science ®Google Scholar
• Tiwari, A.; Verma, A.; Panda, P. K.; Saraf, S.; Jain, A.; Jain, S. K. Stimuli-Responsive Polysaccharides for Colon-Targeted Drug Delivery. In Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications: Advanced Nanocarriers for Therapeutics, Chapter No 20; Makhlouf, A. S. H., Abu-Thabit, N. Y., Eds.; Woodhead Publishing: Cambridge, MA, 2018; Vol. 2, pp 547–562.
   Google Scholar
• Salyers, A. A.; Vercellotti, J. R.; West, S. E. H.; Wilkins, T. D. Fermentation of Mucin and Plant Polysaccharides by Strains of Bacteroides from the Human Colon. Appl. Environ. Microbiol. 1977, 33, 319–322. doi:10.1128/AEM.33.2.319-322.1977.
   PubMed Web of Science ®Google Scholar
• Ashford, M.; Fell, J. T.; Attwood, D.; Sharma, H. L.; Woodhead, P. J. Studies on Pectin Formulations for Colonic Drug Delivery. J. Control. Release 1994, 30, 225–232. doi:10.1016/0168-3659(94)90028-0.
   Web of Science ®Google Scholar
• Ofori, K. K.; Fell, J. T. Biphasic Drug Release from Film Coated Tablets. Int. J. Pharm. 2003, 250, 431–440. doi:10.1016/S0378-5173(02)00578-1.
   PubMed Web of Science ®Google Scholar
• Sriamornsak, P.; Prakongpan, S.; Puttipipatkhachorn, S.; Kennedy, R. A. Development of Sustained Release Theophylline Pallets Coated with Calcium Pectinate. J. Control. Release 1997, 47, 221–232. doi:10.1016/S0168-3659(97)01640-4.
   Web of Science ®Google Scholar
• Dupuis, G.; Chambin, O.; Genelot, C.; Champion, D.; Pourcelot, Y. Colonic Drug Delivery: Influence of Cross Linking Agent on Pectin Beads Properties and Role of Capsule Shell Type. Drug Dev. Ind. Pharm. 2006, 32, 847–855. doi:10.1080/03639040500536718.
   PubMed Web of Science ®Google Scholar
• Wei, H.; Qing, D.; De, Y. C.; Bai, X.; Li, F. F. In-Vitro and in-Vivo Studies of Pectin/Ethylcellulosefilm-Coated Pellets of 5-Fluorouracil for Colonic Targeting. J. Pharm. Pharmacol. 2008, 60, 35–44. doi:10.1211/jpp.60.1.0005.
   PubMed Web of Science ®Google Scholar
• Kumar, R. S.; Kumar, M.; Ganesh, G. N.; Jawahar, N.; Nagasamy, V. D.; Senthil, V. Formulation and Evaluation of Pectin-Hydroxypropyl Methylcellulose Coated Curcumin Pellets for Colon Delivery. Asia. J. Pharm. 2009, 3, 138–142. doi:10.4103/0973-8398.55052.
   Google Scholar
• Lee, C. M.; Kim, D. W.; Lee, H. C.; Lee, K. Y. Pectin Microspheres for Oral Colon Delivery: Preparation Using Spray Drying Method and In Vitro Release of Indomethacin. Biotechnol. Bioprocess Eng. 2004, 9, 191–195. doi:10.1007/BF02942291.
   Web of Science ®Google Scholar
• Momin, M.; Pundarikakshudu, K.; Nagori, S. A. Design and Development of Mixed Film of Pectin: Ethyl Cellulose for Colon Specific Drug Delivery of Sennosides and Triphala. Indian J. Pharm. Sci. 2008, 70, 338–343. doi:10.4103/0250-474X.42998.
   PubMed Web of Science ®Google Scholar
• Cheewatanakornkool, K.; Niratisai, S.; Manchun, S.; Dass, C. R.; Sriamornsak, P. Characterization and In Vitro Release Studies of Oral Microbeads Containing Thiolated Pectin-Doxorubicin Conjugates for Colorectal Cancer Treatment. Asian J. Pharm. Sci. 2017, 12, 509–520. doi:10.1016/j.ajps.2017.07.005.
   PubMed Web of Science ®Google Scholar
• Li, C.; Li, J. B.; Lei, C. Y.; Liu, P. H. Preparation and In Vitro Release Mechanisms of Modified Pectin Matrix Tablets for Colon-Targeted Drug Delivery. Bio. Res. 2017, 12, 1491–1505.
   Google Scholar
• Leclere, L.; Van Cutsem, P.; Michiels, C. Anti-Cancer Activities of pH- or Heat-Modified Pectin. Front. Pharmacol. 2013, 4, 128doi:10.3389/fphar.2013.00128.
   PubMed Web of Science ®Google Scholar
• Majumdar, S.; Roy, S.; Ghosh, B. Design and Gamma Scintigraphic Evaluation of Colon Specific Pectin-EC Pellets of Secnidazole Prepared by Powder Layering Technology. Pharmazie 2011, 66, 843–848.
   PubMed Web of Science ®Google Scholar
• Jana, S.; Gandhi, A.; Sen, K. K.; Basu, S. K. Natural Polymers and Their Application in Drug Delivery and Biomedical Field. J. Pharm. Sci. Tech. 2011, 1, 16–27.
   Google Scholar
• Svagan, A. J.; Kusic, A.; De Gobba, C.; Larsen, F. H.; Sassene, P.; Zhou, Q.; van de Weert, M.; Mullertz, A.; Jørgensen, B.; Ulvskov, P. Rhamnogalacturonan-I Based Microcapsules for Targeted Drug Release. PLoS One. 2016, 11, e0168050. doi:10.1371/journal.pone.0168050.
   PubMed Web of Science ®Google Scholar
• Tan, H.; Chen, W.; Liu, Q.; Yang, G.; Li, K. Pectin Oligosaccharides Ameliorate Colon Cancer by Regulating Oxidative Stress and Inflammation-Activated Signalling Pathways. Front. Immunol. 2018, 9, 1–13. doi:10.3389/fimmu.2018.01504.
   PubMed Web of Science ®Google Scholar
• Ofosua, A. D.; Kwabena, O. K.; Mariam, E. B. G.; Samuel, O. B.; Samuel, O. In Vitro Evaluation of Cocoa Pod Husk Pectin as a Carrier for Chronodelivery of Hydrocortisone Intended for Adrenal Insufficiency. J. Drug. Deliv. 2017, 2017, 1–10.
   Web of Science ®Google Scholar
• Abdalrahim, F. A. A.; Abdulmajid, A. M. S.; Ismail, Z.; Salman, A. A.; Abu-Salah, K. M. Development of Polymeric Nanoparticles of Garcinia Mangostana Xanthones in Eudragit RL100/RS100 for anti-Colon Cancer Drug Delivery. J. Nanomat. 2015, 2015, 1–12. doi:10.1155/2015/701979.
   Web of Science ®Google Scholar
• Srivastava, P.; Malviya, R. Sources of Pectin, Extraction and Its Applications in Pharmaceutical industries-An Overview. Ind. J. Nat. Prod. Res. 2011, 2, 10–18.
   Google Scholar
• Torkova, A. A.; Lisitskaya, K. V.; Filimonov, I. S.; Glazunova, O. A.; Kachalova, G. S.; Golubev, V. N.; Fedorova, T. V. Physicochemical and Functional Properties of Cucurbita Maxima Pumpkin Pectin and Commercial Citrus and Apple Pectins: A Comparative Evaluation. PLoS One 2018, 13, e0204261. doi:10.1371/journal.pone.0204261.
   PubMed Web of Science ®Google Scholar
• Guochuan, S.; Zongping, Z.; Lee, M. H.; Xu, Y.; Kang, S.; Dong, Z.; Wang, M.; Gu, Z.; Li, H.; Chen, W. Chemoprevention of Colorectal Cancer by Artocarpin, a Dietary Phytochemical from Artocarpus heterophyllus. J. Agric. Food Chem. 2017, 65, 3474–3480. doi:10.1021/acs.jafc.7b00278.
   PubMed Web of Science ®Google Scholar
• Zou, M.; Wang, C.; Zhang, X.; Xu, T.; Han, J.; Zhang, X.; Cheng, G. A Suppository-Base-Matrix Tablet for Time-Dependent Colonspecific Delivery System. Braz. J. Pharm. Sci. 2014, 50, 535–541. doi:10.1590/S1984-82502014000300012.
   Web of Science ®Google Scholar
• Maxwell, E. G.; Colquhoun, I. J.; Chau, H. K.; Hotchkiss, A. T.; Waldron, K. W.; Morris, V. J.; Belshaw, N. J. Rhamnogalacturonan I Containing Homogalacturonan Inhibits Colon Cancer Cell Proliferation by Decreasing ICAM1 Expression. Carbohydr. Polym. 2015, 132, 546–553. doi:10.1016/j.carbpol.2015.06.082.
   PubMed Web of Science ®Google Scholar
• Delphi, L.; Sepehri, H.; Khorramizadeh, M. R.; Mansoori, F. Pectic-Oligoshaccharides from Apples Induce Apoptosis and Cell Cycle Arrest in MDA-MB-231 Cells, a Model of Human Breast Cancer. Asian. Pac. J. Cancer. Prev. 2015, 16, 5265–5271. doi:10.7314/APJCP.2015.16.13.5265.
   PubMedGoogle Scholar
• Jaganathan, S. K.; Vellayappan, M. V.; Narasimhan, G.; Supriyanto, E.; Octorina Dewi, D. E.; Narayanan, A. L. T.; Balaji, A.; Subramanian, A. P.; Yusof, M. Chemopreventive Effect of Apple and Berry Fruits against Colon Cancer. World J. Gastroenterol. 2014, 20, 17029–17036. doi:10.3748/wjg.v20.i45.17029.
   PubMed Web of Science ®Google Scholar
• Waldecker, M.; Kautenburger, T.; Daumann, H.; Veeriah, S.; Will, F.; Dietrich, H.; Pool-Zobel, B. L.; Schrenk, D. Histone-Deacetylase Inhibition and Butyrate Formation: Fecal Slurry Incubations with Apple Pectin and Apple Juice Extracts. Nutrition 2008, 24, 366–374. doi:10.1016/j.nut.2007.12.013.
   PubMed Web of Science ®Google Scholar
• Direito, R.; Lima, A.; Rocha, J.; Ferreira, R. B.; Mota, J.; Rebelo, P.; Fernandes, A.; Pinto, R.; Alves, P.; Bronze, R.; et al. Dyospiros Kaki Phenolics Inhibit Colitis and Colon Cancer Cell Proliferation, but Not Gelatinase Activities. J. Nutr. Biochem. 2017, 46, 100–108. doi:10.1016/j.jnutbio.2017.03.002.
   PubMed Web of Science ®Google Scholar
• Yaqub, S.; Farooq, U.; Shafi, A.; Akram, K.; Murtaza, M. A.; Kausar, T.; Siddique, F. Chemistry and Functionality of Bioactive Compounds Present in Persimmon. J. Chem. 2016, 2016, 1–13. doi:10.1155/2016/3424025.
   Web of Science ®Google Scholar
• Salima, T. M.; Vladimir, F. M.; Daria, M. A.; Anna, V. K.; Lubov, G. M.; Yulia, M. Z.; Vasili, A. M. Biological Activity and Pharmacological Application of Pectic Polysaccharides: A Review. Polymers 2018, 10, 1–31.
   Web of Science ®Google Scholar
• Günter, E. A.; Popeyko, O. V. Calcium Pectinate Gel Beads Obtained from Callus Cultures Pectins as Promising Systems for Colon-Targeted Drug Delivery. Carbohydr. Polym. 2016, 147, 490–499. doi:10.1016/j.carbpol.2016.04.026.
   PubMed Web of Science ®Google Scholar
• Subudhi, M. B.; Jain, A.; Jain, A.; Hurkat, P.; Shilpi, S.; Gulbake, A.; Jain, S. K. Eudragit S100 Coated Citrus Pectin Nanoparticles for Colon Targeting of 5-Fluorouracil. Materials (Basel) 2015, 8, 832–849. doi:10.3390/ma8030832.
   PubMed Web of Science ®Google Scholar
• Liu, H. Y.; Huang, Z. L.; Yang, G. H.; Lu, W. Q.; Yu, N. R. Inhibitory Effect of Modified Citrus Pectin on Liver Metastases in a Mouse Colon Cancer Model. WJG 2008, 14, 7386–7391. doi:10.3748/wjg.14.7386.
   PubMed Web of Science ®Google Scholar
• Bergman, M.; Djaldetti, M.; Salman, H.; Bessler, H. Effect of Citrus Pectin on Malignant Cell Proliferation. Biomed. Pharmacother. 2010, 64, 44–47. doi:10.1016/j.biopha.2009.03.004.
   PubMed Web of Science ®Google Scholar
• Prado, S. B. R.; Ferreira, G. F.; Harazono, Y.; Shiga, T. M.; Raz, A.; Nicholas, C. C.; Fabi, J. P. Ripening-Induced Chemical Modifications of Papaya Pectin Inhibit Cancer Cell Proliferation. Sci. Rep. 2017, 7, 1–17.
   PubMed Web of Science ®Google Scholar
• Maxwell, E. G.; Colquhoun, I. J.; Chau, H. K.; Hotchkiss, A. T.; Waldron, K. W.; Morris, V. J.; Belshaw, N. J. Modified Sugar Beet Pectin Induces Apoptosis of Colon Cancer Cells via an Interaction with the Neutral Sugar Side-Chains. Carbohydr. Polym. 2016, 136, 923–929. doi:10.1016/j.carbpol.2015.09.063.
   PubMed Web of Science ®Google Scholar
• Tozaki, H.; Komoike, J.; Tada, C.; Maruyama, T.; Terabe, A.; Suzuki, T.; Yamamoto, A.; Muranishi, S. Chitosan Capsules for Colon Specific Drug Delivery: Improvement of Insulin Absorption from Rat Colon. J. Pharm. Sci. 1997, 86, 1016–1021. doi:10.1021/js970018g.
   PubMed Web of Science ®Google Scholar
• Tozaki, H.; Fujita, T.; Odoriba, T.; Terabe, A.; Suzuki, T.; Tanaka, C.; Okabe, S.; Muranishi, S.; Yamamoto, A. Colon Specific Delivery of R68070, a New Thromboxane Synthetase Inhibitor, Using Chitosan Capsules: Therapeutic Effects against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis in Rats. Life Sci. 1999, 64, 1155–1162. doi:10.1016/S0024-3205(99)00044-2.
   PubMed Web of Science ®Google Scholar
• Tominaga, S.; Takaizawa, T.; Yamada, M. 1998. Colon Drug Delivery System. JP 10 324, 642 (98324, 642) (Cl A61 K47/36); 8 Dec., 1998, JP Appl. 97/73, 599, 26 Mar., 1997, 9PT (Japan).
   Google Scholar
• Tozaki, H.; Odoriba, T.; Okada, N.; Fujita, T.; Terabe, A.; Suzuki, T.; Okabe, S.; Muranishi, S.; Yamamoto, A. Chitosan Capsules for Colon Specific Drug Delivery: Enhanced Localization of 5-Aminosalicylic Acid in the Large Intestine Accelerates Healing of TNBS-Induced Colitis in Rats. J. Control. Release 2002, 82, 51–61. doi:10.1016/S0168-3659(02)00084-6.
   PubMed Web of Science ®Google Scholar
• Zhang, H.; Alsarra, I. A.; Neau, S. H. An In Vitro Evaluation of a Chitosan-Containing Multiparticulate System for Macromolecule Delivery to the Colon. Int. J. Pharm. 2002, 239, 197–205. doi:10.1016/S0378-5173(02)00112-6.
   PubMed Web of Science ®Google Scholar
• Orienti, I.; Cerchiara, T.; Luppi, B.; Bigucci, F.; Zuccari, G.; Zecchi, V. Influence of Different Chitosan Salts on the Release of Sodium Diclofenac in Colon-Specific Delivery. Int. J. Pharm. 2002, 238, 51–59. doi:10.1016/S0378-5173(02)00060-1.
   PubMed Web of Science ®Google Scholar
• Chang, K. L. B.; Lin, J. Swelling Behavior and the Release of Protein from Chitosan-Pectin Composite Particles. Carbo. Polym. 2000, 43, 163–169. doi:10.1016/S0144-8617(00)00145-4.
   Web of Science ®Google Scholar
• Raghavan, C. V.; Muthulingam, C.; Jenita, J.; Ravi, T. K. An In Vitro and In Vivo Investigation into the Suitability of Bacterially Triggered Delivery System for Colon Targeting. Chem. Pharm. Bull. 2002, 50, 892–895. doi:10.1248/cpb.50.892.
   PubMed Web of Science ®Google Scholar
• Lorenzo-Lamosa, M. L.; Lopez, C. R.; Vila-Jato, J. L.; Alonso, M. J. Design of Microencapsulated Chitosan Microspheres for Colonic Drug Delivery. J. Control. Release 1998, 52, 109–118. doi:10.1016/S0168-3659(97)00203-4.
   PubMed Web of Science ®Google Scholar
• Shu, X. Z.; Zhu, K. J.; Song, W. Novel pH-Sensitive Citrate Cross-Linked Chitosan Film for Drug Controlled Release. Int. J. Pharm. 2001, 212, 19–28. doi:10.1016/S0378-5173(00)00582-2.
   PubMed Web of Science ®Google Scholar
• Shimono, N.; Takatori, T.; Ueda, M.; Mori, M.; Higashi, Y.; Nakamura, Y. Chitosan Dispersed System for Colon-Specific Drug Delivery. Int. J. Pharm. 2002, 245, 45–54. doi:10.1016/S0378-5173(02)00344-7.
   PubMed Web of Science ®Google Scholar
• Iglesias, N.; Galbis, E.; Díaz-Blanco, M. J.; Lucas, R.; Benito, E.; De-Paz, M. V. Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release. IJMS 2019, 20, 398. doi:10.3390/ijms20020398.
   Web of Science ®Google Scholar
• Li, J.; Cai, C.; Li, J.; Li, J.; Li, J.; Sun, T.; Wang, L.; Wu, H.; Yu, G. Chitosan-Based Nanomaterials for Drug Delivery. Molecule 2018, 23, 2661. doi:10.3390/molecules23102661.
   PubMed Web of Science ®Google Scholar
• Galbiati, A.; Tabolacci, C.; Rocca, B. M. D.; Mattioli, P.; Beninati, S.; Paradossi, G.; Desideri, A. Targeting Tumor Cells through Chitosan-Folate Modified Microcapsules Loaded with Camptothecin. Bioconjug. Chem. 2011, 22, 1066–1072. doi:10.1021/bc100546s.
   PubMed Web of Science ®Google Scholar
• Yoshida, T.; Lai, T. C.; Kwon, G. S.; Sako, K. pH- and Ion-Sensitive Polymers for Drug Delivery. Exp. Opin. Drug Deliv. 2013, 10, 1497–1513. doi:10.1517/17425247.2013.821978.
   PubMed Web of Science ®Google Scholar
• Zhao, W.; Odelius, K.; Edlund, U.; Zhao, C.; Albertsson, A. C. In Situ Synthesis of Magnetic Field-Responsive Hemicellulose Hydrogels for Drug Delivery. Biomacromolecules 2015, 16, 2522–2528. doi:10.1021/acs.biomac.5b00801.
   PubMed Web of Science ®Google Scholar
• Kadria, A.; Elkhodairy, H.; Elsaghir, A.; Al-Subayiel, A. M. Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique. Biomed. Res. Int. 2014, 2014, 704362–704318. doi:10.1155/2014/704362.
   PubMed Web of Science ®Google Scholar
• Seeli, D. S.; Dhivya, S.; Selvamurugan, N.; Prabaharan, M. Guar Gum Succinate-Sodium Alginate Beads as a pH-Sensitive Carrier for Colon-Specific Drug Delivery. Int. J. Biol. Macromol. 2016, 91, 45–50. doi:10.1016/j.ijbiomac.2016.05.057.
   PubMed Web of Science ®Google Scholar
• Pinhassi, R. I.; Assaraf, Y. G.; Farber, S.; Stark, M.; Ickowicz, D.; Drori, S.; Domb, A. J.; Livney, Y. D. Arabinogalactan-Folic Acid-Drug Conjugate for Targeted Delivery and Target-Activated Release of Anticancer Drugs to Folate Receptor-Overexpressing Cells. Biomacromolecules 2010, 11, 294–303. doi:10.1021/bm900853z.
   PubMed Web of Science ®Google Scholar
• Takei, T.; Sato, M.; Ijima, H.; Kawakami, K. In Situ Gellable Oxidized Citrus Pectin for Localized Delivery of Anticancer Drugs and Prevention of Homotypic Cancer Cell Aggregation. Biomacromolecules 2010, 11, 3525–3530. doi:10.1021/bm1010068.
   PubMed Web of Science ®Google Scholar
• Shukla, S.; Jain, D.; Verma, K.; Verma, S. Pectin-Based Colon Specific Drug Delivery. Chron. Young Sci. 2011, 2, 83–89. doi:10.4103/2229-5186.82978.
   Google Scholar
• Wu, L.; Wang, H.; Xiaohua, Z.; Yinchen, H.; Wangwang, L.; Gongming, Y.; Jiang, A. Pectin-Chitosan Complex: Preparation and Application in Colon-Specific Capsule. Int. J. Agric. Biol. Eng. 2015, 8, 151–160.
   Web of Science ®Google Scholar
• Varshosaz, J.; Emami, J.; Ahmadi, F.; Tavakoli, N.; Minaiyan, M.; Fassihi, A.; Mahzouni, P.; Dorkoosh, F. Preparation of Budesonide-Dextran Conjugates Using Glutarate Spacer as a Colon-Targeted Drug Delivery System: In Vitro/In Vivo Evaluation in Induced Ulcerative Colitis. J. Drug. Target 2011, 19, 140–153. doi:10.3109/10611861003801826.
   PubMed Web of Science ®Google Scholar
• Siew, L. F.; Basit, A. W.; Newton, J. M. The Potential of Organic-Based Amylose-Ethylcellulose Film Coatings as Oral Colon-Specific Drug Delivery Systems. AAPS Pharm. Sci. Tech. 2000, 1, 53–61. doi:10.1208/pt010322.
   Google Scholar
• Karrout, Y.; Neut, C.; Wils, D.; Siepmann, F.; Deremaux, L.; Desreumaux, P.; Siepmann, J. Characterization of Ethylcellulose: Starch-Based Film Coatings for Colon Targeting. Drug Develop. Indus. Pharm. 2009, 35, 1190–1200. doi:10.1080/03639040902858868.
   PubMed Web of Science ®Google Scholar
• Emeje, M.; Nwabunike, P.; Isimi, Y.; Kunle, O.; Ofoefule, S. Preparation and Evaluation of Colon Targeted Drug Delivery Systems for Albendazole Using Kneading, Extrusion and Compaction Technology. Yao Xue Xue Bao 2009, 44, 1152–1158.
   PubMedGoogle Scholar
• Ramteke, K. H.; Nath, L. Formulation, Evaluation and Optimization of Pectin-Bora Rice Beads for Colon Targeted Drug Delivery System. Adv. Pharm. Bull. 2014, 4, 167–177. doi:10.5681/apb.2014.025.
   PubMedGoogle Scholar
• Hsu, F. Y.; Yu, D. S.; Huang, C. C. Development of pH-Sensitive Pectinate/Alginate Microspheres for Colon Drug Delivery. J. Mater. Sci. Mater. Med. 2013, 24, 317–323. doi:10.1007/s10856-012-4798-9.
   PubMed Web of Science ®Google Scholar
• Wang, Q. S.; Wang, G. F.; Zhou, J.; Gao, L. N.; Cui, Y. L. Colon Targeted Oral Drug Delivery System Based on Alginate-Chitosan Microspheres Loaded with Icariin in the Treatment of Ulcerative Colitis. Int. J. Pharm. 2016, 515, 176–185. doi:10.1016/j.ijpharm.2016.10.002.
   PubMed Web of Science ®Google Scholar
• Krishnaiah, Y. S. R.; Satyanarayana, S.; Prasad, Y. V. R.; Rao, S. N. Evaluation of Guar Gum as a Compression Coat for Drug Targeting to Colon. Int. J. Pharm. 1998, 171, 137–146. doi:10.1016/S0378-5173(98)00172-0.
   Web of Science ®Google Scholar
• Krishnaiah, Y. S. R.; Karthikeyan, R. S.; Sankar, V. G.; Satyanarayana, V. Three-Layer Guar Gum Matrix Tablet Formulations for Oral Controlled Delivery of Highly Soluble Trimetazidine Dihydrochloride. J. Control. Release 2002, 81, 45–56. doi:10.1016/S0168-3659(02)00031-7.
   PubMed Web of Science ®Google Scholar
• Krishnaiah, Y. S. R.; Raju, P. V.; Kumar, B. D.; Bhaskar, P.; Satyanarayana, V. Development of Colon Targeted Drug Delivery Systems for Mebendazole. J. Control. Release 2001, 77, 87–95. doi:10.1016/S0168-3659(01)00461-8.
   PubMed Web of Science ®Google Scholar
• Gliko, K. I.; Yagen, B.; Baluom, M.; Rubinstein, A. Phosphated Crosslinked Guar for Colon-Specific Drug Delivery II. In Vitro and In Vivo Evaluation in the Rat. J. Control. Release 2000, 63, 129–134. doi:10.1016/S0168-3659(99)00180-7.
   PubMed Web of Science ®Google Scholar
• Wong, D.; Larrabee, S.; Clifford, K.; Tremblay, J.; Friend, D. R. USP Dissolution Apparatus III (Reciprocating Cylinder) for Screening of Guar-Based Colonic Delivery Formulations. J. Control. Release 1997, 47, 173–179. doi:10.1016/S0168-3659(97)01633-7.
   Web of Science ®Google Scholar
• Cole, E. T.; Scott, R. A. Drug Delivery Composition for Release of Drug in Small Intestine, Colon or Terminal Ileum Comprises Hydroxypropylmethyl Cellulose Capsule Containing the Drug and Provided with a Coating Preventing Release of Drug in Stomach. W.O. 200018377-A1, Apr 06, 2000.
   Google Scholar
• Friend, D. R. Wong, D. Oral Delivery of Drugs to Lower Gastrointestinal Tract Particularly Colon, Without Significant Release of Drug in Upper Gastrointestinal Tract, for Treating Chronic Bowel Diseases e.g. Crohn’s disease. W.O. 9640078-A1, Dec 19, 1996.
   Google Scholar
• Krishnaiah, Y. S.; Satyanarayana, S.; Prasad, Y. V.; Rao, S. N. Gamma Scientigraphic Studies on Guar-Gum Matrix Tablet for Colonic Drug Delivery in Healthy Human Volunteers. J. Control. Release 1998, 55, 245–252. doi:10.1016/S0168-3659(98)00057-1.
   PubMed Web of Science ®Google Scholar
• Krishnaiah, Y. S. R.; Veer Raju, P.; Dinesh Kumar, B.; Satyanarayana, V.; Karthikeyan, R. S.; Bhaskar, P. Pharmacokinetic Evaluation of Guar Gum-Based Colon-Targeted Drug Delivery Systems of Mebendazole in Healthy Volunteers. J. Control. Release 2003, 88, 95–103. doi:10.1016/S0168-3659(02)00483-2.
   PubMed Web of Science ®Google Scholar
• Ji, C. M.; Xu, H. N.; Wu, W. Guar Gum as Potential Film Coating Material for Colon-Specific Delivery of Fluorouracil. J. Biomater. Appl. 2009, 23, 311–329. doi:10.1177/0885328208089617.
   PubMed Web of Science ®Google Scholar
• Hehre, E. J.; Sery, T. W. Dextran Splitting Anaerobic Bacteria from the Human Intestine. J. Bacteriol. 1952, 63, 424–426. doi:10.1128/JB.63.3.424-426.1952.
   PubMed Web of Science ®Google Scholar
• Hennink, W. E. Stenekes, R. J. H. Production of Hydrogel of Dextran or Its Derivative Useful in the Preparation of a Controlled Released agent Involves Crystallization of an Aqueous Solution of the Dextran or Its Derivative Having a Specified Molecular Weight. E.P. 1184032-A1, Mar 06, 2002.
   Google Scholar
• Usher, T. C.; Patel, N.; Tanenbaum, S. W. Complexes of Podophyllotoxin and Dextran, Dextran Sulphate or Polysaccharide Can Be Used to Treat Cancer, Esp. of the Colon and Are Less Toxic, More Water Soluble and More Effective than Podophyllotoxin Used Alone. C.A. 2091410-A, Sep 11, 1994.
   Google Scholar
• McLeod, A. D.; Friend, D. R.; Tozer, T. N. Glucocorticoid-Dextran Conjugates as Potential Prodrugs for Colon-Specific Delivery: Hydrolysis in Rat Gastrointestinal Tract Contents. J. Pharm. Sci. 1994, 83, 1284–1288. doi:10.1002/jps.2600830919.
   PubMed Web of Science ®Google Scholar
• Takeuchi, H.; Yasuji, T.; Yamamoto, H.; Kawashima, Y. Spray-Dried Lactose Composite Particles Containing an Ion Complex of Alginate-Chitosan for Designing a Dry-Coated Tablet Having a Time-Controlled Releasing Function. Pharm. Res. 2000, 17, 94–99. doi:10.1023/a:1007530927887.
   PubMed Web of Science ®Google Scholar
• Agarwal, T.; Narayana, S. N. G. H.; Pal, K.; Pramanik, K.; Giri, S.; Banerjee, I. Calcium Alginate-Carboxymethyl Cellulose Beads for Colon-Targeted Drug Delivery. Int. J. Biol. Macromol. 2015, 75, 409–417. doi:10.1016/j.ijbiomac.2014.12.052.
   PubMed Web of Science ®Google Scholar
• Sinha, V. R.; Kumria, R. Polysaccharides in Colon Specific Drug Delivery. Int. J. Pharm. 2001, 224, 19–38. doi:10.1016/S0378-5173(01)00720-7.
   PubMed Web of Science ®Google Scholar
• Hirayama, F.; Ogata, T.; Yano, H.; Arima, H.; Udo, K.; Takano, M.; Uekama, K. Release Characteristics of a Short-Chain Fatty Acid, Nbutyric Acid, from Its Beta-Cyclodextrin Ester Conjugate in Rat Biological Media. J. Pharm. Sci. 2000, 89, 1486–1495. doi:10.1002/1520-6017(200011)89:11<1486::AID-JPS11>3.3.CO;2-4.
   PubMed Web of Science ®Google Scholar
• Yano, H.; Hirayama, F.; Kamada, M.; Arima, H.; Uekama, K. Colon-Specific Delivery of Prednisolone-Appended Alpha-Cyclodextrin Conjugate: Alleviation of Systemic Side Effect after Oral Administration. J. Control. Release 2002, 79, 103–112. doi:10.1016/S0168-3659(01)00532-6.
   PubMed Web of Science ®Google Scholar
• Siefke, V.; Hanstein, U.; Weckenmann, H. P.; Bauer, K. H.; Bauer, K.; Weckenmann, H.; Heumann, U. Oral Pharmaceutical Forms for Release in the Colon Are Coated with Mixt. Containing Film Former Insoluble in Water and Stomach Juices and Cyclodextrin or Deriv. D.E. 4236025-A1, Apr 28, 1994.
   Google Scholar
• Wilson, C. G.; Mukherji, G.; Sha, H. K. Modified-Release Drug Delivery Technology. In Biopolymers and Colonic Delivery, 2nd ed.; Rathbone, M. J., Had, G. J., Roberts, M. S., Lane, M. E. Informa Healthcare: New York, 2008; Vol. 1, pp 295–309.
   Google Scholar
• Rajpurohit, H.; Sharma, P.; Sharma, S.; Bhandari, A. Polymers for Colon Targeted Drug Delivery. Indian J. Pharm. Sci. 2010, 72, 689–696. doi:10.4103/0250-474X.84576.
   PubMed Web of Science ®Google Scholar
• Jain, A.; Gupta, Y.; Jain, S. K. Perspectives of Biodegradable Natural Polysaccharides for Site-Specific Drug Delivery to the Colon. J. Pharm. Pharm. Sci. 2007, 10, 86–128.
   PubMed Web of Science ®Google Scholar
• Minami, K.; Hirayama, F.; Uekama, K. Colon-Specific Drug Delivery Based on a Cyclodextrin Prodrug: Release Behavior of Biphenylylacetic Acid from Its Cyclodextrin Conjugates in Rat Intestinal Tracts after Oral Administration. J. Pharm. Sci. 1998, 87, 715–720. doi:10.1021/js9704339.
   PubMed Web of Science ®Google Scholar
• Gibson, G. R.; Roberfroid, M. B. Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics. J. Nutr. 1995, 125, 1401–1414. doi:10.1093/jn/125.6.1401.
   PubMed Web of Science ®Google Scholar
• Maris, B.; Verheyden, L.; Van, R. K.; Samyn, C.; Augustijns, P.; Kinget, R.; Van-den, M. G. Synthesis and Characterisation of Inulinazo Hydrogels Designed for Colon Targeting. Int. J. Pharm. 2001, 213, 143–152. doi:10.1016/S0378-5173(00)00654-2.
   PubMed Web of Science ®Google Scholar
• Vervoort, L.; Mooter, G. V.; Augustijns, P.; Kinget, R. Inulin Hydrogels. I. Dynamic and Equilibrium Swelling Properties. Int. J. Pharm. 1998, 172, 127–135. doi:10.1016/S0378-5173(98)00200-2.
   Web of Science ®Google Scholar
• Vervoort, L.; Rombaut, P.; Mooter, G. V.; Augustijns, P.; Kinget, R. Inulin Hydrogels. II. In Vitro Degradation Study. Int. J. Pharm. 1998, 172, 137–145. doi:10.1016/S0378-5173(98)00201-4.
   Web of Science ®Google Scholar
• Vilivalam, V. D.; Illum, I.; Iqbal, I. Starch Capsules: An Alternative System for Oral Drug Delivery. Pharm. Sci. Technol. Today. 2000, 3, 64–69. doi:10.1016/S1461-5347(99)00238-2.
   PubMedGoogle Scholar
• Conway, P. L.; Henriksson, K. A.; Mcnaught, K. J.; Wang, X.; Henriksson, K. A. O.; Brown, I. L. Enhancing a Population of Target Microorganisms in Gastrointestinal Tract of Animal by Providing the Animal with Modified or Unmodified Resistant Starch, e.g. Hydroxypropylated Starch. W.O. 9734592-A1, Sep 25, 1997.
   Google Scholar
• Brown, I. L.; Conway, P. L.; Evans, A. J.; Henriksson, K. A.; Mcnaught, K. J.; Wang, X.; Henriksson, K. A. O. Altering Gastrointestinal Tract Microbial Populations by Administration of Probiotic Bacteria with Optionally Modified Resistant Starch as Carrier and Growth Medium, Useful for Preventing Colorectal Cancer. W.O. 9734591-A1, Sep 25, A61k-031/175, 1997.
   Google Scholar
• Englyst, H. N.; MacFarlane, G. T. Breakdown of Resistant and Readily Digestible Starch of Human Gut Bacteria. J. Sci. Food Agric. 1986, 37, 699–706. doi:10.1002/jsfa.2740370717.
   Web of Science ®Google Scholar
• Cummings, J. H.; Milojevic, S.; Harding, M.; Coward, W. A.; Gibson, G. R.; Louise Botham, R.; Ring, S. G.; Wraight, E. P.; Stockham, M. A.; Allwood, M. C.; Newton, J. M. In-Vivo Studies of Amylose and Ethyl Cellulose Coated Glucose Microspheres as a Model for Drug Delivery to the Colon. J. Control. Release 1996, 40, 123–131. doi:10.1016/0168-3659(95)00186-7.
   Web of Science ®Google Scholar
• Allwood, M. C.; Ring, S. G.; Archer, D. B.; Davies, J. D.; Touitou, E.; Rubinstein, A. Delayed Release Composition Comprising Glassy Amylose to Delay Active Agent Release in Acidic-to-Weakly Basic Aqueous Media but Permitting Release after Enzymatic Hydrolysis, e.g. in the Colon: Capsule for Targeted Delivery of Drugs to the Colon Containing Absorption Promoter and Coated with Polymer Insoluble at pH Below 7, E.P. 343993-a, Nov 29, A61k-009/22, 1989.
   Google Scholar
• Milojevic, S.; Newton, J. M.; Cummings, J. H.; Gibson, G. R.; Louise Botham, R.; Ring, S. G.; Stockham, M.; Allwood, M. C. Amylose as a Coating for Drug Delivery to the Colon: Preparation and In Vitro Evaluation Using Glucose Pellets. J. Control. Release 1996, 38, 85–94. doi:10.1016/0168-3659(95)00113-1.
   Web of Science ®Google Scholar
• Lenaerts, V.; Dumoulin, Y.; Mateescu, M. A. Controlled Release of Theophylline from Cross-Linked Amylose Tablets. J. Control. Release 1991, 15, 39–46. doi:10.1016/0168-3659(91)90101-I.
   Web of Science ®Google Scholar
• Milojevic, S.; Newton, J. M.; Cummings, J. H.; Gibson, G. R.; Louise Botham, R.; Ring, S. G.; Stockham, M.; Allwood, M. C. Amylose as a Coating for Drug Delivery to the Colon: Preparation and In Vitro Evaluation Using 5-Aminosalicylic Acid Pellets. J. Control. Release 1996, 38, 75–84. doi:10.1016/0168-3659(95)00112-3.
   Web of Science ®Google Scholar
• Salyers, A. A.; Brien, M. Cellular Location of Enzymes Involved in Chondroitin Sulfate Breakdown by Bacteroides Thetaiotaomicron. J. Bacteriol. 1980, 143, 772–780. doi:10.1128/JB.143.2.772-780.1980.
   PubMed Web of Science ®Google Scholar
• Rubinstein, A.; Nakar, D.; Sintov, A. Chondroitin Sulphate: A Potential Biodegradable Carrier for Colon-Specific Drug Delivery. Int. J. Pharm. 1992, 84, 141–150. doi:10.1016/0378-5173(92)90054-6.
   Web of Science ®Google Scholar
• Rubinstein, A.; Nakar, D.; Sintov, A. Colonic Drug Delivery: Enhanced Release of Indomethacin from Crosslinked Chondroitin Matrix in Rat Caecal Content. Pharm. Res. 1992b, 09, 276–278. doi:10.1023/A:1018910128452.
   Web of Science ®Google Scholar
• Amrutkar, J. R.; Gattani, S. G. Chitosan-Chondroitin Sulfate Based Matrix Tablets for Colon Specific Delivery of Indomethacin. AAPS PharmSciTech 2009, 10, 670–677. doi:10.1208/s12249-009-9253-y.
   PubMed Web of Science ®Google Scholar
• Cavalcanti, O. A.; Silva, C. C.; Pineda, E. G.; Hechenleitner, A. W. Synthesis and Characterization of Phosphated Crosslinked Chondroitin Sulfate: Potencial Ingredient for Specific Drug Delivery. Acta. Farma. Bona 2005, 24, 234–238.
   Google Scholar
• Amnuaikit, C.; Ikeuchi, I.; Ogawara, K.; Higaki, K.; Kimura, T. Skin Permeation of Propranolol from Polymeric Film Containing Terpene Enhancers for Transdermal Use. Int. J. Pharm. 2005, 289, 167–178. doi:10.1016/j.ijpharm.2004.11.007.
   PubMed Web of Science ®Google Scholar
• Bashardoust, N.; Jenita, J. J. L.; Milani, P. Z. Physicochemical Characterization and Dissolution Study of Ibuprofen Compression-Coated Tablets Using Locust Bean Gum. Dissolution Technol. 2013, 20, 38–43. doi:10.14227/DT200113P38.
   Web of Science ®Google Scholar
• Hirose, K.; Endo, K.; Hasegawa, K. A Convenient Synthesis of Lepidimoide from Okra Mucilage and Its Growth-Promoting Activity in Hypocotyls. Carbohydr. Res. 2004, 339, 9–19. doi:10.1016/j.carres.2003.10.003.
   PubMed Web of Science ®Google Scholar
• Ilango, K. B.; Manisha, M.; Sridurga, D.; Rajsekaran, A.; Kumar, M. S.; Subburaju, T. In Vitro and In Vivo Evaluation of Okra Polysaccharide-Based Colon-Targeted Drug Delivery Systems. Int. J. Pharm. Sci. Rev. Res. 2010, 5, 138–145.
   Google Scholar
• Rajkumari, A.; Kataki, M. S.; Ilango, K. B.; Rajak, P. Studies on the Development of Colon Specific Drug Delivery System of Ibuprofen Using Polysaccharide Extracted from Abelmoschus esculentus L. Asian J. Pharm. Sci. 2012, 7, 67–74.
   Google Scholar
• Rajendra, A.; Bushetti, S. S.; Giri, A. Design and Evaluation of Compression Coated Formulations for an Antiinflammatory Drug Based on Modified Okra Mucilage. J. Appl. Pharm. Sci. 2012, 2, 238–245.
   Google Scholar
• Ashton, W. A.; Jefferies, M.; Morley, R. G.; Pass, G.; Phillips, G. O.; Power, D. M. J. Physical Properties and Applications of Aqueous Solutions of Albizia zygia Gum. J. Sci. Food Agric. 1975, 26, 697–704. doi:10.1002/jsfa.2740260516.
   Web of Science ®Google Scholar
• US National Academy of Sciences. Tropical Legumes, National Academy of Sciences; US National Academy of Sciences: Washington, DC, 1979.
   Google Scholar
• Odeku, O. A.; Fell, J. T. In-Vitro Evaluation of Khaya and Albizia Gums as Compression Coatings for Drug Targeting to the Colon. J. Pharm. Pharmacol. 2005, 57, 163–168. doi:10.1211/0022357055362.
   PubMed Web of Science ®Google Scholar
• Bharaniraja, B.; Kumar, K. J.; Prasad, C. M.; Sen, A. K. Modified Katira Gum for Colon Targeted Drug Delivery. J. Appl. Polym. Sci. 2011, 119, 2644–2651. doi:10.1002/app.32829.
   Web of Science ®Google Scholar
• Odeku, O. A.; Okunlola, A.; Lamprecht, A. Formulation and In Vitro Evaluation of Natural Gum-Based Microbeads for Delivery of Ibuprofen. Trop. J. Pharm. Res. 2014, 13, 1577–1583. doi:10.4314/tjpr.v13i10.2.
   Web of Science ®Google Scholar
• Nayak, A. K.; Pal, D. K. Tamarind  , Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use. Ind. J. Pharm. Edu. Res. 2017, 51, 136–146.
   Web of Science ®Google Scholar
• Mishra, M. U.; Khandare, J. N. Evaluation of Tamarind Seed Polysaccharide as a Biodegradable Carrier for Colon Specific Drug Delivery. Int. J. Pharm. Pharm. Sci. 2010, 3, 139–142.
   Google Scholar
• Pandit, A. P.; Waychal, P. D.; Sayare, A. S.; Patole, V. C. Carboxymethyl Tamarind Seed Kernel Polysaccharide Formulated into Pellets to Target at Colon. IJPER 2018, 52, 363–373. doi:10.5530/ijper.52.3.42.
   Web of Science ®Google Scholar
• Cortina, L. O.; Domenech, C. M. T. Analytical Characterization of Diterpenoid Resins Present in Pictorial Varnishes Using Pyrolysis-Gas Chromatography-Mass Spectrometry with on Line Trimethylsilylation. J. Chrom. A 2005, 1065, 265–278.
   PubMed Web of Science ®Google Scholar
• Shun, Y. L.; Ayres, J. W. Calcium Alginate Beads as Core Carriers of 5-Aminosalicylic Acid. Pharm. Res. 1992, 9, 714–790.
   Web of Science ®Google Scholar
• Umekar, M. J.; Yeole, P. G. Characterization and Evaluation of Natural Copal Gum-Resin as Film Forming Material. Int. J. Green Pharm. 2008, 2, 37–42. doi:10.4103/0973-8258.39163.
   Google Scholar
• Mehboob, R.; Ramnath, A. A.; Satish, N. S.; Waghmode, C. Natural Polysaccharides as Drug Targeting Tool to Colon: Recent Applications and Future Prospective. Int. J. Pharm. Chem. Biol. Sci. 2015, 5, 440–455.
   Google Scholar
• Singh, P. P.; Whistler, R. L.; Tokuzen, R.; Nakahara, W. Scleroglucan, an Antitumor Polysaccharide from Sclerotium Glucanicum. Carbohyd. Res. 1974, 37, 245–247. doi:10.1016/S0008-6215(00)87078-0.
   PubMed Web of Science ®Google Scholar
• Ates, O. Systems Biology of Microbial Exopolysaccharides Production. Front. Bioeng. Biotechnol. 2015, 3, 200–216. doi:10.3389/fbioe.2015.00200.
   PubMed Web of Science ®Google Scholar
• Lima, I. A.; Pomin, S. P.; Cavalcanti, O. A. Development and Characterization of Pullulan-Polymethacrylate Free Films as Potential Material for Enteric Drug Release. Braz. J. Pharm. Sci. 2017, 53, 1–9. doi:10.1590/s2175-97902017000300002.
   Web of Science ®Google Scholar
• Lee, S. J.; Hong, G.-Y.; Jeong, Y.-I.; Kang, M.-S.; Oh, J.-S.; Song, C.-E.; Lee, H. C. Paclitaxel-Incorporated Nanoparticles of Hydrophobized Polysaccharide and Their Antitumor Activity. Int. J. Pharm. 2012, 433, 121–128. doi:10.1016/j.ijpharm.2012.04.048.
   PubMed Web of Science ®Google Scholar
• Babu, R. J.; Sathigari, S.; Kumar, M. T.; Pandit, J. K. Formulation of Controlled Release Gellan Gum Macro Beads of Amoxicillin. Curr. Drug Deliv. 2010, 7, 36–43. doi:10.2174/156720110790396445.
   PubMedGoogle Scholar
• Singh, B. N.; Trombetta, L. D.; Kim, K. H. Biodegradation Behavior of Gellan Gum in Simulated Colonic Media. Pharm. Dev. Technol. 2004, 9, 399–407. doi:10.1081/pdt-200035793.
   PubMed Web of Science ®Google Scholar
• Prezotti, F.; Boni, F.; Ferreira, N.; Silva, D.; Campana-Filho, S.; Almeida, A.; Vasconcelos, T.; Gremião, M.; Cury, B.; Sarmento, B. Gellan Gum/Pectin Beads Are Safe and Efficient for the Targeted Colonic Delivery of Resveratrol. Polymers 2018, 10, 50–14. doi:10.3390/polym10010050.
   Web of Science ®Google Scholar
• Prabhakar, P.; Nisssara, A.; Harish, N. M. Investigation of Colon Specificity of Novel Polymer Khaya Gum with Guar Gum. Pak. J. Pharm. Sci 2010, 23, 259–265.
   PubMed Web of Science ®Google Scholar
• Rana, V.; Rai, P.; Tiwary, A. K.; Singh, R. S.; Kennedy, J. F.; Knill, C. J. Modified Gums: Approaches and Applications in Drug Delivery. Carbohyd. Polym. 2011, 83, 1031–1047. doi:10.1016/j.carbpol.2010.09.010.
   Web of Science ®Google Scholar
• Talukdar, M. M.; Kinget, R. Swelling and Drug Release Behavior of Xanthan Gum Matrix Tablet. Int. J. Pharm. 1995, 120, 63–72. doi:10.1016/0378-5173(94)00410-7.
   Web of Science ®Google Scholar
• Musukula, Y. R. Evaluation of Compression Coated Colon Targeted Tablets of Ketorolac Tromithamine by Using Natural Polymer and Their Combination with HPMC K100M. Int. J. Res. Pharm. Nano. Sci. 2014, 3, 408–417.
   Google Scholar
• Bharaniraja, B.; Kumar, K. J.; Prasad, C. M.; Sen, A. K. Different Approaches of Katira Gum Formulations for Colon Targeting. Int. J. Biol. Macromol. 2011, 49, 305–310. doi:10.1016/j.ijbiomac.2011.05.002.
   PubMed Web of Science ®Google Scholar
• Girotra, P.; Singh, S. K. Formulation Optimization for Colon Targeted Delivery of Katira Gum Matrix Tablets Containing Azathioprine. Int. J. Pharm. Sci. Drug. Res. 2013, 5, 133–140.
   Google Scholar
• Ruhidas, B.; Naskar, D.; Banerjee, S.; Karan, S.; Chatterjee, T. K. Evaluation of Gum Katira as a Model Sustained Release Adjuvant in the Preparation of Etodolac Loaded Microsphere. IJPER 2016, 50, 146–158. doi:10.5530/ijper.50.1.19.
   Web of Science ®Google Scholar
• Karan, S.; Choudhury, H.; Chakra, B. K.; Chatterjee, T. K. Polymeric Microsphere Formulation for Colon Targeted Delivery of 5-Fluorouracil Using Biocompatible Natural Gum Katira. Asian Pac. J. Cancer Prev. 2019, 20, 2181–2194. doi:10.31557/APJCP.2019.20.7.2181.
   PubMedGoogle Scholar
• Kavitha, R.; Krishna, M. G.; Satla, S.; Gaikwad, S. Natural Polysaccharides: Versatile Excipients for Controlled Drug Delivery Systems. Asian J. Pharm. Sci. 2011, 6, 275–286.
   Google Scholar
• Jain, A.; Jain, S. K.; Ganesh, N.; Barve, J.; Beg, A. M. Design and Development of Ligand-Appended Polysaccharidic Nanoparticles for the Delivery of Oxaliplatin in Colorectal Cancer. Nanomedicine 2010, 6, 179–190. doi:10.1016/j.nano.2009.03.002.
   PubMed Web of Science ®Google Scholar
• Xiao, B.; Han, M. K.; Viennois, E.; Wang, L.; Zhang, M.; Si, X.; Merlin, D. Hyaluronic Acid-Functionalized Polymeric Nanoparticles for Colon Cancer-Targeted Combination Chemotherapy. Nanoscale 2015, 7, 17745–17755. doi:10.1039/c5nr04831a.
   PubMed Web of Science ®Google Scholar
• Xiao, B.; Xu, Z.; Viennois, E.; Zhang, Y.; Zhang, Z.; Zhang, M.; Han, M. K.; Kang, Y.; Merlin, D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Molecul. Therap. 2017, 25, 1628–1640. doi:10.1016/j.ymthe.2016.11.020.
   PubMed Web of Science ®Google Scholar
• Kalsoom Khan, A.; Saba, A. U.; Nawazish, S.; Akhtar, F.; Rashid, R.; Mir, S.; Nasir, B.; Iqbal, F.; Afzal, S.; Pervaiz, F.; Murtaza, G. Carrageenan Based Bionanocomposites as Drug Delivery Tool with Special Emphasis on the Influence of Ferromagnetic Nanoparticles. Oxid. Med. Cell. Long. 2017, 2017, 1–13. doi:10.1155/2017/8158315.
   Web of Science ®Google Scholar
• Chen, X.; Han, W.; Zhao, X.; Tang, W.; Wang, F. Epirubicin-Loaded Marine Carrageenan Oligosaccharide Capped Gold Nanoparticle System for pH-Triggered Anticancer Drug Release. Sci. Rep. 2019, 9, 1–10.
   PubMed Web of Science ®Google Scholar
• Kern, M.; Pahlke, G.; Balavenkatraman, K. K.; Böhmer, F. D.; Marko, D. Apple Polyphenols Affect Protein Kinase C Activity and the Onset of Apoptosis in Human Colon Carcinoma Cells. J. Agric. Food Chem. 2007, 55, 4999–5006. doi:10.1021/jf063158x.
   PubMed Web of Science ®Google Scholar
• Li, Y.; Liu, L.; Niu, Y.; Feng, J.; Sun, Y.; Kong, X.; Chen, Y.; Chen, X.; Gan, H.; Cao, S.; Mei, Q. Modified Apple Polysaccharide Prevents against Tumorigenesis in a Mouse Model of Colitis-Associated Colon Cancer: Role of Galectin-3 and Apoptosis in Cancer Prevention. Eur. J. Nutr. 2012, 51, 107–117. doi:10.1007/s00394-011-0194-3.
   PubMed Web of Science ®Google Scholar
• Zhang, D.; Li, Y-h.; Mi, M.; Jiang, F.-L.; Yue, Z-g.; Sun, Y.; Fan, L.; Meng, J.; Zhang, X.; Liu, L.; Mei, Q.-B. Modified Apple Polysaccharides Suppress the Migration and Invasion of Colorectal Cancer Cells Induced by Lipopolysaccharide. Nutr. Res. 2013, 33, 839–848. doi:10.1016/j.nutres.2013.06.004.
   PubMed Web of Science ®Google Scholar
• Thakral, S.; Thakral, N. K.; Majumdar, D. K. Eudragit: A Technology Evaluation. Exp. Opin. Drug Deliv. 2013, 10, 131–149. doi:10.1517/17425247.2013.736962.
   PubMed Web of Science ®Google Scholar
• Varshosaz, J.; Emami, J.; Tavakoli, N.; Minaiyan, M.; Rahmani, N.; Dorkoosh, F.; Mahzouni, P. Pectin Film Coated Pellets for Colon-Targeted Delivery of Budesonide: In-Vitro/In-Vivo Evaluation in Induced Ulcerative Colitis in Rat. Iran. J. Pharm. Res. 2012, 11, 733–745.
   PubMed Web of Science ®Google Scholar
• Kotagale, N.; Maniyar, M.; Somvanshi, S.; Umekar, M.; Patel, C. J. Eudragit-S, Eudragit-L and Cellulose Acetate Phthalate Coated Polysaccharide Tablets for Colonic Targeted Delivery of Azathioprine. Pharm. Dev. Technol. 2010, 15, 431–437. doi:10.3109/10837450903264401.
   PubMed Web of Science ®Google Scholar
• Akhgari, A.; Afrasiabi, G. H.; Sadeghi, F. Combination of Inulin and Time Dependent Polymethacrylates as a Coating System to Achieve Colonic Delivery of Indomethacin. DARU 2009, 17, 199–208.
   Web of Science ®Google Scholar
• Nath, B.; Nath, L. K. Design, Development, and Optimization of Sterculia Gum-Based Tablet Coated with Chitosan/Eudragit RLPO Mixed Blend Polymers for Possible Colonic Drug Delivery. J. Pharmaceutic 2013, 2013, 1–9. doi:10.1155/2013/546324.
   Google Scholar
• Wang, X.; Yu, D. G.; Li, X. Y.; Bligh, S. W.; Williams, G. R. Electrospun Medicated Shellac Nanofibers for Colon-Targeted Drug Delivery. Int. J. Pharm. 2015, 490, 384–390. doi:10.1016/j.ijpharm.2015.05.077.
   PubMed Web of Science ®Google Scholar
• Ravi, V.; Kumar, P.; Siddaramaiah, T. M. Novel Colon Targeted Drug Delivery ++ System Using Natural Polymers. Indian J. Pharm. Sci. 2008, 70, 111–113.
   PubMed Web of Science ®Google Scholar
• Gately, N. M.; Kennedy, J. E. The Development of a Melt-Extruded Shellac Carrier for the Targeted Delivery of Probiotics to the Colon. Pharmaceutic 2017, 9, 1–12.
   Web of Science ®Google Scholar
• Oehme, A.; Valotis, A.; Krammer, G.; Zimmermann, I.; Schreier, P. Preparation and Characterization of Shellac-Coated Anthocyanin Pectin Beads as Dietary Colonic Delivery System. Mol. Nutr. Food Res. 2011, 55, S75–S85. doi:10.1002/mnfr.201000467.
   PubMed Web of Science ®Google Scholar
• Liu, D.; Yan, H.; Kong, Y.; You, Y.; Li, Y.; Wang, L.; Tong, Y.; Wang, J. Preparation of Colon-Targeted Acetylharpagide Tablets and Its Release Properties In Vivo and In Vitro. Front. Pharmacol. 2018, 9, 1–9. doi:10.3389/fphar.2018.00832.
   PubMed Web of Science ®Google Scholar
• Paradkar, M.; Amin, J. Formulation Development and Evaluation of Colon Targeted Delayed Release Methotrexate Pellets for the Treatment of Colonic Carcinoma. Braz. J. Pharm. Sci. 2018, 54, 1–12. doi:10.1590/s2175-97902018000417222.
   Web of Science ®Google Scholar
• Emeje, M.; Nwabunike, P.; Isimi, Y.; Kunle, O.; Ofoefule, S. Preparation and Evaluation of Colon Targeted Drug Delivery Systems for Albendazole Using Kneading, Extrusion and Compaction Technology. Acta. Pharm. Sinic. 2009, 44, 1152–1158.
   PubMedGoogle Scholar
• Ganguly, K.; Aminabhavi, T. M.; Kulkarni, A. R. Colon Targeting of 5-Fluorouracil Using Polyethylene Glycol Cross-Linked Chitosan Microspheres Enteric Coated with Cellulose Acetate Phthalate. Ind. Eng. Chem. Res. 2011, 50, 11797–11807. doi:10.1021/ie201623d.
   Web of Science ®Google Scholar
• Dang, T.; Cui, Y.; Chen, Y. D.; Meng, X. M.; Tang, B. F.; Wu, J. B. Preparation and Characterization of Colon-Specific Microspheres of Diclofenac for Colorectal Cancer. Trop. J. Pharm. Res. 2015, 14, 1541–1547.
   Web of Science ®Google Scholar
• Yus, C.; Gracia, R.; Larrea, A.; Andreu, V.; Irusta, S.; Sebastian, V.; Mendoza, G.; Arruebo, M. Targeted Release of Probiotics from Enteric Microparticulated Formulations. Polymer 2019, 11, 1–14.
   Google Scholar
• Trenktrog, T.; Müller, B. W.; Specht, F. M.; Seifert, J. Enteric Coated Insulin Pellets: Development, Drug Release and In Vivo Evaluation. Eur. J. Pharm. Sci. 1996, 4, 323–329. doi:10.1016/0928-0987(95)00162-X.
   Web of Science ®Google Scholar
• Das, M.; Ghosh, L. Evaluation of Polymer for Compression Coating of 5-Aminosalicylic Acid Matrix Tablet for Colon Targeting. Int. J. Pharm. Pharm. Sci. 2013, 5, 975–1491.
   Google Scholar
• Koch, W. Properties and Uses of Ethylcellulose. Ind. Eng. Chem. 1937, 29, 687–690. doi:10.1021/ie50330a020.
   Google Scholar
• Ahrabi, S. F.; Madsen, G.; Dyrstad, K.; Sande, S. A.; Graffner, C. Development of Pectin Matrix Tablets for Colonic Delivery of Model Drug Ropivacaine. Eur. J. Pharm. Sci. 2000, 10, 43–52. doi:10.1016/S0928-0987(99)00087-1.
   PubMed Web of Science ®Google Scholar
• Gohel, M. C.; Nagori, S. A. A Novel Colonic Drug Delivery System of Ibuprofen. Asian J. Pharm. 2009, 3, 233–239. doi:10.4103/0973-8398.56304.
   Google Scholar
• Sheskey, P. J.; Cook, W. G.; Cable, C. G. Handbook of Pharmaceutical Excipients, 8th ed.; London: Pharmaceutical Press, 2017; pp 191–193
   Google Scholar
• Pawar, P. S.; Saleem, M. A. Formulation and Evaluation of Oral Colon Targeted Tablet of Budesonide. Der. Pharmacia. Lettre 2013, 5, 1–12.
   Google Scholar
• Shah, N.; Shah, T.; Amin, A. Polysaccharides: A Targeting Strategy for Colonic Drug Delivery. Exp. Opin. Drug Deliv. 2011, 8, 779–796. doi:10.1517/17425247.2011.574121.
   PubMed Web of Science ®Google Scholar
• Patel, M. M. Cutting-Edge Technologies in Colon-Targeted Drug Delivery Systems. Exp. Opin. Drug Deliv. 2011, 8, 1247–1258. doi:10.1517/17425247.2011.597739.
   PubMed Web of Science ®Google Scholar
• Charbe, N. B.; McCarron, P. A.; Lane, M. E.; Tambuwala, M. M. Application of Three-Dimensional Printing for Colon Targeted Drug Delivery Systems. Int. J. Pharm. Investig. 2017, 7, 47–59. doi:10.4103/jphi.JPHI_32_17.
   PubMed Web of Science ®Google Scholar
• Zhang, T.; Zhu, G.; Lu, B.; Peng, Q. Oral Nano-Delivery Systems for Colon Targeting Therapy. Pharm. Nanotechnol. 2017, 5, 83–94. doi:10.2174/2211738505666170424122722.
   PubMedGoogle Scholar