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Special Issue

Alcohol and nicotine interactions: pre-clinical models of dependence

, BAppSc (MedSc) & , PhD
Pages 146-154 | Received 28 Jan 2016, Accepted 31 May 2016, Published online: 14 Oct 2016

References

  • Littleton J, Barron S, Prendergast M, Nixon SJ. Smoking kills (alcoholics)! Shouldn’t we do something about it? Alcohol Alcohol (Oxford, Oxfordshire) 2007;42:167–173.
  • World Health Organisation. Report on the global tobacco epidemic. Geneva: WHO; 2013.
  • World Health Organisation. Global status report on alcohol and health. Geneva: WHO; 2014.
  • Dani JA, Harris RA. Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nature Neurosci 2005;8:1465–1470.
  • DiFranza JR, Guerrera MP. Alcoholism and smoking. J Stud Alcohol 1990;51:130–135.
  • Bobo JK, Husten C. Sociocultural influences on smoking and drinking. Alcohol Res Health 2000;24:225–232.
  • National Institutes of Health. Monitoring the Future Report. Ann Arbor: University of Michigan; 2015.
  • Walton KM, Abrams DB, Bailey WC, Clark D, Connolly GN, Djordjevic MV, Eissenberg TE, Fiore MC, Goniewicz ML, Haverkos L, Hecht SS, Henningfield JE, Hughes JR, Oncken CA, Postow L, Rose JE, Wanke KL, Yang L, Hatsukami DK. NIH electronic cigarette workshop: developing a research agenda. Nicotine Tob Res 2015;17:259–269.
  • King BA, Alam S, Promoff G, Arrazola R, Dube SR. Awareness and ever-use of electronic cigarettes among U.S. adults, 2010–2011. Nicotine Tob Res 2013;15:1623–1627.
  • Peters EN, Harrell PT, Hendricks PS, O’Grady KE, Pickworth WB, Vocci FJ. Electronic cigarettes in adults in outpatient substance use treatment: awareness, perceptions, use, and reasons for use. Am J Addict /Am Acad Psychiatrists Alcohol Addict 2015;24:233–239.
  • Etter JF, Bullen C. Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy. Addict (Abingdon, England) 2011;106:2017–2028.
  • de Kloet SF, Mansvelder HD, De Vries TJ. Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors. Biochem Pharmacol 2015;97:425–438.
  • Rahman MA, Hann N, Wilson A, Worrall-Carter L. Electronic cigarettes: patterns of use, health effects, use in smoking cessation and regulatory issues. Tob Induced Dis 2014;12:21.
  • Tomashefski A. The perceived effects of electronic cigarettes on health by adult users: A state of the science systematic literature review. J Am Assoc Nurse Practitioners 2016; 28(9):510–515.
  • St Helen G, Havel C, Dempsey DA, Jacob P, 3rd, Benowitz NL. Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes. Addict (Abingdon, England) 2016;111:535–544.
  • Hershberger AR, Karyadi KA, VanderVeen JD, Cyders MA. Combined expectancies of alcohol and e-cigarette use relate to higher alcohol use. Addict Behaviors 2016;52:13–21.
  • Wills TA, Knight R, Williams RJ, Pagano I, Sargent JD. Risk factors for exclusive e-cigarette use and dual e-cigarette use and tobacco use in adolescents. Pediatrics 2015;135:e43–51.
  • Arrazola RA, Singh T, Corey CG, Husten CG, Neff LJ, Apelberg BJ, Bunnell RE, Choiniere CJ, King BA, Cox S, McAfee T, Caraballo RS. Tobacco use among middle and high school students - United States, 2011–2014. MMWR. Morbidity Mortality Weekly Report 2015;64(14):381–385.
  • Primack BA, Soneji S, Stoolmiller M, Fine MJ, Sargent JD. Progression to traditional cigarette smoking after electronic cigarette use among US adolescents and young adults. JAMA Pediatr 2015;169:1018–1023.
  • Bozarth MA. Evidence for the rewarding effects of ethanol using the conditioned place preference method. Pharmacology, Biochem Behav 1990;35:485–487.
  • Koob GF, Le Moal M. Drug abuse: hedonic homeostatic dysregulation. Sci (New York, N.Y.) 1997;278:52–58.
  • Carroll ME, Anker JJ, Perry JL. Modeling risk factors for nicotine and other drug abuse in the preclinical laboratory. Drug Alcohol Depend 2009;104:S70–78.
  • Doyon WM, Dong Y, Ostroumov A, Thomas AM, Zhang TA, Dani JA. Nicotine decreases ethanol-induced dopamine signaling and increases self-administration via stress hormones. Neuron 2013;79:530–540.
  • Doyon WM, Thomas AM, Ostroumov A, Dong Y, Dani JA. Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system. Biochem Pharmacol 2013;86:1181–1193.
  • Tapper AR, McKinney SL, Nashmi R, Schwarz J, Deshpande P, Labarca C, Whiteaker P, Marks MJ, Collins AC, Lester HA. Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Sci (New York, N.Y.) 2004;306:1029–1032.
  • Tolu S, Eddine R, Marti F, David V, Graupner M, Pons S, Baudonnat M, Husson M, Besson M, Reperant C, Zemdegs J, Pages C, Hay YA, Lambolez B, Caboche J, Gutkin B, Gardier AM, Changeux JP, Faure P, Maskos U. Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement. Mol Psychiatry 2013;18:382–393.
  • Hendrickson LM, Guildford MJ, Tapper AR. Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. Front Psychiatry 2013;4:29.
  • De Biasi M, Dani JA. Reward, addiction, withdrawal to nicotine. Annu Rev Neurosci 2011;34:105–130.
  • Funk D, Marinelli PW, Le AD. Biological processes underlying co-use of alcohol and nicotine: neuronal mechanisms, cross-tolerance, and genetic factors. Alcohol Res Health 2006;29:186–192.
  • Hurst R, Rollema H, Bertrand D. Nicotinic acetylcholine receptors: from basic science to therapeutics. Pharmacol Ther 2013;137:22–54.
  • Le AD, Corrigall WA, Harding JW, Juzytsch W, Li TK. Involvement of nicotinic receptors in alcohol self-administration. Alcohol Clin Exp Res 2000;24:155–163.
  • Pidoplichko VI, Noguchi J, Areola OO, Liang Y, Peterson J, Zhang T, Dani JA. Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction. Learn Memory (Cold Spring Harbor, N.Y.) 2004;11(1):60–69.
  • Sajja RK, Rahman S. Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice. Pharmacol Biochem Behav 2012;102:36–43.
  • Gao M, Jin Y, Yang K, Zhang D, Lukas RJ, Wu J. Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area. J Neurosci 2010;30:13814–13825.
  • Mansvelder HD, Keath JR, McGehee DS. Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron 2002;33:905–919.
  • Albuquerque EX, Pereira EF, Alkondon M, Rogers SW. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev 2009;89:73–120.
  • Gotti C, Clementi F, Fornari A, Gaimarri A, Guiducci S, Manfredi I, Moretti M, Pedrazzi P, Pucci L, Zoli M. Structural and functional diversity of native brain neuronal nicotinic receptors. Biochem Pharmacol 2009;78:703–711.
  • Gotti C, Moretti M, Gaimarri A, Zanardi A, Clementi F, Zoli M. Heterogeneity and complexity of native brain nicotinic receptors. Biochem Pharmacol 2007;74:1102–1111.
  • Fasoli F, Gotti C. Structure of neuronal nicotinic receptors. Curr Top Behav Neurosci 2015;23:1–17.
  • Sargent PB. The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 1993;16:403–443.
  • de Kerchove Klink R, d’Exaerde A, Zoli M, Changeux JP. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 2001;21:1452–1463.
  • Champtiaux N, Gotti C, Cordero-Erausquin M, David DJ, Przybylski C, Lena C, Clementi F, Moretti M, Rossi FM, Le Novere N, McIntosh JM, Gardier AM, Changeux JP. Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci 2003;23:7820–7829.
  • Livingstone PD, Wonnacott S. Nicotinic acetylcholine receptors and the ascending dopamine pathways. Biochem Pharmacol 2009;78:744–755.
  • Borghese CM, Henderson LA, Bleck V, Trudell JR, Harris RA. Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors. J Pharmacol Exp Ther 2003;307:42–52.
  • Hoffman JH, Welte JW, Barnes GM. Co-occurrence of alcohol and cigarette use among adolescents. Addictive Behav 2001;26:63–78.
  • Harrison EL, Desai RA, McKee SA. Nondaily smoking and alcohol use, hazardous drinking, and alcohol diagnoses among young adults: findings from the NESARC. Alcohol Clin Exp Res 2008;32:2081–2087.
  • Riala K, Hakko H, Isohanni M, Jarvelin MR, Rasanen P. Teenage smoking and substance use as predictors of severe alcohol problems in late adolescence and in young adulthood. J Adolesc Health 2004;35:245–254.
  • Poulos CX, Le AD, Parker JL. Impulsivity predicts individual susceptibility to high levels of alcohol self-administration. Behav Pharmacol 1995;6:810–814.
  • Diergaarde L, Pattij T, Poortvliet I, Hogenboom F, de Vries W, Schoffelmeer AN, De Vries TJ. Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats. Biol Psychiatry 2008;63:301–308.
  • Dallery J, Locey ML. Effects of acute and chronic nicotine on impulsive choice in rats. Behav Pharmacol 2005;16:15–23.
  • Perry JL, Carroll ME. The role of impulsive behavior in drug abuse. Psychopharmacology 2008;200:1–26.
  • Tizabi Y, Copeland RL, Jr., Louis VA, Taylor RE. Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res 2002;26:394–399.
  • Tizabi Y, Bai L, Copeland RL, Jr., Taylor RE. Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell. Alcohol Alcohol. (Oxford, Oxfordshire) 2007;42:413–416.
  • Corrigall WA, Coen KM. Selective dopamine antagonists reduce nicotine self-administration. Psychopharmacology 1991;104:171–176.
  • Ikemoto S, McBride WJ, Murphy JM, Lumeng L, Li TK. 6-OHDA-lesions of the nucleus accumbens disrupt the acquisition but not the maintenance of ethanol consumption in the alcohol-preferring P line of rats. Alcoholism. Clin Exp Res 1997;21:1042–1046.
  • Mao D, Gallagher K, McGehee DS. Nicotine potentiation of excitatory inputs to ventral tegmental area dopamine neurons. J Neurosci 2011;31:6710–6720.
  • Jackson KM, Sher KJ, Cooper ML, Wood PK. Adolescent alcohol and tobacco use: onset, persistence and trajectories of use across two samples. Addict (Abingdon, England) 2002;97:517–531.
  • Ostroumov A, Thomas AM, Dani JA, Doyon WM. Cigarettes and alcohol: The influence of nicotine on operant alcohol self-administration and the mesolimbic dopamine system. Biochem Pharmacol 2015;97:550–557.
  • Kemppainen H, Hyytia P, Kiianmaa K. Behavioral consequences of repeated nicotine during adolescence in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol Clin Exp Res 2009;33:340–349.
  • Bito-Onon JJ, Simms JA, Chatterjee S, Holgate J, Bartlett SE. Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats. Addict Biol 2011;16:440–449.
  • Le AD, Wang A, Harding S, Juzytsch W, Shaham Y. Nicotine increases alcohol self-administration and reinstates alcohol seeking in rats. Psychopharmacology 2003;168:216–221.
  • Ribeiro-Carvalho A, Lima CS, Filgueiras CC, Manhães AC, Abreu-Villaça Y. Nicotine and ethanol interact during adolescence: effects on the central cholinergic systems. Brain Res 2008;1232:48–60.
  • Thomas JD, Wasserman EA, West JR, Goodlett CR. Behavioral deficits induced by bingelike exposure to alcohol in neonatal rats: importance of developmental timing and number of episodes. Dev Psychobiology 1996;29:433–452.
  • Rogers DT, Barron S, Littleton JM. Neonatal ethanol exposure produces a hyperalgesia that extends into adolescence, and is associated with increased analgesic and rewarding properties of nicotine in rats. Psychopharmacology 2004;171:204–211.
  • Roguski EE, Sharp BM, Chen H, Matta SG. Full-gestational exposure to nicotine and ethanol augments nicotine self-administration by altering ventral tegmental dopaminergic function due to NMDA receptors in adolescent rats. J Neurochem 2014;128:701–712.
  • Kentroti S, Vernadakis A. Ethanol neurotoxicity in culture: selective loss of cholinergic neurons. J Neurosci Res 1996;44:577–585.
  • Potthoff AD, Ellison G, Nelson L. Ethanol intake increases during continuous administration of amphetamine and nicotine, but not several other drugs. Pharmacol Biochem Behav 1983;18:489–493.
  • Taslim N, Soderstrom K, Dar MS. Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) alpha(4)beta(2)- and alpha(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia. Behav Brain Res 2011;217(2):282–292.
  • de Fiebre CM, Collins AC. A comparison of the development of tolerance to ethanol and cross-tolerance to nicotine after chronic ethanol treatment in long- and short-sleep mice. J Pharmacol Exp Ther 1993;266:1398–1406.
  • Oliver JA, Blank MD, Van Rensburg KJ, MacQueen DA, Brandon TH, Drobes DJ. Nicotine interactions with low-dose alcohol: pharmacological influences on smoking and drinking motivation. J Abnormal Psychol 2013;122:1154–1165.
  • Blomqvist O, Ericson M, Johnson DH, Engel JA, Söderpalm B. Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment. Eur J Pharmacol 1996;314:257–267.
  • Sharma R, Dumontier S, DeRoode D, Sahota P, Thakkar MM. Nicotine infusion in the wake-promoting basal forebrain enhances alcohol-induced activation of nucleus accumbens. Alcohol Clin Exp Res 2014;38:2590–2596.
  • Tritto T, Marley RJ, Bastidas D, Stitzel JA, Collins AC. Potential regulation of nicotine and ethanol actions by alpha4-containing nicotinic receptors. Alcohol (Fayetteville, N.Y.) 2001;24:69–78.
  • Sharpe AL, Samson HH. Repeated nicotine injections decrease operant ethanol self-administration. Alcohol (Fayetteville, N.Y.) 2002;28:1–7.
  • Liu L, Hendrickson LM, Guildford MJ, Zhao-Shea R, Gardner PD, Tapper AR. Nicotinic acetylcholine receptors containing the α4 subunit modulate alcohol reward. Biol Psychiatry 2013;73:738–746.
  • Leao RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. J Neurosci. 2015;35:6241–6253.
  • Ceballos NA. Tobacco use, alcohol dependence, and cognitive performance. J Gen Psychol 2006;133:375–388.
  • Taslim N, Al-Rejaie S, Saeed Dar M. Attenuation of ethanol-induced ataxia by alpha(4)beta(2) nicotinic acetylcholine receptor subtype in mouse cerebellum: a functional interaction. Neuroscience 2008;157:204–213.
  • Gould TJ, Collins AC, Wehner JM. Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition. Nicotine Tob Res 2001;3:17–24.
  • Chatterjee S, Bartlett SE. Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders. CNS Neurol Disord Drug Targets 2010;9:60–76.
  • Perkins KA. Combined effects of nicotine and alcohol on subjective, behavioral and physiological responses in humans. Addict Biol 1997;2:255–268.
  • Hughes JR, Rose GL, Callas PW. Nicotine is more reinforcing in smokers with a past history of alcoholism than in smokers without this history. Alcohol Clin Exp Res 2000;24:1633–1638.
  • Hughes JR, Higgins ST, Bickel WK. Nicotine withdrawal versus other drug withdrawal syndromes: similarities and dissimilarities. Addict (Abingdon, England) 1994;89:1461–1470.
  • Perez E, Quijano-Carde N, De Biasi M. Nicotinic mechanisms modulate ethanol withdrawal and modify time course and symptoms severity of simultaneous withdrawal from alcohol and nicotine. Neuropsychopharmacology 2015;40:2327–2336.
  • Marks JL, Hill EM, Pomerleau CS, Mudd SA, Blow FC. Nicotine dependence and withdrawal in alcoholic and nonalcoholic ever-smokers. J Subst Abuse Treat 1997;14:521–527.
  • Piasecki TM, Jorenby DE, Smith SS, Fiore MC, Baker TB. Smoking withdrawal dynamics: I. Abstinence distress in lapsers and abstainers. J Abnormal Psychol 2003;112:3–13.
  • al’Absi M, Hatsukami D, GL Davis, LE Wittmers. Prospective examination of effects of smoking abstinence on cortisol and withdrawal symptoms as predictors of early smoking relapse. Drug Alcohol Depend 2004;73:267–278.
  • Leventhal AM, Greenberg JB, Trujillo MA, Ameringer KJ, Lisha NE, Pang RD, Monterosso J. Positive and negative affect as predictors of urge to smoke: temporal factors and mediational pathways. Psychol Addict Behav 2013;27:262–267.
  • Brandon TH, Tiffany ST, Obremski KM, Baker TB. Postcessation cigarette use: the process of relapse. Addict Behav 1990;15:105–114.
  • Miller WR, Hedrick KE, Taylor CA. Addictive behaviors and life problems before and after behavioral treatment of problem drinkers. Addict Behav 1983;8:403–412.
  • Cook JW, Fucito LM, Piasecki TM, Piper ME, Schlam TR, Berg KM, Baker TB. Relations of alcohol consumption with smoking cessation milestones and tobacco dependence. J Consulting Clin Psychol 2012;80:1075–1085.
  • Friend KB, Pagano ME. Smoking cessation and alcohol consumption in individuals in treatment for alcohol use disorders. J Addict Dis 2005;24:61–75.
  • Gulliver SB, Kamholz BW, Helstrom AW. Smoking cessation and alcohol abstinence: what do the data tell us? Alcohol Res Health 2006;29:208–212.
  • Lopez-Moreno JA, Trigo-Diaz JM, Rodriguez de Fonseca F, Gonzalez Cuevas G, Gomez de Heras R, Crespo Galan I, Navarro M. Nicotine in alcohol deprivation increases alcohol operant self-administration during reinstatement. Neuropharmacology 2004;47:1036–1044.
  • Clark A, Lindgren S, Brooks SP, Watson WP, Little HJ. Chronic infusion of nicotine can increase operant self-administration of alcohol. Neuropharmacology 2001;41:108–117.
  • Alen F, Gomez R, Gonzalez-Cuevas G, Navarro M, Lopez-Moreno JA. Nicotine causes opposite effects on alcohol intake: evidence in an animal experimental model of abstinence and relapse from alcohol. Nicotine Tob Res 2009;11:1304–1311.
  • Kalivas PW, O’Brien C. Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology 2008;33:166–180.
  • Abreu-Villaca Y, Nunes F, do EQ-GF, Manhaes AC, Filgueiras CC. Combined exposure to nicotine and ethanol in adolescent mice differentially affects anxiety levels during exposure, short-term, and long-term withdrawal. Neuropsychopharmacology 2008;33:599–610.
  • Abreu-Villaca Y, Medeiros AH, Lima CS, Faria FP, Filgueiras CC, Manhaes AC. Combined exposure to nicotine and ethanol in adolescent mice differentially affects memory and learning during exposure and withdrawal. Behav Brain Res 2007;181:136–146.
  • Fahlke C, Engel JA, Eriksson CJ, Hard E, Soderpalm B. Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol (Fayetteville, N.Y.) 1994;11:195–202.
  • Shoaib M, Shippenberg TS. Adrenalectomy attenuates nicotine-induced dopamine release and locomotor activity in rats. Psychopharmacology 1996;128:343–350.
  • Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW, Jr., Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. J Neurosci 2012;32:7563–7571.
  • Funk CK, Zorrilla EP, Lee MJ, Rice KC, Koob GF. Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. Biol Psychiatry 2007;61:78–86.
  • Fahlke C, Hansen S. Effect of local intracerebral corticosterone implants on alcohol intake in the rat. Alcohol Alcohol (Oxford, Oxfordshire) 1999;34:851–861.
  • Ericson M, Blomqvist O, Engel JA, Soderpalm B. Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine. Eur J Pharmacol 1998;358:189–196.
  • Ericson M, Lof E, Stomberg R, Soderpalm B. The smoking cessation medication varenicline attenuates alcohol and nicotine interactions in the rat mesolimbic dopamine system. J Pharmacol Exp Ther 2009;329:225–230.
  • Roni MA, Rahman S. The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice. Psychopharmacology 2014;231:2989–2998.
  • Wouda JA, Riga D, De Vries W, Stegeman M, van Mourik Y, Schetters D, Schoffelmeer AN, Pattij T, De Vries TJ. Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control. Psychopharmacology 2011;216:267–277.
  • Zarrindast MR, Meshkani J, Rezayof A, Beigzadeh R, Rostami P. Nicotinic acetylcholine receptors of the dorsal hippocampus and the basolateral amygdala are involved in ethanol-induced conditioned place preference. Neuroscience 2010;168:505–513.
  • King A, McNamara P, Angstadt M, Phan KL. Neural substrates of alcohol-induced smoking urge in heavy drinking nondaily smokers. Neuropsychopharmacology 2010;35:692–701.
  • Fucito LM, Park A, Gulliver SB, Mattson ME, Gueorguieva RV, O’Malley SS. Cigarette smoking predicts differential benefit from naltrexone for alcohol dependence. Biol Psychiatry 2012;72:832–838.
  • Mitchell JM, Teague CH, Kayser AS, Bartlett SE, Fields HL. Varenicline decreases alcohol consumption in heavy-drinking smokers. Psychopharmacology 2012;223:299–306.
  • Plebani JG, Lynch KG, Rennert L, Pettinati HM, O’Brien CP, Kampman KM. Results from a pilot clinical trial of varenicline for the treatment of alcohol dependence. Drug Alcohol Depend 2013;133:754–758.
  • Funk D, Lo S, Coen K, Le AD. Effects of varenicline on operant self-administration of alcohol and/or nicotine in a rat model of co-abuse. Behav Brain Res 2016;296:157–162.
  • Ericson M, Engel JA, Soderpalm B. Peripheral involvement in nicotine-induced enhancement of ethanol intake. Alcohol (Fayetteville, N.Y.) 2000;21:37–47.
  • Perkins KA, Karelitz JL, Michael VC. Reinforcement enhancing effects of acute nicotine via electronic cigarettes. Drug Alcohol Depend 2015;153:104–108.

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