3,875
Views
57
CrossRef citations to date
0
Altmetric
Reviews

Management of comorbid bipolar disorder and substance use disorders

, MD, MPH ORCID Icon & , PhD
Pages 366-376 | Received 24 Aug 2016, Accepted 03 Feb 2017, Published online: 16 Mar 2017

References

  • Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 1990;264:2511–2518.
  • Grant BF, Stinson FS, Dawson DA, Chou SP, Dufour MC, Compton W, Pickering RP, Kaplan K. Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry 2004;61:807–816.
  • Toftdahl NG, Nordentoft M, Hjorthoj C. Prevalence of substance use disorders in psychiatric patients: a nationwide Danish population-based study. Social Psychiatry Psychiatric Epidemiol 2016;51:129–140.
  • Conway KP, Compton W, Stinson FS, Grant BF. Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions.[see comment]. J Clin Psychiatry 2006;67:247–257.
  • Association AP. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Arlington, VA: American Psychiatric Association; 2013.
  • Grant BF, Saha TD, Ruan WJ, Goldstein RB, Chou SP, Jung J, Zhang H, Smith SM, Pickering RP, Huang B, Hasin DS. Epidemiology of DSM-5 drug use disorder: results from the National Epidemiologic Survey on alcohol and related Conditions-III. JAMA Psychiatry 2016;73:39–47.
  • Lasser K, Boyd JW, Woolhandler S, Himmelstein DU, McCormick D, Bor DH. Smoking and mental illness: a population-based prevalence study. JAMA 2000;284:2606–2610.
  • Bowden CL, Perlis RH, Thase ME, Ketter TA, Ostacher MM, Calabrese JR, Reilly-Harrington NA, Gonzalez JM, Singh V, Nierenberg AA, Sachs GS. Aims and results of the NIMH Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). CNS Neuroscience & Therapeutics 2012;18:243–249.
  • Chengappa KN, Levine J, Gershon S, Kupfer DJ. Lifetime prevalence of substance or alcohol abuse and dependence among subjects with bipolar I and II disorders in a voluntary registry. Bipolar Disord 2000;2:191–195.
  • Salloum IM, Thase ME. Impact of substance abuse on the course and treatment of bipolar disorder. Bipolar Disord 2000;2:269–280.
  • Frye MA, Salloum IM. Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations. Bipolar Disord 2006;8:677–685.
  • Salloum I, Douaihy A, Williams L. Diagnostic and treatment considerations: bipolar patients with comorbid substance use disorders. Psychiatric Annals 2008;38(11):716.
  • Kupfer DJ, Frank E, Grochocinski VJ, Cluss PA, Houck PR, Stapf DA. Demographic and clinical characteristics of individuals in a bipolar disorder case registry. JClin Psychiatry 2002;63:120–125.
  • Weiss RD, Ostacher MJ, Otto MW, Calabrese JR, Fossey M, Wisniewski SR, Bowden CL, Nierenberg AA, Pollack MH, Salloum IM, Simon NM, Thase ME, Sachs GS. Does recovery from substance use disorder matter in patients with bipolar disorder? J Clin Psychiatry 2005;66:730–735; quiz 808-9.
  • Salloum IM, Cornelius JR, Mezzich JE, Kirisci L, Daley DC, Spotts CR, Zuckoff A. Characterizing female bipolar alcoholic patients presenting for initial evaluation. Addict Behav 2001;26:341–348.
  • Weiss RD, Greenfield SF, Najavits LM, Soto JA, Wyner D, Tohen M, Griffin ML. Medication compliance among patients with bipolar disorder and substance use disorder. JClin Psychiatry 1998;59:172–174.
  • Wilens TE, Biederman J, Adamson JJ, Henin A, Sgambati S, Gignac M, Sawtelle R, Santry A, Monuteaux MC. Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: a controlled study. Drug Alcohol Depend 2008;95:188–198.
  • Brown SA, Vik PW, McQuaid JR, Patterson TL, Irwin MR, Grant I. Severity of psychosocial stress and outcome of alcoholism treatment. JAbnormal Psychol 1990 Nov;99: 344–348.
  • Strakowski S, DelBello M, Fleck D, Adler C, Anthenelli R, Keck P, Arnold L, Amicone J. Effect of co-occuring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania. ArchGen Psychiatry 2005;62:851–858.
  • Strakowski S, DelBello M, Fleck D, Adler C, Anthenelli R, Keck P, Arnold L, Amicone J. The effects of co-occurring cannabis use disorders on the course of bipolar disorder following a first hospitalization for mania. Arch Gen Psychiatry 2007;64:57–64.
  • Simon NM, Otto MW, Wisniewski SR, Fossey M, Sagduyu K, Frank E, Sachs GS, Nierenberg AA, Thase ME, Pollack MH, for the S-BDI. Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am JPsychiatry 2004;161:2222–2229.
  • El-Mallakh RS, Hollifield M. Comorbid anxiety in bipolar disorder alters treatment and prognosis. Psychiatric Q 2008;79:139–150.
  • Krishnan KR. Psychiatric and medical comorbidities of bipolar disorder. Psychosomatic Med 2005;67:1–8.
  • Agius M, Lee J, Gardner J, Wotherspoon D. Bipolar Ii disorder and borderline personality disorder-co-morbidity or spectrum? Psychiat Danub 2012;24:S197–S201.
  • Tavormina G, Agius M. An approach to the diagnosis and treatment of patients with bipolar spectrum mood disorders, identifying temperaments. Psychiat Danub 2012;24:S25–S7.
  • Zimmerman M, Martinez JH, Morgan TA, Young D, Chelminski I, Dalrymple K. Distinguishing Bipolar II depression from major depressive disorder with comorbid borderline personality disorder: demographic, clinical, and family history differences. J Clin Psychiatry 2013;74:880–886.
  • Zimmerman M, Morgan TA. Problematic boundaries in the diagnosis of bipolar disorder: the interface with borderline personality disorder. Curr Psychiatry Rep 2013;15:422.
  • Otto MW, Simon NM, Wisniewski SR, Miklowitz DJ, Kogan JN, Reilly-Harrington NA, Frank E, Nierenberg AA, Marangell LB, Sagduyu K, Weiss RD, Miyahara S, Thas ME, Sachs GS, Pollack MH, Investigators S-B. Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. Br JPsychiatry 2006;189:20–25.
  • McIntyre RS, Soczynska JK, Bottas A, Bordbar K, Konarski JZ, Kennedy SH. Anxiety disorders and bipolar disorder: a review. Bipolar Disord 2006;8:665–676.
  • Frank E, Cyranowski JM, Rucci P, Shear MK, Fagiolini A, Thase ME, Cassano GB, Grochocinski VJ, Kostelnik B, Kupfer DJ. Clinical significance of lifetime panic spectrum symptoms in the treatment of patients with bipolar I disorder. Arch Gen Psychiatry 2002;59:905–911.
  • Sharma V. Atypical antipsychotics and suicide in mood and anxiety disorders. Bipolar Disord Suppl 2003;5:48–52.
  • Salloum IM, Thase ME. Impact of substance abuse on the course and treatment of bipolar disorder. Bipolar Disord 2000;2:269–280.
  • Hirschfeld RMA, Vornik LA. Recognition and diagnosis of bipolar disorder. J Clin Psychiatry 2004;65:5–9.
  • Goldberg JF, Garno JL, Callahan AM, Kearns DL, Kerner B, Ackerman SH. Overdiagnosis of bipolar disorder among substance use disorder inpatients with mood instability. J Clin Psychiatry. 2008;69:1751–1757.
  • Albanese MJ, Clodfelter Jr RC, Pardo TB, Ghaemi SN. Underdiagnosis of bipolar disorder in men with substance use disorder. J Psychiatric Practice® 2006;12:124–127.
  • Young RC, Biggs JT, Ziegler VE, al. e. A rating scale for mania: reliability, validity, and sensitivity. Br J Psychiatry 1978;133:429–435.
  • Bech P, Bolwig TG, Kramp P, Rafaelsen OJ. The Bech-Rafaelsen Mania Scale and the Hamilton Depression Scale. Acta Psychiatr Scan 1979;59:420–430.
  • Franken IH, Hendriks VM. Screening and diagnosis of anxiety and mood disorders in substance abuse patients. Am J Addict 2001;10:30–39.
  • Hirschfeld RM, Williams JB, Spitzer RL, Calabrese JR, Flynn L, Keck PE, Jr., Lewis L, McElroy SL, Post RM, Rapport DJ, Russell JM, Sachs GS, Zajecka J. Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire.[comment]. Am J Psychiatry. 2000;157:1873–1875.
  • Hasin DS, Trautman KD, Miele GM, Samet S, Smith M, Endicott J. Psychiatric Research Interview for Substance and Mental Disorders (PRISM): Reliability for substance abusers. Am J Psychiatry 1996;153:1195–1201.
  • Sheehan DV, Lecrubier Y, Sheehan K, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998;59:22–33.
  • Allen JP, Litten RZ, Fertig JB, Babor T. A review of research on the Alcohol Use Disorders Identification Test (AUDIT). [Review] [31 refs]. Alcohol: Clin Exp Res 1997;21:613–619.
  • Cocco KM, Carey KB. Psychometric properties of the drug abuse screening test in psychiatric outpatients. [Article]. Psychol Assess 1998;10:408–414.
  • Judd LL, Schettler PJ, Akiskal HS, Coryell W, Leon AC, Maser JD, Solomon DA. Residual symptom recovery from major affective episodes in bipolar disorders and rapid episode relapse/recurrence. Arch Gen Psychiatry 2008;65:386–394.
  • Salloum IM, Daley DC, Cornelius JR, Kirisci L, Thase ME. Disproportionate lethality in psychiatric patients with concurrent alcohol and cocaine abuse [see comments]. Am J Psychiatry 1996;153:953–955.
  • Sullivan JT, Sykora K, Schneiderman J, Naranjo CA, Sellers EM. Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict 1989;84:1353–1357.
  • Salloum IM, Cornelius JR, Daley DC, Thase ME. The utility of diazepam loading in the treatment of alcohol withdrawal among psychiatric inpatients. Psychopharmacol Bull 1995;31:305–310.
  • Saitz R, Mayo-Smith MF, Roberts MS, Redmond HA, Bernard DR, Calkins DR. Individualized treatment for alcohol withdrawal. A randomized double-blind controlled trial [see comments]. JAMA 1994;272:519–523.
  • Gossop, Michael. The development of a Short Opiate Withdrawal Scale (SOWS). Addict Behav 1990;15:487–490.
  • Fisher ES. Building a medical neighborhood for the medical home. N Engl J Med 2008;359:1202–1205.
  • Salloum IM, Mezzich JE. Outlining the bases of person-centred integrative diagnosis. J Eval Clin Pract 2011;17:354–356.
  • Salloum IM, Mezzich JE. Person-centered diagnosis. Int J Integr Care 2010;10:e027.
  • Mezzich JE, Salloum IM, Cloninger CR, Salvador-Carulla L, Kirmayer LJ, Banzato CE, Wallcraft J, Botbol M. Person-centred integrative diagnosis: conceptual bases and structural model. Can J Psychiatry 2010;55:701–708.
  • Weiss RD, Griffin ML, Jaffee WB, Bender RE, Graff FS, Gallop RJ, Fitzmaurice GM. A “community-friendly” version of integrated group therapy for patients with bipolar disorder and substance dependence: A randomized controlled trial. Drug Alcohol Depend 2009;104:212–219.
  • Weiss RD, Griffin ML, Kolodziej ME, Greenfield SF, Najavits LM, Daley DC, Doreau HR, Hennen JA. A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence.[seecomment]. Am J Psychiatry 2007;164:100–107.
  • Salloum IM, Williams L, Douaihy A. Diagnostic and treatment considerations: bipolar patients with comorbid substance use disorders. Psychiatric Annals 2008;38:716–723.
  • Salloum IM, Douaihy AB, Kelly TM, Cornelius JR, L. K. Integrating pharmacotherapy and a novel individual counseling for alcoholism with bipolar disorder. Alcohol: Clin Exp Res 2008;32:260A.
  • Azorin JM, Bowden CL, Garay RP, Perugi G, Vieta E, Young AH. Possible new ways in the pharmacological treatment of bipolar disorder and comorbid alcoholism. Neuropsychiatr Dis Treat. 2010;6:37–46.
  • Brown ES. Management of comorbid bipolar disorder and substance abuse. J Clin Psychiatry 2006;67:e05.
  • Geller B, Cooper TB, Sun K, Zimerman B, Frazier J, Williams M, Heath J. Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency [see comments]. J Am Acad Child Adolesc Psychiatry. 1998;37:171–178.
  • Brady KT, Myrick H, Henderson S, Coffey SF. The use of divalproex in alcohol relapse prevention: a pilot study. Drug Alcohol Depend 2002;67:323–330.
  • Brady KT, Sonne SC, Malcolm RJ, Randall CL, Dansky BS, Simpson K, Roberts JS, Brondino M. Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder. [Report]. Exp Clin Psychopharmacol 2002 Aug;10:276–285.
  • Salloum IM, Douaihy A, Cornelius JR, Kirisci L, Kelly TM, Hayes J. Divalproex utility in bipolar disorder with co-occurring cocaine dependence: a pilot study. Addict Behav 2007;32:410–415.
  • Brady KT, Sonne SC, Anton R, Ballenger JC. Valproate in the treatment of acute bipolar affective episodes complicated by substance abuse: a pilot study. J Clin Psychiatry 1995;56:118–121.
  • Albanese MJ, Clodfelter RCJ, Khantzian EJ. Divalproex sodium in substance abusers with mood disorder. J Clin Psychiatry 2000;61:916–921.
  • Brown ES, Perantie DC, Dhanani N, Beard L, Orsulak P, Rush AJ. Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study. J Affect Disord 2006;93:219–222.
  • Bowden CL. Valproate. [Review]. Bipolar Disord 2003 Jun;5:189–202.
  • Calabrese JR, Bowden CL, Sachs G, Yatham LN, Behnke K, Mehtonen O-P, Montgomery P, Ascher J, Paska W, Earl N, DeVeaugh-Geiss J, Lamictal 605 Study G. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry 2003;64:1013–1024.
  • Salloum IM, Cornelius JR, Daley DC, Kirisci L, Himmelhoch JM, Thase ME. Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study.[see comment]. Arch Gen Psychiatry 2005;62:37–45.
  • Brown ES, Sunderajan P, Hu LT, Sowell SM, Carmody TJ. A randomized, double-blind, placebo-controlled, trial of lamotrigine therapy in bipolar disorder, depressed or mixed phase and cocaine dependence. Neuropsychopharmacol 2012;37:2347–2354.
  • Sylvia LG, Gold AK, Stange JP, Peckham AD, Deckersbach T, Calabrese JR, Weiss RD, Perlis RH, Nierenberg AA, Ostacher MJ. A randomized, placebo-controlled proof-of-concept trial of adjunctive topiramate for alcohol use disorders in bipolar disorder. Am J Addict 2016;25:94–98.
  • Calabrese JR, Keck PE, Jr., Macfadden W, Minkwitz M, Ketter TA, Weisler RH, Cutler AJ, McCoy R, Wilson E, Mullen J. A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression. Am J Psychiatry 2005;162:1351–1360.
  • Brown ES, Nejtek VA, Perantie DC, Bobadilla L. Quetiapine in bipolar disorder and cocaine dependence. Bipolar Disord 2002;4:406–411.
  • Brown ES, Garza M, Carmody TJ. A randomized, double-blind, placebo-controlled add-on trial of quetiapine in outpatients with bipolar disorder and alcohol use disorders. J Clin Psychiatry 2008;69:701–705.
  • Stedman M, Pettinati HM, Brown ES, Kotz M, Calabrese JR, Raines S. A double-blind, placebo-controlled study with quetiapine as adjunct therapy with lithium or divalproex in bipolar I patients with coexisting alcohol dependence. Alcohol Clin Exp Res 2010;34:1822–1831.
  • Brown ES, Davila D, Nakamura A, Carmody TJ, Rush AJ, Lo A, Holmes T, Adinoff B, Caetano R, Swann AC, Sunderajan P, Bret ME. A randomized, double-blind, placebo-controlled trial of quetiapine in patients with bipolar disorder, mixed or depressed phase, and alcohol dependence. Alcohol Clin Exp Res 2014;38:2113–2118.
  • Brown ES, Carmody TJ, Schmitz JM, Caetano R, Adinoff B, Swann AC, Sunderajan P, Bret ME. A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence. Alcohol Clin Exp Res 2009;33:1863–1869.
  • Brown ES, Beard L, Dobbs L, Rush AJ. Naltrexone in patients with bipolar disorder and alcohol dependence. Depress Anxiety 2006;23:492–495.
  • Salloum IM, Douaihy A, Cornelius JR, Daley DC, Kelly TM, Kirisci L. Open label randomized pilot study of combined naltrexone and valproate in bipolar alcoholics. Alcohol: Clin Exp Res. 2006;30:104A.
  • Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B, Group VANEVIMS. Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders. Biol Psychiatry 2005;57:1128–1137.
  • Mason BJ, Salvato FR, Williams LD, Ritvo EC, Cutler RB. A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence. Arch Gen Psychiatry 1999;56:719–724.
  • Mann K, Bladström A, Torup L, Gual A, van den Brink W. Extending the treatment options in alcohol dependence: a randomized controlled study of as-needed nalmefene. Biol Psychiatry 2013;73:706–713.
  • Tolliver BK, Desantis SM, Brown DG, Prisciandaro JJ, Brady KT. A randomized, double-blind, placebo-controlled clinical trial of acamprosate in alcohol-dependent individuals with bipolar disorder: a preliminary report. Bipolar Disord 2012;14:54–63.
  • Brown ES, Gorman AR, Hynan LS. A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence. J Clin Psychopharmacol 2007;27:498–502.
  • Brown ES, Todd JP, Hu LT, Schmitz JM, Carmody TJ, Nakamura A, Sunderajan P, Rush AJ, Adinoff B, Bret ME, Holmes T, Lo A. A Randomized, Double-Blind, Placebo-Controlled Trial of Citicoline for Cocaine Dependence in Bipolar I Disorder. Am J Psychiatry 2015;172:1014–1021.
  • Brown ES, Gabrielson B. A randomized, double-blind, placebo-controlled trial of citicoline for bipolar and unipolar depression and methamphetamine dependence. J affect Disord 2012;143:257–260.
  • Frye MA, Ebbert JO, Prince CA, Lineberry TW, Geske JR, Patten CA. A Feasibility Study of Varenicline for Smoking Cessation in Bipolar Patients With Subsyndromal Depression. J Clin Psychopharmacol 2013;33:821–823.
  • Cowan AP. Buprenorphine: The Basic Pharmacology Revisited. J Addict Med 2007;1:68–72.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.