Simulated opioid choice linked to opioid use disorder severity among veterans with chronic pain: initial validation of a novel paradigm

References

• Alexander GC, Stoller KB, Haffajee RL, Saloner B. An epidemic in the midst of a pandemic: opioid use disorder and COVID-19. Ann Intern Med. 2020;173:57–58. doi:10.7326/M20-1141.
   PubMed Web of Science ®Google Scholar
• Han B, Volkow ND, Compton WM, McCance-Katz EF. Reported heroin use, use disorder, and injection among adults in the United States, 2002–2018. JAMA. 2020;323:568–71. doi:10.1001/jama.2019.20844.
   PubMed Web of Science ®Google Scholar
• Vowles KE, McEntee ML, Julnes PS, Frohe T, Ney JP, van der Goes DN. Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis. Pain. 2015;156:569–76. doi:10.1097/01.j.pain.0000460357.01998.f1.
   PubMed Web of Science ®Google Scholar
• Florence CS, Zhou C, Luo F, Xu L. The economic burden of prescription opioid overdose, abuse, and dependence in the United States, 2013. Med Care. 2016;54:901–06. doi:10.1097/MLR.0000000000000625.
   PubMed Web of Science ®Google Scholar
• Kaye AD, Jones MR, Kaye AM, Ripoll JG, Galan V, Beakley BD, Calixto F, Bolden JL, Urman RD, Manchikanti L. Prescription opioid abuse in chronic pain: an updated review of opioid abuse predictors and strategies to curb opioid abuse: part 1. Pain Physician. 2017;20:S93–s109. doi:10.36076/ppj.2017.s109.
   PubMed Web of Science ®Google Scholar
• Butler SF, Budman SH, Fernandez KC, Houle B, Benoit C, Katz N, Jamison RN. Development and validation of the current opioid misuse measure. Pain. 2007;130:144–56. doi:10.1016/j.pain.2007.01.014.
   PubMed Web of Science ®Google Scholar
• Zilverstand A, Huang AS, Alia-Klein N, Goldstein RZ. Neuroimaging impaired response inhibition and salience attribution in human drug addiction: a systematic review. Neuron. 2018;98:886–903. doi:10.1016/j.neuron.2018.03.048.
   PubMed Web of Science ®Google Scholar
• Garland EL, Froeliger B, Zeidan F, Partin K, Howard MO. The downward spiral of chronic pain, prescription opioid misuse, and addiction: cognitive, affective, and neuropsychopharmacologic pathways. Neurosci Biobehav Rev. 2013;37:2597–607. doi:10.1016/j.neubiorev.2013.08.006.
   PubMed Web of Science ®Google Scholar
• Berridge KC, Robinson TE. Liking, wanting, and the incentive-sensitization theory of addiction. Am Psychol. 2016;71:670–79. doi:10.1037/amp0000059.
   PubMed Web of Science ®Google Scholar
• Goldstein RZ, Volkow ND. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci. 2011;12:652–69. doi:10.1038/nrn3119.
   PubMed Web of Science ®Google Scholar
• Paulus MP. Decision-making dysfunctions in psychiatry–altered homeostatic processing? Science. 2007;318:602–06. doi:10.1126/science.1142997.
   PubMed Web of Science ®Google Scholar
• Shurman J, Koob GF, Gutstein HB. Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Pain Med. 2010;11:1092–98. doi:10.1111/j.1526-4637.2010.00881.x.
   PubMed Web of Science ®Google Scholar
• Koob GF, Le Moal M. Addiction and the brain antireward system. Annu Rev Psychol. 2008;59:29–53. doi:10.1146/annurev.psych.59.103006.093548.
   PubMed Web of Science ®Google Scholar
• Garfield JB, Lubman DI, Yucel M. Anhedonia in substance use disorders: a systematic review of its nature, course and clinical correlates. Aust N Z J Psychiatry. 2014;48:36–51. doi:10.1177/0004867413508455.
   PubMed Web of Science ®Google Scholar
• Lubman DI, Yucel M, Kettle JW, Scaffidi A, Mackenzie T, Simmons JG, Allen NB. Responsiveness to drug cues and natural rewards in opiate addiction: associations with later heroin use. Arch Gen Psychiatry. 2009;66:205–12. doi:10.1001/archgenpsychiatry.2008.522.
   PubMed Web of Science ®Google Scholar
• Stevens A, Peschk I, Schwarz J. Implicit learning, executive function and hedonic activity in chronic polydrug abusers, currently abstinent polydrug abusers and controls. Addiction. 2007;102:937–46. doi:10.1111/j.1360-0443.2007.01823.x.
   PubMed Web of Science ®Google Scholar
• Zijlstra F, Veltman DJ, Booij J, van den Brink W, Franken IH. Neurobiological substrates of cue-elicited craving and anhedonia in recently abstinent opioid-dependent males. Drug Alcohol Depend. 2009;99:183–92. doi:10.1016/j.drugalcdep.2008.07.012.
   PubMed Web of Science ®Google Scholar
• Lubman DI, Allen NB, Peters LA, Deakin JF. Electrophysiological evidence that drug cues have greater salience than other affective stimuli in opiate addiction. Journal of Psychopharmacol. 2008;22:836–42. doi:10.1177/0269881107083846.
   PubMed Web of Science ®Google Scholar
• Garland EL, Froeliger B, Howard MO. Allostatic dysregulation of natural reward processing in prescription opioid misuse: autonomic and attentional evidence. Biol Psychol. 2015;105:124–29. doi:10.1016/j.biopsycho.2015.01.005.
   PubMed Web of Science ®Google Scholar
• Banks ML, Negus SS. Insights from preclinical choice models on treating drug addiction. Trends Pharmacol Sci. 2017;38:181–94. doi:10.1016/j.tips.2016.11.002.
   PubMed Web of Science ®Google Scholar
• Banks ML, Hutsell BA, Schwienteck KL, Negus SS. Use of Preclinical drug vs. Food choice procedures to evaluate candidate medications for cocaine addiction. Curr Treat Options Psychiatry. 2015;2:136–50. doi:10.1007/s40501-015-0042-9.
   PubMedGoogle Scholar
• Huskinson SL, Woolverton WL, Green L, Myerson J, Freeman KB. Delay discounting of food by rhesus monkeys: cocaine and food choice in isomorphic and allomorphic situations. Exp Clin Psychopharmacol. 2015;23:184–93. doi:10.1037/pha0000015.
   PubMed Web of Science ®Google Scholar
• Moeller SJ, Stoops WW. Cocaine choice procedures in animals, humans, and treatment-seekers: can we bridge the divide? Pharmacol Biochem Behav. 2015;138:133–41. doi:10.1016/j.pbb.2015.09.020.
   PubMed Web of Science ®Google Scholar
• Moeller SJ, Maloney T, Parvaz MA, Dunning JP, Alia-Klein N, Woicik PA, Hajcak G, Telang F, Wang GJ, Volkow ND, et al. Enhanced choice for viewing cocaine pictures in cocaine addiction. Biol Psychiatry. 2009;66:169–76. doi:10.1016/j.biopsych.2009.02.015.
   PubMed Web of Science ®Google Scholar
• Moeller SJ, Maloney T, Parvaz MA, Alia-Klein N, Woicik PA, Telang F, Wang GJ, Volkow ND, Goldstein RZ. Impaired insight in cocaine addiction: laboratory evidence and effects on cocaine-seeking behaviour. Brain. 2010;133:1484–93. doi:10.1093/brain/awq066.
   PubMed Web of Science ®Google Scholar
• Moeller SJ, Parvaz MA, Shumay E, Beebe-Wang N, Konova AB, Alia-Klein N, Volkow ND, Goldstein RZ. Gene x abstinence effects on drug cue reactivity in addiction: multimodal evidence. J Neurosci. 2013;33:10027–36. doi:10.1523/JNEUROSCI.0695-13.2013.
   PubMed Web of Science ®Google Scholar
• Moeller SJ, Zilverstand A, Konova AB, Kundu P, Parvaz MA, Preston-Campbell R, Bachi K, Alia-Klein N, Goldstein RZ. Neural correlates of drug-biased choice in currently using and abstinent individuals with cocaine use disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3:485–94. doi:10.1016/j.bpsc.2017.11.001.
   PubMedGoogle Scholar
• Moeller SJ, Hanley AW, Garland EL. Behavioral preference for viewing drug v. pleasant images predicts current and future opioid misuse among chronic pain patients. Psychol Med. 2020;50:644–52. doi:10.1017/S0033291719000461.
   PubMed Web of Science ®Google Scholar
• Kakko J, Alho H, Baldacchino A, Molina R, Nava FA, Shaya G. Craving in opioid use disorder: from neurobiology to clinical practice. Front Psychiatry. 2019;10:592. doi:10.3389/fpsyt.2019.00592.
   PubMed Web of Science ®Google Scholar
• Sayette MA. The role of craving in substance use disorders: theoretical and methodological issues. Annu Rev Clin Psychol. 2016;12:407–33. doi:10.1146/annurev-clinpsy-021815-093351.
   PubMed Web of Science ®Google Scholar
• Tsui JI, Lira MC, Cheng DM, Winter MR, Alford DP, Liebschutz JM, Edwards RR, Samet JH. Chronic pain, craving, and illicit opioid use among patients receiving opioid agonist therapy. Drug Alcohol Depend. 2016;166:26–31. doi:10.1016/j.drugalcdep.2016.06.024.
   PubMed Web of Science ®Google Scholar
• Wasan AD, Butler SF, Budman SH, Fernandez K, Weiss RD, Greenfield SF, Jamison RN. Does report of craving opioid medication predict aberrant drug behavior among chronic pain patients? Clin J Pain. 2009;25:193–98. doi:10.1097/AJP.0b013e318193a6c4.
   PubMed Web of Science ®Google Scholar
• Wasan AD, Ross EL, Michna E, Chibnik L, Greenfield SF, Weiss RD, Jamison RN. Craving of prescription opioids in patients with chronic pain: a longitudinal outcomes trial. J Pain. 2012;13:146–54. doi:10.1016/j.jpain.2011.10.010.
   PubMed Web of Science ®Google Scholar
• Janiri L, Martinotti G, Dario T, Reina D, Paparello F, Pozzi G, Addolorato G, Di Giannantonio M, De Risio S. Anhedonia and substance-related symptoms in detoxified substance-dependent subjects: a correlation study. Neuropsychobiology. 2005;52:37–44. doi:10.1159/000086176.
   PubMed Web of Science ®Google Scholar
• Cheetham A, Allen NB, Yucel M, Lubman DI. The role of affective dysregulation in drug addiction. Clin Psychol Rev. 2010;30:621–34. doi:10.1016/j.cpr.2010.04.005.
   PubMed Web of Science ®Google Scholar
• Garland EL, Trostheim M, Eikemo M, Ernst G, Leknes S. Anhedonia in chronic pain and prescription opioid misuse. Psychol Med. 2020;50:1977–88. doi:10.1017/S0033291719002010.
   PubMed Web of Science ®Google Scholar
• Leventhal AM, Waters AJ, Kahler CW, Ray LA, Sussman S. Relations between anhedonia and smoking motivation. Nicotine Tob Res. 2009;11:1047–54. doi:10.1093/ntr/ntp098.
   PubMed Web of Science ®Google Scholar
• Moeller SJ, Beebe-Wang N, Woicik PA, Konova AB, Maloney T, Goldstein RZ. Choice to view cocaine images predicts concurrent and prospective drug use in cocaine addiction. Drug Alcohol Depend. 2013;130:178–85. doi:10.1016/j.drugalcdep.2012.11.001.
   PubMed Web of Science ®Google Scholar
• Marsden J, Tai B, Ali R, Hu L, Rush AJ, Volkow N. Measurement-based care using DSM-5 for opioid use disorder: can we make opioid medication treatment more effective? Addiction. 2019;114:1346–53. doi:10.1111/add.14546.
   PubMed Web of Science ®Google Scholar
• Moeller SJ, Tomasi D, Woicik PA, Maloney T, Alia-Klein N, Honorio J, Telang F, Wang GJ, Wang R, Sinha R, et al. Enhanced midbrain response at 6-month follow-up in cocaine addiction, association with reduced drug-related choice. Addict Biol. 2012;17:1013–25. doi:10.1111/j.1369-1600.2012.00440.x.
   PubMed Web of Science ®Google Scholar
• Moeller SJ, Konova AB, Parvaz MA, Tomasi D, Lane RD, Fort C, Goldstein RZ. Functional, structural, and emotional correlates of impaired insight in cocaine addiction. JAMA Psychiatry. 2014;71:61–70. doi:10.1001/jamapsychiatry.2013.2833.
   PubMed Web of Science ®Google Scholar
• Hardy L, Hogarth L. A novel concurrent pictorial choice model of mood-induced relapse in hazardous drinkers. Exp Clin Psychopharmacol. 2017;25:448–55. doi:10.1037/pha0000155.
   PubMed Web of Science ®Google Scholar
• Hogarth L, Hardy L. Depressive statements prime goal-directed alcohol-seeking in individuals who report drinking to cope with negative affect. Psychopharmacol (Berl). 2018;235:269–79. doi:10.1007/s00213-017-4765-8.
   PubMed Web of Science ®Google Scholar
• Hogarth L, Mathew AR, Hitsman B. Current major depression is associated with greater sensitivity to the motivational effect of both negative mood induction and abstinence on tobacco-seeking behavior. Drug Alcohol Depend. 2017;176:1–6. doi:10.1016/j.drugalcdep.2017.02.009.
   PubMed Web of Science ®Google Scholar
• Aigner TG, Balster RL. Choice behavior in rhesus monkeys: cocaine versus food. Science. 1978;201:534–35. doi:10.1126/science.96531.
   PubMed Web of Science ®Google Scholar
• Garland EL, Froeliger BE, Passik SD, Howard MO. Attentional bias for prescription opioid cues among opioid dependent chronic pain patients. J Behav Med. 2013;36:611–20. doi:10.1007/s10865-012-9455-8.
   PubMed Web of Science ®Google Scholar
• Franken IH, Kroon LY, Wiers RW, Jansen A. Selective cognitive processing of drug cues in heroin dependence. J Psychopharmacol. 2000;14:395–400. doi:10.1177/026988110001400408.
   PubMed Web of Science ®Google Scholar
• Zhao H, Yang B, Zhu Q, Zhang G, Xiao Y, Guo X, Huang X, Zhang Z. Eye movement evidence of attentional bias for substance-related cues in heroin dependents on methadone maintenance therapy. Subst Use Misuse. 2017;52:527–34. doi:10.1080/10826084.2016.1264967.
   PubMed Web of Science ®Google Scholar
• Frankland L, Bradley BP, Mogg K. Time course of attentional bias to drug cues in opioid dependence. Psychol Addic Behav. 2016;30:601–06. doi:10.1037/adb0000169.
   PubMed Web of Science ®Google Scholar
• MacLean RR, Sofuoglu M, Brede E, Robinson C, Waters AJ. Attentional bias in opioid users: a systematic review and meta-analysis. Drug Alcohol Depend. 2018;191:270–78.
   PubMed Web of Science ®Google Scholar
• Garland EL, Howard MO. Opioid attentional bias and cue-elicited craving predict future risk of prescription opioid misuse among chronic pain patients. Drug Alcohol Depend. 2014;144:283–87. doi:10.1016/j.drugalcdep.2014.09.014.
   PubMed Web of Science ®Google Scholar
• Teeters JB, Lancaster CL, Brown DG, Back SE. Substance use disorders in military veterans: prevalence and treatment challenges. Subst Abuse Rehabil. 2017;8:69–77. doi:10.2147/SAR.S116720.
   PubMed Web of Science ®Google Scholar
• MacKillop J, Miranda R Jr., Monti PM, Ray LA, Murphy JG, Rohsenow DJ, McGeary JE, Swift RM, Tidey JW, Gwaltney CJ. Alcohol demand, delayed reward discounting, and craving in relation to drinking and alcohol use disorders. J Abnorm Psychol. 2010;119:106–14. doi:10.1037/a0017513.
   PubMed Web of Science ®Google Scholar
• Fatseas M, Serre F, Swendsen J, Auriacombe M. Effects of anxiety and mood disorders on craving and substance use among patients with substance use disorder: an ecological momentary assessment study. Drug Alcohol Depend. 2018;187:242–48. doi:10.1016/j.drugalcdep.2018.03.008.
   PubMed Web of Science ®Google Scholar
• Huhn AS, Harris J, Cleveland HH, Lydon DM, Stankoski D, Cleveland MJ, Deneke E, Bunce SC. Ecological momentary assessment of affect and craving in patients in treatment for prescription opioid dependence. Brain Res Bull. 2016;123:94–101. doi:10.1016/j.brainresbull.2016.01.012.
   PubMed Web of Science ®Google Scholar
• McHugh RK, Fitzmaurice GM, Carroll KM, Griffin ML, Hill KP, Wasan AD, Weiss RD. Assessing craving and its relationship to subsequent prescription opioid use among treatment-seeking prescription opioid dependent patients. Drug Alcohol Depend. 2014;145:121–26. doi:10.1016/j.drugalcdep.2014.10.002.
   PubMed Web of Science ®Google Scholar
• Garland EL, Baker AK, Howard MO. Mindfulness-oriented recovery enhancement reduces opioid attentional bias among prescription opioid-treated chronic pain patients. J Soc Social Work Res. 2017;8:493–509. doi:10.1086/694324.
   Web of Science ®Google Scholar
• Garfield JBB, Cotton SM, Allen NB, Cheetham A, Kras M, Yucel M, Lubman DI. Evidence that anhedonia is a symptom of opioid dependence associated with recent use. Drug Alcohol Depend. 2017;177:29–38. doi:10.1016/j.drugalcdep.2017.03.012.
   PubMed Web of Science ®Google Scholar
• Grattan A, Sullivan MD, Saunders KW, Campbell CI, Von Korff MR. Depression and prescription opioid misuse among chronic opioid therapy recipients with no history of substance abuse. Ann Fam Med. 2012;10:304–11. doi:10.1370/afm.1371.
   PubMed Web of Science ®Google Scholar
• Lubman DI, Garfield JB, Gwini SM, Cheetham A, Cotton SM, Yucel M, Allen NB. Dynamic associations between opioid use and anhedonia: a longitudinal study in opioid dependence. J Psychopharmacol. 2018;32:957–64. doi:10.1177/0269881118791741.
   PubMed Web of Science ®Google Scholar
• Garland EL, Atchley RM, Hanley AW, Zubieta JK, Froeliger B. Mindfulness-oriented recovery enhancement remediates hedonic dysregulation in opioid users: neural and affective evidence of target engagement. Scie Adv. 2019;5:eaax1569. doi:10.1126/sciadv.aax1569.
   PubMed Web of Science ®Google Scholar
• Garland EL, Bryan CJ, Finan PH, Thomas EA, Priddy SE, Riquino MR, Howard MO. Pain, hedonic regulation, and opioid misuse: modulation of momentary experience by mindfulness-oriented recovery enhancement in opioid-treated chronic pain patients. Drug Alcohol Depend. 2017;173:S65–S72. doi:10.1016/j.drugalcdep.2016.07.033.
   PubMed Web of Science ®Google Scholar
• Garfield JB, Cotton SM, Lubman DI. Psychometric properties, validity, and reliability of the temporal experience of pleasure scale state version in an opioid-dependent sample. Drug Alcohol Depend. 2016;161:238–46. doi:10.1016/j.drugalcdep.2016.02.011.
   PubMed Web of Science ®Google Scholar
• Cook JW, Spring B, McChargue D, Hedeker D. Hedonic capacity, cigarette craving, and diminished positive mood. Nicotine Tob Res. 2004;6:39–47. doi:10.1080/14622200310001656849.
   PubMed Web of Science ®Google Scholar
• Martinotti G, Cloninger CR, Janiri L. Temperament and character inventory dimensions and anhedonia in detoxified substance-dependent subjects. Am J Drug Alcohol Abuse. 2008;34:177–83. doi:10.1080/00952990701877078.
   PubMed Web of Science ®Google Scholar