Differential patterns of opioid misuse between younger and older adults – a retrospective observational study using data from South Carolina’s prescription drug monitoring program

References

• Substance Abuse and Mental Health Services Administration. Treatment Improvement Protocol (TIP) 26: treating substance use disorder in older Adults. U.S. Department of Health and Human Services; 2020. https://store.samhsa.gov/product/treatment-improvement-protocol-tip-26-treating-substance-use-disorder-in-older-adults/PEP20-02-01-011.
   Google Scholar
• Kaiser Family Foundation. Opioid overdose deaths by age group 2021. https://www.kff.org/other/state-indicator/opioid-overdose-deaths-by-age-group/.
   Google Scholar
• Le Roux C, Tang Y, Drexler K. Alcohol and opioid use disorder in older adults: neglected and treatable illnesses. Curr Psychiatry Rep. 2016;18:87. doi:10.1007/s11920-016-0718-x.
   PubMed Web of Science ®Google Scholar
• Office of Inspector General. Opioids in medicare part D: concerns about extreme use and questionable prescribing. In: Services USDoHaH, editor; 2017.
   Google Scholar
• Marshall K, Hale D. Older adults and the opioid crisis. Home Healthcare Now. 2019;37:117.
   PubMedGoogle Scholar
• Chang Y-P, Compton P. Opioid misuse/abuse and quality persistent pain management in older adults. J Gerontol Nurs. 2016;42:21–30. doi:10.3928/00989134-20161110-06.
   PubMed Web of Science ®Google Scholar
• West NA, Severtson SG, Green JL, Dart RC. Trends in abuse and misuse of prescription opioids among older adults. Drug Alcohol Depend. 2015;149:117–21. doi:10.1016/j.drugalcdep.2015.01.027.
   PubMed Web of Science ®Google Scholar
• Wu L-T, Blazer DG. Illicit and nonmedical drug use among older adults: a review. J Aging Health. 2010;23:481–504. doi:10.1177/0898264310386224.
   PubMed Web of Science ®Google Scholar
• Simoni-Wastila L, Yang HK. Psychoactive drug abuse in older adults. Am J Geriatr Pharmacother. 2006;4:380–94. doi:10.1016/j.amjopharm.2006.10.002.
   PubMedGoogle Scholar
• Maree RD, Marcum ZA, Saghafi E, Weiner DK, Karp JF. A systematic review of opioid and benzodiazepine misuse in older adults. Am J Geriatric Psychiatry. 2016;24:949–63. doi:10.1016/j.jagp.2016.06.003.
   PubMed Web of Science ®Google Scholar
• Kalapatapu RK, Sullivan MA. Prescription use disorders in older adults. Am J Addict. 2010;19:515–22. doi:10.1111/j.1521-0391.2010.00080.x.
   PubMed Web of Science ®Google Scholar
• Molton IR, Terrill AL. Overview of persistent pain in older adults. Am Psychol. 2014;69:197. doi:10.1037/a0035794.
   PubMed Web of Science ®Google Scholar
• Gossop M, Moos R. Substance misuse among older adults: a neglected but treatable problem. Addiction. 2008;103:347–48.
   PubMed Web of Science ®Google Scholar
• Gfroerer J, Penne M, Pemberton M, Folsom R. Substance abuse treatment need among older adults in 2020: the impact of the aging baby-boom cohort. Drug Alcohol Depend. 2003;69:127–35. doi:10.1016/S0376-8716(02)00307-1.
   PubMed Web of Science ®Google Scholar
• Carew AM, Comiskey C. Treatment for opioid use and outcomes in older adults: a systematic literature review. Drug Alcohol Depend. 2018;182:48–57. doi:10.1016/j.drugalcdep.2017.10.007.
   PubMed Web of Science ®Google Scholar
• Carter MW, Yang BK, Davenport M, Kabel A. Increasing rates of opioid misuse among older adults visiting emergency departments. Innov Aging. 2019;3:igz002–igz. doi:10.1093/geroni/igz002.
   PubMed Web of Science ®Google Scholar
• Kuerbis A. Substance use among older adults: an update on prevalence, etiology, assessment, and intervention. Gerontology. 2020;66:249–58. doi:10.1159/000504363.
   PubMed Web of Science ®Google Scholar
• Wu L-T. Substance use and misuse in older adults: a need for research and intervention. Gerontologist. 2020;60:1184–85. doi:10.1093/geront/gnaa049.
   Web of Science ®Google Scholar
• Substance Abuse and Mental Health Services Administration. Prescription medication misuse and abuse among older adults; 2012. https://acl.gov/sites/default/files/programs/2016-11/Issue%20Brief%205%20Prescription%20Med%20Misuse%20Abuse.pdf.
   Google Scholar
• Makris UE, Abrams RC, Gurland B, Reid MC. Management of persistent pain in the older patient: a clinical review. JAMA. 2014;312:825–37. doi:10.1001/jama.2014.9405.
   PubMed Web of Science ®Google Scholar
• Mailis-Gagnon A, Lakha SF, Furlan A, Nicholson K, Yegneswaran B, Sabatowski R. Systematic review of the quality and generalizability of studies on the effects of opioids on driving and cognitive/psychomotor performance. Clin J Pain. 2012;28:542–55. doi:10.1097/AJP.0b013e3182385332.
   PubMed Web of Science ®Google Scholar
• Seim L, Vijapura P, Pagali S, Burton MC. Common substance use disorders in older adults. Hosp Pract. 2020;48:48–55. doi:10.1080/21548331.2020.1733287.
   PubMedGoogle Scholar
• Guerriero F. Guidance on opioids prescribing for the management of persistent non-cancer pain in older adults. World J Clin Cases. 2017;5:73–81. doi:10.12998/wjcc.v5.i3.73.
   PubMed Web of Science ®Google Scholar
• Park J, Lavin R. Risk factors associated with opioid medication misuse in community-dwelling older adults with chronic pain. Clin J Pain. 2010;26:647–55. doi:10.1097/AJP.0b013e3181e94240.
   PubMed Web of Science ®Google Scholar
• Levi-Minzi MA, Surratt HL, Kurtz SP, Buttram ME. Under treatment of pain: a prescription for opioid misuse among the elderly? Pain Med. 2013;14:1719–29. doi:10.1111/pme.12189.
   PubMed Web of Science ®Google Scholar
• Rosen D, Smith ML, Reynolds CF, III. The prevalence of mental and physical health disorders among older methadone patients. Am J Geriatric Psychiatry. 2008;16:488–97. doi:10.1097/JGP.0b013e31816ff35a.
   PubMed Web of Science ®Google Scholar
• Volkow ND, McLellan AT. Opioid abuse in chronic pain — misconceptions and mitigation strategies. N Engl J Med. 2016;374:1253–63. doi:10.1056/NEJMra1507771.
   PubMed Web of Science ®Google Scholar
• Grey C, Hall PB. Considerations of prescription opioid abuse and misuse among older adults in West Virginia–an under-recognized population at risk. W V Med J. 2016;112:42–47.
   PubMedGoogle Scholar
• Musich S, Wang SS, Slindee L, Kraemer S, Yeh CS. Prevalence and characteristics associated with high dose opioid users among older adults. Geriatr Nurs (Minneap). 2019;40:31–36. doi:10.1016/j.gerinurse.2018.06.001.
   Web of Science ®Google Scholar
• Odani S, Lin LC, Nelson JR, Agaku IT. Misuse of prescription pain relievers, stimulants, tranquilizers, and sedatives among U.S. Older adults aged ≥50 years. Am J Prev Med. 2020;59:860–72. doi:10.1016/j.amepre.2020.04.028.
   PubMed Web of Science ®Google Scholar
• Cochran G, Rosen D, McCarthy RM, Engel RJ. Risk factors for symptoms of prescription opioid misuse: do older adults differ from younger adult patients? J Gerontol Soc Work. 2017;60:443–57. doi:10.1080/01634372.2017.1327469.
   PubMed Web of Science ®Google Scholar
• Han BH, Sherman SE, Palamar JJ. Prescription opioid misuse among middle-aged and older adults in the United States, 2015–2016. Prev Med. 2019;121:94–98. doi:10.1016/j.ypmed.2019.02.018.
   PubMed Web of Science ®Google Scholar
• Substance Abuse and Mental Health Services Administration. Substance abuse among older adults. Rockville (MD): Center for Substance Abuse Treatment; 1998. https://www.ncbi.nlm.nih.gov/books/NBK64419/.
   Google Scholar
• Davidson J. Unseen face of the opioid epidemic: drug abuse among the elderly grows. The Washington Post; 2018. https://www.washingtonpost.com/news/powerpost/wp/2018/05/25/unseen-face-of-the-opioid-epidemic-drug-abuse-among-the-elderly-grows/.
   Google Scholar
• Olfson M, Wang S, Iza M, Crystal S, Blanco C. National trends in the office-based prescription of schedule II opioids. J Clin Psychiatry. 2013;74:12455. doi:10.4088/JCP.13m08349.
   Web of Science ®Google Scholar
• Becker WC, Tobin DG, Fiellin DA. Nonmedical use of opioid analgesics obtained directly from physicians: prevalence and correlates. Arch Intern Med. 2011;171:1034–36. doi:10.1001/archinternmed.2011.217.
   PubMed Web of Science ®Google Scholar
• Schuler MS, Dick AW, Stein BD. Heterogeneity in prescription opioid pain reliever misuse across age groups: 2015–2017 national survey on drug use and health. J Gen Intern Med. 2020;35:792–99. doi:10.1007/s11606-019-05559-6.
   PubMed Web of Science ®Google Scholar
• Shastay A. Opioid abuse in older adults. Home Healthcare Now. 2020;38:336–37. doi:10.1097/NHH.0000000000000930.
   PubMedGoogle Scholar
• Schepis TS, McCabe SE. Prescription tranquilizer/sedative sources for misuse in older adults. Subst Use Misuse. 2019;54:1908–12. doi:10.1080/10826084.2019.1613434.
   PubMed Web of Science ®Google Scholar
• Beaudoin FL, Merchant RC, Clark MA. Prevalence and detection of prescription opioid misuse and prescription opioid use disorder among emergency department patients 50 years of age and older: performance of the prescription drug use questionnaire, patient version. Am J Geriatric Psychiatry. 2016;24:627–36. doi:10.1016/j.jagp.2016.03.010.
   PubMed Web of Science ®Google Scholar
• National Institute on Drug Abuse. South Carolina: Opioid-Involved Deaths and Related Harms; 2020. https://www.drugabuse.gov/drug-topics/opioids/opioid-summaries-by-state/south-carolina-opioid-involved-deaths-related-harms.
   Google Scholar
• Centers for Disease Control and Prevention. PDMPs: what States Need to Know 2021. https://www.cdc.gov/drugoverdose/pdmp/index.html.
   Google Scholar
• Prescription Drug Monitoring Program. 2017.
   Google Scholar
• Ball SJ, Simpson K, Zhang J, Marsden J, Heidari K, Moran WP, Mauldin PD, McCauley JL. High-risk opioid prescribing trends: prescription drug monitoring program data from 2010 to 2018. J Public Health Manage Pract. 2021;27:379–84. doi:10.1097/PHH.0000000000001203.
   PubMed Web of Science ®Google Scholar
• Schumann SO, Zhang J, McCauley JL, Heidari K, Ball SJ. Effect of payor-mandated review of prescription drug monitoring program on opioid prescriber rates. South Med J. 2020;113:415–17. doi:10.14423/SMJ.0000000000001139.
   PubMed Web of Science ®Google Scholar
• Cohen J. Statistical power analysis for the behavioral sciences. New York: Routledge; 2013.
   Google Scholar
• Melfi CA, Croghan TW. Use of claims data for research on treatment and outcomes of depression care. Med Care. 1999;37:AS77–AS80. doi:10.1097/00005650-199904001-00010.
   PubMed Web of Science ®Google Scholar
• Sullivan MD, Edlund MJ, Fan M-Y, DeVries A, Brennan Braden J, Martin BC. Risks for possible and probable opioid misuse among recipients of chronic opioid therapy in commercial and medicaid insurance plans: the TROUP study. Pain. 2010;150:332–39. doi:10.1016/j.pain.2010.05.020.
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. Vital signs: overdoses of prescription opioid pain relievers and other drugs among women--United States, 1999–2010. Morbidity Mortality Weekly Rep. 2013;62:537–42.
   PubMed Web of Science ®Google Scholar
• Logan J, Liu Y, Paulozzi L, Zhang K, Jones C. Opioid prescribing in emergency departments: the prevalence of potentially inappropriate prescribing and misuse. Med Care. 2013;51:646–53. doi:10.1097/MLR.0b013e318293c2c0.
   PubMed Web of Science ®Google Scholar
• Mack KA, Zhang K, Paulozzi L, Jones C. Prescription practices involving opioid analgesics among Americans with medicaid, 2010. J Health Care Poor Underserved. 2015;26:182. doi:10.1353/hpu.2015.0009.
   PubMed Web of Science ®Google Scholar
• Bohnert AS, Valenstein M, Bair MJ, Ganoczy D, McCarthy JF, Ilgen MA, Blow FC. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA. 2011;305:1315–21. doi:10.1001/jama.2011.370.
   PubMed Web of Science ®Google Scholar
• Baumblatt JAG, Wiedeman C, Dunn JR, Schaffner W, Paulozzi LJ, Jones TF. High-risk use by patients prescribed opioids for pain and its role in overdose deaths. JAMA Intern Med. 2014;174:796–801. doi:10.1001/jamainternmed.2013.12711.
   PubMed Web of Science ®Google Scholar
• Han BH, Le A, Funk-White M, Palamar JJ. Cannabis and prescription drug use among older adults with functional impairment. Am J Prev Med. 2021;61:246–50. doi:10.1016/j.amepre.2021.01.042.
   PubMed Web of Science ®Google Scholar
• Tampi RR, Chhatlani A, Ahmad H, Balaram K, Dey J, Escobar R, Lingamchetty T. Substance use disorders among older adults: a review of randomized controlled pharmacotherapy trials. World J Psychiatry. 2019;9:78–82. doi:10.5498/wjp.v9.i5.78.
   PubMed Web of Science ®Google Scholar
• Kim Y, Kim K, Chartier KG, Wike TL, McDonald SE. Adverse childhood experience patterns, major depressive disorder, and substance use disorder in older adults. Aging Ment Health. 2021;25:484–91. doi:10.1080/13607863.2019.1693974.
   PubMed Web of Science ®Google Scholar
• Calcaterra SL, Scarbro S, Hull ML, Forber AD, Binswanger IA, Colborn KL. Prediction of future chronic opioid use among hospitalized patients. J Gen Intern Med. 2018;33:898–905. doi:10.1007/s11606-018-4335-8.
   PubMed Web of Science ®Google Scholar
• Chaudhary MA, Dalton MK, Koehlmoos TP, Schoenfeld AJ, Goralnick E. Identifying patterns and predictors of prescription opioid use after total joint arthroplasty. Mil Med. 2021;186:587–92. doi:10.1093/milmed/usaa573.
   PubMed Web of Science ®Google Scholar
• Chaudhary MA, von Keudell A, Bhulani N, de Jager EC, Kwon NK, Koehlmoos T, Haider AH, Schoenfeld AJ. Prior prescription opioid use and its influence on opioid requirements after orthopedic trauma. J Surg Res. 2019;238:29–34. doi:10.1016/j.jss.2019.01.016.
   PubMed Web of Science ®Google Scholar
• Dalton MK, Chaudhary MA, Andriotti T, Sturgeon D, Learn PA, Jarman MP, Weissman JS, Goralnick E. Patterns and predictors of opioid prescribing and use after rib fractures. Surgery. 2020;168:684–89. doi:10.1016/j.surg.2020.05.015.
   PubMed Web of Science ®Google Scholar
• Fields AC, Cavallaro PM, Correll DJ, Rubin MS, Sequist T, Khawaja A, Yao Y, Bordeianou LG, Bleday R. Predictors of prolonged opioid use following colectomy. Dis Colon Rectum. 2019;62:1117–23. doi:10.1097/DCR.0000000000001429.
   PubMed Web of Science ®Google Scholar
• Lalic S, Gisev N, Bell JS, Korhonen MJ, Ilomäki J. Predictors of persistent prescription opioid analgesic use among people without cancer in Australia. Br J Clin Pharmacol. 2018;84:1267–78. doi:10.1111/bcp.13556.
   PubMed Web of Science ®Google Scholar
• Lentz TA, Rhon DI, George SZ. Predicting opioid use, increased health care utilization and high costs for musculoskeletal pain: what factors mediate pain intensity and disability? J Pain. 2020;21:135–45. doi:10.1016/j.jpain.2019.06.004.
   PubMed Web of Science ®Google Scholar
• Rhon DI, Snodgrass SJ, Cleland JA, Sissel CD, Cook CE. Predictors of chronic prescription opioid use after orthopedic surgery: derivation of a clinical prediction rule. Perioperative Med. 2018;7:25. doi:10.1186/s13741-018-0105-8.
   Web of Science ®Google Scholar
• Tucker JS, Davis JP, Seelam R, Stein BD, D’Amico EJ. Predictors of opioid misuse during emerging adulthood: an examination of adolescent individual, family and peer factors. Drug Alcohol Depend. 2020;214:108188. doi:10.1016/j.drugalcdep.2020.108188.
   PubMed Web of Science ®Google Scholar
• Vitzthum LK, Riviere P, Sheridan P, Nalawade V, Deka R, Furnish T, Mell LK, Rose B, Wallace M, Murphy JD. Predicting persistent opioid use, abuse, and toxicity among cancer survivors. JNCI: J Nat Cancer Inst. 2020;112:720–27. doi:10.1093/jnci/djz200.
   PubMedGoogle Scholar
• Huhn AS, Strain EC, Tompkins DA, Dunn KE. A hidden aspect of the U.S. opioid crisis: rise in first-time treatment admissions for older adults with opioid use disorder. Drug Alcohol Depend. 2018;193:142–47. doi:10.1016/j.drugalcdep.2018.10.002.
   PubMed Web of Science ®Google Scholar
• Henderson AW, Babu KM, Merchant RC, Beaudoin FL. Prescription opioid use and misuse among older adult Rhode Island hospital emergency department patients. R I Med J. 2015;98:28.
   Google Scholar
• Rose AJ, McBain R, Schuler MS, LaRochelle MR, Ganz DA, Kilambi V, Stein BD, Bernson D, Chui KKH, Land T, et al. Effect of age on opioid prescribing, overdose, and mortality in Massachusetts, 2011 to 2015. J Am Geriatr Soc. 2019;67:128–32. doi:10.1111/jgs.15659.
   PubMed Web of Science ®Google Scholar
• Chhatre S, Cook R, Mallik E, Jayadevappa R. Trends in substance use admissions among older adults. BMC Health Serv Res. 2017;17:584. doi:10.1186/s12913-017-2538-z.
   PubMed Web of Science ®Google Scholar
• West NA, Dart RC. Prescription opioid exposures and adverse outcomes among older adults. Pharmacoepidemiol Drug Saf. 2016;25:539–44. doi:10.1002/pds.3934.
   PubMed Web of Science ®Google Scholar