Advanced search
Publication Cover
The American Journal of Drug and Alcohol Abuse
Encompassing All Addictive Disorders
Volume 49, 2023 - Issue 2
Submit an article Journal homepage
177
Views
1
CrossRef citations to date
0
Altmetric
Letter to the Editor

Successful treatment of dextromethorphan use disorder with combined naltrexone and gabapentin: a case report

Nicole Ledwosa Centre for Complex Interventions, Centre for Addiction and Mental Health (CAMH), Toronto, ON, CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8604-3313View further author information
ORCID Icon,
Aurelia I. Andreievb Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaView further author information
,
Tianna Costac Pharmacy Services, Centre for Addiction and Mental Health (CAMH), Toronto, ON, CanadaView further author information
,
Nitin Choprab Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaView further author information
&
Tony P. Georgea Centre for Complex Interventions, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada;b Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaORCID Iconhttps://orcid.org/0000-0003-1645-9767View further author information
ORCID Icon
Pages 266-267 | Received 07 Oct 2022, Accepted 29 Jan 2023, Published online: 15 Mar 2023

References

  • Karami S, Major JM, Calderon S, McAninch JK. Trends in dextromethorphan cough and cold products: 2000–2015 National Poison Data System intentional abuse exposure calls. Clin Toxicol. 2018 July 03;56:656–63. doi:10.1080/15563650.2017.1416124.
  • Romanelli F, Smith KM. Dextromethorphan abuse: clinical effects and management. J Am Pharm Assoc. 2009 Mar-Apr;49:e20–7. doi:10.1331/JAPhA.2009.08091.
  • PubChem Compound Summary for CID 5360696, Dextromethorphan. National Center for Biotechnology Information; [accessed 2022 June 16]. https://pubchem.ncbi.nlm.nih.gov/compound/Dextromethorphan
  • Schifano F, Chiappini S, Miuli A, Mosca A, Santovito MC, Corkery JM, Guirguis A, Pettorruso M, Di Giannantonio M, Martinotti G. Focus on over-the-counter drugs’ misuse: a systematic review on antihistamines, cough medicines, and decongestants. Front Psychiatry. 2021;12:657397. doi:10.3389/fpsyt.2021.657397.
  • Majeed A, Xiong J, Teopiz KM, Ng J, Ho R, Rosenblat JD, Phan L, Cao B, McIntyre RS. Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials. Expert Opin Emerg Drugs. 2021 Mar;26:63–74. doi:10.1080/14728214.2021.1898588.
  • Sills GJ, Rogawski MA. Mechanisms of action of currently used antiseizure drugs. Neuropharmacology. 2020 May 15;168:107966. doi:10.1016/j.neuropharm.2020.107966.
  • Quadir SG, Cottone P, Sabino V. Role of sigma receptors in alcohol addiction. Front Pharmacol. 2019;10:687. doi:10.3389/fphar.2019.00687.
  • Anton RF, Myrick H, Wright TM, Latham PK, Baros AM, Waid LR, Randall PK. Gabapentin combined with naltrexone for the treatment of alcohol dependence. Am J Psychiatry. 2011 Jul;168:709–17. doi:10.1176/appi.ajp.2011.10101436.
  • Martinak B, Bolis RA, Black JR, Fargason RE, Birur B. Dextromethorphan in cough syrup: the poor man’s psychosis. Psychopharmacol Bull. Sep 15 2017;47:59–63.
  • O’malley SS, Krishnan-Sarin S, Farren C, Sinha R, Kreek MJ. Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis. Psychopharmacol (Berl). 2002 Feb;160:19–29. doi:10.1007/s002130100919.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.