METABOLISM OF TERRITREM A IN LIVER MICROSOMES FROM MALE WISTAR RATS: 3. CYTOCHROME P-450 ISOFORMS CATALYZING TRA METABOLISM

References

• Stephen , F. T. , Himanshu , P. , Elam , S. and Ceil , M. R. 1991 . Lanosterol 14a-demethyla6e (P450)4DM>: Effects of P450TWM inhibitors on terol biosynthesis downstream of lanosterol . Lipid Res. , 32 : 893902.
   Google Scholar
• Szedlacsek , S. E. , Duggleby , R. G. and Vlad , M. O. 1991 . Enzyme catalysis as a chain reaction . Biohem. J , 279 : 855 – 861 .
   PubMedGoogle Scholar
• Testa , B. and Jenner , P. 1981 . Inhibitors of cytochrome P4S0s and their mechanism of action . Drug Metab. Rev. , 12 : 1 – 117 .
   PubMed Web of Science ®Google Scholar
• Towbin , H. , Staehelin , T. and Gordon , J. 1979 . Electrqphoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications . Proc. Nntl. .Acad. ScI. USA , 76 : 435.0 – 4354 .
   Google Scholar
• Zeng. , Z. , Andrew , N. W. and Halley , S. A. 1997 . Identification of cytochrome P4503A as the major enzyme sub-family responsible for the metabolism of 22,23-dihydro-13-O-|(2-me"hoxyethoxy>mediyil-avermectin B1 aglycone by rat liver microsomes . Xenobiotica , 27 : 985 – 994 .
   PubMedGoogle Scholar
• Reidy , G. F. , Mehla , I. and Murray , M. 1989 . Inhibition of oxidattve drug metabolism by orphenadrine: in vitro and In vivo evidence for isoenzyme-specific complexation of cytochrome P-450 and inhibition kinetics . MoI. Pharmacol. , 35 : 736 – 743 .
   PubMed Web of Science ®Google Scholar
• Rendis , S. , Sunjic , V. , r Toso , R. and Kajfez , F. 1979 . Interaction of cimetitjine with liver micrasomes . Xenobiottca , 9 : 555 – 564 .
   PubMedGoogle Scholar
• Ryan , D. E. , Thomas , P. E and Korzeniowski , D. 1979 . Separation and characterization of highly purified, forms of liver microsomal cylochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital and 3-methylcholanthrene . Biol. Chem. , 254 : 1365 – 1374 .
   Google Scholar
• Akhtar , M. , Njar. , V. C. and Wright , J. N. 1993 . Mechanistic studies on aromatase and related C-C bond cleaving P-450 enzymes . Steroid Biachem. Mol. Biol. , 44 : 375 – 387 .
   PubMed Web of Science ®Google Scholar
• Alexander. , W. W. , Dene. , E. R. , Paul , E. T. and Wayne , L. 1983 . Regio and1 stereo-selective metabolism of two C1, steroids by five highly purified and reconstituted ral hepatic cytochrome P450 isozymes . J Biol. Chem. , 258 : 8839 – 8847 .
   PubMed Web of Science ®Google Scholar
• Alvares , A. P. and Mannering , C. J. 1970 . Two-substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes . MoI. Pharmacol. , 6 : 206 – 212 .
   PubMed Web of Science ®Google Scholar
• Ander , M , Mannering , W. and G. I. 1966 . Inhibition of drug metabolism. I. Kinetics of the inhibition of the N-demethylation of ethylmorphine by 2-diethytaminoethyl 2,2-diphenylvalerate-HCI ISKF 525A1 And related compounds . Mot Pharmacol. , 2 : 319 – 327 .
   PubMed Web of Science ®Google Scholar
• Arlotto , M. P. , .Sonderfan , A. J. , Kiaassen , C D. and Parkinson , A. 1987 . Studies on the pregnendone 16a-carbonltrile-inducible form of rat liver microsomal P450 and1 UDP-glocuronyltrarisferase . Biochem. Phamacol. , 36 : 3859 – 3866 .
   PubMed Web of Science ®Google Scholar
• Ales , Z. , Suzen. , S. , Buyukbingol , L , Can , E. B. and Iscan. , M. 1997 . Effects of a benzimidazole compound on monnoxygenase activities . Farmacogie , 52 : 703 – 706 .
   PubMedGoogle Scholar
• Buening , M. K. and Franklin , M. R. 1976 . SKF 525-A Inhibition, induction and 542 nm complex formation . Drug Metab. Dlspos. , 4 : 244 – 255 .
   PubMed Web of Science ®Google Scholar
• Chang , T , Levine , M. , Bandiera. , 5. M. , Bel , I and ward , C. D. 1492a . Selective inhibition of W hepatic microsomal cytochrome P-450.1 . Effect of the in vim administration of cimelidine, Pharmamt. Exp.Ther. , 260 : 1441 – 1449 .
   Google Scholar
• Chang. , I. , Levine , M and Bellward , Q. D. 1992b . Selective inhibition of. ral. hepatic mlcrosomal cytachrome P-450. II. Effect of the in vHro administration of cimetidine . J. pharmacot. Exp. Ther. , 260 : 1450 – 1455 .
   PubMed Web of Science ®Google Scholar
• Fischer , R. T. , Stam , S. H. , Johnson , P. R. , Ko , S. S. , Magolda , R. L , GayJor , J. L. and Trzaskos , J. M. 1989 . Mechanistic studies of lanosterol 140-methyl demelhylase: Substrate requirements for the component reactions catalyzed by a single cytochrome P-450 isozyrne . Jjpkl Kes. , 30 : 1621 – 1632 .
   Google Scholar
• Gonzalez , F , Neben , J. , Hardwick , D. W. , Kasper , J. P. and C. B. 1985 . Complete cDNA and protein sequence of a pregnenolone 16o-carbonitrile-lnduced cytochrome P-450. A representative of a new gene family . Biol. Chem. , 260 : 7435 – 7441 .
   Google Scholar
• Gonzalez , F. J. , Song , B. J. and Hardwick , J. P. 1986 . Pregnenolone 16a-carbonltrile-inducible P-450 gene family: Gene conversion and differential regulation . Mol. Cell Biol. , 6 : 2969 – 2976 .
   PubMed Web of Science ®Google Scholar
• Cuengerich , F. P. , Wang , P. and Davidson , N. K. 1982 . Estimation of isoenzymes of microsomal cytochrame P-450 in rats, rabbit, and human using irnmunochemical staining coupled with sodium dodecyl sulfate electrophoresis . Biochemistry , 21 : 1698 – 1706 .
   PubMedGoogle Scholar
• Hayes , J. R. , Mgjbodile. , M. U. K. and Campbell , T. C. 1973 . Effect on protein deficiency on the inducibuity of the hepatic mictosomal drug-metabolizing enzyme system-I. effect on substrate interaction with cytochrome P-450. flfodiem . Pharmacol , 22 : 1005 – 1014 .
   Google Scholar
• Kamataki , T. , Maeda , K. , Yamazoe , Y. , Nagai , T. and Karo , R. 1983 . Sex difference of cytochrome P450 in the rar. Purification, characterization, and quantitatton of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats . Arch. Blochem. Btophys. , 255 : 758 – 770 .
   Google Scholar
• Kato , R. and Yarfiazoe , Y. 1992 . Sex specific cytochrome P450 as a cause of sex-and species-related differences In drug toxicity . Toxlcol. Lea. , 64/65 : 661 – 667 .
   Web of Science ®Google Scholar
• Laemmli , U. K. 1970 . Cleavage of structural proteins during the assembly of me head of bacteriophage T1 . Nature , 227 : 680 – 685 .
   PubMed Web of Science ®Google Scholar
• Ling , K. H. 1994 . Terrttrem, tremorgenic mycotoxins isolated from Asperglllus tetreus.J . Taxtcol. Toxin Rev. , 13 : 243 – 252 .
   Web of Science ®Google Scholar
• Ling , K. H. , Yang , C. K. and Peng , F. T. 1979 . Territrem, tremorgenic mycotoxins of Aspergillus terreus . Appt. Environ. Mlcroblol. , 37 : 355 – 357 .
   PubMed Web of Science ®Google Scholar
• Lowry , O. K , Rosebrough , N. , Fair , A. L and Randall , R. I. 1951 . Protein determinations with FoIIn phenol reagent.J . Biol. Chem. , 193 : 265 – 275 .
   Web of Science ®Google Scholar
• Negata , K. , Gonzalez , F. I , Yamazoe , Y. and Kato , R. 1990 . Purification and characterization of four catalytically active testosterone 6ß-hydroxylase P450s from rat liver microsomes: Comparison of a novel form with three structurally and functionally related forms . Biochent. , 107 : 716 – 725 .
   Web of Science ®Google Scholar
• Omar , R. F. , Gelboin , H. V. and Rahimtula , A. D. 1996 . 'Effect of cytochrome P450 induction on the metabolism and toxlcity of ochratoxln A . Bochern, Pharmacol. , 51 : 207 – 216 .
   PubMed Web of Science ®Google Scholar
• Omura , T. and Sato , R. 1964 . The carbon monoxide-binding pigment of liver micrasomes I. Evidence for Its hemoprotein nature . J. BioI. Chem. , 239 : 2370 – 2378 .
   PubMed Web of Science ®Google Scholar
• Peng , F. C , Un Wu , S. W and Wan , B. L. 2001 . Metabolism of TRA in liver microsomes from male Wistar rats: (1 ) Identification of mctabolites.and their metabolic pathway . Toxical. Environ. Health A , 64 : 101 – 115 .
   Google Scholar
• Phillips , A. H and Langdon , R. G. 1962 . Hepatic triphosphopyridine nucleotide-cytochrome c reductase: Isolation, characterization and kinetic studies . Biol, Chem. , 237 : 2652 – 2660 .
   Google Scholar