FUNCTIONALIZED CHITOSAN AND ITS USE IN PHARMACEUTICAL, BIOMEDICAL, AND BIOTECHNOLOGICAL RESEARCH

References

• Abdel-Naby , M. A. , Ismail , A. M. S. , Abdel-Fattah , A. M. , and Abdel-Fattah , A. F. ( 1999 ). Preparation and some properties of immobilized Penicillinum funiculosum 258 destranase , Process Biochem. , 34 , 391 – 398 .
   Google Scholar
• Aiedeh , K. M. , Taha , M. O. , Al-Hiari , Y. , Bustanji , Y. , and Alkhatib , H. S. ( 2007 ). Effect of ionic crosslinking on the drug release properties of chitosan diacetate matrices , J. Pharm. Sci. , 96 ( 1 ), 38 – 43 .
   PubMed Web of Science ®Google Scholar
• Aly , A. S. ( 1998 ). Self-dissolving chitosan. I: Preparation, characterization and evaluation for drug delivery system , Angew. Makromol. Chem. , 259 , 13 – 18 .
   Google Scholar
• Azevedo , E. P. , Saldanha , T. D. P. , Navarro , M. V. M. , Medeiros , A. C. , Ginani , M. F. , and Raffin , F. N. (2006). Mechanical properties and release studies of chitosan fils impregnated with silver sulfadiazine, J. Appl. Polym. Sci. , 102(4), 3462–3470.
   Web of Science ®Google Scholar
• Bernkop-Schnürch , A. , Giggi , D. , and Pinter , Y. ( 2004 ). Thiolated chitosans: An oral drug delivery system , J. Control. Release , 94 , 177 – 186 .
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch , A. , Paikl , C. , and Valenta , C. ( 1997 ). Novel bioadhesive chitosan–EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase N , Pharm. Res. , 14 , 917 – 922 .
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch , A. , Telsning , J. , and Hornof , M. ( 2003 ). Development and in vitro evaluation of a mucoadhesive oral delivery system for antisense oligonucleotides , Sci. Pharm. , 71 , 165 – 177 .
   Google Scholar
• Bersch , P. C. , Nies , B. , and Liebrndorfer , A. ( 1995 ). In vivo evaluation of biocompatibility of different wound dressing materials , J. Mater. Sci. Mater. Med. , 6 ( 4 ), 201 – 205 .
   Google Scholar
• Berscht , P. C. , Nies , B. , Liebendörfer , A. , and Kreuter , J. ( 1995 ). In vivo evaluation of biocompatibility of different wound dressing materials , J. Mater. Sci. Mater. Med. , 6 ( 4 ), 201 – 205 .
   Web of Science ®Google Scholar
• Boden , S. D. ( 2002 ). Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute , Eur. Spine J. , 27 ( Suppl. 16 ), 26 – 31 .
   Google Scholar
• Bolgul , Y. , Hekimoglu , S. , Sahinerdemli , I. , and Kas , H. S. ( 1998 ). Evaluation of oxprenolol hydrochloride permeation through isolated human skin and pharmacodynamic effect in rats, STP , Pharm. Sci. , 8 , 197 – 201 .
   Google Scholar
• Bugamelli , F. , Raggi , M. A. , Orienti , I. , and Zecchi , V. ( 1998 ). Controlled insulin release from chitosan microparticles , Arch. Pharm. , 331 , 133 – 138 .
   PubMed Web of Science ®Google Scholar
• Burger , C. , Valcarenghi , D. , Sandri , S. , and Rodrigues , C. A. ( 2001 ). Cross-linking chitosan-Fe(III), an oral phosphate binder: Studies in vitro and in vivo , Int J. Pharm. , 223 , 29 – 33 .
   PubMed Web of Science ®Google Scholar
• Campos , M. , Cordi , L. , Duran , N. , and Mei , L. ( 2006 ). Antibacterial activity of chitosan solution for wound dressing , Macromol. Symp. , 245–246 ( 1 ), 515 – 518 .
   Google Scholar
• Carvalho , G. M. J. , Alves , T. L. M. , and Freire , D. M. G. ( 2000 ). L-DOPA production by immobilized tyrosinase , Appl. Biochem. Biotechnol. , 84 , 791 – 800 .
   PubMed Web of Science ®Google Scholar
• Cerchiara , T. , Luppi , B. , Bigucci , F. , and Zecchi , V. ( 2003 ). Chitosan salts as nasal sustained delivery systems for peptidic drugs , J. Pharm. Pharmacol. , 55 , 1623 – 1627 .
   PubMed Web of Science ®Google Scholar
• Chow , K. S. , Khor , E. , and Wan , A. C. A. ( 2001 ). Porous chitin matrices for tissue engineering: Fabrication and in-vico cytotoxic assessment , J. Polym. Res. , 8 , 27 – 35 .
   Web of Science ®Google Scholar
• Chung , T. W. , Yang , J. , Akaike , T. , Cho , K. Y. , Nah , J. W. , Kim , S. I. , and Cho , C. S. ( 2002 ). Preparation of alginate/galactosylated chitosan scaffold for hepatocyte attachment , Biomaterials , 23 , 2827 – 2834 .
   PubMed Web of Science ®Google Scholar
• Dal Pozzo , A. , Vanini , L. , Fagnoni , M. , Guerrini , M. , De Benedittis , A. , and Muzzarelli , R. ( 2000 ). Preparation and characterization of poly(ethylene glycol)-crosslinked reacetylated chitosans , Carbohydr. Polym. , 42 , 201 – 206 .
   Google Scholar
• Denkbas , E. B. , Seyyal , M. , and Piskin , E. ( 2000 ). Implantable 5-fluorouracil loaded chitosan scaffolds prepared by wet spinning , J. Membr. Sci. , 172 , 33 – 38 .
   Web of Science ®Google Scholar
• Diebold , Y. , Jarrin , M. , Saez , V. , Carvalho , L. S. E. , Orea , M. , Calonge , M. , Seijo , B. , and Alonso , J. M. ( 2006 ). Ocular drug delivery by liposome-chitosan nanoparticle complexes (LCS-NP) , Biomaterials , 28 , 1553 – 1564 .
   PubMed Web of Science ®Google Scholar
• Diedeh , K. M. , Taha , M. O. , Al-Hiari , Y. , Bustanji , Y. , and Alkhatib , S. H. ( 2007 ). Effect of ionic crosslinking on the drug release properties of chitosan diacetate matrices , J. Pharm Sci. , 96 ( 1 ), 38 – 43 .
   PubMed Web of Science ®Google Scholar
• Don , T. M. , King , C. F. , and Chiu , W. Y. ( 2002 ). Synthesis and properties of chitosan-modified poly(vinyl acetate) , J. Appl. Polym. Sci. , 86 ( 12 ), 3057 – 3063 .
   Web of Science ®Google Scholar
• Drury , J. L. and Mooney , D. J. ( 2003 ). Hydrogels for tissue engineering: Scaffold design variables and applications , Biomaterials , 24 , 4337 .
   PubMed Web of Science ®Google Scholar
• El-Gibaly , I. ( 2002 ). Development and in vitro evaluation of novel floating chitosan microcapsules for oral use: Comparison with non-floating chitosan microspheres , Int. J. Pharm. , 5 , 7 – 21 .
   Google Scholar
• Felt , O. , Buri , P. , and Gurny , R. (1998). Chitosan: A unique polysaccharide for drug delivery, Drug Dev. Ind. Pharm. , 24, 978–993.
   Google Scholar
• Fernandez-Urrusuno , R. , Cavlo , P. , Remunan-Lopez , C. , Vila-Jato , J. L. , and Alonso , M. J. ( 1999 ). Enhancement of nasal absorption of insulin using chitosan nanoparticles , Pharm. Res. , 16 , 1576 – 1581 .
   PubMed Web of Science ®Google Scholar
• Filipovic-Grcic , J. , Voinovich , D. , Moneghini , M. , Becirevic-Lacan , M. , Magarotto , L. , and Jalsenjak , I. ( 2000 ). Chitosan microspheres with hydrocortisone and hydrocortisone-hydroxyproply-β-cyclodextrin inclusion complex , Eur. J. Pharm. Sci. , 9 , 373 – 379 .
   PubMed Web of Science ®Google Scholar
• Fini , A. and Orienti , I. ( 2003 ). The role of chitosan in drug delievery: Current and potential applications , Am. J. Drug Deliv. , 1 ( 1 ), 43 – 59 .
   Google Scholar
• Gavini , E. , Sanna , V. , Juliano , C. , Bonferoni , M. C. , and Giunchedi , P. ( 2002 ). Mucoadhesive vaginal tablets as veterinary delivery system for the controlled release of an antimicrobial drug, acriflavine , AAPS Pharm Sci Tech. , 3 , 20 .
   PubMedGoogle Scholar
• Genta , I. , Conti , B. , Perugini , P. , Pavanetto , F. , Spadaro , A. , and Puglisi , G. ( 1997 ). Bioadhesive microspheres for ophthalmic administration of acyclovir , J. Pharm. Pharmacol. , 49 , 737 – 742 .
   PubMed Web of Science ®Google Scholar
• Giunchedi , P. , Genta , I. , Conti , B. , Muzzarelli , R. A. A. , and Conte , U. ( 1998 ). Preparation and characterization of ampicillin loaded methylpyrrolidinone chitosan and chitosan microspheres , Biomaterials , 19 , 157 – 161 .
   PubMed Web of Science ®Google Scholar
• Giunchedi , P. , Juliano , C. , Gavini , E. , Cossu , M. , and Sorrenti , M. ( 2002 ). Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres , Eur. J. Pharm. Biopharm. , 53 , 233 – 239 .
   PubMed Web of Science ®Google Scholar
• Gong , H. P. , Zhong , Y. H. , Li , J. C. , Gong , Y. D. , Zhao , N. M. , and Zhang , X. F. ( 2000 ). Studies on nerve cell affinity of chitosan-derived materials , J. Biomed. Mater. Res. , 52 , 285 – 295 .
   PubMed Web of Science ®Google Scholar
• Harris , J. M. ( 1992 ). Poly(ethylene glycol) Chemistry: Biotechnical and Biomedical Application , Plenum Press , New York .
   Google Scholar
• Harris , J. M. ( 1997 ). Introduction to biomedical and biotechnical applications of polyethylene glycol , Papers Present. Meet. Am. Chem. Soc. Div. Polym. Chem. Polym. Prepr. , 38 , 520 – 521 .
   Google Scholar
• Harris , J. M. , Struck , E. C. , Case , M. G. , Paley , M. P. , Yalpani , M. , Van Alstine , J. M. , and Brooks , D. E. ( 1984 ). Synthesis and characterization of poly(ethylene glycol) derivatives , J. Polym. Sci. Part A Polym. Chem. , 22 , 341 – 352 .
   Web of Science ®Google Scholar
• He , P. , Davis , S. S. , and Illum , L. ( 1999 ). Chitosan microspheres prepared by spray drying , Int. J. Pharm. , 187 , 53 – 65 .
   PubMed Web of Science ®Google Scholar
• Horof , M. D. , Weyenberg , W. , Ludwig , A. , and Bernkop-Schnürch , A. ( 2003 ). A mucoadhesive ocular insert: Development and in vivo evaluation in humans , J. Control. Release , 89 , 419 – 428 .
   PubMed Web of Science ®Google Scholar
• Hoshino , M. , Namikawa , T. , Kato , M. , Terai , H. , Taguchi , S. , and Takaoka , K. ( 2007 ). Repair of bone defects in revision hip arthroplasty by implantation of a new bone-inducing material comprised of recombinant human BMP-2, Beta-TCP powder, and a biodegradable polymer: An experimental study in dogs , J. Orthop. Res. , 25 ( 8 ), 1042 – 1051 .
   PubMed Web of Science ®Google Scholar
• Hu , S. G. , Jou , C. H. , and Yang , M.C. ( 2003 ). Antibacterial and biodegradability properties of polyhydroxyalkanoates grafted with chitosan and chitooligosaccharides via ozone treatment , J. Appl. Polym. Sci. , 88 ( 12 ), 2797 – 2803 .
   Google Scholar
• Huh , M. W. , Kang , I. K. , Lee , D. H. , Kim , W. S. , Lee , D. H. , and Park , L. S. ( 2001 ). Preparation and antibacterial activity of PET/chitosan nanofibrous mats using an electrospinning technique , J. Appl. Polym. Sci. , 81 ( 11 ), 2769 – 2778 .
   Web of Science ®Google Scholar
• Ikada , Y. ( 1984 ). Blood-compatible polymers , Adv. Polym. Sci. , 57 ( 1 ), 103 – 115 .
   Google Scholar
• Illum , L. , Watts , P. , Fisher , A. N. , Gill , I. J. , and Davis , S. S. ( 2000 ). Novel chitosan-based delivery systems for the nasal administration of a LHRH analogue, STP , Pharm. Sci. , 10 , 89 – 94 .
   Google Scholar
• Jain , A. , Gupta , Y. , and Jain , S. K. (2007). Perspectives of biodegradable natural polysaccharide for site-specific drug delivery to the colon, J. Pharm. Pharm. Sci. , 10(1), 86–128.
   PubMed Web of Science ®Google Scholar
• Je , J. Y. and Kim , S. K. ( 2006 ). Reactive oxygen species scavenging activity of aminoderivatized chitosan with different degree of deacetylation , Bioorg. Med. Chem. , 14 , 5989 – 5994 .
   PubMed Web of Science ®Google Scholar
• Ji , X. , Zhong , Z. , Chen , X. , Xing , R. , Liu , S. , Wang , L. , and Li , P. ( 2007 ). Preparation of 1, 3, 5-thiadiazine-2-thione derivatives of chitosan and their potential antioxidant activity in vitro , Bioorg. Med. Chem. Lett. , 17 , 4275 – 4279 .
   PubMed Web of Science ®Google Scholar
• Jou , C. H. , Lin , S. M. , Hwang , M. C. , Yu , D. G. , Chou , W. L. , Lee , J. S. , and Yang , M. C. ( 2007 ). Biofunctional properties of polyester fibers grafted with chitosan and collagen , Polym. Adv. Technol. , 18 ( 3 ), 235 – 239 .
   Web of Science ®Google Scholar
• Jung , B. O. , Kim , C. H. , Choi , K. S. , Lee , Y. M. , and Kim , J. J. ( 1999 ). Preparation of amphiphilic chitosan and their antimicrobial activities , J. Appl. Polym. Sci. , 72 ( 13 ), 1713 – 1719 .
   Web of Science ®Google Scholar
• Kast , C. E. ( 2002 ). Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clotrimazole , J. Control. Release , 81 , 354 – 374 .
   Google Scholar
• Kawase , M. , Michibayashi , N. , Nakashima , Y. , Kurikawa , N. , Yagi , Y. , and Mizoguchi , T. ( 1997 ). Application of glutaraldehyde-crosslinked chitosan as a scaffold for hepatocyte attachment , Biol. Pharm. Bull. , 20 , 708 – 710 .
   PubMed Web of Science ®Google Scholar
• Kim , S. Y. , Cho , S. M. , Lee , Y. M. , and Kim , S. J. ( 2000 ). Thermo- and pH-responsive behaviors of graft copolymer and blend based on chitosan and N-isopropylacrylamide , J. Appl. Polym. Sci. , 78 ( 7 ), 1381 – 1391 .
   Web of Science ®Google Scholar
• Kim , Y. H. , Gihm , S. H. , Park , C. R. , Lee , K. Y. , Kim , T. W. , Chung , H. , Kwon , I. C. , and Jeong , S. Y. ( 2001 ). Structural characteristics of size-controlled self-aggregates of deoxycholic acid-modified chitosan and their application as a DNA delivery carrier , Bioconjug. Chem. , 12 , 932 – 938 .
   PubMed Web of Science ®Google Scholar
• Kim , I. Y. , Kim , S. J. , Shin , M. S. , Lee , Y. M. , Shin , D. I. , and Kim , S. I. ( 2002 ). pH- and thermal characteristics of graft hydogels based on chitosan and poly(dimethylsiloxane) , J. Appl. Polym. Sci. , 85 , 2661 – 2666 .
   Web of Science ®Google Scholar
• Kopatz , J. ( 2004 ). A model for non-viral gene delivery , J. Gene Med. , 6 , 769 – 776 .
   PubMed Web of Science ®Google Scholar
• Kosaraju , S. L. ( 2005 ). Colon targeted delivery systems: Review of polysaccharides for encapsulation and delivery , Crit. Rev. Food Sci. Nutr. , 45 ( 4 ), 251 – 258 .
   PubMed Web of Science ®Google Scholar
• Kumar , T. R. , Shanmugasundaram , N. , and Babu , M. ( 2003 ). Biocompatible collagen scaffolds from a human amniotic membrane: Physicochemical and in vitro culture characteristic , J. Biomater. Sci. , 14 ( 7 ), 689 – 706 .
   PubMed Web of Science ®Google Scholar
• Kumbar , S. G. and Amabhavi , T. M. ( 2003 ). Synthesis of modified chitosan microspheres , J. Appl. Polym. Sci. , 89 , 2940 – 2949 .
   Web of Science ®Google Scholar
• Kumbar , S. G. , Kulkarni , A. R. , and Aminabhavi , T. M. ( 2002 ). Crosslinked chitosan microspheres for encapsulation of diclofenac sodium: Effect of cross-linking agent , J. Microencapsul. , 19 , 173 – 180 .
   PubMed Web of Science ®Google Scholar
• Kweon , D. K. and Kang , D. W. ( 1999 ). Drug-release behavior of chitosan-g-poly(vinyl alcohol) copolymer matrix , J. Appl. Polym. Sci. , 74 ( 2 ), 458 – 464 .
   Google Scholar
• Lee , J. E. , Jeong , M. H. , Ahn , H. J. , Kim , J. K. , Choi , K. , Chang , C. B. , Kim , H. J. , Seong , S. C. , and Lee , M. C. ( 2005 ). Evaluation of chondrogenesis in collagen/chitosan/glycosaminoglycan scaffolds for cartilage tissue engineering , Tissue Eng. Regen. Med. , 2 ( 1 ), 41 – 49 .
   Google Scholar
• Lee , K. Y. , Kwon , I. C. , and Kim , Y. H. ( 1998 ). Chitosan self-aggregates as a gene delivery system , J. Control. Release , 51 , 213 – 220 .
   PubMed Web of Science ®Google Scholar
• Lee , T. C. J. and Sung , H. W. ( 1998 ). Chemical modification of biomedical materials with genipin, Patent WO 98/19718 .
   Google Scholar
• Leong , K. W. , Mao , H. Q. , Truong-Le , V. L. , Roy , K. , Walsh , S. M. , and August , J. T. ( 1998 ). DNS-polycation nanospheres as non-viral gene delivery vehicles , J. Control. Release , 53 , 183 – 193 .
   PubMed Web of Science ®Google Scholar
• Li , Y. , Liu , L. , and Fang , F. ( 2003 ). Plasma-induced grafting of hydroxyethyl methacrylate (HEMA) onto chitosan membranes by a swelling method , Polym. Int. , 52 ( 2 ), 285 – 290 .
   Web of Science ®Google Scholar
• Li , W. G. , Zhao , X. D. , Yao , K. D. , and Liu , Q. G. (2002). Atomic force characterization of the interaction forces between bovine serum albumin and cross-linked allkylated chitosan membranes in media of different pH, Polym. Int. , 51(12), 1459–1463.
   Google Scholar
• Liu , Y. , Cai , S. , Shu , X. Z. , Shelby , J. , and Prestwich , G. D. ( 2007 ). Realease of basic fibroblast growth factor from a crosslinked glycosaminoglycan hydrogel promotes wound healing , Wound Repair Regen. , 15 ( 2 ), 245 – 251 .
   PubMed Web of Science ®Google Scholar
• Liu , C. G. , Desai , H. G. K. , Chen , G. X. , and Park , J. H. ( 2004 ). Preparation and characterizaion of nanoparticles containing trypsin based on hydrophobically modified chitosan , J. Agric. Food Chem. , 53 ( 5 ), 1728 – 1733 .
   Google Scholar
• Liu , X. F. , Guan , Y. L. , Yang , D. Z. , Li , Z. , and Yao , K. D. ( 2001 ). Antibacterial action of chitosan and carboxymethylated chitosan , J. Appl. Polym. Sci. , 79 , 1324 – 1335 .
   Web of Science ®Google Scholar
• Lonso , M. J. and Sanchez , A. ( 2003 ). The potential of chitosan in ocular drug delivery , J. Pharm. Pharmacol. , 55 , 451 – 463 .
   Google Scholar
• Ma , J. , Wang , H. , He , B. , and Chen , J. ( 2001 ). A preliminary in vitro study on the fabrication and tissue engineering application of a novel chitosan bilayer material as a scaffold of human neofetal dermal fibroblasts , Biomaterials , 22 , 331 – 336 .
   PubMed Web of Science ®Google Scholar
• Madihally , S. V. and Matthew , H. W. T. ( 1999 ). Porous chitosan scaffolds for tissue engineering , Biomaterials , 20 ( 12 ), 1133 – 1142 .
   PubMed Web of Science ®Google Scholar
• Malafaya , P. B. , Pedro , A. J. , Peterbauer , A. , Gabriel , C. , Redl , H. , and Reis , R. L. ( 2005 ). Chitosan particles agglomerated scaffolds for cartilage and osteochondral tissue engineering approaches with adipose tissue derived stem cells , J. Mater. Sci. Mater. Med. , 16 ( 12 ), 1077 – 1085 .
   PubMed Web of Science ®Google Scholar
• Mansouri , M. , Lavigne , P. , Corsi , K. , Benderdour , M. , and Beaumont , E. ( 2004 ). Chitosan-DNA nanoparticles as non-viral vectors in gene therapy , Eur. J. Pharm. Biopharm. , 57 , 1 .
   PubMed Web of Science ®Google Scholar
• Mao , C. , Yuan , J. , Mei , H. , Zhu , A. , Shen , J. , and Lin , S. ( 2004a ). Introduction of photocrosslinkable chitosan to polyethylene film by radiation grafting and its blood compatibility , Mater. Sci. Eng. , C 24 ( 4 ), 479 – 485 .
   Google Scholar
• Mao , J. , Zhao , L. , Yao , K. , Shang , Q. , Yang , G. , and Cao , Y. ( 2002 ). Study of novel chitosan-gelatin artificial skin in vitro , J. Biomed. Mater. Res. , 64 A ( 2 ), 301 – 308 .
   Google Scholar
• Mao , C. , Zhao , W. B. , Zhu , A. P. , Shen , J. , and Lin , S. C. ( 2004b ). A photochemical method for the surface modification of poly(vinyl chloride) with O-butyrylchitosan to improve blood compatibility , Process Biochem. , 39 ( 9 ), 1151 – 1157 .
   Google Scholar
• Marie , E. , Landfester , K. , and Antonietti , M. ( 2002 ). Synthesis of chitosan-stabilized polymer dispersions, capsules, and chitosan grafting products via miniemulsion , Biomacromolecules , 3 , 475 – 481 .
   PubMed Web of Science ®Google Scholar
• Merkovich , E. A. , Carruette , M. L. , Babak , V. G. , Vikhoreva , G. A. , Gal'braikh , L. S. , and Kim , V. E. ( 2001 ). Kinetics of the initial stage of gelation in chitosan solutions containing glutaric aldehyde: Viscosimetric study , Colloid J. , 3 , 350 .
   Google Scholar
• Mi , F. L. , Sung , H. W. , and Shyu , S. S. ( 2002a ). Drug release from chitosan–alginate complex beads reinforced by a naturally occurring cross-linking agent , Carbohydr. Polym. , 48 , 61 – 72 .
   Web of Science ®Google Scholar
• Mi , F. L. , Tan , Y. C. , Liang , H. F. , and Sung , H. W. ( 2002b ). In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant , Biomaterials , 23 , 181 – 191 .
   PubMed Web of Science ®Google Scholar
• Mi , F. L. , Wu , Y. B. , Shyu , S. S. , Schoung , J. Y. , Huang , Y. B. , Tsai , Y. H. , and Hao , J. Y. ( 2001 ). Control of wound infection using a bilayer chitosan wound dressing with sustainable antibiotic delivery , J. Biomed. Mater. Res. , 59 ( 3 ), 438 – 449 .
   Google Scholar
• Miao , Y. , Chia , L. S. , Goh , N. K. , and Tan , S. N. ( 2001 ). Amperometric glucose biosensor based on immobilization of glucose oxidase in chitosan matrix cross-linked with glutaraldehyde , Electroanalysis , 13 , 347 – 349 .
   Web of Science ®Google Scholar
• Mizuno , K. , Yamamura , K. , Yano , K. , Osada , T. , Saeki , S. , Takimoto , N. , Sakurai T., and Nimura , Y. ( 2003 ). Effect of chitosan film containing basic fibroblast growth factor on wound healing in genetically diabetic mice , J. Biomed. Mater. Res. , 64 A ( 1 ), 177 – 181 .
   Google Scholar
• Mori , T. , Murakami , M. , Okumura , M. , Kadosawa , T. , Uede , T. , and Fujinaga T. (2005). Mechanism of macrophage activation by chitin derivatives, J. Vet. Med. Sci. , 67, 51.
   PubMed Web of Science ®Google Scholar
• Muzzarelli , R. A. A. ( 1989 ). Amphoteric derivatives of chitosan and their biological signifiance , in: Chitin and Chitosan: Sources, Chemistry, Biochemistry, Physical Properties, and Applications , eds. G. Skjåk-Braek , T. Anthonsen , and P. Sandford , 87 – 99 , Elsiever Applied Science , London .
   Google Scholar
• Muzzarelli , R. A. A. ( 1997 ). Human enzymatic activities related to the therapeutic administration of chitin derivative , Cell. Mol. Life Sci. , 53 ( 1 ) 131 – 140 .
   PubMed Web of Science ®Google Scholar
• Muzzarelli , C. and Muzzarelli , R. A. A. ( 2002 ). Natural and artificial chitosan–inorganic composites , J. Inorg. Biochem. , 92 , 89 – 94 .
   PubMed Web of Science ®Google Scholar
• Mwale , F. , Iordanova , M. , Demers , C. N. , Steffen , T. , Roughley , P. , and Antonoiu , J. ( 2005 ). Biological evaluation of chitosan salts cross-linked to genipin as a cell scaffold for disk tissue engineering , Tissue Eng. , 11 ( 1–2 ), 130 – 140 .
   PubMedGoogle Scholar
• Needleman , I. G. and Smales , F. C. ( 1995 ). In vitro assessment of bioadhesion for periodontal and buccal drug delivery , Biomaterials , 16 , 617 – 624 .
   PubMed Web of Science ®Google Scholar
• Norazril , S. A. , Aminuddin , B. S. , Norhayati , M. M. , Mazlyzam , A. L. , and Fauziah , O. ( 2004 ). Comparison of chitosan scaffold and chitosan-collagen scaffold , Med. J. Malaysia , 59 ( Suppl. B ), 186 .
   PubMedGoogle Scholar
• Orienti , I. , Cerchiara , T. , Luppi , B. , Bigucci , F. , Zuccari , G. , and Zecchi , V. ( 2002 ). Influence of different chitosan salt on the release of sodium diclofenac in colon-specific delivery , Int. J. Pharm. , 238 , 52 – 59 .
   Google Scholar
• Pan , J. , Bao , Z. , Li , J. , Zhang , L. , Wu , C. , and Yu , Y. ( 2005 ). Chitosan-based scaffolds for hepatocyte culture , Key Eng. Mater. , 288–289 , 91 – 94 .
   Google Scholar
• Park , C. R. and Munday , D. L. ( 2004 ). Evaluation of selected polysaccharide excipients in buccoadhesive tablets for sustained release of nicotine . Drug Dev. Ind. Pharm. , 30 , 609 – 617 .
   PubMed Web of Science ®Google Scholar
• Park , I. K. , Ihm , J. E. , Park , Y. H. , Choi , Y. J. , Kim , S. I. , Kim , W. J. , Akaike , T. , and Cho , C. S. ( 2003 ). Galactosylated chitosan (GC)-g-poly(vinyl pyrrolidone) (PVP) as hepatocyte-targeting DNA carrier. Preparation and physicochemical characterization of GC-graft-PVP/DNA complex (1) , J. Control. Release , 86 , 349 – 359 .
   PubMed Web of Science ®Google Scholar
• Pourjavadi , A. , Mahdavinia , G. R. , and Zohuriaan-Mehr , M. J. ( 2003 ). Modified chitosan. II. H-chitoPAN, a novel pH-responsive superabsrobent hydrogel , J. Appl. Polym. Sci. , 90 , 3115 – 3121 .
   Web of Science ®Google Scholar
• Prabaharan , M. and Mano , J. F. ( 2005 ). Chitosan-based particles as drug delivery systems , Drug Deliv. , 12 , 41 .
   PubMed Web of Science ®Google Scholar
• Prabaharan , M. , Rodriguez-Perez , M. A. , Saja , J. A. , and Mano , J. A. ( 2006 ). Preparation and characterization of poly (L-lactic acid)-chitosan hybrid scaffolds with drug release capability , J. Biomed. Mater. Res. Part B Appl. Biomater. , 81 B ( 2 ), 427 – 434 .
   Google Scholar
• Prashanth , K. V. and Tharanathan , R. N. ( 2007 ). Chitin/chitosan: Modifications and their application potential—An overview , Trends Food Sci. Technol. , 18 , 117 – 131 .
   Web of Science ®Google Scholar
• Qi , L. and Xu , Z. ( 2006 ). In vivo antitumor activity of chitosan nanoparticles , Bioorg. Med. Chem. Lett. , 16 , 4243 – 4245 .
   PubMed Web of Science ®Google Scholar
• Ramakrishnan , V. , Lathika , K. M. , D'Souza , S. J. , Singh , B. B. , and Raghavan , K. G. ( 1997 ). Investigation with chitosan-oxalate oxidase-catalase conjugates for degrading oxalate from hyperoxaluric rat chyme , Indian J. Biochem. Biophys. , 34 , 373 – 378 .
   PubMed Web of Science ®Google Scholar
• Rao , B. S. and Murthy , K. V. ( 2000 ). Preparation and in vitro evaluation of chitosan matrices cross-linked by formaldehyde vapors , Drug Dev. Ind. Pharm. , 26 , 1085 – 1090 .
   PubMed Web of Science ®Google Scholar
• Ravi Kumar , M. N. V. , Muzzarelli , R. A. A. , Muzzarelli , C. , Shashiwa , H. , and Domb , A. J. ( 2004 ). Chitosan chemistry and pharmaceutical perspectives , Chem. Rev. , 104 ( 12 ), 6017 .
   PubMed Web of Science ®Google Scholar
• Rinaudo , M. ( 2006 ). Chitin and chitosan: Properties and applications , Prog. Polym. Sci. , 31 , 603 – 632 .
   Web of Science ®Google Scholar
• Rutnakornpituk , M. and Ngamdee , P. ( 2006 ). Surface and mechanical properties of microporous membranes of poly(ethylene glycol)-polydimethylsiloxane copolymer/chitosan , Polymer , 47 , 7909 – 7917 .
   Google Scholar
• Rutnakornpituk , M. , Ngamdee , P. , and Phinyocheep , P. (2005). Synthesis, characterization and properties of chitosan modified with poly (ethylene glycol)-polydimethylsiloxane amphiphilic block copolymers, Polymer , 46, 9742–9752.
   Web of Science ®Google Scholar
• Saito , H. , Wu , X. , Harris , J. M. , and Hoffman , A. S. ( 1997 ). Graft copolymers of poly(ethylene glycol) (PEG) and chitosan , Macromol. Rapid Commun. , 18 , 547 – 550 .
   Web of Science ®Google Scholar
• Saito , N. , Okada , T. , Toba , S. , Miyamoto , S. , and Takaoka , K. ( 1999 ). New synthetic absorbable polymers as BMP carriers: Plastic properties of poly-D,L-lactic acid-polyethylene glycol block copolymers , J. Biomed. Mater. Res. , 47 ( 1 ), 104 – 110 .
   PubMed Web of Science ®Google Scholar
• Sashiwa , H. and Aiba , S. I. ( 2004 ). Chemically modified chitin and chitosan s biomaterials , Prog. Polym. Sci. , 29 , 887 – 908 .
   Web of Science ®Google Scholar
• Singh , D. K. and Ray , A. R. ( 2000 ). Biomedical applications of chitin, chitosan, and their derivatives , Polym. Rev. , 40 ( 1 ), 69 – 83 .
   Google Scholar
• Sinswat , P. and Tengamnuay , P. ( 2003 ). Effect of chitosan on nasal absorption , Int. J. Pharm. , 257 , 15 – 22 .
   PubMed Web of Science ®Google Scholar
• Soane , R. J. , Hinchcliffe , M. , Davis , S. S. , and Illum , L. ( 2001 ). Clearance characteristics of chitosan-based formulations in the sheep nasal cavity , Int. J. Pharm. , 17 , 183 – 191 .
   Google Scholar
• Spagna , G. , Barbagallo , R. N. , Greco , E. , Manenti , I. , and Pifferi , P. G. ( 2002 ). A mixture of purified glycosidases from Aspergillus niger for oenological application immobilised by inclusion in chitosan gels , Enzyme Microb. Technol. , 30 , 80 – 89 .
   Web of Science ®Google Scholar
• Suh , J. K. F. and Matthew , H. W. T. ( 2000 ). Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: A review , Biomaterials , 21 , 2589 – 2598 .
   PubMed Web of Science ®Google Scholar
• Sun , T. , Xu , P. , Liu , Q. , Xue , J. , and Xie , W. ( 2003 ). Graft copolymerization of methacrylic acid onto carboxymethyl chitosan , Eur. Polym. J , 39 ( 1 ), 189 – 192 .
   Web of Science ®Google Scholar
• Tan , W. , Krishnarai , R. , and Desai , T. A. ( 2000 ). Influence of chitosan on cell viability and proliferation in three-dimensional collagen gels , in Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society: 23–28 July 2000, Navy Pier Convention Center, Chicago, Illinois, USA , vol. 2 , 1509 – 1524 , IEEE , Piscataway , N.J.
   Google Scholar
• Tanodekaew , S. , Prasitsilp , M. , Swasdison , S. , Thavornyutikarn , B. , Posthsree , T. , and Pateepasen , R. ( 2004 ). Preparation of acrylic grafted chitin for wound dressing application , Biomaterials , 25 , 1453 – 1460 .
   PubMed Web of Science ®Google Scholar
• Thacharodi , D. and Rao , K. P. ( 1995 ). Development and in vitro evaluation of chitosan-based transdermal drug delivery systems for the controlled delivery of propanolol hydrochloride , Biomaterials , 16 , 145 – 148 .
   PubMed Web of Science ®Google Scholar
• Tozaki , H. , Komoike , J. , Tada , C. , Maruyama , T. , Terabe , A. , Suzuki , T. , Yamamoto , A. , and Muranishi , S. ( 1997 ). Chitosan capsules for colon-specific drug delivery, improvement of insulin absorption from the rat colon , J. Pharm. Sci. , 86 , 1016 – 1021 .
   PubMed Web of Science ®Google Scholar
• Turker , S. , Onur , E. , and Ozer , Y. ( 2004 ). Nasal route and drug delivery systems , Pharm. World Sci. , 26 , 137 – 142 .
   PubMed Web of Science ®Google Scholar
• Valenta , C. , Christen , B. , and Bernkop-Schnürch , A. ( 1998 ). Chitosan–EDTA conjugate: A novel polymer for topical gels , J. Pharm. Pharmacol , 50 , 445 – 452 .
   PubMed Web of Science ®Google Scholar
• van der Lubben , I. M. , Kersten , G. , Fretz , M. M. , Beuvery , C. , Coos Verhoef , J. , and Junginger , H. E. ( 2003 ). Chitosan microparticles for mucosal vaccination against diphtheria: Oral and nasal efficacy studies in mice , Vaccine , 28 , 1400 – 1408 .
   Google Scholar
• Varshosaz , J. , Sandrai , H. , and Heidari , A. ( 2006 ). Nasal delivery of insulin using bioadhesive chitosan gels , Drug Deliv. , 13 ( 1 ), 31 – 38 .
   PubMed Web of Science ®Google Scholar
• Vazquer-Duhalt , R. , Tinoco , R. , D'Antonio , P. , Topoleski , L. D. , and Payne , G. F. ( 2002 ). Enzyme conjugation to the polysaccharide chitosan: Smart biocatalysts and biocatalytic hydrogels , Bioconjug. Chem. , 12 , 301 – 306 .
   Google Scholar
• Wang , M. , Chen , L. J. , Ni , J. , Weng , J. , and Yue , C. Y. ( 2001 ). Manufacture and evaluation of bioactive and biodegradable materials and scaffolds for tissue engineering , J. Mater. Sci. Mater. Med. , 12 ( 10 ), 855 – 860 .
   PubMed Web of Science ®Google Scholar
• Wang , L. , Khor , E. , Wee , A. , and Lim , L. Y. (2002a). Chitosan-alginate PEC membranes as a wound dressing: Assessment of incisional wound healing, J. Biomed. Mater. Res. , 63(5), 610–618.
   PubMed Web of Science ®Google Scholar
• Wang , X. , Ma , J. , Wang , Y. , and He , B. ( 2002b ). Bone repair in radii and tibias of rabbits with phosphorylated chitosan reinforced calcium phosphate cements , Biomaterials , 23 , 4167 – 4176 .
   PubMed Web of Science ®Google Scholar
• Wasaki , N. , Yamane , S. T. , and Majima , T. ( 2004 ). Feasibility of polysaccharide hybrid materials for scaffolds in cartilage tissue engineering , Biomacromolecules , 5 , 828 .
   PubMed Web of Science ®Google Scholar
• Wu , T. , Zivanovic , S. , Draughon , F. A. , Conway , W. S. , and Sams , E. C. ( 2005 ). Physicochemical properties and bioactivity of fungal chitin and chitosan , J. Agric. Food Chem. , 53 ( 10 ), 3888 – 3894 .
   PubMed Web of Science ®Google Scholar
• Xie , W. , Xu , P. X. , Liu , Q. , and Xue , J. ( 2002 ). Graft-copolymerization of methylacrylic acid onto hydroxypropyl chitosan , Polym. Bull. , 49 ( 1 ), 47 – 54 .
   Google Scholar
• Xu , H. H. , Quinn , J. B. , Takagi , S. , and Chow , L. C. ( 2004 ). Synergistic reinforcement of in situ hardening calcium phosphate composite scaffold for bone tissue engineering , Biomaterials , 25 , 1029 – 1037 .
   PubMed Web of Science ®Google Scholar
• Yamamoto , H. and Amaike , M. ( 1997 ). Biodegradation of cross-linked chitosan gel by a microorganism , Macromolecules , 30 , 3936 – 3937 .
   Web of Science ®Google Scholar
• Yamada , K. , Chen , T. H. , Kumar , G. , Vesnovsky , O. , Topoleski , L. D. T. , and Payne , G. F. ( 2000 ). Chitosan based water-resistant adhesive. Analogy to mussel glue , Biomacromolecules , 1 , 252 – 258 .
   PubMed Web of Science ®Google Scholar
• Yamane , S. , Iwasaki , N. , Majima , T. , and Funakoshi , T. ( 2005 ). Chitosan-based hyaluronic acid hybrid biomaterial for a novel scaffold in cartilage tissue engineering , Biomaterials , 26 , 611 – 619 .
   PubMed Web of Science ®Google Scholar
• Yang , J. M. and Lin , H. T. ( 2004 ). Properties of chitosan containing PP-g-AA-g-NIPAAm bigraft nonwoven fabric for wound dressing , J. Membr. Sci. , 243 ( 1–2 ), 1 – 7 .
   Web of Science ®Google Scholar
• Yang , S. , Tirmizi , S. A. , Burns , A. , Barney , A. A. , and Risen , W. M. ( 1989 ). Chitaline materials: Soluble chitosan-polyaniline copolymers and their conductive doped forms , Synth. Met. , 32 ( 2 ), 191 – 200 .
   Web of Science ®Google Scholar
• Yazdani-Pedram , M. , Retuert , J. , and Quijada , R. ( 2000 ). Hydrogels based on modified chitosan, 1. Synthesis and swelling behavior of poly(acrylic acid) grafted chitosan , Macromol. Chem. Phys. , 201 ( 4 ), 923 – 930 .
   Google Scholar
• Yoshikawa , S. , Takayama , T. , and Tsubokawa N. ( 1998 ). Grafting reaction of living polymer cations with amino groups on chitosan powder , J. Appl. Polym. Sci. , 68 ( 11 ), 1883 – 1889 .
   Google Scholar
• Zalipsky , S. ( 1995 ). Chemistry of polyethylene glycol conjugates with biologically active molecules , Adv. Drug Deliv. Rev. , 16 , 157 – 182 .
   Web of Science ®Google Scholar
• Zhang , Y. , Ni , M. , Zhang , M. , and Ratner , B. ( 2003 ). Calcium phosphate-chitosan composite scaffolds for bone tissue engineering , Tissue Eng. , 9 , 337 – 345 .
   PubMedGoogle Scholar
• Zhao , F. , Yin , Y. , Lu , W. W. , Leong , J. C. , Zhang , W. , Zhang , J. , Zhang , M. , and Yao , K. ( 2002 ). Preparation and histological evaluation of biomimetic three-dimensional hydroxyapatite/chitosan-gelatin network composite scaffolds , Biomaterials , 23 , 3227 – 3234 .
   PubMed Web of Science ®Google Scholar