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Original Articles

INVITED REVIEW POLYMERIC DELIVERY SYSTEMS FOR CONTROLLED DRUG RELEASE

Pages 1-48 | Received 14 Feb 1980, Published online: 30 Mar 2007

REFERENCES

  • Robinson , J.R. , ed., Sustained and controlled release drug delivery systems, , Marcel Dekker , New York ( 1978 ).
  • Paul , D.R. and Harris , F.W. , eds., Controlled release polymeric formulations, , American Chemical Society Symposium Series 33, Washington ( 1976 ).
  • Tanquary , A.C. and Lacey , R.E. , eds., Controlled release of biologically active agents, Vol. 47 of Advances in Experimental Medicine and Biology, , Plenum Press , New York ( 1974 ).
  • Kostelnik , R.J. , ed., Polymeric delivery systems, , Midland Macromolecular Symposium 5, Gordon and Breach , New York ( 1978 ).
  • Cardarclli , N.F. , ed., Controlled release pesticides formulations, , CRC Press , Boca Raton , Florida ( 1976 ).
  • Kydonieus , A. , ed., Controlled release technology, , CRC Press , Boca Raton , Florida ( 1980 ).
  • Cardarelli , N.F. , ed., Controlled Release Pesticide Symposium, , University of Akron , Ohio ( 1974 ).
  • Harris , F.W. , ed., Proceedings 1975 International Controlled Release Pesticide Symposium. , Wright State University , Dayton , Ohio ( 1975 ).
  • Cardarelli , N.F. , ed., Proceedings of the 1976 Controlled Release Pesticide Symposium, , Akron . Ohio ( 1976 ).
  • Scher . H.B., ed., Controlled release pesticides, , American Chemical Society Symposium Series Vol. 53 , Washington ( 1977 ).
  • Goulding , R.F. , ed., Proceedings of the 1977 Controlled Release Pesticide Symposium, , Oregon Stale University , Corvallis , Oregon ( 1977 ).
  • Montemarrano , G.A. , ed., Proceedings of the 5th International Symposium on Controlled Release of Bioactive Materials, National Bureau of Standards, , Gethersburg , Maryland ( 1978 ).
  • Baker , R.W. , ed., Proceedings of the 6th International Symposium on Controlled Release of Bioactive Materials, , Academic Press , New York (In press).
  • Armaly , M.F. and Rao , K.R. in “ The effect of the pilocarpine Ocusert with different release rates on ocular pressure ,” Invest. Ophthal. , 12 , 491 ( 1973 ).
  • Armaly , M.F. and Rao , K.R. “ The effect of the pilocarpine Ocusert on ocular pressure, ” in Symposium of Ocular Therapy, , I.H. Leopold , ed., C.V. Mosby Co. , St Louis ., Vol. 6 , 80 ( 1973 ).
  • Ditchings , R.A. and Smith , R.J. “ Experience with Pilocarpine Ocuserts ,” Trans Ophthalmol Soc. , UK. 97 ,202( 1977 ).
  • Hillman , J.S. , Walker , A. , and Davies , E.M. “ Management of chronic glaucoma with pilocarpine Ocuserts ,” Trans Ophthalmol Soc , US, 97 , 206 ( 1977 ).
  • Miller , H.A. and Morlot , C. Preliminary note on the use of the pilocarpine Ocusert in primary glaucoma , Bull. Soc. Ophthalmol Fr. , 77 , 397 ( 1979 ).
  • Stewart , R.H. and Novak , S. “ Introduction of the Ocusert Ocular System to an Ophthalmic Practice ,” Ann. Ophthal. , 10 , 325 ( 1978 ).
  • Friedrich , R.L. “ The Pilocarpine Ocusert: A New Drug Delivery System ,” Ann Ophthal, 6 , 1279 , ( 1974 ).
  • Macoul , K.L. and Pavan Langston , D. “ Pilocarpine Ocusert system for sustained control of ocular hypertension ,” Arch. Ophthal. , 93 , 587 ( 1975 ).
  • Worthen , M. , Zimmerman , J. , and Wind , L.A. “ An Evaluation of the Pilocarpine Ocusert ,” Invest. Ophthalmol , 13 , 296 ( 1974 ).
  • Conn , H. Personal Communication , ( 1980 ).
  • Sholiton , D. Personal Communication , ( 1980 ).
  • Katz , J.I. , Kaufman , H.E. , Bresling , C , and Katz , I.M. “ Slow release artificial tears and the treatment of keratitis sicca ,” Ophthalmology , 85 ,787 ( 1978 ),
  • Lamberts , D.W. , Langston , D.P. , and Chu , W. “ A clinical study of slow-releasing artificial tears ,” Ophthalmology. , 85 , 794 ( 1978 ).
  • Refojo , M.F. , Lui , H.S. , Leong , F.L. , and Sidebottom , D. “ Release of a nitrosourea derivative from refillable silicone rubber implants for the treatment of intraocular malignancies ,” J. Bioeng. , 2 , 437 ( 1978 ).
  • Takkar , D. , Jeyaseelan , S , Kinra , G. , Laumas , K.R. and Hingorani , V. “ Endometrial histology and progesterone levels in women using norethindrone acetate implants for contraception ,” Contraception , 17 ,103( 1978 ).
  • Zentner , G.M. , Cardinal , J.R. and Kim , S.W. “ Progestin permeation through polymer membranes II. Diffusion studies on hydrogel membranes ,” J. Pharm. Sci. , 67 , 1352 ( 1978 ).
  • Greene , W.A. and Foote , R.H. “ Release rate of testosterone and estrogens from polydimethylsiloxane implants for extended periods in vivo compared with loss in vitro ,” Int. J. Fertil. , 23 , 128 ( 1978 ).
  • Coutinho , E.M. , Da Silva , A.R. , Mattos , C.E. , Nielsen , N.C. , Osier , M. and Wiese , J. “ Contraception with long-acting subdermal implants I. An effective and acceptable modality in international clinical trials ,” Contraception , 18 , 315 ( 1978 ).
  • Humpel , M. , Kuhne , G. , Schulze , P.E. and Speck , U. “ Injectable depot contraceptive on D-Norgestrel basis I. Pharmacokinetic studies in dogs and baboons ,” Contraception , 15 , 401 ( 1977 ).
  • Spona , J. , Weiner , E. , Nieuweboer , B. , Humpel , M. , Schneider , W.H. and Johansson , E.D. “Injectable depot contraceptives on D-Norgestrel basis II, Clinical pharmacokinetic studies with D-Norgestrel undecylate in women,” Contraception , 15, 413 (1977).
  • Hillier , S.G. , Jha , P. , Griffiths , K. , and Laurnas , K.R. “ Longierm contraception by steroid releasing implants VI. Serum concentrations of norethindrone in women bearing a single silastic implant releasing norethindrone acetate ,” Contraception , 15 , 473 ( 1977 ).
  • Seth , U. , Yadava , H.S. , Agarwal , N. , Laurnas , K.R. and Hingorani , V. “ Effect of a subdermal silastic implant containing norethindrone acetate on human lactation ,” Contraception , 16 , 383 ( 1977 ).
  • Place , V.A. and Pharriss B.B. “ Progress in the development of the ProgestasertTM 65 Progesterone Therapeutic System for Contraception ,” J. Reprod. Med. , 13 , 66 ( 1974 ).
  • Benagiano , G. , and Ermini , M. “ Continuous Steroid Treatment by Subdermal Polysiloxane Implants ,” Acta Eur Fertil. , 3 , 119 ( 1972 ).
  • Zador , G. , Nilsson , B.A. , Nilsson , B. , Sjoberg , N.D. , Westrom , L. and Wiese , J. Clinical Experience with the Uterine Progesterone System (Progestasert®) Contraception , 13 , 559 ( 1976 ).
  • Baker , R.W. , Tuttle , M.E. , Lonsdale , H.K. , and Ayres , J.W. “ Development of an Estriol-Releasing Intrauterine Device ,” J. Pharm. Sci. , 68 , 20 ( 1979 ).
  • Coutinho , E.M. , Mattos , C.E. , Sant'anna , A.R. , Filho , J.A. , Silva , M.C. and Tatum , H.J. “ Further Studies on Long-Term Contraception by Subcutaneous Silastic® Capsules Containing Megestrol acetate ,” Contraception. , 5 , 389 ( 1972 ).
  • Benagiano , G. , Ermini , M. , Carenza , L. , and Donini , P. “ Studies on Sustained Contraceptive Effects with Subcutaneous Polydimethylsiloxane Implants II. Maintenance of Ovarian Function in Patients with Megestrol Acetate Implants ,” Acta Endocrinol , 73 , 347 ( 1973 ).
  • Zaffaroni , A. “ Special Requirements for Hormone Releasing Intrauterine Devices ,” Acta Endocrinol Suppl. , 185 , 423 ( 1974 ).
  • Shahani , S.M. , Kulkarni , P.P. , Bhate , P.A. and Palel , K.L. “ Metabolic and Endocrine Studies in Women Using Norethindrone Acetate ,” Contraception , 19 , 135 ( 1979 ).
  • Odlind , V. , Weiner , E. , and Johansson , E.D. “ Plasma Levels of Norethindrone and Effect upon Ovarian Function during Treatment with Silastic Implants Containing Norethindrone ,” Contraception , 19 , 197 ( 1979 ).
  • Beck , L.R. , Cowsar , D.R. , Lewis , D.H. , Cosgrove , R.J. , Jr., Riddle , C.T. , Lowry , S.L. and Epperly , T. “ A New Long-Acting Injectable Microcapsule System for the Administration of Progesterone ,” Fertil Sleril. , 31 , 545 ( 1979 ).
  • Nilsson , C.G. , Johansson , E.D. , Jackanicz , T.M. , Luukkainen , T. “ Biodegradable Polylactate as a Steroid-Releasing Polymer ” “ Intrauterine Administration of D-Norgestrol ,” Am, J. Obstet. Gynecol. , 122 ,90( 1975 ).
  • Bhalnagar , S. , Srivastava , U.K. , Takkar , D. , Chandra , V.L. , Hingorani , V , and Laurnas , K.R. “ Long-Term Contraception by Steroid-Releasing Implants II. Contraception by a Single Silastic Implant Containing Norethindrone Acetate in Women ,” Contraception , 11 , 505 ( 1975 ).
  • Bloch . R., Kraicer, P.F., Binder, H., and Lobel, E. “ Composite Membrane Estradiol Implant ,” J. Pharm. Sci. , 64 , 832 ( 1975 ).
  • Anderson , L.C. , Wise , D.L. , and Howes , J.F. “ An Injectable Sustained Release Fertility Control System ,” Contraception , 13 , 375 ( 1976 ).
  • Zaffaroni , A. “ Controlled Delivery Therapy is Here ,” Chemtech. , 6 , 756 ( 1976 ).
  • Leafe , T.D. , Sarner , S.F. , Woodland , J.W. , Yolles , S. , Blake , D.A. , and Meyer , F.J. “ Injection Method for Delivery of Long-Acting Narcotic Antagonists ,” Adv. Biochem. Psychopharmacol. , 8 , 569 ( 1973 ).
  • Abrahams , R.A. , and Ronel , S.M. “ Biocompatible Implants for the Sustained Zero-Order Release of Narcotic Antagonists ,” J. Biomed. Mater. Res. , 9 , 355 ( 1975 ).
  • Schwope , A.D. , Wise , D.L. , and Howes , J.F. "Laclic/Glycolic Acid Polymers as Narcotic Antagonist Delivery Systems," Life Sci. , 17 , 1877 ( 1975 ).
  • Chandrasckaran , S.K. , Bayne , W. , and Shaw , J.E. “ Pharmacokinetics of Drug Permeation through Human Skin ,” J. Pharm. Sci. , 67 , 1370 ( 1978 ).
  • Scheuplcin , R.and Blank , I. “ Permeability of the Skin ,” Physiol. Rev. , 51 , 702 ( 1971 ).
  • Michaels , A. , Chandrasekaran , S. and Shaw , J. “ Drug Permeation Through Human Skin: Theory and in vitro Experimental Measurement ,” A.I.Ch.E. Journal. , 21 , 985 ( 1975 ).
  • Halpcrn , B.D. , Solomon , O. , Kopec , L. , Korostoff , E. , and Ackerman , J.L. “ Release of Inorganic Fluoride Ion from Rigid Polymer Matrices, ” in Controlled Release Polymeric Formulations, , D.R. Paul and F.W. Harris, eds., American Chemical Society , Washington , pg 135 ( 1976 ).
  • Cowsar , D.R. , Tarwater , O.R. , and Tanquary , A.C. “ Controlled Release of Fluoride from Hydrogels for Dental Applications, ” in Hydrogels for Medical and Related Applications, , J.D. Andrade, ed., American Chemical Society , Washington , pg 180 ( 1976 ).
  • Goodson , J.M. , Haffajee , A. , and Socransky , S.S. “ Periodontal Therapy by Local Delivery of Tetracycline ,” J. Clin. Periodontology. , 6 , 83 ( 1979 ).
  • Pickup , J.L. , Keen , H. , Parsons , J.A. , and Alberti , K. “Continuous Subcutaneous Insulin Infusion: An Approach to Normal Glycemia,” Brit. J. Med. , 1, 204 (1978).
  • Genuth , S. , and Martin , P. “ Control of Hyperglycemia in Adult Diabetics by Pulsed Insulin Delivery ,” Diabetes , 26 , 571 ( 1977 ).
  • Slama , G. , Hautecouverture , M. , Assan , R. , and Tchobroutsky , G. “ One to Five Days of Continuous Intravenous Infusion on Seven Diabetic Patients ,” Diabetes , 23 , 732 ( 1974 ).
  • Tamborlane , W.V. , Sherwin , R.S. , Genel , M. , and Felig , P. “ Reduction to Normal of Plasma Glucose in Juvenile Diabetes by Subcutaneous Administration of Insulin with a Portable Infusion Pump ,” New Engl. J. Med. , 300 , 573 ( 1979 ).
  • Creque , H.M. , Langer , R. ,and Folkman , J. “ One Month Sustained Release of Insulin from a Polymer Implant ,” Diabetes , 29 , 37 ( 1980 ).
  • Hsieh , D.S.T. , Langer , R. , and Folkman , J. “ Magnetic Modulation of Relase of Macromolecules from Polymers ,” Proc. Nat. Acad. Sci. , submitted.
  • Preis , I. and Langer , R. “ A Single Step Immunization by Sustained Antigen Release ,” J. Immunol, Methods , 28 , 593 ( 1979 ).
  • Langer , R. “ Sustained Release Polymers and Their Use in SingleStep Methods for Immunization, ” in Immunological Techniques, Methods in Enzymology, , H. Van Vunakis and J.J. Langone , eds., Academic Press , N .Y., in press, ( 1980 ).
  • Senge , T. , Tunn , U. , and Ammari , B. “ The Use of Gentamycin-Polymethylmethacrylate Chains for the Treatment of Soft-Tissue Wounds in the Region of Urinary Tract ,” Urology , 17 , 52 ( 1978 ).
  • Wise , D.L. , McCormick, G.J., Willet. G.P., Anderson, L.C., and Howes, J.F. “ Sustained Release of Sulphadiazine ,” J. Pharm. Pharmacol., 30 , 686 , ( 1978 ).
  • Welch , A.B. “ Antibiotics in Acrylic Bone Cement, In Vivo Studies ,” J. Biomed. Mat. Res. , 12 , 843 ( 1978 ).
  • Olanoff , L. , Koinis , T. , and Anderson , J.M. “ Controlled Release of Tetracycline I. In Vitro Studies With a Trilaminate 2-Hydroxyethyl Methacrylate-Methyl Methacrylate System ,” J. Pharm. Sci. , 68 , 1147 ( 1979 ).
  • Olanoff , L. and Anderson , J.M. “ Controlled Release of Tetracycline II. Development of an In Vivo Flow Limited Pharmacokinetic Model ,” J. Pharm. Sci. , 68 , 1151 ( 1979 ).
  • Yolles , S. “ Time-Release Depot for Anticancer Drugs: Release of Drugs Covalently Bonded to Polymers ,” J. Parent Drug Assoc. , 32 , 188 ( 1978 ).
  • Yolles , S. , Aslund , B. , Morton , J.F. , Olson , O.T. , and Rosenberg , B. “ Timed-Release Depot for Anticancer Agents ,” Acta Pharm. Suec. , 15 , 382 ( 1978 ).
  • Langer , R. and Folkman , J. Polymers for the Sustained Release of Proteins and Other Macromolecules , Nature. , 263 , 797 ( 1976 ).
  • Langer , R. and Folkman , J. Sustained Release of Macromolecules from Polymers, in Polymeric Delivery Systems, Midland Macromolecular Monograph, #5. R.J. Kostelnik , Ed., Gordon and Breach , N .Y., pg. 175 ( 1978 ).
  • Langer , R. and Folkman , J. “ Controlled Release of Macromolecules from Polymers, ” in Biomedical Polymers, , E.P. Goldberg and A.K. Nakajima , eds., Academic Press , New York , in press.
  • Langer , R. , Brem , H. , Falterman , K. , Klein , M. , and Folkman , J. “ Isolation of a Cartilage Factor That Inhibits Tumor Neovascularication ,” Science , 193 , 70 ( 1976 ).
  • Brem , S. , Preis , I. , Langer , R. , Brem , H. , Folkman , J. , and Patz , A. “ Inhibition of Neovascularization by an Extract Derived From Vitreous ,” Am. J. Ophthal. , 84 , 323 ( 1977 ).
  • Polverini , P. , Cotran , R. , Gimbrone , M. , and Unanue , E. “ Activated Macrophages Induce Vascular Proliferation ,” Nature. , 269 , 804 ( 1977 ).
  • Gospodarowicz , D. , Bialecki , H. , and Thakral , T.K. “ The Angiogenic Activity of the Fibroblast and Epidermal Growth Factor. ” Exp. Eye Res. , 28 , 501 ( 1979 ).
  • Conn , H. , Berman , M. , Kenyon , K. , Langer , R. , and Gage , J. “ Stromal Vascularization Prevents Corneal Ulceration ,” Invest. Ophthal. , 19 , 362 ( 1980 ).
  • Ausprunk , D. , Falterman , K. , and Folkman , J. “ The Sequence of Events in the Regression of Corneal Capillaries ,” Lab. Invest. , 38 , 284 ( 1978 ).
  • Langer , R. , FefTerman , M. , Gryska , P.V. , and Bergman , K. “ A Simple Method for Studying Chemotaxis Using Sustained Release of Attractants from Inert Polymers ,” Can. J. Microbiol. , 26 , 274 ( 1980 ).
  • Heaton , M.B. “ A Technique for Introducing Localized Long-Lasting Implants in the Chick Embryo. ” J. Embryol. Exp. Morphol. , 39 , 261 ( 1977 ).
  • Chien , Y.W. , Rozek , L.F. and Lambert . H.J. “ Microsealed Drug Delivery Systems I, In Vitro-ln Vivo Correlation on Subcutaneous Release of Deoxycorticosterone acetate and Prolonged Hyperten-sive Animal Model for Cardiovascular Studies ,” J. Pharm. Sci. , 67 , 214 ( 1978 ).
  • Erickson , C.K. , Koch , K.I. , Mehta , C.S. , and McGinity , J.W. “ Sustained Release of Alcohol: Subcutaneous Silastic Implants in Mice ,” Science , 199 , 1457 ( 1978 ).
  • Erickson , C.K. , Koch , K.I. , Mehta , C.S. , and McGinity , J.W. “Chronic Dependence with a Sustained Ethanol Release Implant in Mice,” Life Sci. , 22, 1745 ( 1978).
  • Matsumura , K. , Shors , E.C. , Fu , P.C. , Cohen , A.H. , and Ben field , J.R. “ Sustained-Release Implants of Chemical Carcinogens in the Canine Tracheobronchial Tree ,” Ann. Thorac. Surg. , 25 , 112 ( 1978 ).
  • McGinity , J.W. and Mehta , C.S. “ Preparation of a Sustained Morphine Delivery System in Rats ,” Pharmacol. Biochem. Behav. , 9 , 705 ( 1979 ).
  • Cardarelli , N.F. New Concepts in the Application of Controlled Release Systems to Agriculture, in Controlled Release Polymeric Formulations, , D.R. Paul and F.W. Harris , eds., American Chemical Society , Washington , pg. 208 ( 1976 ).
  • Koestler , R.C. , “ KNOX OUT® 2 FM Insecticide, Microencapsulated Diazinon, ” 6th International Symposium on the Controlled Release of Bioactive Materials, , R. Baker, ed., Academic Press , New York , in press.
  • Bierl , B.A. , DeVilbiss , E.D. and Plimmer , J.R. “ Use of Pheromones in Insect Control Programs: Slow Release Formulations, ” in Controlled Release Polymeric Formulations, , D.R. Paul and F.W. Harris, eds., American Chemical Society , Washington , pg. 265 ( 1976 ).
  • Kydonieus , A.F. , Smith , I.K. , and Beroza , M. “ Controlled Release of Pheromones through Multi-Layered Polymeric Dispensers, ” in Controlled Release Polymeric Formulations, , D.R. Paul and F.W. Harris , eds., American Chemical Society , Washington , pg. 283 ( 1976 ).
  • Castelli , V.J. and Yeager , W.L. “ Organomctallic Polymers: Development of Controlled Release Antifoulants, ” in Controlled Release Polymeric Formulations, , D.R. Paul and F.W. Harris , eds., American Chemical Society , Washington , pg. 239 ( 1976 ).
  • Walker , K.W. Development of Field Evaluation of Controlled Release Molluscicides: A Progress Report, in Controlled Release Polymeric Formulations, , D.R. Paul and F.W. Harris , eds., American Chemical Society , Washington , pg. 295 ( 1976 ).
  • Kydonieus , A.F. , Smith , J.K. , and Beroza , M. “ Application of a New Controlled Release Concept in Household Products, ” in Controlled Release Polymeric Formulation, , D.R. Paul and F.W. Harris , eds., American Chemical Society , Washington , pg. 295 ( 1976 ).
  • Lee , V.H. and Robinson, J.R. “ Methods to Achieve Sustained Drug Delivery–The Physical Approach: Oral and Parenteral Dosage Forms, ” in Sustained and Controlled Release Drug Delivery Systems, , J.R. Robinson, ed., Marcel Dekker , New York , pg. 123 ( 1978 ).
  • Baker , R.W. and Lonsdale , H.K. Controlled Release: Mechanisms and Rates, in Controlled Release of Biologically Active Agents, , Vol. 47 of Advances in Experimental Biology and Medicine, A.C. Tanquary and R.E. Lacey , eds., Plenum Press , New York , pg. 15 ( 1974 ).
  • Paul , D.R. Polymers in Controlled Release Technology, in Controlled Release Polymeric Formulations. , D.R. Paul and F.W. Harris , eds., American Chemical Society , Washington , pg. 1 ( 1976 ).
  • Chang , T.M.S. Artificial Cells, , C.C. Thomas , Springfield , Illinois ( 1972 ).
  • Vandegaer , J.E. , ed., Microencapsulation-Process and Applications, , Plenum Press , New York ( 1974 ).
  • Thies , C. “ Physicochemical Aspects of Microencapsulation ,” Polymer Plast. Technol. Eng. , 5 , 1 ( 1975 ).
  • Chang , T.M.S. “ Encapsulation of Enzymes, Cell Contents, Cells, Vaccines, Antigens, Antiserum, Cofactors, Hormones, and Proteins, ” in Biomedical Applications of Immobilized Enzymes and Proteins, , Vol. 1 , T.M.S. Chang , ed., Plenum Press , New York , pg. 69 ( 1977 ).
  • Gregoriadis , G. “ Targeting of Drugs ,” Nature , 265 , 407 ( 1977 ).
  • Flynn , G.L. , Yalkowsky , S.H. , and Roseman , T.J. “ Mass Transport Phenomena and Models: Theoretical Concepts ,” J. Pharm. Sci. , 63 ,479 ( 1974 ).
  • Crank , J. The Mathematics of Diffusion, , Clarendon Press , Oxford ( 1975 ).
  • Crank , J. and Park , G.S. , eds., Diffusion in Polymers, , Academic Press , New York ( 1968 ).
  • Hopfenberg , H.B. , ed., Permeability of Plastic Films and Coatings to Gases, Vapors, and Liquids, , Vol. 6 , Polymer Science and Technology, Plenum Press , New York ( 1974 ).
  • Michaels , A.S. “ Applications of the Theory of Molecular Transport in Polymers to the Design of Controlled Drug Delivery Systems ,” Polymer Preprints , 20 ( 1 ), 332 ( 1979 ).
  • Zenter , G.M. , Cardinal , J.R. , and Kim , S.W. “ Progestin Permeation through Polymer Membranes I. Diffusion Studies on Plasma-Soaked-Membranes ,” J. Pharm. Sci. , 67 , 1347 ( 1978 ).
  • Desai , S.J. , Singh , P. , Simonelli , A.P. , and Higuchi , W.I. “ Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices II: Quantitation of Procedures ,” J. Pharm. Sci. , 55 , 1224 ( 1965 ).
  • Meares , P. Polymers: Structure and Bulk Properties, , Van Nostrand , London , Chapter 12 ( 1965 ).
  • Lieb , W.R. and Stein , W.D. “ Biological Membranes Behave as Non-Porous Polymeric Sheets with Respect to the Diffusion of Non-Electrolytes ,” Nature , 224 , 240 ( 1969 ).
  • Zenter , G.M. , Cardinal , J.R. , Feijen , J. , and Song , S.K. “ Progestin Permeation through Polymer Membranes III. Polymerization Solvent Effect on Progesterone Permeation through Hydrogel Membranes ,” J. Pharm. Sci. , 68 , 794 ( 1979 ).
  • Zenter , G.M. , Cardinal , J.R. , Feijen , J. , and Song , S.K. “Progestin Permeation through Polymer Membranes IV. Mechanism of Steroid Permeation and Functional Group Contributions to Diffusion through Hydrogel Films,” J. Pharm. Sci. , 68, 970 (1979).
  • Anderson , J. and Quinn , J. Restricted Transport in Small Pores , Biophys. J. , 14 , 130 ( 1974 ).
  • Folkman , J. and Long , D.M. “ The Use of Silicone Rubber as a Carrier for Prolonged Drug Therapy ,” J.Surg. Res. , 4 , 139 ( 1964 ).
  • Higuchi , T. “ Rate of Release of Medicaments from Ointment Bases Containing Drugs in Suspension ,” J. Pharm. Sci. , 50 , 874 ( 1961 ).
  • Higuchi , T. “ Mechanism of Sustained-Action Medication ,” J, Pharm. Sci. , 52 , 1145 ( 1963 ).
  • Roseman , T. J. and Higuchi , W.I. “ Release of Medroxyprogesterone Acetate from a Silicone Polymer ,” 59 , 353 ( 1972 ).
  • Samuelov , Y. , Donbrow , M. and Friedman , M. “ Sustained Release of Drugs from Ethylcellulose-Polyethylene Glycol Films and Kinetics of Drug Release ,” J. Pharm. Sci. , 68 : 325 ( 1979 ).
  • Desai , S.J. , Simonelli , A.P. , and Higuchi , W.I. “ Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices ,” J. Pharm. Sci. , 54 , 1459 ( 1965 ).
  • Desai , S.J. , Singh , P. , Simonelli , A.P. , and Higuchi , W.I. “ Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices III. Quantitative Studies Involving the Polyethylene Plastic Matrix ,” J. Pharm. Sci. , 55 , 1230 ( 1966 ).
  • Desai , S.J. , Singh , P. , Simonelli , A.P. , and Higuchi , W.I. “ Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices IV. Some Studies involving the Polyvinyl Chloride Matrix ,” J. Pharm. Sci. , 55 , 1235 ( 1966 ).
  • Chien , Y. “ Methods to Achieve Sustained Drug Delivery—The Physical Approach: Implants, ” in Sustained and Controlled Release Drug Delivery Systems, , Robinson , J.R. ed., Marcel Dekker , New York , pg. 211 ( 1978 ).
  • Brooke , D. and Washkuhn , R.J. “ Zero Order Drug Delivery System: Theory and Preliminary Testing ,” J. Pharm. Sci. , 66 , 159 ( 1977 ).
  • Lipper , A. and Higuchi , W.I. “ Analysis of Theoretical Behavior of a Proposed Zero-Order Drug Delivery System ,” J. Pharm. Sci. , 66 , 163 ( 1977 ).
  • Rhine , W. , Sukhatme , V. , Hsieh , D.S.T. and Langer , R.S. “ A New Approach to Achieve Zero-Order Release Kinetics from Diffusion Controlled Polymer Matrix Systems, ” in 6th International Symposium on Controlled Release of Bioactive Materials. , R. Baker, ed., Academic Press , New York , in press.
  • Stannett , V.T. , Koros , W.J. , Paul , D.R. , Lonsdale , H.K. , and Baker , R.W. , “ Recent Advances in Membrane Science and Technology ,” Advances in Polymer Science. , 32 , 69 ( 1979 ).
  • Langer , R. and Folkman , J. The Use of Polymers for the Sustained Release of Proteins and Other Macromolecules , Polymer Preprints , 18 ( 2 ), 379 ( 1977 ).
  • Langer , R. , Rhine , W. , Hsieh , D. , and Bawa , R. “ Polymers for the Sustained Release of Macromolecules: Applications and Control of Release Kinetics, ” in 6th International Symposium on Controlled Release of Bioactive Materials, , R. Baker , ed., Academic Press , New York , in press.
  • Rhine , W. , Hsich , D.S.T. , and Langer , R. Polymers for the Sustained Release of Macromolecules: Methods to Fabricate Reproducible Systems and Control Release Kinetics , J. Pharm. Sci. , 69 : 265, ( 1980 ).
  • Rhine , W. , Hsieh , D. , and Langer , R. “ Kinetics of Polymeric Delivery Systems for Proteins and other Macromolecules ,” Polymer Preprints. , 20 ( 1 ), 596 ( 1979 ).
  • Langer , R. “ Bioavailability of Macromolecular Drugs and I ts Control, ” in Bioavailability and the Pharmacokinetic Control of Drug Response, , V.F. Smolen , ed., J. Wiley and Sons . in press, 1980 .
  • Lazarus , J. , Pagliery , M. , and Lachman , L. “ Factors Influencing the Release of a Drug from a Prolonged-Action Matrix. ” J. Pharm. Sci. , 53 , 798 ( 1966 ).
  • Hopfenberg , H.B. Controlled Release from Erodible Slabs, Cylinders, and Spheres, in Controlled Release Polymeric Formulations, , D.R. Paul and F.W. Harris, eds., American Chemical Society , Washington , pg. 26 ( 1976 ).
  • Cooney , D.O. “ Effect of Geometry on the Dissolution of Pharmaceutical tablets and other solids ,” A.I.C.h.E. Journal , 18 ,446( 1972 ).
  • Heller , J. and Baker , R.W. “ Theory and Practice of Controlled Drug Delivery from Bioerodibte Polymers, ” in 6th International Symposium on Controlled Release of Bioactive Materials, , R.W. Baker , ed., Academic Press , New York , in press.
  • Torchilin , V.P. , Tischenko , E.G. , Smirnov , V.N. , and Chazov , E.I. “ Immobilization of Enzymes on Slowly Soluble Carriers ,” J. Biomed. Mat. Res. , 11 , 223 ( 1977 ).
  • Heller , J. , Baker , R.W. , Gale , R.M. , and Rodin , J.O. “ Controlled Drug Release by Polymer Dissolution I. Partial Esters of Maleic Anhydride Copolymers—Properties and Theory ,” J. Appl. Poiym.Sci. , 22 , 1991 ( 1978 ).
  • Heller , J. and Trescony , P.V. “Controlled Drug Release by Polymer Dissolution II. Enzyme-Mediated Device,” J. Pharm. Sci. , 68, 919 (1979).
  • Yolles , S. , Eldridgc , J. , Leafe , T. , Woodland , J. , Blake , D. , and Meyer , F. “ Long-Acting Systems for Narcotic Antagonists, ” in Controlled Release of Biologically Active Agents. , Vol. 47 in Advances in Experimental Biology and Medicine, A.C, Tanquary and R.E, Lacey, eds., Plenum Press , New York , pg. 177 ,( 1974 ).
  • Wise , D.L. , Schwope , A.D. , Harrigan , S.E. , McCarthy , D.A. , and Howes , J.F. Sustained Delivery of a Narcotic Antagonist from Lactic/Glycolic Acid Copolymer Implants , in Polymeric Delivery Systems. Midland Macromolecular Monograph 5, , R.J. Kostelnik , ed., Gordon and Breach , New York , pg. 75 ( 1978 ).
  • Wise , D.L. , Gregory , J.B. , Newberne , P.M. , Bartholow , L.C. , and Stanbury , J.B. “ Results on Biodegradable Cylindrical Subdermal Implants for Fertility Control, ” in Polymeric Delivery Systems, Midland Macromolecular Monograph 5. , R.J. Kostelnik , ed., Gordon and Breach , New York , pg. 121 ( 1978 ).
  • Gupta , D.V.S. and Sparks , R.E. "Mathematical Model for Long-Term Progesterone Release from Injectable Poly(Lactic Acid) Microcapsules In Vitro," in 6th International Symposium on Controlled Release of Bioactive Materials. , R.W. Baker, ed., Academic Press , New York , in press.
  • Harrigan , S.E. , McCarthy , D.A. , Reuning , R. , and Thies , C. “ Release of Naltrexone Pamoate from Injectable Microcapsules, ” in Polymeric Delivery Systems. Midland Macromolecular Monograph 5, , R.J. Kostelnik , ed., Gordon and Breach , New York , pg. 91 ( 1978 ).
  • Gurny , R. , Peppas , N.A. , Harrington , D.D. and Banker , G.S. “ Development of Biodegradable and Injectable Lactices for Controlled Release of Potent Drugs ,” Drug Devel. Ind. Pharmacy , in press.
  • Sidman , K.R. , Schwope , A.D. , Steber , W.D. , Rudolph , S.E. , and Poulin , S.B. “ Biodegradable, Implantable Drug Delivery Depots based on Synthetic Polypeptides, ” in 6th International Symposium on Controlled Release of Bioactive Materials, , R.W. Baker, ed., Academic Press , New York , in press.
  • Capozza , R.C. , Sendelback , L. , and Balkenhol , W.J. “ Preparation and Evaluation of a Bioerodible Naltrexone Delivery System, ” in Polymeric Delivery Systems. Midland Macromolecular Monograph 5. , RJ. Kostelnik, ed., Gordon and Breach , New York , pg. 59 ( 1978 ).
  • Donaruma , L.G. “ Synthetic Biologically Active Polymers, ” Progress in Polymer Sci., , 4 , A.D. Jenkins , ed., Pergamon Press , Oxford ( 1975 ).
  • Ringsdorf , H. “ Synthetic Polymeric Drugs ” in Polymeric Delivery Systems. Midland Macromolecular Symposium 5, , R.J. Kostelnik, ed., Gordon and Breach , New York , pg. 197 ( 1978 ).
  • Trouct , A. “ Carriers for Bioactive Materials, ” in Polymeric Delivery Systems, Midland Macromolecular Symposium 5. , R.J. Kostelnik, ed., Gordon and Breach , New York , pg. 157 ( 1978 ).
  • Goldberg , E. “ Polymeric Affinity Drugs, ” in Polymeric Delivery Systems. Midland Macromolecular Symposium 5. , R.J. Kostelnik , ed., Gordon and Breach , New York , pg. 227 ( 1978 ).
  • Harris , F.W. , Aulabaugh , A.E. , Case , R.D. , Dykes , M.K. , and Feld , W.A. “ Polymers Containing Pendent Herbicide Substituents: Preliminary Hydrolysis Studies, ” in Controlled Release of Polymeric Formulations, , D.R. Paul and F.W. Harris, eds., American Chemical Society , Washington , pg. 222 ( 1976 ).
  • Petersen , R.V. , Anderson, J.H., Fang, S.M., Feijen, J., Gregonis, D.E. and Kim, S.W. “ Studies on Norcthindrone Covalently Bonded to Poly-N5-3 (Hydroxy-n-propyl)L-glutamine, ” Polymer Preprints , 20 , ( 2 ) ( 1979 ).
  • Hopfenberg , H.B. and Hsu , K.C. “ Swelling-Controlled, Constant Rate Delivery Systems ,” Polymer Engineering and Science. , 18 , 1186 ( 1978 ).
  • Langer , R. , Rhine , W. , Hsieh , D.S.T. , and Folkman , J. “ Control of Release Kinetics of Macromolecules such as insulin from Polymers ,” J. Meb. Sci. , in press ( 1980 ).
  • Blackshcar , PJ. “ Implantable Drug-Delivery Systems ,” Scientific American , 241 , 66 ( 1979 ).
  • Theeuwes , F. “ Elementary Osmotic Pump ,” J. Pharm Sci. , 64 , 1987 ( 1975 ).
  • Capozza , R. , Eckenhoff , B. , and Yum , S.I. “ Design and Performance of the Implantable Osmotic Minipump ,” Biomed. Eng. , 1 , 281 ( 1977 ).
  • Parsons , J.A. , Rothwell , D. , and Sharpe , J.F. “ A Miniature Syringe Pump for Continuous Administration of Drugs and Hormones: The Mill-Hill Infuser ,” Lancet , 1 , 77 ( 1977 ).
  • Chandrasekaran , S.K. , Benson , H. , and Urquhart , J. “ Methods to Achieve Controlled Drug Delivery—The Biomedical Engineering Approach, ” in Sustained and Controlled Release Drug Delivery Systems, , Robinson, J., ed., Marcel Dekker , New York , pg. 557 ( 1978 ).

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