Advanced search
Publication Cover
Journal of Obstetrics and Gynaecology Volume 20, 2000 - Issue 4
Submit an article Journal homepage
91
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Fetal fibronectin as a predictor of preterm birth

G. J. Daskalakis, N. E. Papantoniou, N. B. Koutsodimas, Angelika Papapanagiotou, A. J. Antsaklis Department of Obstetrics and Gynaecology, `Alexandra' Maternity Hospital, University of Athens; Department of Biochemistry, University of Athens, Greece; Department of Obstetrics and Gynaecology, `Alexandra' Maternrnity Hospital, University of Athens
Pages 347-353 | Published online: 02 Jul 2009

  • Andersen H. F., Nugent C. E., Wanty S. D. and Hayashi R. H. (1990) Prediction of risk for preterm delivery by ultrasonographic measurement of the cervical length. American Journal of Obstetrics and Gynecology, 163, 859-867.
  • Bartnicki J., Casal D., Kreaden U., Saling E. and Vetter K. (1996) Fetal fibronectin in vaginal specimens predicts preterm delivery and very-low-birth-weight infants. American Journal of Obstetrics and Gynecology, 174, 971-974.
  • Bittar R., Yamasaki A., Sasaki S. and Zugaib M. (1996) Cervical fetal fibronectin in patients at increased risk for preterm delivery. American Journal of Obstetrics and Gynecology, 175, 178-181.
  • Behrman R. E. (1985) Preventing low birth weight: a pediatric perspective. Journal of Pediatrics, 107, 842-854.
  • Besinger R. E., Compton A. A. and Hayashi R. H. (1987) The presence or absence of fetal breathing movements as a predictor of outcome in preterm labor. American Journal of Obstetrics and Gynecology, 157, 753-757.
  • Burrus D., Ernest J. and Veille J. C. (1995) Fetal fibronectin, interleukin-6 and C-reactive protein are useful in establishing prognostic subcategories of idiopathic preterm labor. American Journal of Obstetrics and Gynecology, 173, 1258-1262.
  • Copper R. L., Goldenberg R. L., Creasy R. K., DuBard M. B., Davis R. O., Entman S. S., lams J. D. and Cliver S. P. (1993) A multicenter study of preterm birth weight and gestational age-specific neonatal mortality. American Journal of Obstetrics and Gynecology, 168, 78-83.
  • Creasy R. K. and Merkatz I. R. (1990) Prevention of preterm birth: clinical opinion. Obstetrics and Gynecology, 76, Supplement 1, 25-45.
  • Creasy R. K. (1993) Preterm birth prevention. Where are we? American Journal of Obstetrics and Gynecology, 168, 1223-1230.
  • Faron G., Boulvain M., Lescrainier J. P. and Vokaer A. (1997) A single cervical fetal fibronectin screening test in a population at low risk for preterm delivery: an improvement on clinical indicators? British Journal of Obstetrics and Gynaecology, 104, 697-701.
  • Feinberg R. F., Kliman H. J. and Lockwood C. J. (1991) Is oncofetal fibronectin a trophoblast glue for human implantation? American Journal of Pathology, 138, 537-543.
  • Friedman S. A., De Groot C. J. M., Taylor R. N., Golditsch B. D. and Roberts J. M. (1994) Plasma cellular fibronectin as a measure of endothelial involvement in preeclampsia and intrauterine growth retardation. American Journal of Obstetrics and Gynecology, 170, 838-841.
  • Garite T. J. (1985) Premature rupture of membranes: an enigma of the obstetrician. American Journal of Obstetrics and Gynecology, 151, 1001-1005.
  • Goldenberg R., Mercer B., Meis P., Copper R., Das A. and McNellis D. (1996a) The preterm prediction study: fetal fibronectin testing and spontaneous preterm birth. Obstetrics and Gynecology, 87, 643-648.
  • Goldenberg R., Thom E., Moawad A., Johnson F., Roberts J. and Caritis S. (1996b) The preterm prediction study: fetal fibronectin, bacterial vaginosis, and peripartum infection. Obstetrics and Gynecology, 87, 656-660.
  • Goldenberg R., Mercer B., Iams J., Moawad A., Meis P., Das A., McNellis D., Miodovnik M., Menard K., Caritis S., Thurnau G. and Bottoms S. (1997) The preterm prediction study: patterns of cervicovaginal fetal fibronectin as predictors of spontaneous preterm delivery. American Journal of Obstetrics and Gynecology, 177, 8-12.
  • Greenhagen J. B., Van Wagoner J., Dudley D., Hunter C., Mitchell M., Logsdon V., Kasal D. and Varner M. (1996) Value of fetal fibronectin as a predictor of preterm delivery for a low-risk population. American Journal of Obstetrics and Gynecology, 175, 1054-1056.
  • Hellemans P., Gerris J. and Verdonk P. (1995) Fetal fibronectin detection for the prediction of preterm birth in low risk women. British Journal of Obstetrics and Gynaecology, 102, 207-212.
  • Hillier S. L., Nugent R. P., Eschenbach D. A., Krohn M. A., Gibbs R. S., Martin D. H., Cotch M. F., Edelman R., Pastorek J. G., Rao A. V., McNellis D., Regan J. A., Carey J. C. and Klebanoff M. A. (1995) Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. New England Journal of Medicine, 333, 1737-1742.
  • Huel G., Keller E., Gueguen S., Robert C., Bouyer J., Papiernik E., Mamelle N. and Lauman B. (1989) Effective prevention of preterm birth: the French experience measured at Haguenau. Birth Defects Original Article Series, 25, 1-234.
  • Iams J. D. (1989) Current status of prematurity prevention. Journal of the American Medical Association, 262, 265-266.
  • Iams J. D., Casal D., McGregor J. A., Goodwin T. M., Kreaden U. S., Lowensohn R. and Lockitch G. (1995) Fetal fibronectin improves the accuracy of diagnosis of preterm labor. American Journal of Obstetrics and Gynecology, 173, 141-145.
  • Iams J., Goldenberg R., Mercer B., Moawad A., Thom E., Meis P., McNellis D., Caritis S., Miodovnik M., Menard M., Thurnau G., Bottoms S. and Roberts J. (1998) The preterm prediction study: recurrence risk of spontaneous preterm birth. American Journal of Obstetrics and Gynecology, 178, 1035-1040.
  • Inglis S., Jeremias J., Kuno K., Lescale K., Peeper Q., Chervenak F. and Witkin S. (1994) Detection of tumor necrosis factor-a, interleukin-6 and fetal fibronectin in the lower genital tract during pregnancy: relation to outcome. American Journal of Obstetrics and Gynecology, 171, 5-10.
  • Jackson G. M., Edwin S. S., Varner M. W., Casal D. and Mitchel M. D. (1993) Regulation of fetal fibronectin production in human chorion cells. American Journal of Obstetrics and Gynecology, 169, 1431-1435.
  • Keirse M. J. N. C., Grant A. and King J. F. (1989) Preterm labour. In: Effective Care in Pregnancy and Childbirth, edited by Chalmers I., Enkin M. and Keirse M. J. N. C., Vol. 1., pp. 694-745. Oxford, Oxford University Press.
  • Kurki T., Sivonen A., Renkonen O. V., Savia E. and Ylikorkala O. (1992) Bacterial vaginosis in early pregnancy and pregnancy outcome. Obstetrics and Gynecology, 80, 173-177.
  • Leeson S. and Maresh M. (1993) Fibronectin: a predictor of preterm delivery? British Journal of Obstetrics and Gynaecology, 100, 304-306.
  • Leeson S. C., Maresh M. J. A., Martindale E. A., Mahmood T., Muotune A., Hawkes N. and Baldwin K. J. (1996) Detection of fetal fibronectin as a predictor of preterm delivery in high risk asymptomatic pregnancies. British Journal of Obstetrics and Gynaecology, 103, 48-53.
  • Lockwood C., Senyei A., Dische R., Casal D., Shah K., Thung S., Jones L., Deligdisch L. and Garite T (1991) Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery. New England Journal of Medicine, 325, 669-674.
  • Lockwood C., Wein R., Lapinski R., Casal D., Berkowitz G., Alvarez M. and Berkowitz R. (1993) The presence of cervical and vaginal fetal fibronectin predicts preterm delivery in an inner-city obstetric population. American Journal of Obstetrics and Gynecology, 169, 798-804.
  • Lukes A. S., Thorp J. M., Eucker B. and Pahel-Short L. (1997) Predictors of positivity for fetal fibronectin in patients with symptoms of preterm labor. American Journal of Obstetrics and Gynecology, 176, 639-641.
  • Malak T. M., Sizmur F., Bell S. C. and Taylor D. J. (1996) Fetal fibronectin in cervicovaginal secretions as a predictor of preterm birth. British Journal of Obstetrics and Gynaecology, 103, 648-653.
  • Matsuura H. and Hakomori S. I. (1985) The oncofetal domain of fibronectin defined by the monoclonal antibody FDC-6: its presence in fibronectins from fetal and tumor tissues and its absence from adult tissues and plasma. Proceedings of the National Academy of Sciences of the USA, 82, 6517-6521.
  • Matsuura H., Takio K., Titani K., Greene T., Levery S. B., Salyan M. E. and Hakomori S. (1988) The oncofetal structure of human fibronectin defined by monoclonal antibody FDC-6 unique structural requirement for the antigen specificity provided by a glycosylhexapeptide. Journal of Biological Chemistry, 263, 3314-3322.
  • Matsuura H., Greene T. and Hakomori S. I. (1989) An alpha-N-acetylgalactosaminylation at the threonine residue of adefined peptide sequence creates the oncofetal peptide epitipe in human fibronectin. Journal of Biological Chemistry, 264, 10472-10476.
  • McCormick M. (1991) Trends in rates of low birth weight in the United States. In: Advances in the Prevention of Low Birth Weight, edited by Berendes H. W., Kessel S. and Yaffe S., pp. 3-11. Washington DC: National Center for Education in Maternal and Child Health.
  • McLean M., Walters W. A. W. and Smith R. (1993) Prediction and early diagnosis of preterm labour. A critical review. Obstetrical and Gynecological Survey, 48, 209-225.
  • Morrison J. C., Allbert J. R., McLaughlin B. N., Whitworth N. S., Roberts W. E. and Martin R. W. (1993) Oncofetal fibronectin in patients with false labor as a predictor of preterm delivery. American Journal of Obstetrics and Gynecology, 168, 538-542.
  • Morrison J., Naef R. III, Botti J., Katz M., Belluomini J. and McLaughlin B. (1996) Prediction of spontaneous preterm birth by fetal fibronectin and uterine activity. Obstetrics and Gynecology, 87, 649-655.
  • Mosher D. F. (1984) Physiology of fibronectin. Annual Review of Medicine, 35, 561-575.
  • Nageotte M., Casal D. and Senyei A. (1994) Fetal fibronectin in patients at increased risk for premature birth. American Journal of Obstetrics and Gynecology, 170, 20-25.
  • Oliveira T., De Souza E., Mariani-Neto C. and Camano L. (1998) Fetal fibronectin as a predictor of preterm delivery in twin gestations. International Journal of Gynaecology and Obstetrics, 62, 135-139.
  • Parker J., Bell R. and Brennecke S. (1995) Fetal fibronectin in the cervicovaginal fluid of women with threatened preterm labour as a predictor of delivery before 34 weeks' gestation. Australian and New Zealand Journal of Obstetrics and Gynaecology, 35, 257-261.
  • Peaceman A., Andrews W., Thorp J., Cliver S., Lukes A., Iams J., Coultrip L., Eriksen N., Holbrook R., Elliott J., Ingardia C. and Pietrantoni M. (1997) Fetal fibronectin as a predictor of preterm birth in patients with symptoms: a multicenter trial. American Journal of Obstetrics and Gynecology, 177, 13-18.
  • Riduan J. M., Hillier S. L., Utomo B., Wiknjosastro G., Linnan M. and Kandun N. (1993) Bacterial vaginosis and prematurity in Indonesia: association in early and late pregnancy. American Journal of Obstetrics and Gynecology, 169, 175-178.
  • Rizzo G., Capponi A., Arduini D., Lorido C. and Romanini C. (1996) The value of fetal fibronectin in cervical and vaginal secretions and of ultrasonographic examination of the uterine cervix in predicting premature delivery for patients with preterm labor and intact membranes. American Journal of Obstetrics and Gynecology, 175, 1146-1151.
  • Rizzo G., Capponi A., Vlachopoulou A., Angelini E., Grassi C. and Romanini C. (1997) The diagnostic value of interleukin-8 and fetal fibronectin concentrations in cervical secretions in patients with preterm labor and intact membranes. Journal of Perinatal Medicine, 25, 461-468.
  • Romero R., Avila C., Brekus C. A. and Morotti R. (1991) The role of systemic and intrauterine infection in preterm parturition. Annuals of the New York Academy of Sciences, 622, 355-375.
  • Rozenberg P., Goffinet F., Malagrida L., Giudicelli Y., Perdu M., Houssin I., Femme S. and Nisand I. (1997) Evaluating the risk of preterm delivery: a comparison of fetal fibronectin and transvaginal ultrasonographic measurement of cervical length. American Journal of Obstetrics and Gynecology, 176, 196-199.
  • Rust O. A., Bofill J. A., Arriola R. M., Andrew M. E. and Morrison J. C. (1996) The clinical efficacy of oral tocolytic therapy. American Journal of Obstetrics and Gynecology, 175, 838-842.
  • Sadovsky Y. and Friedman S. A. (1992) Fetal fibronectin and preterm labor. New England Journal of Medicine, 326, 709.
  • Shimoya K., Hashimoto K., Shimizu T., Saji F. and Murata Y. (1998) Effect of sexual intercourse on fetal fibronectin concentration in cervicovaginal secretions. American Journal of Obstetrics and Gynecology, 179, 255-256.
  • Sibille Y., Lwebuga-Mukase J. S., Polomski L., Merrill W. W., Ingbar D. H. and Gee J. B. L. (1986) An in vitro model for polymorphonuclear-leukocyte-induced injury to an extracellular matrix: Relative contribution of oxidants and clastase to fibronectin release from amniotic membranes. American Review of Respiratory Diseases, 134, 134-140.
  • Vartio T. (1983) Fibronectin: multiple interactions assigned to structural domains. Medical Biology, 61, 283-295.
  • Wennerholm U. B., Holm B., Mattsby-Baltzer I., Nielsen T., Platz-Christensen J., Sundell G., Hosseini N. and Hgberg H. (1997) Fetal fibronectin, endotoxin, bacterial vaginosis and cervical length as predictors of preterm birth and neonatal morbidity in twin pregnancies. British Journal of Obstetrics and Gynaecology, 104, 1398-1404.
  • Zhu B. C. R. and Laine R. A. (1987) Development study of human fetal placental fibronectin: alterations in carbohydrates of tissue fibronectin during gestation. Archives of Biochemistry and Biophysics, 252, 1-6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.