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Gynaecology

Metformin in the treatment of clomiphene citrate-resistant women with polycystic ovary syndrome undergoing in vitro fertilisation treatment: A randomised controlled trial

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Pages 651-655 | Published online: 15 Sep 2009

References

  • Cano F, Garcia-Velasco J A, Millet A, Remohi J, Simon C, Pellicer A. Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women. Journal of Assisted Reproduction and Genetics 1997; 14: 254–261
  • De Leo V, Marca A, Peraglia F. Insulin-lowering agents in the management of polycystic ovary syndrome. Endocrine Reviews 2003; 24: 633–667
  • Diamanti-Kandrakis E, Kouli C, Tsianateli T, Bergiele A. Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome. European Journal of Endocrinology 1998; 138: 269–274
  • Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews 1997; 18: 774–800
  • Fedorcsak P, Dale P O, Storeng R, Abyholm T, Tanbo T. The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome: an open-label randomized cross-over trial. Gynecological Endocrinology 2003; 17: 207–214
  • Franks S. The polycystic ovary syndrome. New England Journal of Medicine 1995; 333: 853–861
  • Glueck C J, Awadalla S G, Phillips H, Cameron D, Wang P, Fontaine R N. Polycystic ovary syndrome, infertility, familial thrombophilia, familial hypofibrinolysis, recurrent loss of in vitro fertilized embryos, and miscarriage. Fertility and Sterility 2000; 74: 394–397
  • Glueck C J, Wang P, Goldenberg N, Sieve-Smith L. Pregnancy outcome among women with polycystic ovary syndrome treated with metformin. Human Reproduction 2002; 11: 2858–2864
  • Gordis L. Epidemiology2nd ed. WB Saunders, Philadelphia 2000; 115
  • Jakubowicz D J, Iuorno M J, Jakubowicz S, Roberts K A, Nestler J E. Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 2002; 87: 524–529
  • Khattab S, Fotouh I A, Mohesn I A, Metwally M, Moaz M. Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach. Reproductive Biomedicine Online 2006; 13: 194–197
  • Kjotrod S B, von During V, Carlsen S M. Metformin treatment before IVF/ICSI in women with polycystic ovary syndrome: a prospective, randomized, double blind study. Human Reproduction 2004; 19: 1315–1322
  • Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, et al. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-months trial, followed by open, long-term clinical evaluation. Journal of Clinical Endocrinology and Metabolism 2000; 85: 139–146
  • Moll E, van der Veen F, van Wely M. The role of metformin in polycystic ovary syndrome: a systematic review. Human Reproduction Update 2007; 13: 527–537
  • Nestler J E. Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and clinical implications. Seminars in Reproductive Endocrinology 1997; 15: 111–122
  • Nestler J E, Stovall D, Akhter N, Iuorno M J, Jakubowicz D J. Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome. Fertility and Sterility 2002; 77: 209–215
  • Qublan H S, Malkawi H Y. Metformin in the treatment of clomiphene citrate-resistant women with high BMI and primary infertility: clinical results and reproductive outcome. Journal of Obstetrics and Gynaecology 2005; 25: 55–59
  • Rizk B, Aboulhar M, Smitz J, Ron-El R. The role of vascular endothelial growth factor and interleukins in the pathogenesis of severe ovarian hyperstimulation syndrome. Human Reproduction Update 1997; 3: 255–266
  • Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Human Reproduction 2004; 19: 41–47
  • Stadtmauer L A, Toma S K, Riehl R M, Talbert L M. Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes associated with modulation insulin-like growth factors. Fertility and Sterility 2001; 75: 505–509
  • Stadtmauer L A, Toma S K, Riehl R M, Talbert L M. Impact of metformin therapy on ovarian stimulation and outcome in coasted patients with polycystic ovary syndrome undergoing in vitro fertilization. Reproductive Biomedicine Online 2002; 5: 112–116
  • Tang T, Glanville J, Orsi N, Barth J H, Balen A H. The use of metformin for women with PCOS undergoing IVF treatment. Human Reproduction 2006; 21: 1416–1425
  • Tasdemir S, Ficicioglu C, Yalti S, Gurbuz B, Basaran T, Yildirim G. The effect of metformin treatment to ovarian response in cases in with PCOS. Archives of Gynecology and Obstetrics 2004; 269: 121–124
  • Vanky E, Salvensen K A, Heimstad R, Fougner K J, Romundstad P, Carlsen S M. Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of randomized study. Human Reproduction 2004; 19: 1734–1740
  • WHO. WHO Laboratory Manual for the examination of human semen and semen-cervical mucus interaction3rd ed. Cambridge University Press, Cambridge 1992; 3

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