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Original Article

Serum concentrations of Ang-2 and Flt-1 may be predictive of pregnancy outcome in women with pregnancies of uncertain viability: a phase I exploratory prognostic factor study

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Pages 321-326 | Received 07 Apr 2017, Accepted 07 Jun 2017, Published online: 26 Oct 2017

References

  • Abdallah Y, Daemen A, Kirk E, Pexsters A, Naji O, Stalder C, et al. 2011. Limitations of current definitions of miscarriage using mean gestational sac diameter and crown-rump length measurements: a multicenter observational study. Ultrasound in Obstetrics & Gynecology 38:497–502.
  • Babinszki A, Nyari T, Jordan S, Nasseri A, Mukherjee T, Copperman AB. 2001. Three-dimensional measurement of gestational and yolk sac volumes as predictors of pregnancy outcome in the first trimester. American Journal of Perinatology 18:203–211.
  • Banerjee S, Aslam N, Woelfer B, Lawrence A, Elson J, Jurkovic D. 2001. Expectant management of early pregnancies of unknown location: a prospective evaluation of methods to predict spontaneous resolution of pregnancy. BJOG 108:158–163.
  • Barnhart K, Sammel MD, Chung K, Zhou L, Hummel AC, Guo W. 2004. Decline of serum human chorionic gonadotropin and spontaneous complete abortion: defining the normal curve. Obstetrics & Gynecology 104: 975–981.
  • Bateman BG, Nunley WC Jr., Kolp LA, Kitchin JD 3rd, Felder R. 1990. Vaginal sonography findings and hCG dynamics of early intrauterine and tubal pregnancies. Obstetrics & Gynecology 75:421–427.
  • Bernard KG, Cooperberg PL. 1985. Sonographic differentiation between blighted ovum and early viable pregnancy. American Journal of Roentgenology 144:597–602.
  • Bottomley C, Van Belle V, Pexsters A, Papageorghiou AT, Mukri F, Kirk E, et al. 2011. A model and scoring system to predict outcome of intrauterine pregnancies of uncertain viability. Ultrasound in Obstetrics & Gynecology 37:588–595.
  • Braunstein GD, Rasor J, Danzer H, Adler D, Wade ME. 1976. Serum human chorionic gonadotropin levels throughout normal pregnancy. American Journal of Obstetrics and Gynecology 126:678–681.
  • Brown DL, Emerson DS, Felker RE, Cartier MS, Smith WC. 1990. Diagnosis of early embryonic demise by endovaginal sonography. Journal of Ultrasound in Medicine 9:631–636.
  • Carlson TR, Feng Y, Maisonpierre PC, Mrksich M, Morla AO. 2001. Direct cell adhesion to the angiopoietins mediated by integrins. The Journal of Biological Chemistry 276:26516–26525.
  • Carmeliet P. 2000. Mechanisms of angiogenesis and arteriogenesis. Nature Medicine 6:389–395.
  • Clark DE, Smith SK, Licence D, Evans AL, Charnock-Jones DS. 1998. Comparison of expression patterns for placenta growth factor, vascular endothelial growth factor (VEGF), VEGF-B and VEGF-C in the human placenta throughout gestation. Journal of Endocrinology 159:459–467.
  • Condous G, Okaro E, Bourne T. 2003. The conservative management of early pregnancy complications: a review of the literature. Ultrasound in Obstetrics and Gynecology 22:420–430.
  • Daponte A, Deligeoroglou E, Pournaras S, Hadjichristodoulou C, Garas A, Anastasiadou F, et al. 2013. Interleukin-15 (IL-15) and anti-C1q antibodies as serum biomarkers for ectopic pregnancy and missed abortion. Clinical and Developmental Immunology 2013:637513.
  • Daponte A, Deligeoroglou E, Pournaras S, Tsezou A, Garas A, Anastasiadou F, et al. 2013. Angiopoietin-1 and angiopoietin-2 as serum biomarkers for ectopic pregnancy and missed abortion: a case-control study. Clinica Chimica Acta 415:145–151.
  • Daponte A, Pournaras S, Polyzos NP, Tsezou A, Skentou H, Anastasiadou F, et al. 2011. Soluble FMS-like tyrosine kinase-1 (sFlt-1) and serum placental growth factor (PlGF) as biomarkers for ectopic pregnancy and missed abortion. Journal of Clinical Endocrinology and Metabolism 96:E1444–E1451.
  • Daya S, Woods S, Ward S, Lappalainen R, Caco C. 1991. Transvaginal ultrasound scanning in early pregnancy and correlation with human chorionic gonadotropin levels. Journal of Clinical Ultrasound 19:139–142.
  • Dietz PM, England LJ, Callaghan WM, Pearl M, Wier ML, Kharrazi M. 2007. A comparison of LMP-based and ultrasound based estimates of gestational age using linked California livebirth and prenatal screening records. Paediatric and Perinatal Epidemiology 21:62–71.
  • Elson J, Salim R, Tailor A, Banerjee S, Zosmer N, Jurkovic D. 2003. Prediction of early pregnancy viability in the absence of an ultrasonically detectable embryo. Ultrasound in Obstetrics and Gynecology 21:57–61.
  • Falco P, Milano V, Pilu G, David C, G. Grisolia G, Rizzo N, et al. 1996. Sonography of pregnancies with first-trimester bleeding and a viable embryo: a study of prognostic indicators by logistic regression analysis. Ultrasound in Obstetrics & Gynecology 7:165–169.
  • Folkman J, Klagsbrun M. 1987. Angiogenic factors. Science (New York, N.Y.) 235:442–447.
  • Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB. 2002. Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2. Journal of Clinical Endocrinology and Metabolism 87:4213–4224.
  • Goldstein RB. 1990. Endovaginal sonography in very early pregnancy: new observations. Radiology 176:7–8.
  • Hahlin M, Thorburn J, Bryman I. 1995. The expectant management of early pregnancies of uncertain site. Human Reproduction (Oxford, England) 10:1223–1227.
  • Hately W, Case J, Campbell S. 1995. Establishing the death of an embryo by ultrasound: report of a public inquiry with recommendations. Ultrasound in Obstetrics and Gynecology 5:353–357.
  • Horne AW, Shaw JL, Murdoch A, McDonald SE, Williams AR, Jabbour NH, et al. 2011. Placental growth factor: a promising diagnostic biomarker for tubal ectopic pregnancy. Journal of Clinical Endocrinology and Metabolism 96:E104–E108.
  • Jeve Y, Rana R, Bhide A, Thangaratinam S. 2011. Accuracy of first-trimester ultrasound in the diagnosis of early embryonic demise: a systematic review. Ultrasound in Obstetrics & Gynecology 38:489–496.
  • Kadar N, Caldwell BV, Romero R. 1981. A method of screening for ectopic pregnancy and its indications. Obstetrics and Gynecology 58:162–166.
  • Levi CS, Lyons EA, Zheng XH, Lindsay DJ, Holt SC. 1990. Endovaginal US: demonstration of cardiac activity in embryos of less than 5.0 mm in crown-rump length. Radiology 176:71–74.
  • Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, et al. 1997. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277:55–60.
  • McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM, et al. 2005. REporting recommendations for tumour MARKer prognostic studies (REMARK). British Journal of Cancer 93:387–391.
  • Mol BW, Lijmer JG, Ankum WM, van der Veen F, Bossuyt PM. 1998. The accuracy of single serum progesterone measurement in the diagnosis of ectopic pregnancy: a meta-analysis. Human Reproduction 13:3220–3227.
  • Moons KG, Royston P, Vergouwe Y, Grobbee DE, Altman DG. 2009. Prognosis and prognostic research: what, why, and how? BMJ (Clinical Research Ed.) 338:b375.
  • Muttukrishna S, Suri S, Groome N, Jauniaux E. 2008. Relationships between TGFbeta proteins and oxygen concentrations inside the first trimester human gestational sac. PLoS One 3:e2302.
  • Muttukrishna S, Swer M, Suri S, Jamil A, Calleja-Agius J, Gangooly S, et al. 2011. Soluble Flt-1 and PlGF: new markers of early pregnancy loss? PLoS One 6:e18041.
  • Nagamatsu T, Fujii T, Kusumi M, Zou L, Yamashita T, Osuga Y, et al. 2004. Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia. Endocrinology 145:4838–4845.
  • NICE. 2012. Ectopic pregnancy and miscarriage: diagnosis and initial management. London: NICE.
  • Nyberg DA, Filly RA. 2003. Predicting pregnancy failure in ‘empty’ gestational sacs. Ultrasound in Obstetrics & Gynecology 21:9–12.
  • Nyberg DA, Filly RA, Filho DL, Laing FC, Mahony BS. 1986. Abnormal pregnancy: early diagnosis by US and serum chorionic gonadotropin levels. Radiology 158:393–396.
  • Pennell RG, Needleman L, Pajak T, Baltarowich O, Vilaro M, Goldberg BB, et al. 1991. Prospective comparison of vaginal and abdominal sonography in normal early pregnancy. Journal of Ultrasound in Medicine 10:63–67.
  • Plaisier M, Dennert I, Rost E, Koolwijk P, van Hinsbergh VW, Helmerhorst FM. 2009. Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions. Human Reproduction 24:185–197.
  • Richardson A, Raine-Fenning N, Deb S, Campbell B, Vedhara K. 2017. Anxiety associated with diagnostic uncertainties in early pregnancy. Ultrasound in Obstetrics and Gynecology 50:247–254.
  • Rull K, Tomberg K, Koks S, Mannik J, Mols M, Sirotkina M, et al. 2013. Increased placental expression and maternal serum levels of apoptosis-inducing TRAIL in recurrent miscarriage. Placenta 34:141–148.
  • Savitz DA, Terry JW, Dole N, Thorp JM, Siega-Riz AM, Herring AH. 2002. Comparison of pregnancy dating by last menstrual period, ultrasound scanning and their combination. American Journal of Obstetrics and Gynecology 187:1660–1666.
  • Schouwink MH, Fong BF, Mol BW, van der Veen F. 2000. Ultrasonographic criteria for non-viability of first trimester intra-uterine pregnancy. Early Pregnancy 4:203–213.
  • Seeber BE, Barnhart KT. 2006. Suspected ectopic pregnancy. Obstetrics and Gynecology 107:399–413.
  • Seeber BE, ammel MD, Guo W, Zhou L, Hummel A, Barnhart KT. 2006. Application of redefined human chorionic gonadotropin curves for the diagnosis of women at risk for ectopic pregnancy. Fertility and Sterility 86:454–459.
  • Tongsong T, Wanapirak C, Srisomboon J, Sirichotiyakul S, Polsrisuthikul T, Pongsatha S. 1994. Transvaginal ultrasound in threatened abortions with empty gestational sacs. International Journal of Gynaecology and Obstetrics 46:297–301.
  • Warren WB, Timor-Tritsch I, Peisner DB, Raju S, Rosen MG. 1989. Dating the early pregnancy by sequential appearance of embryonic structures. American Journal of Obstetrics and Gynecology 161:747–753.
  • Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. 2000. Vascular-specific growth factors and blood vessel formation. Nature 407:242–248.
  • Zhang EG, Smith SK, Baker PN, Charnock-Jones DS. 2001. The regulation and localization of angiopoietin-1, -2, and their receptor Tie2 in normal and pathologic human placentae. Molecular Medicine 7:624–635.

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