Are we managing women with Recurrent Miscarriage appropriately? A snapshot survey of clinical practice within the United Kingdom

References

• Brenner B, Hoffman R, Carp H, Dulitsky M, Younis J, 2005. Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study. Journal of Thrombosis and Haemostasis 3:227–229.
   PubMed Web of Science ®Google Scholar
• Bussen S, Sütterlin M, Steck T. 1999. Endocrine abnormalities during the follicular phase in women with recurrent spontaneous abortion. Human Reproduction 14:18–20.
   PubMed Web of Science ®Google Scholar
• Carp H, Dolitzky M, Inbal A. 2003. Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia. Journal of Thrombosis and Haemostasis 1:433–438.
   PubMed Web of Science ®Google Scholar
• Chien PF. 2009. Surveying clinical surveys. BJOG: An International Journal of Obstetrics and Gynaecology 116:1285–1289.
   PubMed Web of Science ®Google Scholar
• Clark P, Walker ID, Langhorne P, Crichton L, Thomson A, Greaves M, et al. 2010. SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage. Blood 115:4162–4167.
   PubMed Web of Science ®Google Scholar
• Clifford K, Rai R, Regan L. 1997. Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Human Reproduction 12:387–389.
   PubMed Web of Science ®Google Scholar
• Clifford K, Rai R, Watson H, Regan L. 1994. An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases. Human Reproduction 9:1328–1332.
   PubMed Web of Science ®Google Scholar
• Coomarasamy A, Devall AJ, Brosens JJ, Quenby S, Stephensen MD, Siera S, et al. 2020. Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence. American Journal of Obstetrics and Gynaecology 223:167–176.
   PubMed Web of Science ®Google Scholar
• Coomarasamy A, Devall AJ, Cheed V, Harb H, Middleton LJ, Gallos ID, et al. 2019. A randomized trial of progesterone in women with bleeding in early pregnancy. The New England Journal of Medicine 380:1815–1824.
   PubMed Web of Science ®Google Scholar
• Coomarasamy A, Williams H, Truchanowicz E, Seed PT, Small R, Quenby S, et al. 2016. PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages – a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation. Health Technology Assessment 20:1–92.
   Web of Science ®Google Scholar
• de Jong PG, Quenby S, Bloemenkamp KWM, Braams-Lisman BAM, de Bruin JP, Coomarasamy A, et al. 2015. ALIFE2 study: low-molecular-weight heparin for women with recurrent miscarriage and inherited thrombophilia-study protocol for a randomized controlled trial. Trials 16:208.
   PubMed Web of Science ®Google Scholar
• Dhillon-Smith RK, Middleton LJ, Sunner KK, Cheed V, Baker K, Farrell-Carver S, et al. 2019. Levothyroxine in women with thyroid peroxidase antibodies before conception. N. Engl. J. Med 380:1316–1325.
   PubMed Web of Science ®Google Scholar
• Empson M, Lassere M, Craig J, Scott J. 2005. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database of Systematic Reviews 2:CD002859.
   Google Scholar
• ESHRE Guideline Group on RPL, Bender Atik R, Christiansen OB, Elson J, Kolte AM, Lewis S, Middeldorp S, et al. 2018. ESHRE guideline: recurrent pregnancy loss. Human Reproduction Open: 2.
   Google Scholar
• Esplin MS, Branch DW, Silver R, Stagnaro-Green A. 1998. Thyroid autoantibodies are not associated with recurrent pregnancy loss. American Journal of Obstetrics and Gynecology 179:1583–1586.
   PubMed Web of Science ®Google Scholar
• Franssen MT, Korevaar JC, van der Veen F, Boer K, Leschot NJ, Goddijn M. 2007. Management of recurrent miscarriage: evaluating the impact of a guideline. Human Reproduction 22:1298–1303.
   PubMed Web of Science ®Google Scholar
• Haas DM, Ramsey PS. 2008. Progestogen for preventing miscarriage. Cochrane Database of Systematic Reviews 2:CD003511.
   Google Scholar
• Jakubowicz DJ, Iuorno MJ, Jakubowicz S, Roberts KA, Nestler JE. 2002. Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism 87:524–529.
   PubMed Web of Science ®Google Scholar
• Jauniaux E, Farquharson RG, Christiansen OB, Exalto NE. 2006. Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Human Reproduction 21:2216–2222.
   PubMed Web of Science ®Google Scholar
• Kaandorp SP, Goddijn M, van der Post JA, Hutten BA, Verhoeve HR, Hamulvak K, et al. 2010. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. The New England Journal of Medicine 362:1586–1596.
   PubMed Web of Science ®Google Scholar
• Keeling D, Mackie I, Moore GW, Greer IA, Greaves M. 2012. Guidelines on the investigation and management of antiphospholipid syndrome. British Journal of Haematology 157:47–58.
   PubMed Web of Science ®Google Scholar
• Li TC, Makris M, Tomsu M, Tuckerman E, Laird S. 2002. Recurrent miscarriage: aetiology, management and prognosis. Human Reproduction Update 8:463–481.
   PubMed Web of Science ®Google Scholar
• Li TC, Spuijbroek MD, Tuckerman E, Anstie B, Loxley M, Laird S. 2000. Endocrinological and endometrial factors in recurrent miscarriage. BJOG: An International Journal of Obstetrics and Gynaecology 107:1471–1479.
   PubMed Web of Science ®Google Scholar
• Mak A, Cheung MW, Cheak AA, Ho RC. 2010. Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression. Rheumatology 49:281–288.
   PubMed Web of Science ®Google Scholar
• McEvoy MD, Hand WR, Stiegler MP, DiLorenzo AN, Ehrenfeld KM, Moran KR, et al. 2016. A smartphone-based decision support tool improves test performance concerning application of the guidelines for managing regional anesthesia in the patient receiving antithombotic or thrombolytic therapy. Anesthesiology 124:186–198.
   PubMed Web of Science ®Google Scholar
• NICE. National Institute for Heath and Care Excellence. Ectopic pregnancy and miscarriage: diagnosis and initial management NICE guideline [NG126], April 2019. [cited 2020 June 18]. Available from: https://www.nice.org.uk/guidance/ng126.
   Google Scholar
• Ogueh O, Chen MF, Spurll G, Benjamin A. 2001. Outcome of pregnancy in women with hereditary thrombophilia. International Journal of Gynaecology and Obstetrics: The Official Organ of the International Federation of Gynaecology and Obstetrics 74:247–253.
   PubMed Web of Science ®Google Scholar
• Palomba S, Falbo A, Orio F, Zullo F. 2009. Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Fertility and Sterility 92:1646–1658.
   PubMed Web of Science ®Google Scholar
• Practice Committee of American Society for Reproductive Medicine. 2013. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertility and Sterility 99:63.
   PubMed Web of Science ®Google Scholar
• Rai R, Backos M, Rushworth F, Regan L. 2000. Polycystic ovaries and recurrent miscarriage-a reappraisal. Human Reproduction 15:612–615.
   PubMed Web of Science ®Google Scholar
• Rai R, Sacks G, Trew G. 2005. Natural killer cells and reproductive failure-theory, practice and prejudice. Human Reproduction (Oxford, England) 20:1123–1126.
   PubMed Web of Science ®Google Scholar
• Rao VR, Lakshmi A, Sadhnani MD. 2008. Prevalence of hypothyroidism in recurrent pregnancy loss in first trimester. Indian Journal of Medical Sciences 62:357–361.
   PubMedGoogle Scholar
• RCOG. Royal College of Obstetricians and Gynaecologists Recurrent Miscarriage, Investigation and Treatment of Couples (Green-top 17), May 2011. [cited 2020 June 18]. Available from: https://www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg17/.
   Google Scholar
• Rushworth FH, Backos M, Rai R, Chilcott IT, Baxter N, Regan L. 2000. Prospective pregnancy outcome in untreated recurrent miscarriers with thyroid autoantibodies. Human Reproduction 15:1637–1639.
   PubMed Web of Science ®Google Scholar
• Russell CD, Young I, Leung V, Morris K. 2015. Healthcare workers’ decision-making about transmission-based infection control precautions is improved by a guidance summary card. Journal of Hospital Infection 90:235–239.
   PubMed Web of Science ®Google Scholar
• Smith R, Shakespeare J, Williams Z, Knight M, Foster C. 2017. Physical activity for pregnant women: an infographic for healthcare professionals. The British Journal of General Practice: The Journal of the Royal College of General Practitioners 67:460.
   PubMed Web of Science ®Google Scholar
• Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, et al. 2018. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Clin. Endocrinol. 89:251–268.
   PubMed Web of Science ®Google Scholar
• The Dutch Society of Obstetrics and Gynaecology (NVOG). 2007. Guideline recurrent miscarriage. The Netherlands: The Dutch Society of Obstetrics and Gynaecology (NVOG).
   Google Scholar
• Triolo G, Ferrante A, Ciccia F, Accardo-Palumbo A, Perino A, Castelli A, et al. 2003. Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss associated with antiphospholipid antibodies. Arthritis and Rheumatism 48:728–731.
   PubMed Web of Science ®Google Scholar
• Tuckerman E, Laird SM, Prakash A, Li TC. 2007. Prognostic value of the measurement of uterine natural killer cells in the endometrium of women with recurrent miscarriage. Human Reproduction 22:2208–2213.
   PubMed Web of Science ®Google Scholar
• van den Boogaard E, Hermens RPMG, Franssen AMHW, Doornbos JPR, Kremer JAM, van der Veen F, et al. 2013. Recurrent miscarriage: do professionals adhere to their guidelines. Human Reproduction 28:2898–2904.
   PubMed Web of Science ®Google Scholar
• van den Boogaard E, Hermens RP, Leschot NJ, Baron R, Vollebergh JH, Bernadus RE, et al. 2011. Identification of barriers for good adherence to a guideline on recurrent miscarriage. Acta Obstetricia et Gynecologica Scandinavica 90:186–191.
   PubMed Web of Science ®Google Scholar
• van den Boogaard E, Vissenberg R, Land JA, van Wely M, van der Post JA, Goddijn M, et al. 2011. Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review. Human Reproduction Update 17:605–619.
   PubMed Web of Science ®Google Scholar
• Ware Branch D, Gibson M, Silver R. 2010. Recurrent miscarriage. The New England Journal of Medicine 363:1740–1747.
   PubMed Web of Science ®Google Scholar
• Wold AS, Arici A. 2005. Natural killer cells and reproductive failure. Current Opinion in Obstetrics & Gynecology 17:237–241.
   PubMed Web of Science ®Google Scholar
• Ziakas PD, Pavlou M, Voulgarelis M. 2010. Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss: a systematic review and meta-analysis. Obstetrics and Gynecology 115:1256–1262.
   PubMed Web of Science ®Google Scholar