109
Views
0
CrossRef citations to date
0
Altmetric
Review Articles

Characteristics of recent clinical investigations into systemic therapy against cervical cancer: systematic analysis of trial details from Clinicaltrials.gov

, &

References

  • Ager BJ, Gallardo-Rincón D, de León DC, Chávez-Blanco A, Chuang L, Dueñas-González A, et al. 2018. Advancing clinical research globally: cervical cancer research network from Mexico. Gynecologic Oncology Reports 25:90–93.
  • Bashir R, Dunn AG. 2016. Systematic review protocol assessing the processes for linking clinical trial registries and their published results. BMJ Open 6:e013048.
  • Califf RM, Zarin DA, Kramer JM, Sherman RE, Aberle LH, Tasneem A, et al. 2012. Characteristics of clinical trials registered in ClinicalTrials.gov, 2007–2010’. JAMA 307:1838–1847.
  • Canadian Cancer Scociety. 2018. Chemotherapy for cervical cancer, Canadian Cancer Scociety. Available from: http://www.cancer.ca/en/cancer-information/cancer-type/cervical/treatment/chemotherapy/?region=on(http://www.cancer.ca/en/cancer-information/cancertype/cervical/treatment/chemotherapy/?region=on
  • Cetina L, Coronel J, Duen A, Cervantes-madrid D. 2012. Emerging drugs for cervical cancer. Expert Opinion Emerging Drugs 17: 203–218.
  • Cetina L, Crombet T, Jiménez-Lima R, Zapata S, Ramos M, Avila S, et al. 2015. A pilot study of nimotuzumab plus single agent chemotherapy as second- or third-line treatment or more in patients with recurrent, persistent or metastatic cervical cancer. Cancer Biology & Therapy 16:684–689.
  • Chan JK, Deng W, Higgins RV, Tewari KS, Bonebrake AJ, Hicks M, et al. 2017. A phase II evaluation of brivanib in the treatment of persistent or recurrent carcinoma of the cervix: an NRG oncology/gynecologic oncology – group study. Gynecologic Oncology 146:554–559.
  • Chen YJA, Del Priore G. 2015. The role of cisplatin alternative regimens with radiotherapy in cervical cancer. Gynecologic Oncology Reports 11:38–40.
  • Cristina A, Rachele DM, Reisner G, Erlich F, Fontes MS, Moralez G. 2016. A phase I study of mTOR inhibitor everolimus in association with cisplatin and radiotherapy for the treatment of locally advanced cervix cancer: PHOENIX I. Cancer Chemotherapy and Pharmacology 78:101–109.
  • Davidson S. 2011. Treatment for advanced cervical cancer: impact on quality of life’. Critical Reviews in Oncology/Hematology 79:24–30.
  • Duenas-Gonzalez A, Serrano-Olvera A, Cetina L, Coronel J. 2014. New molecular targets against cervical cancer. International Journal of Women’s Health 6:1023–1031.
  • Galluzzi L, Vacchelli E, Bravo-San Pedro J-M, Buqué A, Senovilla L, Baracco EE, et al. 2014. Classification of current anticancer immunotherapies’. Oncotarget 5:12472–12508.
  • Glass HE, Glass LM, Difrancesco JJ. 2015. ClinicalTrials.gov: an underutilized source of research data about the design and conduct of commercial clinical trials. Therapeutic Innovation & Regulatory Science 49:218–224.
  • Green J, Kirwan J, Tierney J, Symonds P, Fresco L, Williams C, et al. 2001. Concomitant chemotherapy and radiation therapy for cancer of the uterine cervix. The Cochrane Database of Systematic Reviews CD002225.
  • Guo C, Manjili MH, Subjeck JR, Sarkar D, Fisher PB, Wang X-Y, et al. 2013. Therapeutic cancer vaccines: past, present, and future. Advances in Cancer Research 119:421–475.
  • Hirsch BR, Califf RM, Cheng SK, Tasneem A, Horton J, Chiswell K, et al. 2013. Characteristics of oncology clinical trials. JAMA Internal Medicine 173:972–979.
  • Hreshchyshyn MM, Aron BS, Boronow RC, Franklin EW, Shingleton HM, Blessing JA, et al. 1979. Hydroxyurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. International Journal of Radiation Oncology, Biology, Physics 5:317–322.
  • Kitchener HC, Hoskins W, Small W, Thomas GM, Trimble EL. 2010. The development of priority cervical cancer trials: a Gynecologic Cancer InterGroup report. International Journal of Gynecological Cancer 20:1092–1100.
  • Kunos CA, Andrews SJ, Moore KN, Chon HS, Ivy SP. 2019. Randomized phase II trial of triapine-cisplatin-radiotherapy for locally advanced stage uterine cervix or vaginal cancers . Frontiers in Oncology 9:1067.
  • Kunos CA, Radivoyevitch T, Waggoner S, Debernardo R, Zanotti K, Resnick K, et al. 2013. Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers . Gynecologic Oncology 130:75–80.
  • Kunos CA, Waggoner S, von Gruenigen V, Eldermire E, Pink J, Dowlati A, et al. 2010. Phase I trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical cancer. Clinical Cancer Research 16:1298–1306.
  • Li K, Shi M, Qin S. 2018. Current status and study progress of recombinant human endostatin in cancer treatment. Oncology and Therapy 6:21–43.
  • Longoria TC, Tewari KS. 2015. Pharmacologic management of advanced cervical cancer: antiangiogenesis therapy and immunotherapeutic considerations. Drugs 75:1853–1865.
  • Malkasian GD, Decker DG, Mussey E, Johnson CE. 1964. Preliminary observations on carcinoma of the cervix treated with 5-fluorouracil. American Journal of Obstetrics and Gynecology 88:82–85.
  • Maria J, Prat A, Gil-moreno A, Pérez J, Parera M. 2008. Update on novel therapeutic agents for cervical cancer. Gynecologic Oncology 110:S72–S76.
  • Matulonis UA, Wright A, Campos S, Konstantinopoulos P, Peralta A, MacNeill K, et al. 2017. A single arm, single stage phase II trial of trametinib (GSK1120212) and GSK2141795 in persistent or recurrent cervical cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr CT142.
  • Milosevic MF, Townsley CA, Chaudary N, Clarke B, Pintilie M, Fan S, et al. 2016. Sorafenib increases tumor hypoxia in cervical cancer patients treated with radiation therapy: results of a phase 1 clinical study. International Journal of Radiation Oncology, Biology, Physics 94:111–117.
  • Miyamoto T, Takabe Y, Watanabe M, Terasima T. 1978. Effectiveness of a sequential combination of bleomycin and mitomycin-c on an advanced cervical cancer. Cancer 41:403–414.
  • Moore KN, Sill MW, Miller DS, McCourt C, De Geest K, Rose PG, et al. 2012. A phase I trial of tailored radiation therapy with concomitant cetuximab and cisplatin in the treatment of patients with cervical cancer: a gynecologic oncology group study. Gynecologic Oncology 127:456–461.
  • Naidoo J, Page DB, Wolchok JD. 2014. Immune checkpoint blockade. Hematology/Oncology Clinics of North America 28:585–600.
  • NCT00025233. 2002. Bevacizumab in treating patients with persistent or recurrent cancer of the cervix [Internet]. Available from: ClinicalTrials.gov
  • NCT00049556. 2002. Gefitinib in treating patients with cervical cancer [Internet]. Available from: ClinicalTrials.gov
  • NCT00101192. 2004. Cetuximab and cisplatin in treating patients with advanced, persistent, or recurrent cervical cancer [Internet]. Available from: ClinicalTrials.gov
  • NCT00104910. 2005. Cetuximab, cisplatin, and radiation therapy in treating patients with stage IB, stage II, stage III, or stage IVA cervical cancer [Internet]. Available from: ClinicalTrials.gov
  • NCT00389974. 2007. Sunitinib malate in treating patients with uterine cervical cancer that is stage IVB, recurrent, or cannot be removed by surgery [Internet]. Available from: ClinicalTrials.gov
  • NCT00430781. 2006. Pazopanib plus lapatinib compared to lapatinib alone and pazopanib alone in subjects with metastatic cervical cancer [Internet]. Available from: ClinicalTrials.gov
  • NCT00499031. 2007. Cetuximab in treating patients with persistent or recurrent cervical cancer [Internet]. Available from: ClinicalTrials.gov
  • NCT00518193. 2007. Phase II study, association of cisplatine topotecan and cetuximab in patients whith late or in progress epithelial cancer of the cervix (ERBUS) [Internet]. Available from: ClinicalTrials.gov
  • NCT00803062. 2008. Paclitaxel and cisplatin or topotecan with or without bevacizumab in treating patients with stage IVB, recurrent, or persistent cervical cancer [Internet]. Available from: ClinicalTrials.gov
  • NCT00997009. 2009. Study of adding cetuximab to chemotherapy for the treatment of advanced and/or recurrent cervical cancer (MITO CERV 2) [Internet]. Available from: ClinicalTrials.gov
  • NCT02095119. 2008. A monoclonal antibody, nimotuzumab, as treatment for recurrent or metastatic cervical cancer [Internet]. Available from: ClinicalTrials.gov
  • Oaknin A, Rodriguez-freixinos V. 2016. Bevacizumab in the treatment of cervical cancer – current evidence and next steps. European Oncology & Haematology 12:32–43.
  • Panesar K, Hons B. 2015. Stage-based treatment for cervical cancer. US Pharm 40:HS5–HS9.
  • Caruso C. 2018. Pembrolizumab OK'd for cervical cancer. Cancer Discovery 8:904.
  • Peng H, Chen L, Chen Y-P, Li W-F, Tang L-L, Lin A-H, et al. 2018. The current status of clinical trials focusing on nasopharyngeal carcinoma: a comprehensive analysis of ClinicalTrials.gov database’. PLoS One 13: e0196730.
  • Pfaendler KS, Tewari KS. 2016. Changing paradigms in the systemic treatment of advanced cervical cancer. Am J Obstet Gynecol 214:22–30.
  • Piver MS, Barlow JJ, Vongtama V, Webester J. 1974. Hydroxyurea and radiation therapy in advanced cervical cancer. American Journal of Obstetrics and Gynecology 120:969–972.
  • Piver MS, Barlow JJ, Vongtama V, Blumenson L. 1977. Hydroxyurea as a radiation sensitizer in women with carcinoma of the uterine cervix. American Journal of Obstetrics and Gynecology 129:379–383.
  • Sagae S, Monk BJ, Pujade-Lauraine E, Gaffney DK, Narayan K, Ryu SY, et al. 2016. Advances and concepts in cervical cancer trials: a road map for the future. International Journal of Gynecological Cancer 26:199–207.
  • Schmid BC, Oehler MK. 2015. Improvements in progression-free and overall survival due to the use of anti-angiogenic agents in gynecologic cancers. Current Treatment Options in Oncology 16:318.
  • Seoud M, Lundqvist EÅ, Fujiwara K. 2015. Targeted therapy in gynecologic cancers: ready for prime time? International Journal of Gynaecology and Obstetrics131 Suppl 2:S150–S152.
  • Soonthornthum T, Arias-Pulido H, Joste N, Lomo L, Muller C, Rutledge T, et al. 2011. Epidermal growth factor receptor as a biomarker for cervical cancer. Annals of Oncology 22:2166–2178.
  • Symonds RP, Gourley C, Davidson S, Carty K, McCartney E, Rai D, et al. 2015. Cediranib combined with carboplatin and paclitaxel in patients with metastatic or recurrent cervical cancer (CIRCCa): a randomised, double-blind, placebo-controlled phase 2 trial. The Lancet. Oncology 16:1515–1524.
  • Thaker PH, Salani R, Brady WE, Lankes HA, Cohn DE, Mutch DG, et al. 2017. A phase I trial of paclitaxel, cisplatin, and veliparib in the treatment of persistent or recurrent carcinoma of the cervix: an NRG Oncology Study (NCT#01281852). Annals of Oncology 28:505–511.
  • Tipples K, Powell M. 2011. Clinical trials in cervical cancer. In: Kehoe S, Edmondson RJ, Gore M, McNeish IA, editors. Gynaecological cancers: biology and therapeutics. Cambridge: Cambridge University Press, p. 223–232.
  • WHO (ed.). 2014. Comprehensive cervical cancer control: a guide to essential practice. 2nd ed. Geneva: World Health Organization.
  • Zhang Y, Yang Z, Zhou Y, Pan J, Liu Y. 2015. Efficacy of concurrent single-agent chemotherapy using radiotherapy in patients with cervical cancer: a meta-analysis. International Journal of Clinical and Experimental Medicine 8:8661–8673.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.