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Research Paper

Thymoquinone ameliorates oxidative damage and histopathological changes of developing brain neurotoxicity

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References

  • Grandjean P, Bellinger D, Bergman A, et al. The faroes statement: human health effects of developmental exposure to chemicals in our environment. Basic Clin Pharmacol Toxicol. 2008;102(2):73–75.
  • Flora G, Gupta D, Tiwari A. Toxicity of lead: a review with recent updates. Interdiscip Toxicol. 2012;5(2):47–58.
  • Cory-Slechta DA, Virgolini MB, Rossi-George A, et al. Lifetime consequences of combined maternal lead and stress. Basic Clin Pharmacol Toxicol. 2008;102(2):218–227.
  • Sanders T, Liu Y, Buchner V, et al. Neurotoxic effects and biomarkers of lead exposure: a review. Rev Environ Health. 2009;24(1):15–45.
  • Liu J, Han D, Li Y, et al. Lead affects apoptosis and related gene XIAP and Smac expression in the hippocampus of developing rats. Neurochem Res. 2010;35(3):473–479.
  • Bokara KK, Brown E, McCormick R, et al. Lead-induced increase in antioxidant enzymes and lipid peroxidation products in developing rat brain. Biometals. 2008;21(1):9–16.
  • Bokara KK, Blaylock I, Denise SB, et al. Influence of lead acetate on glutathione and its related enzymes in different regions of rat brain. J Appl Toxicol. 2009;29(5):452–458.
  • Posser T, de Aguiar CBNM, Garcez RC, et al. Exposure of C6 glioma cells to Pb(II) increases the phosphorylation of p38MAPK and JNK1/2 but not of ERK1/2. Arch Toxicol. 2007;81(6):407–414.
  • Ashafaq M, Tabassum H, Vishnoi S, et al. Tannic acid alleviates lead acetate-induced neurochemical perturbations in rat brain. Neurosci Lett. 2016;617:94–100.
  • Taborsky J, Kunt M, Kloucek P, et al. Identification of potential sources of thymoquinone and related compounds in Asteraceae, Cupressaceae, Lamiaceae, and Ranunculaceae families. Cent Eur J Chem. 2012;10(6):1899–1906.
  • Farooqui Z, Ahmed F, Rizwan S, et al. Protective effect of Nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney. Biomed Pharmacother. 2017;85:7–15.
  • Barkat MA, Harshita, Ahmad J, et al. Insights into the targeting potential of thymoquinone for therapeutic intervention against triple-negative breast cancer. Curr Drug Targets. 2018;19(1):70–80.
  • Ozer EK, Goktas MT, Toker A, et al. Thymoquinone protects against the sepsis induced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ damage in rats. Pharmacol Rep. 2017;69(4):683–690.
  • Ustyol L, Demirören K, Kandemir I, et al. Comparative nephroprotective effects of silymarin, N-acetylcysteine, and thymoquinone against carbon tetrachloride-induced nephrotoxicity in rats. Iran Red Crescent MedJ. 2017;19(1):e37746.
  • Hosseinian S, Rad AK, Bideskan AE, et al. Thymoquinone ameliorates renal damage in unilateral ureteral obstruction in rats. Pharmacol Rep. 2017;69(4):648–657.
  • Khalilullah H. Anti-epileptic action of thymoquinone in Molecular and Therapeutic: actions of Thymoquinone. Younnus H, editor. Singapore: Springer; 2018. p. 75–80.
  • Amin B, Hosseinzadeh H. Black Cumin (Nigella sativa) and its active constituent, thymoquinone: an overview on the analgesic and anti-inflammatory effects. Planta Med. 2016;82(1–2):8–16.
  • Elkhayat ES, Alorainy MS, El-Ashmawy IM, et al. Potential antidepressant constituents of Nigella sativa seeds. Pharmacogn Mag. 2016;12(1):S27–31.
  • Khan RA, Najmi AK, Khuroo AH, et al. Ameliorating effects of thymoquinone in rodent models of schizophrenia. Afr J Pharm Pharmacol. 2014;8(15):413–421.
  • Sayeed MSB, Asaduzzaman M, Morshed H, et al. The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. J Ethnopharmacol. 2013;148(3):780–786.
  • Chen L, Li B, Chen B, et al. Thymoquinone alleviates the experimental diabetic peripheral neuropathy by modulation of inflammation. Sci Rep. 2016;6:31656.
  • Adu EK, Yeboah S. The efficacy of the vaginal plug formation after mating for pregnancy diagnosis, and embyonic resorption in utero in the greater cane rat (Thryonomys swinderianus, Temminck). Trop Anim Health Prod. 2000;32(1):1–10.
  • Villeda-Hernandez J, Mendez Armenta M, Barroso-Moguel R, et al. Morphometric analysis of brain lesions in rat fetuses prenatally exposed to low-level lead acetate: correlation with lipid peroxidation. Histol Histopathol. 2006;21(6):609–617.
  • Kassab RB, El-Hennamy RE. The role of thymoquinone as a potent antioxidant in ameliorating the neurotoxic effect of sodium arsenate in female rat. Egypt J Basic Appl Sci. 2017;4(3):160–167.
  • Sepehri H, Ganji F. The protective role of ascorbic acid on hippocampal CA1 pyramidal neurons in a rat model of maternal lead exposure. J Chem Neuroanat. 2016;74(C):5–10.
  • Mustafa HN, Hegazy GA, Awdan SAE, et al. Protective role of CoQ10 or L-carnitine on the integrity of the myocardium in doxorubicin induced toxicity. Tissue Cell. 2017;49(3):410–426.
  • Mustafa HN, El Awdan SA, Hegazy GA, et al. Prophylactic role of coenzyme Q10 and Cynara scolymus L on doxorubicin-induced toxicity in rats: biochemical and immunohistochemical study. Indian J Pharmacol. 2015;47(6):649–656.
  • Mustafa HN, Hussein AM. Does allicin combined with vitamin B-complex have superior potentials than alpha-tocopherol alone in ameliorating lead acetate-induced Purkinje cell alterations in rats? An immunohistochemical and ultrastructural study. Folia Morphol (Warsz). 2016;75(1):76–86.
  • Wang Y, Wang S. Effects of lead exposure on histological structure and antioxidant capacity in the cerebellum of 30-day-old mice. Neural Regen Res. 2011;6(14):1077–1081.
  • Attia AM, Ibrahim FA, Nabil GM, et al. Antioxidant effects of ginger (Zingiber officinale Roscoe) against lead acetate-induced hepatotoxicity in rats. Afr J Pharm Pharmacol. 2013;7(20):1213–1219.
  • Yang J, Song S, Li J, et al. Neuroprotective effect of curcumin on hippocampal injury in 6-OHDA-induced Parkinson’s disease rat. Pathol Res Pract. 2014;210(6):357–362.
  • Chang BJ, Jang BJ, Son TG, et al. Ascorbic acid ameliorates oxidative damage induced by maternal low-level lead exposure in the hippocampus of rat pups during gestation and lactation. Food Chem Toxicol. 2012;50(2):104–108.
  • Dribben WH, Creeley CE, Farber N. Low-level lead exposure triggers neuronal apoptosis in the developing mouse brain. Neurotoxicol Teratol. 2011;33(4):473–480.
  • Hamed EA, Meki AR, Abd El-Mottaleb NA. Protective effect of green tea on lead-induced oxidative damage in rat’s blood and brain tissue homogenates. J Physiol Biochem. 2010;66(2):143–151.
  • Flora SJ, Gautam P, Kushwaha P. Lead and ethanol co-exposure lead to blood oxidative stress and subsequent neuronal apoptosis in rats. Alcohol Alcohol. 2012;47(2):92–101.
  • Dalia M. Effect of using pectin on lead toxicity. J Am Sci. 2010;6(12):541–554.
  • Hassan A, Jassim H. Effect of treating lactating rats with lead acetate and its interaction with vitamin E or C on neurobehavior, development and some biochemical parameters in their pups. Iraqi J Vet Sci. 2010;24(1):45–52.
  • Abdel Moneim AE. Flaxseed oil as a neuroprotective agent on lead acetate-induced monoamineric alterations and neurotoxicity in rats. Biol Trace Elem Res. 2012;148(3):363–370.
  • Sadek K. Barley phenolic compounds impedes oxidative stress in lead acetate intoxicated rabbits. Oxid Antioxid Med Sci. 2012;1(2):141–146.
  • Benammi H, Erazi H, El Hiba O, et al. Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I. PLoS One. 2017;12(3):e0172715.
  • Chen JJ, Dai L, Zhao LX, et al. Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis. Sci Rep. 2015;5:10278.
  • Chibowska K, Baranowska-Bosiacka I, Falkowska A, et al. Effect of Lead (Pb) on Inflammatory Processes in the Brain. Int J Mol Sci. 2016;17(12):2140.
  • Ebrahimi SS, Oryan S, Izadpanah E, et al. Thymoquinone exerts neuroprotective effect in animal model of Parkinson’s disease. Toxicol Lett. 2017;276:108–114.
  • Shao Y, Feng Y, Xie Y, et al. Protective effects of thymoquinone against convulsant activity induced by lithium-pilocarpine in a model of status epilepticus. Neurochem Res. 2016;41(12):3399–3406.
  • Gokce EC, Kahveci R, Gokce A, et al. Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis. J Neurosurg Spine. 2016;24(6):949–959.
  • Farkhondeh T, Samarghandian S, Shahri AMP, et al. The neuroprotective effects of thymoquinone: a review. Dose Response. 2018;16(2):1559325818761455.

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