266
Views
0
CrossRef citations to date
0
Altmetric
Articles

Modulatory effects of concomitant quercetin/sitagliptin administration on the ovarian histological and biochemical alterations provoked by doxorubicin in a streptozotocin-induced diabetic rat model

ORCID Icon, ORCID Icon, , ORCID Icon & ORCID Icon

References

  • Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International diabetes federation diabetes atlas. Diabetes Res Clin Pract. 2019;157:107843.
  • Ling S, Brown K, Miksza JK, et al. Risk of cancer incidence and mortality associated with diabetes: a systematic review with trend analysis of 203 cohorts. Nutr Metab Cardiovasc Dis. 2021;31:14–22.
  • Gallo M, Muscogiuri G, Felicetti F, et al. Adverse glycaemic effects of cancer therapy: indications for a rational approach to cancer patients with diabetes. Metabolism. 2018;78:141–154.
  • Milluzzo A, Tumminia A, Vella V, et al. Short-term adverse effects of anticancer drugs in patients with type 2 diabetes. J Chemother. 2019;31:150–159.
  • Pereyra CE, Dantas RF, Ferreira SB, et al. The diverse mechanisms and anticancer potential of naphthoquinones. Cancer Cell Int. 2019;19:1–20.
  • Samare-Najaf M, Zal F, Safari S, et al. Stereological and histopathological evaluation of doxorubicin-induced toxicity in female rats’ ovary and uterus and palliative effects of quercetin and vitamin E. Hum Exp Toxicol. 2020;39:1710–1724.
  • He M, Zhang T, Yang Y and Wang C. Mechanisms of Oocyte Maturation and Related Epigenetic Regulation. Front Cell Dev Biol. 2021;9:1–18. DOI:10.3389/fcell.2021.654028.
  • Batiha O, Alahmad NA, Sindiani A, et al. Genetics of female infertility: molecular study of newborn ovary homeobox gene in poor ovarian responders. J Hum Reprod Sci. 2019;12:85–91.
  • Chen Y, Yang W, Shi X, et al. The factors and pathways regulating the activation of mammalian primordial follicles in vivo. Front Cell Dev Biol. 2020;8:1018.
  • Li L, Wang B, Zhang W, et al. A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency. Hum Reprod. 2017;32:248–255.
  • Zhang T, He WH, Feng LL, et al. Effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. Regul Toxicol Pharmacol. 2017;86:1–10.
  • Kishi H, Kitahara Y, Imai F, et al. Expression of the gonadotropin receptors during follicular development. Reprod Med Biol. 2018;17:11–19.
  • Casarini L, Lazzaretti C, Paradiso E, et al. Membrane estrogen receptor (GPER) and follicle-stimulating hormone receptor (FSHR) heteromeric complexes promote human ovarian follicle survival. Iscience. 2020;23:101812.
  • Zhai Q-Y, Ge W, Wang -J-J, et al. Exposure to Zinc oxide nanoparticles during pregnancy induces oocyte DNA damage and affects ovarian reserve of mouse offspring. Aging (Albany NY). 2018;10:2170.
  • Qing X, Shi D, Lv X, et al. Prognostic significance of 8-hydroxy-2′-deoxyguanosine in solid tumors: a meta-analysis. BMC Cancer. 2019;19:1–15.
  • Lesjak M, Beara I, Simin N, et al. Antioxidant and anti-inflammatory activities of quercetin and its derivatives. J Funct Foods. 2018;40:68–75.
  • Minaei A, Sabzichi M, Ramezani F, et al. Co-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cells. Mol Biol Rep. 2016;43:99–105.
  • Shawky LM, Morsi AA, El Bana E, et al. The biological impacts of sitagliptin on the pancreas of a rat model of type 2 diabetes mellitus: drug interactions with metformin. Biology (Basel). 2020;9:1–27.
  • El-Agamy DS, Abo-Haded HM, Elkablawy MA. Cardioprotective effects of sitagliptin against doxorubicin-induced cardiotoxicity in rats. Exp Biol Med. 2016;241(14):1577–1587.
  • NIH. Guide for the Care and Use of Laboratory Animals. 8th ed. New York: National Academies Press; 2011. Washington DC (USA).
  • Shawky LM, El BEA, Morsi AA. Stem cells and metformin synergistically promote healing in experimentally induced cutaneous wound injury in diabetic rats. Folia Histochem Cytobiol. 2019;57(3):127–138.
  • Samare-Najaf M, Zal F, Safari S. Primary and secondary markers of doxorubicin-induced female infertility and the alleviative properties of quercetin and vitamin E in a rat model. Reprod Toxicol. 2020;96:316–326.
  • Grotto D, Maria LS, Valentini J, et al. Importance of the lipid peroxidation biomarkers and methodological aspects for malondialdehyde quantification. Quim Nova. 2009;32(1):169–174.
  • Sun YI, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988;34(3):497–500.
  • Montgomery HAC, Dymock JF. Nitric oxide assay. Analyst. 1961;86:414.
  • El‐Attrouny MM, Iraqi MM, Sabike II II, et al. Comparative evaluation of growth performance, carcass characteristics and timed series gene expression profile of GH and IGF-1 in two Egyptian indigenous chicken breeds versus Rhode Island Red. J Anim Breed Genet. 2021;138(4):463–473.
  • Abdelatty AM, Badr OAM, Mohamed SA, et al. Long term conjugated linoleic acid supplementation modestly improved growth performance but induced testicular tissue apoptosis and reduced sperm quality in male rabbit. PLoS One. 2020;15(1):e0226070.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT Method. Methods. 2001;25(4):402–408.
  • Bancroft JD, and Layton C. The Hematoxylins and Eosin. In: Suvarna KS, Suvarna KS, Suvarna KS, editors. Bancroft’s theory and practice of histological techniques E-Book. 8th ed. Elsevier Health Sciences, Amsterdam,; 2019. p. 126–138.
  • Kiernan JA. Immunohistochemistry. In: Kiernan J, editor. Histological and histochemical methods. Theory and practice. 4th ed. Scion Publishing Ltd; Banbury (UK) 2015. p. 454–490.
  • Nishi K, Gunasekaran VP, Arunachalam J, et al. Doxorubicin-induced female reproductive toxicity: an assessment of ovarian follicular apoptosis, cyclicity and reproductive tissue histology in Wistar rats. Drug Chem Toxicol. 2018;41(1):72–81.
  • Olawale F, I I AUI II, U I A. Long-Term Hyperglycemia Impairs Hormonal Balance and Induces Oxidative Damage in Ovaries of Streptozotocin-Induced Diabetic Wistar Rat. Niger J Physiol Sci. 2020;35(1):46–51.
  • Niringiyumukiza JD, Cai H, Chen L, et al. Protective properties of glycogen synthase kinase-3 inhibition against doxorubicin-induced oxidative damage to mouse ovarian reserve. Biomed Pharmacother. 2019;116:108963.
  • Marano S, Minnelli C, Ripani L, et al. Insights into the antioxidant mechanism of newly synthesized benzoxazinic nitrones: in vitro and in silico studies with dpph model radical. Antioxidants (Basel, Switzerland). 2021;10(8). DOI:10.3390/antiox10081224
  • Mis L, Comba B, and Uslu S, et al. Effect of Wheatgrass on DNA damage, oxidative stress index and histological findings in diabetic rats. Int J Morph. 2018;36(4):1235–1240.
  • Poetsch AR. The genomics of oxidative DNA damage, repair, and resulting mutagenesis. Comput Struct Biotechnol J. 2020;18:207–219.
  • Mohan UP, TP PB, Iqbal STA, et al. Mechanisms of Doxorubicin-Mediated Reproductive Toxicity–A Review. Reprod Toxicol. 2021;102:80–89.
  • Morsi AA, Ahmed SB, and Saleh NM, et al. Caspase-3 activities and androgen receptor expression in rats’ testis during the early biochemical and histopathological changes induced by a carcinogen, Diethylnitrosamine: role of probiotics and pyridazine derivatives. Int J Cancer and Biomed Res. 2021;5(4):39–57.
  • Kim S, Kim S-W, Han S-J, et al. Molecular mechanism and prevention strategy of chemotherapy-and radiotherapy-induced ovarian damage. Int J Mol Sci. 2021;22:7484.
  • Xiao S, Zhang J, Liu M, et al. Doxorubicin has dose-dependent toxicity on mouse ovarian follicle development, hormone secretion, and oocyte maturation. Toxicol Sci. 2017;157:320–329.
  • Spears N, Lopes F, and Stefansdottir A, et al. Ovarian damage from chemotherapy and current approaches to its protection. Hum Reprod Update. 2019;25(6):673–693.
  • Sagara M, Suzuki K, Aoki C, et al. Impact of teneligliptin on oxidative stress and endothelial function in type 2 diabetes patients with chronic kidney disease: a case–control study. Cardiovasc Diabetol. 2016;15:1–10.
  • Makino H, Matsuo M, Hishida A, et al. Effect of linagliptin on oxidative stress markers in patients with type 2 diabetes: a pilot study. Diabetol Int. 2019;10:148–152.
  • Luo M, Tian R, Yang Z, et al. Quercetin suppressed NADPH oxidase-derived oxidative stress via heme oxygenase-1 induction in macrophages. Arch Biochem Biophys. 2019;671:69–76.
  • Carlos-Reyes Á, López-González JS, Meneses-Flores M, et al. Dietary compounds as epigenetic modulating agents in cancer. Front Genet. 2019;10:79.
  • Li S, Yuan S, Zhao Q, et al. Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it. Biomed Pharmacother. 2018;100:441–447.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.